Cited by 338Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic DiseasesDiabetes and associated disorders

The DOI matches its Crossref record; 146 of the 147 references it cites were found in a registry or an index.

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

Open access

Donath, Marc Y., Dalmas, Élise, Sauter, Nadine S., Böni-Schnetzler, Marianne·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.05.001

Open this paper in CoChat — free account Open PDF

Abstract

The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by infection or injury and plays a role in response to overnutrition. Initially, this metabolic activation of the immune system is a physiological response, but it may become deleterious with time. Therefore, therapeutic interventions should aim at modulating the immune system rather than simply damping it. In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1β pathway, and clinical translation.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2013.05.001

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
Maedler, K., Schumann, D., Sauter, N. S., Ellingsgaard, H., Bosco, D., Baertschiger, R. M., Iwakura, Y., Oberholzer, J., Wollheim, C. B., Gauthier, B. R., et al. (2006) · Diabetes · doi:10.2337/db05-1430 · Cited by 156
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

Show all 147 references

Research works printed but not linked: 1

Jansson, 2007, Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis, J. Appl. Physiol., 102, 821

Sorted by citations

Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“Arpaia et al., 2013; Brown et al., 2003; Chang et al., 2014; Donohoe et al., 2012; Kalina et al., 2002; Kim et al., 2016; Le Poul et al., 2003; Macia et al., 2015; Maslowski et al., 2009; Millard et al., 2002; Nilsson et al., 2003; Singh et al., 2010; Smith et al., 2013; Thangaraju et al., 2009a,…”
Background
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
Oguntibeju, O. O. (2019) · Europe PMC (PubMed Central) · Cited by 758
The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 675
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition
Hameed, I., Masoodi, S. R., Mir, S. A., Nabi, M., Ghazanfar, K., & Ganai, B. A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.598 · Cited by 531
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
Dror, E., Dalmas, É., Meier, D. T., Wueest, S., Thévenet, J., Thienel, C., Timper, K., Nordmann, T. M., Traub, S., Schulze, F., et al. (2017) · Nature Immunology · doi:10.1038/ni.3659 · Cited by 411
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Ying, W., Fu, W., Lee, Y. S., & Olefsky, J. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0286-3 · Cited by 410
Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB
Catrysse, L., & van Loo, G. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.01.006 · Cited by 329
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 327
The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression
Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
Li, P., Liu, S., Lu, M. M., Bandyopadhyay, G. K., Oh, D., Imamura, T., Johnson, A. M. F., Sears, D. D., Shen, Z., Cui, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.025 · Cited by 305
Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control
Próchnicki, T., & Latz, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.018 · Cited by 301
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
Ying, W., Lee, Y. S., Dong, Y. W., Seidman, J. S., Yang, M., Isaac, R., Seo, J. B., Yang, B.-H., Wollam, J., Riopel, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.003 · Cited by 281
Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms
Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications
Pollack, R. M., Donath, M. Y., LeRoith, D., & Leibowitz, G. (2016) · Diabetes Care · doi:10.2337/dcs15-3015 · Cited by 266
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
Ballak, D. B., Stienstra, R., Tack, C. J., Dinarello, C. A., & van Diepen, J. A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.005 · Cited by 265
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0232 · Cited by 254
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Esser, N., Paquot, N., & Scheen, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.974804 · Cited by 255
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
Frati, G., Schirone, L., Chimenti, I., Yee, D., Biondi‐Zoccai, G., Volpe, M., & Sciarretta, S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx011 · Cited by 248
T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes
Dalmas, É., Venteclef, N., Caer, C., Poitou, C., Cremer, I., Aron‐Wisnewsky, J., Lacroix‐Desmazes, S., Bayry, J., Kaveri, S. V., Clément, K., et al. (2014) · Diabetes · doi:10.2337/db13-1511 · Cited by 256
Natural history of β-cell adaptation and failure in type 2 diabetes
Alejandro, E. U., Gregg, B. E., Blandino-Rosano, M., CRAS-MÉNEUR, C. M. H., & Bernal‐Mizrachi, E. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.002 · Cited by 250
Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction
Westwell-Roper, C. Y., Ehses, J. A., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db13-0863 · Cited by 232
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease
Börgeson, E., Johnson, A. M. F., Lee, Y. S., Till, A., Syed, G. H., Shah, S. T. A., Guiry, P. J., Dalli, J., Colas, R. A., Serhan, C. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.003 · Cited by 225
