The DOI matches its Crossref record; 146 of the 147 references it cites were found in a registry or an index.
Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity
Open accessAbstract
The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by infection or injury and plays a role in response to overnutrition. Initially, this metabolic activation of the immune system is a physiological response, but it may become deleterious with time. Therefore, therapeutic interventions should aim at modulating the immune system rather than simply damping it. In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1β pathway, and clinical translation.
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“T2D is associated with inflammation of the insulin-producing β cells of the pancreatic islets and the white adipose tissue itself, which results in decreased insulin production and increased insulin resistance, respectively (comprehensively reviewed by (Donath et al., 2013)).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Donath et al., 2013
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BackgroundType 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
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The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 675
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition
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Metadata
- Authors
- Donath, M. Y., Dalmas, É., Sauter, N. S., & Böni-Schnetzler, M.
- Affiliations
- University Hospital of Basel (CH)
- Corresponding author
- Donath, Marc Y.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 17
- Issue
- 6
- Pages
- 860-872
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2053963810
- Cited by
- 338
- References
- 147
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 9 · 2023: 25 · 2022: 28 · 2021: 39 · 2020: 33 · 2019: 29 · 2018: 24 · 2017: 30 · 2016: 20 · 2015: 33 · 2014: 29 · 2013: 5
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- obesity, diabetes mellitus, insulitis, islet dysfunction, immune system, overnutrition, immunomodulatory therapy
- MeSH terms
- Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Immunity, Innate, Inflammation, Insulin, Islets of Langerhans, Macrophages, Obesity, Interleukin-1beta
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