mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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mTOR Signaling in Growth Control and Disease

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Mitochondrial quality control in lung diseases: current research and future directions

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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

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OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

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Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

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GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

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Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells

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Reciprocal regulation of photosynthesis and mitochondrial respiration by TOR kinase in Chlamydomonas reinhardtii

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Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study

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Cell lineage-specific mitochondrial resilience during mammalian organogenesis

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HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway

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How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer

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The TOR complex controls ATP levels to regulate actin cytoskeleton dynamics in Arabidopsis

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TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression

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Anti-Aging Drugs and the Related Signal Pathways

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Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E

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Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer

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The Cutting Edge: The Role of mTOR Signaling in Laminopathies

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The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis

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The 40 S -LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity

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Crosstalks between translation and metabolism in cancer

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Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance

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Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases

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Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity

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Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases

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MTOR Signaling and Metabolism in Early T Cell Development

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Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

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EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax

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mTORC1 in energy expenditure: consequences for obesity

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Mitochondrial medicine: “from bench to bedside” 3PM-guided concept

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Largen: A Molecular Regulator of Mammalian Cell Size Control

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The p53 Target Gene SIVA Enables Non–Small Cell Lung Cancer Development

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Altered Mitochondrial Signalling and Metabolism in Cancer

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Chronic kidney disease attenuates the plasma metabolome response to insulin

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Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway

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Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation

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Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

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Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics

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Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems

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Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy

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Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

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Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

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R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes

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The association between metabolic risk factors, nonalcoholic fatty liver disease, and the incidence of liver cancer: a nationwide population-based cohort study

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Role of Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases

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Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function

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Hyperactivation of mammalian target of rapamycin complex 1 by HIV‐1 is necessary for virion production and latent viral reactivation

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The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks

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Skeletal muscle–specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration

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Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

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Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart

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Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells

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Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation

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Azoxystrobin Impairs Neuronal Migration and Induces ROS Dependent Apoptosis in Cortical Neurons

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Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia

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O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

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Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila

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Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway

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Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells

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Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway

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Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function

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2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies

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Therapeutic Antiaging Strategies

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mTOR signaling: A pivotal player in Treg cell dysfunction in systemic lupus erythematosus

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Human macrophage differentiation induces OCTN2–mediated L-carnitine transport through stimulation of mTOR–STAT3 axis

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Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches

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Suvorexant improves mitochondrial dynamics with the regulation of orexinergic and mTOR activation in rats exhibiting PTSD-like symptoms

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Mitochondrial tRNA pseudouridylation governs erythropoiesis

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The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors

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NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets

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4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

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Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells

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Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice

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IL-38 Exerts Anti-Inflammatory and Antifibrotic Effects in Thyroid-Associated Ophthalmopathy

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Dissection of two routes to naïve pluripotency using different kinase inhibitors

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