Islet inflammation in type 2 diabetes
Böni‐Schnetzler, M., & Meier, D. T. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00745-4 · Cited by 225
Vitamin D Switches BAF Complexes to Protect β Cells
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A. F. M., Huddy, T. F., Wang, Y., Ross, B., Estepa, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.013 · Cited by 207
mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells
Ardestani, A. D., Lupše, B., Kido, Y., Leibowitz, G., & Maedler, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.004 · Cited by 198
Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids
Finkbeiner, S. R., Freeman, J. J., Wieck, M. M., El-Nachef, W., Altheim, C. H., Tsai, Y.-H., Huang, S., Dyal, R., White, E. S., Grikscheit, T. C., et al. (2015) · Biology Open · doi:10.1242/bio.013235 · Cited by 174
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
Herder, C., Dalmas, É., Böni‐Schnetzler, M., & Donath, M. Y. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.001 · Cited by 176
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production
Dalmas, É., Lehmann, F., Dror, E., Wueest, S., Thienel, C., Borsigova, M., Stawiski, M., Traunecker, E., Lucchini, F. C., Dapito, D. H., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.015 · Cited by 175
Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes
Butcher, M. J., Hallinger, D. R., Garcia, E., Machida, Y., Chakrabarti, S., Nadler, J. L., Galkina, E., & Imai, Y. (2014) · Diabetologia · doi:10.1007/s00125-013-3116-5 · Cited by 161
Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review
Ghorbani, A., Rashidi, R., & Shafiee-Nick, R. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.127 · Cited by 179
Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats
Yu, S., Cheng, Y., Zhang, L., Yin, Y., Xue, J., Li, B., Gong, Z., Gao, J., & Mu, Y. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1474-8 · Cited by 158
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Macdougall, C. E., Wood, E. G., Loschko, J., Scagliotti, V., Cassidy, F. C., Robinson, M. E., Feldhahn, N., Castellano, L., Voisin, M.-B., Marelli‐Berg, F. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.007 · Cited by 163
Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook
Qayyum, N., Haseeb, M., Kim, M. S., & Choi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052754 · Cited by 157
Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance
Gabel, K., Kroeger, C. M., Trepanowski, J. F., Hoddy, K. K., Cienfuegos, S., Kalam, F., & Varady, K. A. (2019) · Obesity · doi:10.1002/oby.22564 · Cited by 144
NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
Góra, I. M., Ciechanowska, A., & Ładyżyński, P. (2021) · Cells · doi:10.3390/cells10020314 · Cited by 159
Current and emerging avenues for Alzheimer's disease drug targets
Loera‐Valencia, R., Cedazo-Mínguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 142
Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
Sharma, R. B., & Alonso, L. C. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0492-2 · Cited by 139
Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications
Meshkani, R., & Vakili, S. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.08.015 · Cited by 136
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 141
Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives
Borse, S., Chhipa, A. S., Sharma, V., Singh, D. P., & Nivsarkar, M. (2020) · Medical Principles and Practice · doi:10.1159/000511002 · Cited by 146
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
Wang, Y., Tang, B., Long, L., Luo, P., Xiang, W., Li, X., Wang, H., Jiang, Q., Tan, X., Luo, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20315-9 · Cited by 113
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. M., & Mann, M. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.012 · Cited by 109
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
Marselli, L., Piron, A., Suleiman, M., Colli, M. L., Yi, X., Khamis, A., Carrat, G., Rutter, G. A., Bugliani, M., Giusti, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108466 · Cited by 126
G protein-coupled receptors as targets for anti-diabetic therapeutics
Oh, D. Y., & Olefsky, J. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.4 · Cited by 110
Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity
Weitz, J., Makhmutova, M., Almaça, J., Stertmann, J., Aamodt, K. I., Briššová, M., Speier, S., Rodriguez‐Diaz, R., & Caicedo, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4416-y · Cited by 111
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83657 · Cited by 109
Marine natural products with anti-inflammatory activity
Cheung, R. C. F., Ng, T. B., Wong, J. H., Chen, Y., & Chan, W. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7244-3 · Cited by 112
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
Molla, M. D., Akalu, Y., Geto, Z., Dagnew, B., Ayelign, B., & Shibabaw, T. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s277457 · Cited by 119
Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults
Deng, C., Xiang, Y., Tan, T., Ren, Z., Cao, C., Huang, G., Li, W., & Zhou, Z. (2015) · Diabetes Care · doi:10.2337/dc15-1765 · Cited by 105
Hyperglycaemia, oxidative stress and inflammatory markers
