The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
Open accessAbstract
Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase α subunit AAK-2 is activated by AMP and functions to extend lifespan. In addition, either an environmental stressor that increases the AMP:ATP ratio or mutations that lower insulin-like signaling extend lifespan in an aak-2 -dependent manner. Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals.
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AMPK has been shown to decrease the senescence-associated secretory phenotype and extend lifespan.
“The role of AMPK as a regulator of senescence is interesting and has been shown to decrease the senescence-associated secretory phenotype and to extend lifespan41,42.”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [41]
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- Authors
- Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-12-01
- Volume
- 18
- Issue
- 24
- Pages
- 3004-3009
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC535911
- OpenAlex
- W2130016073
- Cited by
- 643
- References
- 37
- Citations by year
- 2026: 25 · 2025: 16 · 2024: 29 · 2023: 33 · 2022: 23 · 2021: 26 · 2020: 34 · 2019: 25 · 2018: 32 · 2017: 35 · 2016: 46 · 2015: 51 · 2014: 38 · 2013: 36 · 2012: 29
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- AMPK, aak-2, AMP/ATP ratio, energy sensing, lifespan extension, insulin-like signaling, Caenorhabditis elegans, aging, environmental stress, life expectancy prediction
- MeSH terms
- Adenosine Monophosphate, Adenosine Triphosphate, Age Factors, Aging, Animals, Crosses, Genetic, Energy Metabolism, Insulin, Longevity, Multienzyme Complexes, Temperature, Signal Transduction, Mutagenesis, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Sequence Analysis, DNA, DNA Primers, Gene Transfer Techniques, Animals, Genetically Modified, Immunoprecipitation, Green Fluorescent Proteins, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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