Cited by 643Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

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Apfeld, Javier, O'Connor, Greg, McDonagh, Tom, DiStefano, Peter S., Curtis, Rory·2004·Genes & Development

Abstract

Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans AMP-activated protein kinase α subunit AAK-2 is activated by AMP and functions to extend lifespan. In addition, either an environmental stressor that increases the AMP:ATP ratio or mutations that lower insulin-like signaling extend lifespan in an aak-2 -dependent manner. Thus, AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals.

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Authors
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R.
Venue
Genes & Development
Published
2004-12-01
Volume
18
Issue
24
Pages
3004-3009
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2130016073
Cited by
643
References
37
Citations by year
2026: 25 · 2025: 16 · 2024: 29 · 2023: 33 · 2022: 23 · 2021: 26 · 2020: 34 · 2019: 25 · 2018: 32 · 2017: 35 · 2016: 46 · 2015: 51 · 2014: 38 · 2013: 36 · 2012: 29
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
AMPK, aak-2, AMP/ATP ratio, energy sensing, lifespan extension, insulin-like signaling, Caenorhabditis elegans, aging, environmental stress, life expectancy prediction
MeSH terms
Adenosine Monophosphate, Adenosine Triphosphate, Age Factors, Aging, Animals, Crosses, Genetic, Energy Metabolism, Insulin, Longevity, Multienzyme Complexes, Temperature, Signal Transduction, Mutagenesis, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Sequence Analysis, DNA, DNA Primers, Gene Transfer Techniques, Animals, Genetically Modified, Immunoprecipitation, Green Fluorescent Proteins, AMP-Activated Protein Kinases

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