Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Obesity

Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works

Frontiers in Microbiology

Nevalainen, H. K. M., & Peterson, R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00075 · Cited by 1,615 · see citing works

The Science and Translation of Lactate Shuttle Theory

Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486 · see citing works

Monocarboxylate transporters in cancer

Payen, V. L., Mina, E., Hée, V. F. V., Porporato, P. E., & Sonveaux, P. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.07.006 · Cited by 665 · see citing works

Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, gpr81

Liu, C., Wu, J., Zhu, J., Kuei, C., Yu, J., Shelton, J., Sutton, S. W., Li, X., Yun, S. J., Mirzadegan, T., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806409200 · Cited by 606 · see citing works

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605 · see citing works

Obesity Statistics

Smith, K. B., & Smith, M. S. (2016) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2015.10.001 · Cited by 591 · see citing works

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

Hoque, R., Farooq, A., Ghani, A., Gorelick, F. S., & Mehal, W. Z. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.014 · Cited by 576 · see citing works

Mediators of Inflammation

Larsen, G. L., & Henson, P. M. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.002003 · Cited by 543 · see citing works

An update on the use and investigation of probiotics in health and disease

Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A. (2013) · Gut · doi:10.1136/gutjnl-2012-302504 · Cited by 503 · see citing works

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

Vegiopoulos, A., Müller‐Decker, K., Strzoda, D., Schmitt, I. M., Chichelnitskiy, E., Ostertag, A., Díaz, M. B., Rozman, J., de Angelis, M. H., Nüsing, R. M., et al. (2010) · Science · doi:10.1126/science.1186034 · Cited by 459 · see citing works

Lactate metabolism: historical context, prior misinterpretations, and current understanding

Ferguson, B. S., Rogatzki, M. J., Goodwin, M. L., Kane, D. A., Rightmire, Z. B., & Gladden, L. B. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3795-6 · Cited by 451 · see citing works

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., & Offermanns, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.012 · Cited by 443 · see citing works

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

Morrison, S. F., Madden, C. J., & Tupone, D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.007 · Cited by 427 · see citing works

Beige Can Be Slimming

Ishibashi, J., & Seale, P. (2010) · Science · doi:10.1126/science.1190816 · Cited by 344 · see citing works

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

Cai, T., Ren, N., Jin, L., Cheng, K., Kash, S. F., Chen, R., Wright, S. D., Taggart, A. K. P., & Waters, M. G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.088 · Cited by 305 · see citing works

Lactate production in adipose tissue; a regulated function with extra‐adipose implications

DiGirolamo, M., Newby, F. D., & Lovejoy, J. C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.7.1563593 · Cited by 281 · see citing works

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

Carrière, A., Jeanson, Y., Berger-Müller, S., André, M., Chenouard, V., Arnaud, E., Barreau, C., Walther, R., Galinier, A., Wdziekonski, B., et al. (2014) · Diabetes · doi:10.2337/db13-1885 · Cited by 263 · see citing works

Lactobacillus rhamnosus GG Treatment Potentiates Intestinal Hypoxia-Inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-Induced Liver Injury

Wang, Y., Kirpich, I., Liu, Y., Ma, Z., Barve, S. S., McClain, C. J., & Feng, W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.039 · Cited by 255 · see citing works

Beyond the Sympathetic Tone: The New Brown Fat Activators

Villarroya, F., & Vidal-Puig, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.020 · Cited by 209 · see citing works

Effects of Green Tea Polyphenol (−)-Epigallocatechin-3-gallate on Newly Developed High-Fat/Western-Style Diet-Induced Obesity and Metabolic Syndrome in Mice

Chen, Y., Cheung, C., Reuhl, K. R., Liu, A. B., Lee, M., Lu, Y., & Yang, C. S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2029016 · Cited by 195 · see citing works

Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles

Roth, D. A., & Brooks, G. A. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90505-s · Cited by 182 · see citing works

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

Yao, L., Cui, X., Chen, Q., Yang, X., Fang, F., Zhang, J., Liu, G., Jin, W., & Chang, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.069 · Cited by 144 · see citing works

Diagnosis and management of the metabolic syndrome in obesity

Liberopoulos, E. N., Mikhailidis, D. P., & Elisaf, M. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00221.x · Cited by 129 · see citing works

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

Ge, H., Weiszmann, J., Reagan, J. D., Gupte, J., Baribault, H., Gyuris, T., Chen, J., Tian, H., & Li, Y. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700513-jlr200 · Cited by 127 · see citing works

Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention

Fischer, S. M., Hawk, E. T., & Lubet, R. A. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0166 · Cited by 116 · see citing works

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT

Contreras, C., Nogueiras, R., Diéguez, C., Medina‐Gómez, G., & López, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.002 · Cited by 100 · see citing works

Dairy Consumption and Risk of Frailty in Older Adults: A Prospective Cohort Study

Lana, A., Rodríguez‐Artalejo, F., & López‐García, E. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13626 · Cited by 97 · see citing works

Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Anti-lipolytic G-protein-coupled Receptor 81 (GPR81/Gpr81)

Jeninga, E. H., Bugge, A. K., Nielsen, R., Kersten, S., Hamers, N., Dani, C., Wabitsch, M., Berger, R., Stunnenberg, H. G., Mandrup, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040741 · Cited by 97 · see citing works

Effects of high fat diet on GPR109A and GPR81 gene expression

Wanders, D., Graff, E. C., & Judd, R. L. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.082 · Cited by 89 · see citing works

Obesity: A Global Public Health Challenge

James, W. P. T. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2017.273052 · Cited by 89 · see citing works

Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice

Wang, J., Li, D., Wang, P., Hu, X., & Chen, F. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.001 · Cited by 85 · see citing works

Associations between yogurt consumption and weight gain and risk of obesity and metabolic syndrome: A systematic review

Sayon-Orea, C., Martínez-González, M. A., Ruiz-Canela, M., & Bes-Rastrollo, M. (2017) · Advances in Nutrition · doi:10.3945/an.115.011536 · Cited by 84 · see citing works

Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study

Martínez‐González, M. Á., Sayón-Orea, C., Ruiz‐Canela, M., de la Fuente, C., Gea, A., & Bes‐Rastrollo, M. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.05.015 · Cited by 74 · see citing works

Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise

Rooney, K. B., & Trayhurn, P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004673 · Cited by 66 · see citing works

MicroRNAs in obesity-associated disorders

Abente, E. J., Subramanian, M., Ramachandran, V., & Najafi-Shoushtari, S. H. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.09.018 · Cited by 63 · see citing works

Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2Pathway

Wang, W., Chen, J., Mao, J., Li, H., Wang, M., Zhang, H., Li, H., & Chen, W. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01691 · Cited by 58 · see citing works

Trans-Cinnamic Acid Increases Adiponectin and the Phosphorylation of AMP-Activated Protein Kinase through G-Protein-Coupled Receptor Signaling in 3T3-L1 Adipocytes

Kopp, C., SINGH, S. P., Regenhard, P., Müller, U., Sauerwein, H., & Mielenz, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022906 · Cited by 57 · see citing works

The Effect of Lactic Acid on Adipose Tissue Metabolism in Vitro

Björntorp, P. A. (1965) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1965.tb04268.x · Cited by 50 · see citing works

Yogurt consumption and abdominal obesity reversion in the PREDIMED study

Santiago, S., Sayón-Orea, C., Babió, N., Ruiz‐Canela, M., Martí, A., Corella, D., Estruch, R., Fitó, M., Arós, F., Ros, E., et al. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.11.012 · Cited by 50 · see citing works

Obesity and Overweight in Asian People.

Goda, A., & Masuyama, T. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-1087 · Cited by 34 · see citing works

Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation

Harada, N., Hirano, I., Inui, H., & Yamaji, R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.198 · Cited by 24 · see citing works

Understanding lactate sensing and signalling

Certo, M., Llibre, A., Lee, W., & Mauro, C. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.07.004 · Cited by 195 · see citing works

Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

Mu, W.-J., Zhu, J.-Y., Chen, M., & Guo, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111512 · Cited by 99 · see citing works

Emerging roles of lysine lactyltransferases and lactylation

Zong, Z., Ren, J., Yang, B., Zhang, L., & Zhou, F. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01635-8 · Cited by 94 · see citing works

The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions

Lund, J. T., Breum, A. W., Gil, C., Falk, S., Sass, F., Isidor, M. S., Dmytriyeva, O., Ranea‐Robles, P., Mathiesen, C. V., Basse, A. L., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00780-4 · Cited by 49 · see citing works

Probiotic Yogurt Alleviates High-Fat Diet-Induced Lipid Accumulation and Insulin Resistance in Mice via the Adiponectin Pathway

