mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Bioconductor: open software development for computational biology and bioinformatics

Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Taneike, M., Nishida, K., Omiya, S., Zarrinpashneh, E., Misaka, T., Kitazume-Taneike, R., Austin, R., Takaoka, M., Yamaguchi, O., Gambello, M. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0152628 · Cited by 57

eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease

Wolf, D. A., Lin, Y., Duan, H., & Cheng, Y. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa018 · Cited by 59

Differential redox-regulation and mitochondrial dynamics in normal and leukemic hematopoietic stem cells: A potential window for leukemia therapy

Mattes, K., Vellenga, E., & Schepers, H. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102814 · Cited by 62

Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis

Chimin, P., Andrade, M. L., Belchior, T., Paschoal, V. A., Magdalon, J., Yamashita, A. S., Castro, É., Castoldi, Â., Chaves‐Filho, A. B., Yoshinaga, M. Y., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m074518 · Cited by 58

Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward

Laguesse, S., Morisot, N., Shin, J. H., Liu, F., Adrover, M. F., Sakhai, S. A., Lopez, M. F., Phamluong, K., Griffin, W. C., Becker, H. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.037 · Cited by 56

Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Ganji, C., Muppala, V., Khan, M., Nagaraju, G. P., & Farran, B. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103469 · Cited by 57

Targeting mTOR for Anti-Aging and Anti-Cancer Therapy

Fu, W., & Wu, G. (2023) · Molecules · doi:10.3390/molecules28073157 · Cited by 62

Metabolic control via the mitochondrial protein import machinery

Opalińska, M., & Meisinger, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.11.001 · Cited by 58

Is REDD1 a Metabolic Éminence Grise ?

Lipina, C., & Hundal, H. S. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.08.005 · Cited by 60

Adult-onset obesity is triggered by impaired mitochondrial gene expression

Perks, K. L., Ferreira, N., Richman, T. R., Ermer, J. A., Kuznetsova, I., Shearwood, A.-M. J., Lee, R. G., Viola, H. M., Johnstone, V., Matthews, V. B., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700677 · Cited by 56

Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis

Fali, T., Fabre-Mersseman, V., Yamamoto, T., Bayard, C., Papagno, L., Fastenackels, S., Zoorab, R., Koup, R. A., Boddaert, J., Sauce, D., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.95319 · Cited by 59

mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

Yi, S. A., Sepic, S., Schulman, B. A., Ordureau, A., & An, H. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.04.026 · Cited by 52

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

Karniely, S., Weekes, M. P., Antrobus, R., Rorbach, J., Haute, L. V., Umrania, Y., Smith, D. L., Stanton, R. J., Minczuk, M. A., Lehner, P. J., et al. (2016) · mBio · doi:10.1128/mbio.00029-16 · Cited by 56

Protein Kinase CK2 in Cancer Energetics

Silva-Pavez, E., & Tapia, J. C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00893 · Cited by 54

The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives

Jurcău, A. (2021) · Nutrients · doi:10.3390/nu13020282 · Cited by 54

Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue

Nagao, H., Nishizawa, H., Bamba, T., Nakayama, Y., Isozumi, N., Nagamori, S., Kanai, Y., Tanaka, Y., Kita, S., Fukuda, S., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770172 · Cited by 53

Linking Cancer Cachexia‐Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism

Hardee, J. P., Montalvo, R. N., & Carson, J. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8018197 · Cited by 53

The clock is ticking: the impact of ageing on T cell metabolism

Quinn, K. M., Palchaudhuri, R., Palmer, C. S., & Gruta, N. L. L. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1091 · Cited by 52

High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice

Liu, R., Chen, L., Wang, Y., Zhang, G., Cheng, Y., Feng, Z., Bai, X., & Liu, J. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108330 · Cited by 54

Regulation of mitochondrial plasticity by the i-AAA protease YME1L

Ohba, Y., MacVicar, T., & Langer, T. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0120 · Cited by 54

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer

Holloway, R. W., & Marignani, P. A. (2021) · Cancers · doi:10.3390/cancers13122922 · Cited by 56

The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer

Fontana, F., & Limonta, P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.024 · Cited by 53

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Levy, T., Voeltzke, K., Hruby, L. A., Alasad, K., Bas, Z., Snaebjornsson, M. T., Marciano, R., Scharov, K., Planque, M., Vriens, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48386-y · Cited by 55

Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease

Kiraly, S., Stanley, J., & Eden, E. R. (2025) · Antioxidants · doi:10.3390/antiox14020125 · Cited by 58

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

Oka, S., Hirata, T., Suzuki, W., Naito, D., Chen, Y., Chin, A., Yaginuma, H., Saito, T., Nagarajan, N., Zhai, P., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.807735 · Cited by 55

Anti-tumor Effects of Everolimus and Metformin Are Complementary and Glucose-dependent in Breast Cancer Cells

Ariaans, G., Jalving, M., Vries, E. G. E. D., & Jong, S. D. (2017) · BMC Cancer · doi:10.1186/s12885-017-3230-8 · Cited by 51

Aging, senescence and mitochondria: the PGC-1/ERR axis

Vernier, M., & Giguère, V. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0196 · Cited by 52

Mitochondrial regulation in stem cells

Wang, Y., Barthez, M., & Chen, D. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.10.003 · Cited by 56

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Tsukumo, Y., Alain, T., Fonseca, B. D., Nadon, R., & Sonenberg, N. (2016) · Nature Communications · doi:10.1038/ncomms11776 · Cited by 54

Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome

Ravera, S., Dufour, C., Cesaro, S., Bottega, R., Faleschini, M., Cuccarolo, P., Corsolini, F., Usai, C., Columbaro, M., Cipolli, M., et al. (2016) · Scientific Reports · doi:10.1038/srep25441 · Cited by 51

Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

Nogueira, V., Patra, K. C., & Hay, N. (2018) · eLife · doi:10.7554/elife.32213 · Cited by 53

Nitric oxide triggers the assembly of “type II” stress granules linked to decreased cell viability

Aulas, A., Lyons, S. M., Fay, M. M., Anderson, P., & Ivanov, P. V. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1173-x · Cited by 51

Complement's favourite organelle—Mitochondria?

Rahman, J., Singh, P., Merle, N. S., Niyonzima, N., & Kemper, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15238 · Cited by 50

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5′-TOP mRNAs restricts viral infection

Hopkins, K. C., Tartell, M. A., Herrmann, C., Hackett, B. A., Taschuk, F., Panda, D., Menghani, S. V., Sabin, L. R., & Cherry, S. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418805112 · Cited by 50

Nutrients, neurogenesis and brain ageing: From disease mechanisms to therapeutic opportunities

Fidaleo, M., Cavallucci, V., & Pani, G. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.05.016 · Cited by 51

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

D’Orazi, G., Cordani, M., & Cirone, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03677-7 · Cited by 51

Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

Gao, Y., Bai, X., Zhang, D., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3206 · Cited by 49

Dysregulation of mRNA translation and energy metabolism in cancer

Leibovitch, M., & Topisirović, I. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.11.001 · Cited by 46

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR

Veiga, S. R., Ge, X., Mercer, C. A., Hernández‐Álvarez, M. I., Thomas, H. E., Hernández‐Losa, J., y Cajal, S. R., Antonio Zorzano, A., Thomas, G., & Kozma, S. C. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0177 · Cited by 49

17‐α estradiol ameliorates age‐associated sarcopenia and improves late‐life physical function in male mice but not in females or castrated males

Garratt, M., Leander, D. C., Pifer, K., Bower, B., Herrera, J. J., Day, S. M., Fiehn, O., Brooks, S. V., & Miller, R. A. (2019) · Aging Cell · doi:10.1111/acel.12920 · Cited by 51

Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells

Kučić, N., Rački, V., Šverko, R., Vidović, T., Grahovac, I., & Mršić‐Pelčić, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168429 · Cited by 48

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

Jobava, R., Mao, Y., Guan, B., Hu, D., Krokowski, D., Chen, C.-W., Shu, X. E., Chukwurah, E., Wu, J., Gao, Z., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.029 · Cited by 49

Metabolic Regulation of Mitochondrial Protein Biogenesis from a Neuronal Perspective

Hees, J. T., & Harbauer, A. B. (2022) · Biomolecules · doi:10.3390/biom12111595 · Cited by 53

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential

Fonseka, O., Gare, S. R., Chen, X., Zhang, J., Alatawi, N. H. O., Ross, C., & Liu, W. (2025) · Cells · doi:10.3390/cells14050324 · Cited by 52

Inhibition of mitochondrial translation effectively sensitizes renal cell carcinoma to chemotherapy

