Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613 · see citing works

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

Reduced Number of Hypocretin Neurons in Human Narcolepsy

Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089 · see citing works

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works

Transcriptional regulation of adipogenesisPreprint

Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,902 · see citing works

Hypocretin (orexin) deficiency in human narcolepsy

Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776 · see citing works

Obesity in Young Men after Famine Exposure in Utero and Early Infancy

Ravelli, G.-P., Stein, Z. A., & Susser, M. W. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950701 · Cited by 1,647 · see citing works

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630 · see citing works

A role for brown adipose tissue in diet-induced thermogenesis

Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606 · see citing works

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works

Obesity at the age of 50 y in men and women exposed to famine prenatally

Ravelli, A. C. J., van der Meulen, J., Osmond, C., Barker, D. J. P., & Bleker, O. P. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.811 · Cited by 1,165 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Lin, H. Y.-F., Bloch, K. D., & Peterson, R. T. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.54 · Cited by 1,039 · see citing works

<i>Associations between Sleep Loss and Increased Risk of Obesity and Diabetes</i>

Knutson, K. L., & Van Cauter, E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.033 · Cited by 810 · see citing works

Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene

Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804 · see citing works

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works

Adipocyte Differentiation and Gene Expression

Ntambi, J. M., & Kim, Y. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.3122s · Cited by 780 · see citing works

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

Smas, C. M., & Sul, H. S. (1993) · Cell · doi:10.1016/0092-8674(93)90252-l · Cited by 677 · see citing works

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605 · see citing works

Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy

Nishino, S., Ripley, B. A., Overeem, S., Nevšímalová, S., Lammers, G. J., Vaňková, J., Okun, M. L., Rogers, W. M., Brooks, S. N., & Mignot, E. J.-M. (2001) · Annals of Neurology · doi:10.1002/ana.1130 · Cited by 451 · see citing works

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Tateishi, K., Okada, Y., Kallin, E. M., & Zhang, Y. (2009) · Nature · doi:10.1038/nature07777 · Cited by 442 · see citing works

CNS origins of the sympathetic nervous system outflow to brown adipose tissue

Bamshad, M., Song, C. K., & Bartness, T. J. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1569 · Cited by 437 · see citing works

Increased body-mass index in patients with narcolepsy

Schuld, A., Hebebrand, J., Geller, F., & Pollmächer, T. (2000) · The Lancet · doi:10.1016/s0140-6736(05)74704-8 · Cited by 331 · see citing works

Independent Feeding and Metabolic Actions of Orexins in Mice

Lubkin, M., & Stricker‐Krongrad, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9750 · Cited by 325 · see citing works

Biogenic amines in development

Curzon, G. (1981) · Early Human Development · doi:10.1016/0378-3782(81)90059-1 · Cited by 323 · see citing works

The dorsomedial hypothalamus: a new player in thermoregulation

DiMicco, J. A., & Zaretsky, D. V. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00498.2006 · Cited by 300 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315737 · Cited by 281 · see citing works

Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

Deadwyler, S. A., Porrino, L. J., Siegel, J. M., & Hampson, R. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3878-07.2007 · Cited by 265 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15737 · Cited by 265 · see citing works

Brown Fat and the Myth of Diet-Induced Thermogenesis

Kozak, L. P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.009 · Cited by 243 · see citing works

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

Tseng, Y.-H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M., Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1259 · Cited by 222 · see citing works

Hypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity

Kok, S. W., Overeem, S., Visscher, T. L. S., Lammers, G. J., Seidell, J. C., Pijl, H., & Meinders, A. E. (2003) · Obesity Research · doi:10.1038/oby.2003.156 · Cited by 202 · see citing works

Differential Roles of Smad1 and p38 Kinase in Regulation of Peroxisome Proliferator-activating Receptor γ during Bone Morphogenetic Protein 2-induced Adipogenesis

Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T., & Yoneda, T. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0356 · Cited by 187 · see citing works

Endocrine and nutritional regulation of fetal adipose tissue development

Symonds, M. E., Mostyn, A., Pearce, S., Budge, H., & Stephenson, T. J. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1790293 · Cited by 179 · see citing works

Orexin-A expression in human peripheral tissues

Nakabayashi, M., Suzuki, T., Takahashi, K., Totsune, K., Muramatsu, Y., Kaneko, C., Date, F., Takeyama, J., Darnel, A. D., Moriya, T., et al. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00206-5 · Cited by 174 · see citing works

Pref-1 (Preadipocyte Factor 1) Activates the MEK/Extracellular Signal-Regulated Kinase Pathway To Inhibit Adipocyte Differentiation

Kim, K., Kim, J.-H., Wang, Y., & Sul, H. S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02207-06 · Cited by 155 · see citing works

Transcriptional Repression of pref-1by Glucocorticoids Promotes 3T3-L1 Adipocyte Differentiation

Smas, C. M., Chen, L., Zhao, L., Latasa, M.-J., & Sul, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12632 · Cited by 153 · see citing works

