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Cited by 328Sodium Intake and HealthRenin-Angiotensin System StudiesElectrolyte and hormonal disorders

The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.

Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance

Open access
Rakova, Natalia, Jüttner, Kathrin, Dahlmann, Anke, Schröder, Agnes, Linz, Peter, Kopp, Christoph, Rauh, Manfred, Goller, Ulrike, Beck, Luis, Agureev, Alexander, Vassilieva, Galina, Lenkova, Liubov, Johannes, Bernd, Wabel, Peter, Moissl, Ulrich, Vienken, Jörg, Gerzer, Rupert, Eckardt, Kai-Uwe, Müller, Dominik N., Kirsch, Karl, Morukov, Boris, Luft, Friedrich C., Titze, Jens·2013·Cell Metabolism
DOI 10.1016/j.cmet.2012.11.013
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Abstract

The steady-state concept of Na(+) homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na(+) is rapidly eliminated into urine, thereby achieving constant total-body Na(+) and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the predicted constancy in urinary excretion and total-body Na(+) content. At constant salt intake, daily Na(+) excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na(+) storage. Changes in total-body Na(+) (±200-400 mmol) exhibited longer infradian rhythm periods (about monthly and longer period lengths) without parallel changes in body weight and extracellular water and were directly related to urinary aldosterone excretion and inversely to urinary cortisol, suggesting rhythmic hormonal control. Our findings define rhythmic Na(+) excretory and retention patterns independent of blood pressure or body water, which occur independent of salt intake.

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Crossref · 10.1016/j.cmet.2012.11.013

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  1. Kirkendall, 1976, The effect of dietary sodium chloride on blood pressure, body fluids, electrolytes, renal function, and serum lipids of normotensive man, J. Lab. Clin. Med., 87, 411

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Metadata

Authors
Rakova, N., Jüttner, K., Dahlmann, A., Schröder, A., Linz, P., Kopp, C., Rauh, M., Goller, U., Beck, L., Agureev, A., Vassilieva, G., Lenkova, L., Johannes, B., Wabel, P., Moissl, U., Vienken, J., Gerzer, R., Eckardt, K.-U., Müller, D. N., Kirsch, K., Morukov, B., Luft, F. C., & Titze, J.
Affiliations
  • Russian Academy of Sciences (RU)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
  • Fresenius Medical Care (Germany) (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • Vanderbilt University (US)
Corresponding author
Titze, Jens
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2013-01
Volume
17
Issue
1
Pages
125-131
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2012.11.013
OpenAlex
W1975967728
Cited by
328
References
33
Citations by year
2026: 7 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 28 · 2021: 37 · 2020: 25 · 2019: 37 · 2018: 25 · 2017: 38 · 2016: 25 · 2015: 33 · 2014: 23 · 2013: 12
FWCI
28.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • elib (German Aerospace Center) (submittedVersion)
Funders
Bundesministerium für Wirtschaft und Technologie
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords
sodium homeostasis, infradian rhythms, circaseptan rhythm, sodium excretion, aldosterone, cortisol, salt restriction, extracellular water
MeSH terms
Adult, Aldosterone, Blood Pressure, Humans, Hydrocortisone, Ions, Male, Periodicity, Sodium, Sodium Chloride, Dietary, Space Simulation

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