Wang, B., Ao, J., Yu, D., Rao, T., Ruan, Y., & Yao, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.115 · Cited by 51

Suppression of mitochondrial respiration with local anesthetic ropivacaine targets breast cancer cells

Gong, X., Dan, J., Li, F., & Wang, L. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.05.21 · Cited by 48

Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons

Thelen, M. P., Wirth, B., & Kye, M. J. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01101-6 · Cited by 52

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

Lee, Y., Kim, S. G., Lee, B., Zhang, Y., Kim, Y., Kim, S., Kim, E., Kang, H., & Han, K. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00201 · Cited by 47

Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise

Sawan, S. A., van Vliet, S., Parel, J. T., Beals, J. W., Mazzulla, M., West, D. W. D., Philp, A., Li, Z., Paluska, S. A., Burd, N. A., et al. (2018) · Physiological Reports · doi:10.14814/phy2.13628 · Cited by 52

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Momcilovic, M., McMickle, R., Abt, E., Seki, A., Simko, S. A., Magyar, C., Stout, D. B., Fishbein, M. C., Walser, T. C., Dubinett, S. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0797 · Cited by 46

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology

Kumar, P., Goettemoeller, A. M., Espinosa‐García, C., Tobin, B. R., Tfaily, A., Nelson, R. S., Natu, A., Dammer, E. B., Santiago, J. V., Malepati, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47028-7 · Cited by 53

Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis

Das, R., Xu, S., Nguyen, T. T., Quan, X., Choi, S.-K., Kim, S., Lee, E. Y., Cha, S., & Park, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.703116 · Cited by 47

Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview

Lunová, M., Smolková, B., Lynnyk, A., Uzhytchak, M., Jirsa, M., Kubinová, Š., Dejneka, A., & Lunov, O. (2019) · Cancers · doi:10.3390/cancers11010082 · Cited by 47

Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis

Roque, W., Cuevas-Mora, K., & Romero, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020643 · Cited by 47

Translational control by oncogenic signaling pathways

Gao, B., & Roux, P. P. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.11.006 · Cited by 46

Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects

Granata, S., Gassa, A. D., Carraro, A., Brunelli, M., Stallone, G., Lupo, A., & Zaza, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050735 · Cited by 45

Adiponectin Enhances Quiescence Exit of Murine Hematopoietic Stem Cells and Hematopoietic Recovery Through mTORC1 Potentiation

Masamoto, Y., Arai, S., Sato, T., Kubota, N., Takamoto, I., Kadowaki, T., & Kurokawa, M. (2017) · Stem Cells · doi:10.1002/stem.2640 · Cited by 49

SOX4 Promotes Proliferative Signals by Regulating Glycolysis through AKT Activation in Melanoma Cells

Dai, W., Xu, X., Li, S., Ma, J., Shi, Q., Guo, S., Liu, L., Guo, W., Xu, P., He, Y., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.06.026 · Cited by 45

Translating the Game: Ribosomes as Active Players

Calamita, P., Gatti, G., Miluzio, A., Scagliola, A., & Biffo, S. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00533 · Cited by 45

A concert of RNA-binding proteins coordinates mitochondrial function

Schatton, D., & Rugarli, E. I. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1553927 · Cited by 45

B cell activation via immunometabolism in systemic lupus erythematosus

Iwata, S., Hajime, M., & Tanaka, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155421 · Cited by 44

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants

Konstantakou, E. G., Voutsinas, G. E., Velentzas, A. D., Bassogianni, A.-S., Paronis, E., Balafas, E., Kostomitsopoulos, N. G., Syrigos, K. N., Anastasiadou, E., & Stravopodis, D. J. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0399-9 · Cited by 44

Mechano‐signalling pathways in an experimental intensive critical illness myopathy model

Corpeño, R., Salah, H. A., Gastaldello, S., Martínez-Redondo, V., Ruas, J. L., Fury, W., Bai, Y., Gromada, J., Sartori, R., D, D. C. G., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271973 · Cited by 43

The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells

Mohrin, M., & Chen, D. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000244 · Cited by 46

Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

Katreddy, R. R., Bollu, L. R., Su, F., Xian, N., Srivastava, S., Thomas, R., Dai, Y., Wu, B., Xu, Y., Rea, M. A., et al. (2018) · Oncogenesis · doi:10.1038/s41389-017-0021-7 · Cited by 44

mTOR Inhibition Role in Cellular Mechanisms

Zaza, G., Granata, S., Caletti, C., Signorini, L. F., Stallone, G., & Lupo, A. (2018) · Transplantation · doi:10.1097/tp.0000000000001806 · Cited by 46