Tang, C., Zhao, H., Kong, L., Meng, F., Zhou, L., Lu, Z., & Lu, Y. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05670 · Cited by 33 · see citing works

A synthetic microbial consortium protects against obesity by regulating vitamin B6 metabolism

Chen, X., Gao, M., Wang, L., Qiang, G., Wu, Y., Huang, H., & Kang, G. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2304901 · Cited by 32 · see citing works

Lactate: elucidating its indispensable role in human health

Zhang, S., Wang, J., Xu, Z., Cheng, Z., Shao, B., & Yu, J. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02519-z · Cited by 35 · see citing works

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Lecoutre, S., Maqdasy, S., Rizo‐Roca, D., Renzi, G., Vlassakev, I., Alaeddine, L. M., Higos, R., Jalkanen, J., Zhong, J., Zareifi, D., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01083-y · Cited by 29 · see citing works

Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice

Wei, B., Peng, Z., Xiao, M., Huang, T., Yang, S., Liu, K., Wu, M. T., Zheng, W., Xie, M., & Xiong, T. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03149 · Cited by 29 · see citing works

Exercise-Induced Adipose Tissue Thermogenesis and Browning: How to Explain the Conflicting Findings?

Zhu, Y., Qi, Z., & Ding, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113142 · Cited by 26 · see citing works

Dietary d ‐Lactate Intake Facilitates Inflammatory Resolution by Modulating M1 Macrophage Polarization

Yan, Y., Xiu, L., Yang, Q., Zhang, H., Hettinga, K. A., Li, H., & Chen, W. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200196 · Cited by 20 · see citing works

A polysaccharide from Sargassum pallidum reduces obesity in high-fat diet-induced obese mice by modulating glycolipid metabolism

Yuan, D., Huang, Q., Li, C., & Fu, X. (2022) · Food & Function · doi:10.1039/d2fo00890d · Cited by 19 · see citing works

The PKA‐SREBP1c Pathway Plays a Key Role in the Protective Effects of Lactobacillus johnsonii JNU3402 Against Diet‐Induced Fatty Liver in Mice

Hong, E., Kang, H., Yang, G., Oh, S., & Kim, E. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200496 · Cited by 19 · see citing works

The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment options

Tajbakhsh, A., Hayat, S. M. G., Karami, N., Savardashtaki, A., Butler, A. E., Rizzo, M., & Sahebkar, A. (2022) · Obesity Reviews · doi:10.1111/obr.13487 · Cited by 18 · see citing works

Lactate shuttling drives the browning of white adipose tissue after burn

Barayan, D., Abdullahi, A., Knuth, C. M., Khalaf, F., Rehou, S., Screaton, R. A., & Jeschke, M. G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00084.2023 · Cited by 18 · see citing works

Dairy products and constituents: a review of their effects on obesity and related metabolic diseases

Li, A., Han, X., Liu, L., Zhang, G., Du, P., Zhang, C., Li, C., & Chen, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2257782 · Cited by 18 · see citing works

Yogurt Alleviates Imiquimod-Induced Psoriasis by Activating the Lactate/GPR81 Signaling Axis in Mice

Qian, J., Li, X., Yin, Z., Dai, Y., Zhang, H., Li, H., Peng, C., & Chen, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05049 · Cited by 17 · see citing works

Structural characterization of a α-d-glucan from Ginkgo biloba seeds and its protective effects on non-alcoholic fatty liver disease in mice

Liang, S., Yao, Z., Chen, J., Jin, Q. Y., Dai, Y., & Li, H. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123022 · Cited by 16 · see citing works

Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis

Tang, Y., Wang, Y., Wang, Y. Y., Liao, Z., & Xiao, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1265175 · Cited by 16 · see citing works

Mechanism of Fatty Acid Metabolism and Regulation by Lactate During Exercise in White Adipose and Skeletal Muscle Tissue: A Review

Huang, S., Shangguan, R., Chen, S., Lai, X., Han, H., & Sun, J. (2025) · Sports Medicine - Open · doi:10.1186/s40798-025-00862-5 · Cited by 14 · see citing works

Regulation and Mechanisms of L-Lactic Acid and D-Lactic Acid Production in Baijiu Brewing: Insights for Flavor Optimization and Industrial Application

Zhou, Y., & Hua, J. (2025) · Fermentation · doi:10.3390/fermentation11040213 · Cited by 14 · see citing works

