Cited by 121Atherosclerosis and Cardiovascular DiseasesGenetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative Stress

Dietary Restriction Reduces Atherosclerosis and Oxidative Stress in the Aorta of Apolipoprotein E-Deficient Mice

Guo, ZhongMao, Mitchell-Raymundo, Felicia, Yang, Hong, Ikeno, Yuji, Nelson, James, Diaz, Vivian, Richardson, Arlan, Reddick, Robert·2002·Mechanisms of Ageing and Development

Abstract

Dietary restriction (DR) has been shown to inhibit almost all the age-related diseases, e.g. cardiomyopathy and cancers, in rodents. However, there is little information for the effect of DR on atherosclerosis. In the present study, we examined the effect of DR on the development of atherosclerosis in mice homozygous knockout for apolipoprotein E gene (ApoE(-/-)). The ApoE(-/-) mice were fed either ad libitum (AL) or 60% of the diet consumed by the mice fed AL. Atherosclerotic lesions in the proximal aorta of these mice were measured. Our results showed that ApoE(-/-) mice fed the calorie-restricted diet had smaller and relatively early stages of atherosclerotic lesions (e.g. foam cells and free lipids) when compared to ApoE(-/-) mice fed AL, who developed more advanced lesions (e.g. fibrous caps and acellular areas). In addition, ApoE(-/-) mice fed the calorie-restricted diet showed a significant decrease in the level of lipid hydroperoxides and the production of superoxide and hydrogen peroxide in the aorta as compared to ApoE(-/-) mice fed AL. These observations suggest that reduction of oxidative stress in the arterial wall may contribute to the anti-atherogenic effect of DR in ApoE(-/-) mice.

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Crossref · 10.1016/s0047-6374(02)00008-8

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Authors
Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Guo, ZhongMao
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2002-04
Volume
123
Issue
8
Pages
1121-1131
ISSN
0047-6374 (ISSN-L)
OpenAlex
W2034827383
Cited by
121
References
60
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 8
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • National Institute on Aging (AG16998, P01 AG-13319, R01AG016998)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
dietary restriction, caloric restriction, atherosclerosis, ApoE-deficient mice, oxidative stress, lipid peroxidation, superoxide, hydrogen peroxide, aortic lesions, foam cells, antiatherogenic effects, aging
MeSH terms
Animals, Aorta, Apolipoproteins E, Arteriosclerosis, Energy Intake, Cholesterol, Diet, Disease Models, Animal, Hydrogen Peroxide, Lipoproteins, LDL, Male, Superoxides, Lipid Peroxidation, Mice, Knockout, Oxidative Stress, Mice

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