Cited by 338Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic DiseasesDiabetes and associated disorders

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Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

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Donath, Marc Y., Dalmas, Élise, Sauter, Nadine S., Böni-Schnetzler, Marianne·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.05.001

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Abstract

The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by infection or injury and plays a role in response to overnutrition. Initially, this metabolic activation of the immune system is a physiological response, but it may become deleterious with time. Therefore, therapeutic interventions should aim at modulating the immune system rather than simply damping it. In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1β pathway, and clinical translation.

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Authors: Donath, M. Y., Dalmas, É., Sauter, N. S., & Böni-Schnetzler, M.
Affiliations: University Hospital of Basel (CH)
Corresponding author: Donath, Marc Y.
ORCID: Donath, Marc Y.
Dalmas, Élise
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-06
Volume: 17
Issue: 6
Pages: 860-872
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.05.001
OpenAlex: W2053963810
Cited by: 338
References: 147
Citations by year: 2026: 16 · 2025: 18 · 2024: 9 · 2023: 25 · 2022: 28 · 2021: 39 · 2020: 33 · 2019: 29 · 2018: 24 · 2017: 30 · 2016: 20 · 2015: 33 · 2014: 29 · 2013: 5
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: obesity, diabetes mellitus, insulitis, islet dysfunction, immune system, overnutrition, immunomodulatory therapy
MeSH terms: Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Immunity, Innate, Inflammation, Insulin, Islets of Langerhans, Macrophages, Obesity, Interleukin-1beta

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Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

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