The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Open accessAbstract
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)-resolvins, protectins, and maresins-are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.
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“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.368, 369”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [369]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×
“…2014 ª2014 Elsevier Inc. 27 as Ly6ChiCCR2hiCX3CR1low, have considerable plasticity and differentiate into reparative monocytes andmacrophages during the resolution of fibrosis and tissue regeneration (Ramachandran et al., 2012; Godwin et al., 2013; Nahrendorf and Swirski, 2013; Wynn et al., 2013).”
BackgroundAdipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
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Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041
Self-citationMozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered proinflammatory, but is also the natural precursor to specialized proresolving mediators of inflammation.(368,369) In prospective studies, higher biomarker levels of arachidonic acid are linked to significantly lower risk of CHD.”
Mammalian lipoxygenases and their biological relevance
Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 644
The role of inflammation and genetics in periodontal disease
Loos, B. G., & Dyke, T. E. V. (2020) · Periodontology 2000 · doi:10.1111/prd.12297 · Cited by 661
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583
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Metadata
- Authors
- Spite, M., Clària, J., & Serhan, C. N.
- Affiliations
- University of Louisville (US)
- Hospital Clínic de Barcelona (ES)
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 21-36
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3947989
- OpenAlex
- W2065295548
- Cited by
- 464
- References
- 130
- Citations by year
- 2026: 37 · 2025: 28 · 2024: 20 · 2023: 23 · 2022: 33 · 2021: 49 · 2020: 43 · 2019: 53 · 2018: 27 · 2017: 47 · 2016: 35 · 2015: 48 · 2014: 20
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (4r37gm038765-19)
- National Heart, Lung, and Blood Institute (HL-106173, R01HL106173)
- National Institute of General Medical Sciences (P20GM103492, P01GM095467, GM-095467, GM 103492, GM038765, R01GM038765, R37-GM038765)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- resolvins, protectins, maresins, inflammation resolution, low-grade inflammation, metabolic disorders, tissue regeneration, neutrophil recruitment, autacoids
- MeSH terms
- Animals, Fatty Acids, Unsaturated, Humans, Inflammation, Metabolic Diseases
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