mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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mTOR Signaling in Growth Control and Disease

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Cellular energy utilization and molecular origin of standard metabolic rate in mammals

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Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress

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The mTORC2 signaling network: targets and cross-talks

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Potential therapeutic effects of mTOR inhibition in atherosclerosis

Kurdi, A., Meyer, G. R. Y. D., & Martinet, W. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12820 · Cited by 111

Role of AMPK/mTOR, mitochondria, and ROS in the pathogenesis of endometriosis

Assaf, L., Eid, A. A., & Nassif, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120805 · Cited by 119

Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers

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Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration

Yoon, W. H., Sandoval, H., Nagarkar-Jaiswal, S., Jaiswal, M., Yamamoto, S., Haelterman, N. A. T., Putluri, N., Putluri, V., Sreekumar, A., Tos, T., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.038 · Cited by 104

Monoamine oxidase‐A is a novel driver of stress‐induced premature senescence through inhibition of parkin‐mediated mitophagy

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Mitochondrial dysfunction and its association with age-related disorders

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Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

Caino, M. C., & Altieri, D. C. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0460 · Cited by 105

mTOR and the health benefits of exercise

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Nutrient Sensing and the Oxidative Stress Response

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Translational control of aberrant stress responses as a hallmark of cancer

El-Naggar, A. M., & Sorensen, P. H. B. (2018) · The Journal of Pathology · doi:10.1002/path.5030 · Cited by 105

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S., Ayers, G. D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108944 · Cited by 109

Cancer Plasticity: The Role of mRNA Translation

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Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma

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Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy

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Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

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Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

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Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

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Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

van der Rijt, S., Molenaars, M., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594416 · Cited by 102

Molecular mechanisms of mTOR regulation by stress

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Translational Control during Developmental TransitionsPreprint

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Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Singh, K., Chen, Y., Hassanzadeh, S., Han, K., Judy, J., Seifuddin, F., Tunc, I., Sack, M. N., & Pirooznia, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.599261 · Cited by 99

The pathobiology of polycystic kidney disease from a metabolic viewpoint

Menezes, L. F., & Germino, G. G. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0183-y · Cited by 96

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

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Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation

Monteleon, C. L., Agnihotri, T., Dahal, A., Liu, M., Rebecca, V. W., Beatty, G. L., Amaravadi, R. K., & Ridky, T. W. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.02.035 · Cited by 92

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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Quiescence Entry, Maintenance, and Exit in Adult Stem Cells

Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 94

Enhanced Cardiac Akt/Protein Kinase B Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function via Transcriptional Repression of Mitochondrion-Targeted Nuclear Genes

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The role of mitochondria in rheumatic diseases

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Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

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mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

Cayo, Á., Segovia, R., Venturini, W., Moore‐Carrasco, R., Valenzuela, C. A., & Brown, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158149 · Cited by 96

Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC

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mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85

Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming

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Transcriptional Regulation of Energy Metabolism in Cancer Cells

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Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis

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Metabolic Reprogramming of Non-Hodgkin's B-Cell Lymphomas and Potential Therapeutic Strategies

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4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in mice

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mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity

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mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics

Zhang, H., Xiao, X., Pan, Z., & Dokudovskaya, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02493-4 · Cited by 94

An evolutionary perspective of AMPK–TOR signaling in the three domains of life

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Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

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PI(3,4)P2 Signaling in Cancer and Metabolism

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Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure

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A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

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Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

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GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors

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A transcript-specific eIF3 complex mediates global translational control of energy metabolism

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Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

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MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism

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The mTORC1/4E-BP pathway coordinates hemoglobin production with L -leucine availability

Chung, J., Bauer, D. E., Ghamari, A., Nizzi, C. P., Deck, K. M., Kingsley, P. D., Yien, Y. Y., Huston, N. C., Chen, C., Schultz, I. J., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa5903 · Cited by 84

Translational regulation of mitochondrial biogenesis

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Mitochondria: The metabolic switch of cellular oncogenic transformation

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Unraveling Interfaces between Energy Metabolism and Cell Cycle in Plants

Siqueira, J. A., Hardoim, P. R., Ferreira, P. C. G., Nunes‐Nesi, A., & Hemerly, A. S. (2018) · Trends in Plant Science · doi:10.1016/j.tplants.2018.05.005 · Cited by 75

Lymphangioleiomyomatosis: A Monogenic Model of Malignancy

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The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence

Mohrin, M., Widjaja, A., Liu, Y., Luo, H., & Chen, D. (2018) · Aging Cell · doi:10.1111/acel.12756 · Cited by 79

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy

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Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming

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The Target of Rapamycin and Mechanisms of Cell Growth

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Natural Selection Shapes Codon Usage in the Human Genome

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mTOR-sensitive translation: Cleared fog reveals more trees

Masvidal, L., Hulea, L., Furic, L., Topisirović, I., & Larsson, O. S. (2017) · RNA Biology · doi:10.1080/15476286.2017.1290041 · Cited by 69

Mitochondrial metabolism in neural stem cells and implications for neurodevelopmental and neurodegenerative diseases

Garone, C., Giorgio, F. D., & Carli, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05041-w · Cited by 80

Signaling Pathways Regulating Redox Balance in Cancer Metabolism

Santis, M. C. D., Porporato, P. E., Martini, M., & Morandi, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00126 · Cited by 77

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

Galloway, A., Kaskar, A., Ditsova, D., Atrih, A., Yoshikawa, H., Gómez-Moreira, C., Suska, O., Warmiński, M., Grzela, R., Lamond, A. I., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab465 · Cited by 74

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

Wang, J., Xu, Y., Wan, H., & Hu, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.063 · Cited by 72

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

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Is REDD1 a metabolic double agent? Lessons from physiology and pathology

Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 72

Translational control and the cancer cell response to stress

Robichaud, N., & Sonenberg, N. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.05.007 · Cited by 73

Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas

Shen, H. M., Yu, M., Tsoli, M., Chang, C., Joshi, S. M., Liu, J., Ryall, S. T., Chornenkyy, Y., Siddaway, R., Hawkins, C. E., et al. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz140 · Cited by 71

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

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Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise

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Targeting mTOR in Acute Lymphoblastic Leukemia

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The role of mTOR in age-related diseases

Chrienová, Ž., Nepovimová, E., & Kuča, K. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1955873 · Cited by 72

Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma

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Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

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Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition

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Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy

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Regulation of gene expression via translational buffering

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