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Cited by 583Fatty Acid Research and HealthInflammatory mediators and NSAID effectsSphingolipid Metabolism and Signaling

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

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Serhan, Charles N., Chiang, Nan, Dalli, Jesmond·2015·Seminars in Immunology
DOI 10.1016/j.smim.2015.03.004PMC PMC4515371
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Abstract

Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.

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  • These mediators reduce cytokine production (e.g., IL-6, TNF-α), enhance macrophage phagocytosis, and inhibit neutrophil infiltration.

    “These mediators reduce cytokine production (e.g., IL-6, TNF-α), enhance macrophage phagocytosis, and inhibit neutrophil infiltration [100].”

    From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [100]

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Cited by

Sorted by citations

Authors
Serhan, C. N., Chiang, N., & Dalli, J.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Serhan, Charles N.
ORCID
Venue
Seminars in Immunology
Publisher
Elsevier BV
Published
2015-05
Volume
27
Issue
3
Pages
200-215
ISSN
1044-5323 (ISSN-L)
DOI
10.1016/j.smim.2015.03.004
PMC
PMC4515371
OpenAlex
W2037231636
Cited by
583
References
24
Citations by year
2026: 41 · 2025: 48 · 2024: 47 · 2023: 44 · 2022: 47 · 2021: 62 · 2020: 51 · 2019: 58 · 2018: 51 · 2017: 67 · 2016: 53 · 2015: 14
FWCI
7.92
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (R01GM038765, P01GM095467)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords
inflammation resolution, specialized pro-resolving mediators, lipoxins, resolvins, protectins, maresins, omega-3 polyunsaturated fatty acids, anti-inflammatory mechanism, microbial clearance, tissue regeneration, wound healing, neurobiology
MeSH terms
Acute Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Docosahexaenoic Acids, Fatty Acids, Essential, Homeostasis, Humans, Inflammation, Wound Healing, Reperfusion Injury, Fatty Acids, Omega-3, Inflammation Mediators, Lipoxins, Lipid Metabolism, Mice

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