Beyond the Sympathetic Tone: The New Brown Fat Activators

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

López, M., Varela, L., Vazquez, M. J., Rodríguez‐Cuenca, S., González, C. R., Velagapudi, V., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2207 · Cited by 682 · see citing works

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573 · see citing works

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

Li, Y., Kleiner, S., Wu, J., Sah, R., Gupta, R. K., Banks, A. S., Cohen, P., Khandekar, M. J., Boström, P., Mepani, R. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.034 · Cited by 340 · see citing works

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

Sellayah, D., Bharaj, P., & Sikder, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.010 · Cited by 259 · see citing works

Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice

Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244 · see citing works

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

Ma, S., Yu, H., Zhao, Z., Luo, Z., Chen, J., Ni, Y., Jin, R., Ma, L., Wang, P., Zhu, Z., et al. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs001 · Cited by 239 · see citing works

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat‐Durebex, C., Ananthakrishnan, G., Rohner‐Jeanrenaud, F., Drucker, D. J., DiMarchi, R. D., et al. (2012) · Diabetes · doi:10.2337/db11-1556 · Cited by 238 · see citing works

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

Kiefer, F. W., Vernochet, C., O’Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.2757 · Cited by 210 · see citing works

A Novel Regulatory Pathway of Brown Fat Thermogenesis

Alvarez, R., de Andrés, J., Yubero, P., Viñas, O., Mampel, T., Iglesias, R., Giralt, M., & Villarroya, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5666 · Cited by 194 · see citing works

Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation

Brito, N. A., Brito, M. N., & Bartness, T. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00068.2008 · Cited by 137 · see citing works

Toxicity of Weight Loss Agents

Yen, M., & Ewald, M. B. (2012) · Journal of Medical Toxicology · doi:10.1007/s13181-012-0213-7 · Cited by 132 · see citing works

Orexin neurons are indispensable for stress-induced thermogenesis in mice

Zhang, W., Sunanaga, J., Takahashi, Y., Mori, T., Sakurai, T., Kanmura, Y., & Kuwaki, T. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195099 · Cited by 128 · see citing works

Cardiotrophin-1 Is a Key Regulator of Glucose and Lipid Metabolism

Moreno-Aliaga, M. J., Pérez-Echarri, N., Marcos‐Gómeź, B., Larequi, E., Gil-Bea, F. J., Viollet, B., Gimenez-Lopez, I., Martínez, J. A., Prìeto, J., & Bustos, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.013 · Cited by 113 · see citing works

A new biomarker for mitochondrial disease

Turnbull, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70172-7 · Cited by 6 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Obesity Pathogenesis: An Endocrine Society Scientific Statement

Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727 · see citing works

Toward an understanding of how immune cells control brown and beige adipobiology

Villarroya, F., Cereijo, R., Villarroya, J., Gavaldà-Navarro, A., & Giralt, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.006 · Cited by 198 · see citing works

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178 · see citing works

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154 · see citing works

Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice

Yao, Z., Yan, Y., Zheng, X., Wang, M., Zhang, H., Li, H., & Chen, W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05899 · Cited by 49 · see citing works

Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice

Worsch, S., Heikenwalder, M., Hauner, H., & Bader, B. L. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0291-x · Cited by 34 · see citing works

Brown Adipose Tissue: More Than an Effector of Thermogenesis?a

Cannon, B., Houštěk, J., & Nedergaard, J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08325.x · Cited by 124 · see citing works

Influence of amphetamine on brown adipose thermogenesis.

Pj, W. (1983) · PubMed · Cited by 12 · see citing works

Energy expenditure and thermogenesis: animal studies on brown adipose tissue.

Trayhurn, P. (1990) · PubMed · Cited by 12 · see citing works

Thermogenesis in normal rabbits and rats: no role for brown adipose tissue?

Brockway, J. M., & Lobley, G. E. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013692 · Cited by 7 · see citing works

Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice

Trayhurn, P., Douglas, J. B., & McGuckin, M. M. (1982) · Nature · doi:10.1038/298059a0 · Cited by 153 · see citing works