High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats

Cheng, B., Du, J., Tian, S., Zhang, Z., Chen, W., & Liu, Y. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02397-2 · Cited by 12 · see citing works

Lactate induces the development of beige adipocytes via an increase in the level of reactive oxygen species

Esaki, N., Matsui, T., & Tsuda, T. (2023) · Food & Function · doi:10.1039/d3fo03287f · Cited by 10 · see citing works

Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate

Jin, W., Chen, G., Chen, W., Qiao, G., Deng, Y., Li, K., & Cai, W. L. (2024) · Aesthetic Plastic Surgery · doi:10.1007/s00266-024-04265-x · Cited by 10 · see citing works

Dietary Lactate Intake and Physical Exercise Synergistically Reverse Brown Adipose Tissue Whitening to Ameliorate Diet-Induced Obesity

Yao, Z., Liang, S., Chen, J., Zhang, H., Chen, W., & Li, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06899 · Cited by 9 · see citing works

The effect of Xuezhikang capsule on gene expression profile in brown adipose tissue of obese spontaneously hypertensive rats

Zhang, S., Jiang, Y., Wang, X., Zhang, H., Gu, P., Gong, Z., Jiang, W., Zhang, Y., & Zhu, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115700 · Cited by 9 · see citing works

Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate

Ottosen, R. N., Seefeldt, J. M., Hansen, J., Nielsen, R. R., Møller, N., Johannsen, M., & Poulsen, T. B. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04849 · Cited by 8 · see citing works

Potato protease inhibitor II prevents obesity by inducing browning of white adipose tissue in mice via β3 adrenergic receptor signaling pathway

Zhang, N., Liu, J., Wang, M., Guo, X., Fan, B., & Wang, F. (2022) · Phytotherapy Research · doi:10.1002/ptr.7451 · Cited by 7 · see citing works

A Combination of Exercise and Yogurt Intake Protects Mice against Obesity by Synergistic Promotion of Adipose Browning

Yao, Z., Liang, S., Chen, J., Dai, Y., Zhang, H., Li, H., & Chen, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00982 · Cited by 6 · see citing works

Lactate coordinated with exercise promoted the browning of inguinal white adipose tissue

Chen, X., Li, Y., Zhang, J., Huang, W., Su, J., & Zhang, J. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-01004-9 · Cited by 6 · see citing works

Lactate‐induced metabolic remodeling and myofiber type transitions via activation of the Ca2+‐NFATC1 signaling pathway

Zhou, Y., Liu, X., Qi, Z., Huang, C., Yang, L., & Lin, D. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31290 · Cited by 6 · see citing works

Adipose thermogenic mechanisms by cold, exercise and intermittent fasting: Similarities, disparities and the application in treatment

Chen, L.-S., & Liu, L. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.07.024 · Cited by 5 · see citing works

Lactate utilization in Lace1 knockout mice promotes browning of inguinal white adipose tissue

Kim, Y. J., Lee, S. G., Jang, S., Kim, W. K., Oh, K., Bae, K., Kim, H. J., & Seong, J. K. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01324-w · Cited by 4 · see citing works

Mouse models for metabolic health research: molecular mechanism of exercise effects on health improvement through adipose tissue remodelling

Kim, H. J., Kim, Y. J., & Seong, J. K. (2025) · The Journal of Physiology · doi:10.1113/jp285975 · Cited by 4 · see citing works

Can Exercise-Mediated Adipose Browning Provide an Alternative Explanation for the Obesity Paradox?

Zhao, J., Li, X., Liang, C., & Yan, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051790 · Cited by 4 · see citing works

Emerging Mechanisms of Lactate Regulation of Biological Processes

Fink, E. C., & Chouchani, E. T. (2025) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-091724-051147 · Cited by 2 · see citing works

Exogenous lactate infusion enhanced VMH neuroplasticity and visceral fat reduction via PGC-1α-ERα pathway in female rats

Tian, S., Han, J., Zhang, Z., Du, J., Chen, W., & Liu, Y. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-06097-2 · Cited by 2 · see citing works

Dietary D-lactate intake ameliorates metabolic syndrome via enhancing brown adipose tissue thermogenesis in diet-induced obese mice

Yao, Z., Chen, J., Li, X., Liang, S., Zhang, H., Li, H., & Chen, W. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105284 · Cited by 2 · see citing works

Short-Term Effects of Poly-L-Lactic Acid-b-Polyethylene Glycol Microsphere Injection on Different Adipose Tissue Types in Rats