Butkowski, E., & Jelinek, H. F. (2016) · Redox Report · doi:10.1080/13510002.2016.1215643 · Cited by 103
Amylin at the interface between metabolic and neurodegenerative disorders
Lutz, T. A., & Meyer, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00216 · Cited by 97
Diet components can suppress inflammation and reduce cancer risk
Hardman, W. E. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.3.233 · Cited by 100
Antidiabetic Potential of Monoterpenes: A Case of Small Molecules Punching above Their Weight
Habtemariam, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010004 · Cited by 100
M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice
Qian, B., Yang, Y., Tang, N., Wang, J., Sun, P. G., Yang, N., Chen, F., Wu, T., Sun, T., Li, Y., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05489-1 · Cited by 102
Type 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 101
Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes
Go, H.-K., Rahman, M. M., Kim, G.-B., Na, C.-S., Song, C.-H., Kim, J.-S., Kim, S., & Kang, H. (2015) · Nutrients · doi:10.3390/nu7105411 · Cited by 102
Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas
Yan, C., Gao, N., Sun, H., Yin, J., Lee, P. S. Y., Zhou, L., Fan, X., & Yu, F. X. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.01.019 · Cited by 96
Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
Imai, Y., Cousins, R. S., Liu, S., Phelps, B. M., & Promes, J. A. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14037 · Cited by 93
Arachidonic acid sex-dependently affects obesity through linking gut microbiota-driven inflammation to hypothalamus-adipose-liver axis
Zhuang, P., Shou, Q., Lu, Y., Wang, G., Qiu, J., Wang, J., He, L., Chen, J., Jiao, J., & Zhang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.003 · Cited by 94
Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption
Gianfrancesco, M. A., Dehairs, J., L’homme, L., Herinckx, G., Esser, N., Jansen, O., Habraken, Y., Lassence, C., Swinnen, J. V., Rider, M. H., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.001 · Cited by 97
Nutrition Regulates Innate Immunity in Health and Disease
Nobs, S. P., Zmora, N., & Elinav, E. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120919-094440 · Cited by 92
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity
Quarta, C., Clemmensen, C., Zhu, Z., Yang, B. S., Joseph, S. S., Lutter, D., Yi, C., Graf, E., García‐Cáceres, C., Legutko, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.023 · Cited by 89
The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis
Tian, Z., McLaughlin, J. T., Verma, A., Chinoy, H., & Heald, A. H. (2021) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000244 · Cited by 80
Inflammatory markers and cardiometabolic diseases
Esser, N., Paquot, N., & Scheen, A. J. (2015) · Acta Clinica Belgica · doi:10.1179/2295333715y.0000000004 · Cited by 82
METTL3 is required for maintaining β-cell function
Li, X., Jiang, Y., Sun, X., Wu, Y., & Chen, Z. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154702 · Cited by 78
Type 1 and Type 2 Diabetes Mellitus: Commonalities, Differences and the Importance of Exercise and Nutrition
Krause, M. D. S., & VITO, G. D. (2023) · Nutrients · doi:10.3390/nu15194279 · Cited by 76
IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
Westwell-Roper, C. Y., Chehroudi, C., Denroche, H. C., Courtade, J. A., Ehses, J. A., & Verchere, C. B. (2014) · Diabetologia · doi:10.1007/s00125-014-3447-x · Cited by 75
Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity
Liu, J., Raynal, S., Bailbé, D., Gausserès, B., Carbonne, C., Autier, V., Movassat, J., Kergoat, M., & Portha, B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.02.001 · Cited by 76
Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells
Timper, K., Dalmas, E., Dror, E., Rütti, S., Thienel, C., Sauter, N. S., Bouzakri, K., Bédat, B., Pattou, F., Kerr-Conte, J., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.003 · Cited by 67
Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes
Herder, C., Maalmi, H., Straßburger, K., Zaharia, O., Ratter, J. M., Karusheva, Y., Elhadad, M. A., Bódis, K. B., Bongaerts, B. W. C., Rathmann, W., et al. (2021) · Diabetes · doi:10.2337/db20-1054 · Cited by 78
Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes
Westwell-Roper, C. Y., Nąckiewicz, D., Dan, M., & Ehses, J. A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.4 · Cited by 74
Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism
Postler, T. S., Peng, V., Bhatt, D. M., & Ghosh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97441-x · Cited by 73
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
Böni‐Schnetzler, M., Häuselmann, S. P., Dalmas, É., Meier, D. T., Thienel, C., Traub, S., Schulze, F., Steiger, L., Dror, E., Martin, P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.063 · Cited by 77
The protective effects of Chinese yam polysaccharide against obesity-induced insulin resistance
Cheng, Z., Hu, M., Tao, J., Yang, H., Yan, P., An, G., & Wang, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.023 · Cited by 68
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease
Loaeza-Reyes, K. J., Zenteno, E., Rodríguez, A. M., Rosas, R. T., Argueta‐Figueroa, L., Salinas-Marín, R., Castillo-Real, L. M., Pina-Canseco, M. D. S., & Pérez-Cervera, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.751637 · Cited by 70
Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas
