The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter
Open accessAbstract
Summary Mitochondrial Ca2+ uptake via the uniporter is central to cell metabolism, signaling and survival. Recent studies identified MCU as the uniporter’s likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decodes dynamic cytoplasmic [Ca2+] ([Ca2+]c) signals, to tune out small [Ca2+]c increases yet permit pulse transmission, remains unknown. We report that loss of MICU1 in mouse liver and cultured cells causes mitochondrial Ca2+ accumulation during small [Ca2+]c elevations, yet an attenuated response to agonist-induced [Ca2+]c pulses. The latter reflects loss of positive cooperativity, likely via the EF-hands. MICU1 faces the intermembrane space and responds to [Ca2+]c changes. Prolonged MICU1 loss leads to an adaptive increase in matrix Ca2+ binding, yet cells show impaired oxidative metabolism and sensitization to Ca2+ overload. Collectively, the data indicate that MICU1 senses the [Ca2+]c to establish the uniporter’s threshold and gain, thereby allowing mitochondria to properly decode different inputs.
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Cites
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Self-citationThe machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
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Self-citationEnjoy the Trip: Calcium in Mitochondria Back and Forth
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Metadata
- Authors
- Csordás, G., Golenár, T., Seifert, E. L., Kamer, K. J., Sancak, Y., Perocchi, F., Moffat, C., Weaver, D., Perez, S. D. L. F., Bogorad, R., Koteliansky, V., Adijanto, J., Mootha, V. K., & Hajnóczky, G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 17
- Issue
- 6
- Pages
- 976-987
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2156007429
- Cited by
- 490
- References
- 61
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Csordás, G., Golenár, T., Seifert, E. L., Kamer, K. J., Sancak, Y., Perocchi, F., Moffat, C., Weaver, D., Perez, S. D. L. F., Bogorad, R., Koteliansky, V., Adijanto, J., Mootha, V. K., & Hajnóczky, G. (2013). MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.04.020
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