Yang, W., Niu, H., He, T., Zhang, Z., Wang, S., Ren, S., & Wang, L. (2024) · Aesthetic Surgery Journal Open Forum · doi:10.1093/asjof/ojae100 · Cited by 1 · see citing works

Organic acids in four representative fermented alcoholic beverages: absorption, metabolic fate, and molecular mechanisms of health benefits

Tian, X., Zhang, R., Zhang, H., Liang, Y., Ma, Y., Yang, Z., & Han, F. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2685875 · Cited by 1 · see citing works

Central lactate uptake during exercise contributes to hypothalamic fibroblast growth factor 21 induction and systemic fat mobilization

Mansouri, F., Nikooie, R., Mehrtash, M., & Hamidi, M. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112864 · Cited by 1 · see citing works

A Mechanistic Basis for the Bioactive Properties of Traditional Fermented Foods——Chiral Lactate–GPR81 Signaling in Nutrition and Disease

Gao, T., Zhao, Z., Wang, X., Du, H., Tang, C., Xu, R., Jing, N., & Yan, Y. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2569546

Global profiling of protein lactylation in pancreatic ductal adenocarcinoma

Toledo, D., Oluwole, S. A., Owiredu, S., Carr, G., & Agatemor, C. (2026) · Scientific Reports · doi:10.1038/s41598-026-43771-7

Infections virales respiratoires et tissus adipeux blancs : Exemple de la grippe et de la COVID-19

Barthelemy, J. (2022) · doi:10.70675/6439a82ez7179z48e3zbb8ez93846ae0ac14

Exercise-induced protein lactylation: From molecular mechanisms to precision health applications

Chen, W., Meng, Y., Zhong, Q., & Shi, R. (2026) · iScience · doi:10.1016/j.isci.2026.115661

Dietary lactic acid ameliorates high-fat diet-induced obesity by promoting lactate transport and activating GPR81-mediated thermogenesis

Lin, Y., Kang, X., Hong, K., Tang, Y., Xue, H., Liu, X., Han, X., Guo, J., Huang, W., Zhan, J., et al. (2026) · Food Innovation and Advances · doi:10.48130/fia-0026-0022

Octanoic Acid‐Rich Enteral Nutrition Alleviates Sepsis‐Associated Metabolic Disorders by Suppressing White Adipose Tissue Browning in Mice

Zheng, C., Li, X., Xing, C., & Cao, C. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72020

PLLA Microspheres Regulate Adipocyte Dedifferentiation via Lactate: A Novel Strategy for Fat Graft Survival Enhancement

Ling, J., Jiang, C., & Li, F. (2026) · Aesthetic Plastic Surgery · doi:10.1007/s00266-026-06040-6

Supplementation of L-Lactic Acid Regulates Antioxidant Capacity and Improved Intestinal Integrity and Microbial Diversity in Weaned Piglet

Purba, A., Chen, X., Li, S., Wang, X., Pirzado, S. A., Qiu, K., Zheng, A., Jiang, X., Irawan, A., & Liu, G. (2026) · Italian Journal of Animal Science · doi:10.1080/1828051x.2026.2682622

A Combination of Exercise and Yogurt Intake Protects Mice against Obesity by Synergistic Promotion of Adipose Browning

Yao, Z., Liang, S., Chen, J., Dai, Y., Zhang, H., Li, H., & Chen, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00982 · Cited by 6 · see citing works

Dietary Lactate Intake and Physical Exercise Synergistically Reverse Brown Adipose Tissue Whitening to Ameliorate Diet-Induced Obesity

Yao, Z., Liang, S., Chen, J., Zhang, H., Chen, W., & Li, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06899 · Cited by 9 · see citing works

Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, gpr81

Liu, C., Wu, J., Zhu, J., Kuei, C., Yu, J., Shelton, J., Sutton, S. W., Li, X., Yun, S. J., Mirzadegan, T., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806409200 · Cited by 606 · see citing works

Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARγ signaling

Park, S. S., Lee, Y., Kang, H., Yang, G., Hong, E. J., Lim, J. Y., Oh, S., & Kim, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-56817-w · Cited by 65 · see citing works

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

Cai, T., Ren, N., Jin, L., Cheng, K., Kash, S. F., Chen, R., Wright, S. D., Taggart, A. K. P., & Waters, M. G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.088 · Cited by 305 · see citing works