NARCOLEPSY1

Daniels, L. E. (1934) · Medicine · doi:10.1097/00005792-193413010-00001 · Cited by 147 · see citing works

Mouse Embryo Fibroblast (MEF) Feeder Cell Preparation

Conner, D. A. (2000) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2302s51 · Cited by 142 · see citing works

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice

Haynes, A. C., Chapman, H., Taylor, C., Moore, G. B. T., Cawthorne, M. A., Tadayyon, M., Clapham, J. C., & Arch, J. R. S. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00358-5 · Cited by 142 · see citing works

Orexin-A Regulates Body Temperature in Coordination with Arousal Status

Yoshimichi, G., Yoshimatsu, H., Masaki, T., & Sakata, T. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600513 · Cited by 138 · see citing works

Increased prevalence of obesity in narcoleptic patients and relatives

Dahmen, N., Bierbrauer, J., & Kasten, M. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170057 · Cited by 138 · see citing works

Novel adipocyte lines from brown fat: A model system for the study of differentiation, energy metabolism, and insulin action

Klein, J. C., Faßhauer, M., Klein, H. H., Benito, M., & Kahn, C. R. (2002) · BioEssays · doi:10.1002/bies.10058 · Cited by 136 · see citing works

Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α

Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, J. B., Kristiansen, K., & MacDougald, O. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1272-1282.2005 · Cited by 135 · see citing works

Decreased plasma orexin-A levels in obese individuals

Adam, J. A., Menheere, P. P. C. A., van Dielen, F., Soeters, P. B., Buurman, W. A., & Greve, J.-W. M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801868 · Cited by 134 · see citing works

Oxidative Metabolism in Cells Isolated from Brown Adipose Tissue

Prusiner, S. B., Cannon, B., & Lindberg, O. R. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00413.x · Cited by 131 · see citing works

Orexin neurons are indispensable for stress-induced thermogenesis in mice

Zhang, W., Sunanaga, J., Takahashi, Y., Mori, T., Sakurai, T., Kanmura, Y., & Kuwaki, T. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195099 · Cited by 128 · see citing works

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

Tsuneki, H., Murata, S., Anzawa, Y., Soeda, Y., Tokai, E., Wada, T., Kimura, I., Yanagisawa, M., Sakurai, T., & Sasaoka, T. (2008) · Diabetologia · doi:10.1007/s00125-008-0929-8 · Cited by 124 · see citing works

Spontaneous Food Choice in Narcolepsy

Lammers, G. J., Pijl, H., Iestra, J. A., Langius, J. A. E., Buunk, G., & Meinders, A. E. (1996) · SLEEP · doi:10.1093/sleep/19.1.75 · Cited by 122 · see citing works

Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

Ross, S. R., Choy, L., Graves, R. A., Fox, N. W., SOLEVEVA, V., Klaus, S., Ricquier, D., & Spiegelman, B. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7561 · Cited by 121 · see citing works

Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy

Zhang, S., Zeitzer, J. M., Sakurai, T., Nishino, S., & Mignot, E. J.-M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129510 · Cited by 105 · see citing works

Characteristics of Narcolepsy in Preteenaged Children

Kotagal, S., Hartse, K. M., & Walsh, J. K. (1990) · PEDIATRICS · doi:10.1542/peds.85.2.205 · Cited by 104 · see citing works

OX1Orexin Receptors Activate Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells via Multiple Mechanisms: The Role of Ca2+Influx in OX1Receptor Signaling

Ammoun, S., Johansson, L., Ekholm, M. E., Holmqvist, T., Danis, A. S., Korhonen, L., Sergeeva, O. A., Haas, H. L., Åkerman, K. E. O., & Kukkonen, J. P. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0389 · Cited by 96 · see citing works

Biogenic amines in development

Parvez, H. S., & Parvez, S. (1980) · Medical Entomology and Zoology · Cited by 91 · see citing works

Role of orexin in the regulation of glucose homeostasis

Tsuneki, H., Wada, T., & Sasaoka, T. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02008.x · Cited by 85 · see citing works

Neuronal effects of orexins: relevant to sympathetic and cardiovascular functions

Shirasaka, T., Kunitake, T., Takasaki, M., & Kannan, H. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00352-4 · Cited by 81 · see citing works

Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress

Samson, W. K., Bagley, S. L., Ferguson, A. V., & White, M. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00496.2006 · Cited by 75 · see citing works

Hypocretin/orexin and energy expenditure

Teske, J. A., Billington, C. J., & Kotz, C. M. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02075.x · Cited by 67 · see citing works

Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models

Fujiki, N., Yoshida, Y., Zhang, S., Sakurai, T., Yanagisawa, M., & Nishino, S. (2006) · Peptides · doi:10.1016/j.peptides.2006.03.011 · Cited by 61 · see citing works

The neurobiology of human obesity

Eikelis, N., & Esler, M. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031385 · Cited by 61 · see citing works

The Endogenous Actions of Hypothalamic Peptides on Brown Adipose Tissue Thermogenesis in the Rat

Verty, A. N. A., Allen, A. M., & Oldfield, B. J. (2010) · Endocrinology · doi:10.1210/en.2009-1235 · Cited by 59 · see citing works

Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats

Wang, J., Osaka, T., & Inoue, S. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02322-9 · Cited by 58 · see citing works

Regulation of OX1orexin/hypocretin receptor‐coupling to phospholipase C by Ca2+influx

Johansson, L., Ekholm, M. E., & Kukkonen, J. P. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706959 · Cited by 57 · see citing works

Injection of orexin A into the diagonal band of Broca induces symphatetic and hyperthermic reactions

Monda, M., Viggiano, A., Viggiano, A., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.084 · Cited by 55 · see citing works

Orexins and the treatment of obesity

Smart, D., Haynes, A. C., Williams, G. H., & Arch, J. R. S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01429-2 · Cited by 51 · see citing works

Circadian distribution of motor activity and immobility in narcolepsy: Assessment with continuous motor activity monitoring

Middelkoop, H. A. M., Lammers, G. J., van Hilten, B. J., Ruwhof, C., Pijl, H., & KAMPHUISEN, H. A. C. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb02957.x · Cited by 49 · see citing works

Parodoxical effect of orexin A: hypophagia induced by hyperthermia

Monda, M., Viggiano, A., & Luca, V. D. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03953-7 · Cited by 47 · see citing works

Sympathetic and hyperthermic reactions by orexin A: Role of cerebral catecholaminergic neurons

Monda, M., Viggiano, A., Viggiano, A., et al. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.10.002 · Cited by 43 · see citing works

Increased body mass index (BMI) in male narcoleptic patients, but not in HLA-DR2-positive healthy male volunteers

Schuld, A., Beitinger, P. A., Dalal, M. A., Geller, F., Wetter, T. C., Albert, E. D., Hebebrand, J., & Pollmächer, T. (2002) · Sleep Medicine · doi:10.1016/s1389-9457(02)00012-6 · Cited by 41 · see citing works

Chronic intraparaventricular nuclear administration of orexin A in male rats does not alter thyroid axis or uncoupling protein-1 in brown adipose tissue

Russell, S. H., Small, C. J., Sunter, D., Morgan, I., Dakin, C. L., Cohen, M. A., & Bloom, S. R. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00349-4 · Cited by 37 · see citing works

NARCOLEPSY

CAVE, H. A. (1931) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1931.02230070056004 · Cited by 33 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Adaptive thermogenesis in adipocytes: Is beige the new brown?

Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes &amp; Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573 · see citing works

Sleep modulates haematopoiesis and protects against atherosclerosis

McAlpine, C. S., Kiss, M. G., Rattik, S., He, S., Vassalli, A., Valet, C., Anzai, A., Chan, C. T., Mindur, J. E., Kahles, F., et al. (2019) · Nature · doi:10.1038/s41586-019-0948-2 · Cited by 447 · see citing works

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

Wu, L., Zhang, L., Li, B., Jiang, H., Duan, Y., Xie, Z., Shuai, L., Li, J., & Li, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00122 · Cited by 255 · see citing works

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Kuryłowicz, A., & Puzianowska-Kuźnicka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176241 · Cited by 219 · see citing works

An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis

Tupone, D., Madden, C. J., Cano, G., & Morrison, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3909-11.2011 · Cited by 228 · see citing works

Beyond the Sympathetic Tone: The New Brown Fat Activators

Villarroya, F., & Vidal-Puig, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.020 · Cited by 209 · see citing works

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178 · see citing works

Brown adipose tissue: Development, metabolism and beyond

Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173 · see citing works

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154 · see citing works

Obesity: A neuroimmunometabolic perspective

Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123 · see citing works

Brown Adipose Tissue: Mechanisms and Potential Therapeutic Targets

Tam, C. S., Lecoultre, V., & Ravussin, E. (2012) · Circulation · doi:10.1161/circulationaha.111.042929 · Cited by 116 · see citing works

Connecting insufficient sleep and insomnia with metabolic dysfunction

Duan, D., Kim, L. J., Jun, J. C., & Polotsky, V. Y. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14926 · Cited by 110 · see citing works

Brown Adipose Tissue: More Than an Effector of Thermogenesis?a

Cannon, B., Houštěk, J., & Nedergaard, J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08325.x · Cited by 124 · see citing works

Influence of amphetamine on brown adipose thermogenesis.

Pj, W. (1983) · PubMed · Cited by 12 · see citing works

Energy expenditure and thermogenesis: animal studies on brown adipose tissue.

Trayhurn, P. (1990) · PubMed · Cited by 12 · see citing works

Thermogenesis in normal rabbits and rats: no role for brown adipose tissue?

Brockway, J. M., & Lobley, G. E. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013692 · Cited by 7 · see citing works

Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice

Trayhurn, P., Douglas, J. B., & McGuckin, M. M. (1982) · Nature · doi:10.1038/298059a0 · Cited by 153 · see citing works