The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation
Open accessAbstract
Energy release from cellular storage is mandatory for survival during fasting. This is achieved through lipolysis and liver gluconeogenesis. We show here that in the mouse, gut-derived serotonin (GDS) is upregulated during fasting and that it favors both mechanisms. In adipocytes, GDS signals through the Htr2b receptor to favor lipolysis by increasing phosphorylation and activity of hormone-sensitive lipase. In hepatocytes, GDS signaling through Htr2b promotes gluconeogenesis by enhancing activity of two rate-limiting gluconeogenic enzymes, FBPase and G6Pase. In addition, GDS signaling in hepatocytes prevents glucose uptake in a Glut2-dependent manner, thereby further favoring maintenance of blood glucose levels. As a result, inhibition of GDS synthesis can improve glucose intolerance caused by high-fat diet. Hence, GDS opposes deleterious consequences of food deprivation by favoring lipolysis and liver gluconeogenesis while preventing glucose uptake by hepatocytes. As a result, pharmacological inhibition of its synthesis may contribute to improve type 2 diabetes.
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Cites
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Self-citationMechanisms for Insulin Resistance: Common Threads and Missing Links
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“Circulating levels of insulin and leptin were normal in fed and fasted Tph1gutD/D mice (Figures S2D and S2E), and there was no evidence of transformation of white fat into brown fat in Tph1gutD/D mice as reported for FGF21-deficient animals (Fisher et al., 2012) (Figure S2C).”
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Cited by
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180
The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Martin, A. M., Sun, E. W., Rogers, G. B., & Keating, D. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00428 · Cited by 384
Gut Microbiota-Dependent Modulation of Energy Metabolism
Heiss, C. N., & Olofsson, L. E. (2018) · Journal of Innate Immunity · doi:10.1159/000481519 · Cited by 310
Non-conventional features of peripheral serotonin signalling — the gut and beyond
Spohn, S. N., & Mawe, G. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.51 · Cited by 282
Inter-organ cross-talk in metabolic syndrome
Priest, C., & Tontonoz, P. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0145-5 · Cited by 279
Metadata
- Authors
- Sumara, G., Sumara, O., Kim, J. K., & Karsenty, G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 16
- Issue
- 5
- Pages
- 588-600
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2138071306
- Cited by
- 224
- References
- 13
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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