Saisho, Y. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.132 · Cited by 68
Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions
Zhang, D., Xie, T., & Leung, P. S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495395 · Cited by 65
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
Fu, A., Álvarez-Pérez, J. C., Avizonis, D. Z., Kin, T., Ficarro, S. B., Choi, D. W., Karaköse, E., Badur, M. G., Evans, L., Rosselot, C., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0199-4 · Cited by 65
EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway
Xie, H., Sun, J., Chen, Y., Zong, M., Li, S., & Wang, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/214836 · Cited by 63
Improving glycaemic control in type 2 diabetes: S timulate insulin secretion or provide beta‐cell rest?
van Raalte, D. H., & Verchere, C. B. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12935 · Cited by 63
Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies
Furman, B. L., Candasamy, M., Bhattamisra, S. K., & Veettil, S. K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112264 · Cited by 67
Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease
Cosentino, C., & Regazzi, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041765 · Cited by 61
Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage
Kong, X., Lu, A., Yao, X.-M., Hua, Q., Li, X.-Y., Li, Q., Zhang, H., Meng, G., & Su, Q. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9692546 · Cited by 61
β-cell neogenesis: A rising star to rescue diabetes mellitus
Niu, F., Liu, W., Ren, Y., Tian, Y., Shi, W., Li, M., Li, Y., Xiong, Y., & Lü, Q. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.10.008 · Cited by 68
Creating the amylin story
Lutz, T. A. (2022) · Appetite · doi:10.1016/j.appet.2022.105965 · Cited by 59
Death and Dysfunction of Transplanted β-Cells: Lessons Learned From Type 2 Diabetes?
Potter, K. J., Westwell-Roper, C. Y., Klimek-Abercrombie, A. M., Warnock, G. L., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db12-0364 · Cited by 59
Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Su, W., Wei, P., Gong, H., Liu, Y., Zhang, Y., Lian, Y., Cao, Z., Wu, R., Liu, L., Wang, B., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0985-4 · Cited by 58
Emerging role for kynurenines in metabolic pathologies
Liu, J., Movassat, J., & Portha, B. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000529 · Cited by 62
Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes
Cerf, M. E. (2020) · Metabolites · doi:10.3390/metabo10110452 · Cited by 55
Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates
Westwell-Roper, C. Y., Denroche, H. C., Ehses, J. A., & Verchere, C. B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712455 · Cited by 54
Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
Mosli, R. H., & Mosli, H. H. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s149832 · Cited by 53
The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations
Ardestani, A. D., & Maedler, K. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00167 · Cited by 57
Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus
Lempesis, I. G., & Georgakopoulou, V. (2023) · World Journal of Experimental Medicine · doi:10.5493/wjem.v13.i3.7 · Cited by 58
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
Ballak, D. B., Li, S., Cavalli, G., Stahl, J. L., Tengesdal, I. W., van Diepen, J. A., Klück, V., Swartzwelter, B. J., Azam, T., Tack, C. J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003698 · Cited by 55
Insulin Resistance in Osteoarthritis: Similar Mechanisms to Type 2 Diabetes Mellitus
Tchetina, E. V., Markova, G. A., & Sharapova, E. P. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/4143802 · Cited by 58
Dynamic pathology of islet endocrine cells in type 2 diabetes: β‐Cell growth, death, regeneration and their clinical implications
Yagihashi, S., Inaba, W., & Mizukami, H. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12424 · Cited by 50
Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes
Li, X., Wu, Y., Song, Y., Ding, N., Lu, M. M., Jia, L., Zhao, Y., Liu, M. R., & Chen, Z. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.07.016 · Cited by 50
Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?
Achim, A., Stanek, A., Homorodean, C., Spînu, M., Onea, H., Lazăr, F.-L., Marc, M., Ruzsa, Z., & Olinic, D.-M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169801 · Cited by 57

Authors: Donath, M. Y., Dalmas, É., Sauter, N. S., & Böni-Schnetzler, M.
Affiliations: University Hospital of Basel (CH)
Corresponding author: Donath, Marc Y.
ORCID: Donath, Marc Y.
Dalmas, Élise
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-06
Volume: 17
Issue: 6
Pages: 860-872
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.05.001
OpenAlex: W2053963810
Cited by: 338
References: 147
Citations by year: 2026: 16 · 2025: 18 · 2024: 9 · 2023: 25 · 2022: 28 · 2021: 39 · 2020: 33 · 2019: 29 · 2018: 24 · 2017: 30 · 2016: 20 · 2015: 33 · 2014: 29 · 2013: 5
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: obesity, diabetes mellitus, insulitis, islet dysfunction, immune system, overnutrition, immunomodulatory therapy
MeSH terms: Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Immunity, Innate, Inflammation, Insulin, Islets of Langerhans, Macrophages, Obesity, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks