The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies
Open accessAbstract
SUMMARY A common thread among conserved lifespan regulators lies within intertwined roles in metabolism and energy homeostasis. We show that heterozygous mutations of adenosine monophosphate (AMP) biosynthetic enzymes extend Drosophila lifespan. The lifespan benefit of these mutations depends upon increased AMP to adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to ATP ratios and adenosine monophosphate-activated protein kinase (AMPK). Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended lifespan, while AMPK RNAi reduced lifespan. Supplementing adenine, a substrate for AMP biosynthesis, to the diet of long-lived AMP biosynthesis mutants reversed lifespan extension. Remarkably, this simple change in diet also blocked the pro-longevity effects of dietary restriction. These data establish AMP biosynthesis, adenosine nucleotide ratios, and AMPK as determinants of adult lifespan, provide a mechanistic link between cellular anabolism and energy sensing pathways, and indicate that dietary adenine manipulations might alter metabolism to influence animal lifespan.
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Cites
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610
AMPK at the Nexus of Energetics and Aging
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.024 · Cited by 372
Fat Body Biology in the Last Decade
Li, S., Yu, X., & Feng, Q. (2019) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-112007 · Cited by 331
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325
Metadata
- Authors
- Stenesen, D., Suh, J. M., Seo, J., Yu, K., Lee, K.-S., Kim, J.-S., Min, K.-J., & Graff, J. M.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 17
- Issue
- 1
- Pages
- 101-112
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2021469756
- Cited by
- 192
- References
- 10
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stenesen, D., Suh, J. M., Seo, J., Yu, K., Lee, K.-S., Kim, J.-S., Min, K.-J., & Graff, J. M. (2013). Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.12.006
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