The pathogenesis of mesothelioma is driven by a dysregulated translatome

Grosso, S., Marini, A., Gyurászová, K., Voorde, J. V., Sfakianos, A., Garland, G. D., Rubio, A., Mordue, R., Chernova, T., Morone, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25173-7 · Cited by 44

Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma

Ishio, T., Kumar, S., Shimono, J., Daenthanasanmak, A., Dubois, S. P., Lin, Y., Bryant, B. R., Petrus, M. N., Bachy, E., Huang, D. W., et al. (2021) · Blood · doi:10.1182/blood.2021012734 · Cited by 41

Cellular consequences of oxidative stress in riboflavin responsive multiple acyl-CoA dehydrogenation deficiency patient fibroblasts

Cornelius, N., Corydon, T. J., Gregersen, N. V., & Olsen, R. K. J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu146 · Cited by 43

Neural Stem Cell Activation and the Role of Protein Synthesis

Baser, A., Skabkin, M. A., & Martín-Villalba, A. (2017) · Brain Plasticity · doi:10.3233/bpl-160038 · Cited by 43

Mitochondrial dysfunction and potential anticancer therapy

LLeonart, M. E., Grodzicki, R., Graifer, D. M., & Lyakhovich, A. (2017) · Medicinal Research Reviews · doi:10.1002/med.21459 · Cited by 43

The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan

Carvalho, G. B., Drago, I., Hoxha, S., Yamada, R., Mahneva, O., Bruce, K. D., Obando, A. S., Conti, B., & Ja, W. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618994114 · Cited by 44

Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment

Wang, L., Guo, C., Li, X., Yu, X., Li, X., Xu, K., Jiang, B., Jia, X., Li, C., & Shi, D. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.05.044 · Cited by 43

Calcium Mechanisms in Limb-Girdle Muscular Dystrophy with CAPN3 Mutations

Lasa-Elgarresta, J., Mosqueira‐Martín, L., Naldaiz‐Gastesi, N., Sáenz, A., de Munaín, A. L., & Vallejo‐Illarramendi, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184548 · Cited by 43

Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice

Yin, Q., Ni, Q., Wang, Y., Zhang, H., Li, W., Nie, A., Wang, S., Gu, Y., Wang, Q., & Ning, G. (2020) · Nature Communications · doi:10.1038/s41467-020-15935-0 · Cited by 42

Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer

Senapati, P., Kato, H., Lee, M., Leung, A., Thai, C., Sanchez, A., Gallagher, E. J., LeRoith, D., Seewaldt, V. L., Ann, D. K., et al. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0290-9 · Cited by 43

Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy

Han, B., Lin, X., & Hu, H. (2024) · Translational Breast Cancer Research · doi:10.21037/tbcr-24-29 · Cited by 44

The role of mTOR in lipid homeostasis and diabetes progression

Chakrabarti, P., & Kandror, K. V. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000187 · Cited by 44

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

Leroux, L., Lorent, J., Graber, T. E., Chaparro, V., Masvidal, L., Aguirre, M., Fonseca, B. D., van Kempen, L. C. L. T., Alain, T., Larsson, O. S., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00244-18 · Cited by 42

Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer

Köseoğlu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180874 · Cited by 41

Pharmacological relevance of CDK inhibitors in Alzheimer's disease

Malhotra, N., Gupta, R. V., & Kumar, P. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105115 · Cited by 42

Energy sensing and cancer: LKB1 function and lessons learnt from Peutz–Jeghers syndrome

Shorning, B. Y., & Clarke, A. R. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.015 · Cited by 45

Metabolism of Preimplantation Embryo Development

Kaneko, K. J. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.04.010 · Cited by 48

N-Acetyl-L-cysteine Protects the Enterocyte against Oxidative Damage by Modulation of Mitochondrial Function

Xiao, H., Wu, M., Shao, F., Guan, G., Huang, B., Tan, B., & Yin, Y. (2016) · Mediators of Inflammation · doi:10.1155/2016/8364279 · Cited by 42

Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats

Ren, T., Zhu, Y., Xia, X., Ding, Y., Guo, J. H., & Kan, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0218 · Cited by 41

Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Jacobs, R. A., Aboouf, M. A., Köster-Hegmann, C., Muttathukunnel, P., Laouafa, S., Arias‐Reyes, C., Thiersch, M., Soliz, J., Gassmann, M., & Gasser, E. M. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02465-8 · Cited by 42

TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A

Hwang, J., Kim, K. M., Oh, H. T., Yoo, G. D., Jeong, M. G., Lee, H., Park, J., Jeong, K., Kim, Y. K., Ko, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28247-2 · Cited by 43

mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model

Jeffries, M. A., McLane, L. E., Khandker, L., Mather, M. L., Evangelou, A. V., Kantak, D., Bourne, J. N., Macklin, W. B., & Wood, T. L. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1377-20.2021 · Cited by 44

The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes

Huynh, T. V., Rethi, L., Rethi, L., Chen, C., Chen, Y., & Kao, Y. (2023) · Cells · doi:10.3390/cells12091223 · Cited by 42

Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

Xu, B., Gogol, M., Gaudenz, K., & Gerton, J. L. (2016) · BMC Genomics · doi:10.1186/s12864-015-2354-y · Cited by 40

Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals

Hofmann, J. N., Birmann, B. M., Teras, L. R., Pfeiffer, R. M., Wang, Y., Albanes, D., Baris, D., Colditz, G. A., Roos, A. J. D., Giles, G. G., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2406 · Cited by 40

AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model

YALVAÇ, M. E., Amornvit, J., Chen, L., Shontz, K. M., Lewis, S., & Sahenk, Z. (2018) · Gene Therapy · doi:10.1038/s41434-018-0009-8 · Cited by 41

Impact of Immunosuppressive Drugs on the Metabolism of T Cells

Pallet, N., Fernández-Ramos, A. A., & Loriot, M. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.009 · Cited by 42

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Sletten, A. C., Davidson, J. W., Yağabasan, B., Moores, S., Schwaiger-Haber, M., Fujiwara, H., Gale, S. E., Jiang, X., Sidhu, R., Gelman, S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25457-y · Cited by 40

Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion

Asahara, S., Inoue, H., Watanabe, H., & Kido, Y. (2022) · Biomolecules · doi:10.3390/biom12050614 · Cited by 39

eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation

Yu, Y., Tian, L., Xiao, F., Cheng, J. Q., Gong, Y., Liu, X., Zhang, Z., Yang, X., He, S., Li, C., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.02.052 · Cited by 40

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

Zhou, X., & Torres, V. E. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.981963 · Cited by 42

mTOR Dysregulation, Insulin Resistance, and Hypertension

Stanciu, S. M., Jinga, M., Miricescu, D., Ștefani, C., Nica, R. I., Stănescu-Spînu, I.-I., Văcăroiu, I. A., Greabu, M., & Nica, S. (2024) · Biomedicines · doi:10.3390/biomedicines12081802 · Cited by 44

Targeting Mitochondrial Network Architecture in Down Syndrome and Aging

Mollo, N., Cicatiello, R., Aurilia, M., Scognamiglio, R., Genesio, R., Charalambous, M., Paladino, S., Conti, A. M. F., Nitsch, L., & Izzo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093134 · Cited by 41

Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion

Caino, M. C., & Altieri, D. C. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1084448 · Cited by 41

Abstract B06: Translational control of mitochondria through mTORC1/4E-BP signaling pathway

Morita, M., Prudent, J., McBride, H. M., Bergeron, J. J. M., & Sonenberg, N. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-b06

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita, M., Gravel, S.-P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991572 · Cited by 552

The Translational Regulation in mTOR Pathway

Yang, M., Lu, Y., Piao, W., & Jin, H. (2022) · Biomolecules · doi:10.3390/biom12060802 · Cited by 217

Deficiency in mTORC1‐controlled C/EBPβ‐mRNA translation improves metabolic health in mice

Zidek, L. M., Ackermann, T., Hartleben, G., Eichwald, S., Kortman, G., Kiehntopf, M., Leutz, A., Sonenberg, N., Wang, Z., von Maltzahn, J., et al. (2015) · EMBO Reports · doi:10.15252/embr.201439837 · Cited by 48

Article Deficiency in mTORC1-controlled C/EBPb-mRNA translation improves metabolic health in mice

Zidek, L. M., Ackermann, T., Hartleben, G., Eichwald, S., Kortman, G., Kiehntopf, M., Leutz, A., Sonenberg, N., Wang, Z.-Q., von Maltzahn, J., et al. (2016)