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Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Open accessAbstract
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic diseases is sustained and detrimental. The resolution of inflammation involves the termination of neutrophil recruitment, counterregulation of proinflammatory mediators, stimulation of macrophage-mediated clearance, and tissue remodeling. Specialized proresolving lipid mediators (SPMs)-resolvins, protectins, and maresins-are novel autacoids that resolve inflammation, protect organs, and stimulate tissue regeneration. Here, we review evidence that the failure of resolution programs contributes to metabolic diseases and that SPMs may play pivotal roles in their resolution.
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“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered pro-inflammatory, but is also the natural precursor to specialized proresolving mediators (SPMs) of inflammation.368, 369”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [369]
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Pro-resolving lipid mediators are leads for resolution physiology
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Self-citationMozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
“Arachidonic acid, the prototypical metabolite of LA, is also commonly considered proinflammatory, but is also the natural precursor to specialized proresolving mediators of inflammation.(368,369) In prospective studies, higher biomarker levels of arachidonic acid are linked to significantly lower risk of CHD.”
Mammalian lipoxygenases and their biological relevance
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Metadata
- Authors
- Spite, M., Clària, J., & Serhan, C. N.
- Affiliations
- University of Louisville (US)
- Hospital Clínic de Barcelona (ES)
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 21-36
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3947989
- OpenAlex
- W2065295548
- Cited by
- 464
- References
- 130
- Citations by year
- 2026: 37 · 2025: 28 · 2024: 20 · 2023: 23 · 2022: 33 · 2021: 49 · 2020: 43 · 2019: 53 · 2018: 27 · 2017: 47 · 2016: 35 · 2015: 48 · 2014: 20
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (4r37gm038765-19)
- National Heart, Lung, and Blood Institute (HL-106173, R01HL106173)
- National Institute of General Medical Sciences (P20GM103492, P01GM095467, GM-095467, GM 103492, GM038765, R01GM038765, R37-GM038765)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- resolvins, protectins, maresins, inflammation resolution, low-grade inflammation, metabolic disorders, tissue regeneration, neutrophil recruitment, autacoids
- MeSH terms
- Animals, Fatty Acids, Unsaturated, Humans, Inflammation, Metabolic Diseases
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