The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes
Open accessAbstract
Summary Endothelial dysfunction is a central hallmark of diabetes. The transcriptional coactivator PGC-1α is a powerful regulator of metabolism, but its role in endothelial cells remains poorly understood. We show here that endothelial PGC-1α expression is high in diabetic rodents and humans and that PGC-1α powerfully blocks endothelial migration in cell culture and vasculogenesis in vivo. Mechanistically, PGC-1α induces Notch signaling, blunts activation of Rac/Akt/eNOS signaling, and renders endothelial cells unresponsive to established angiogenic factors. Transgenic overexpression of PGC-1α in the endothelium mimics multiple diabetic phenotypes, including aberrant re-endothelialization after carotid injury, blunted wound healing, and reduced blood flow recovery after hindlimb ischemia. Conversely, deletion of endothelial PGC-1α rescues the blunted wound healing and recovery from hindlimb ischemia seen in type 1 and type 2 diabetes. Endothelial PGC-1α thus potently inhibits endothelial function and angiogenesis, and induction of endothelial PGC-1α contributes to multiple aspects of vascular dysfunction in diabetes.
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Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
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Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
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Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
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PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
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“, 2010), as well as anti-ROS and anti-inflammatory properties (Borniquel et al., 2006; Kim et al., 2007; Valle et al., 2005).”
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Metadata
- Authors
- Sawada, N., Jiang, A., Takizawa, F., Safdar, A., Manika, A., Tesmenitsky, Y., Kang, K.-T., Bischoff, J., Kalwa, H., Sartoretto, J. L., Kamei, Y., Benjamin, L. E., Watada, H., Ogawa, Y., Higashikuni, Y., Kessinger, C. W., Jaffer, F. A., Michel, T., Sata, M., Croce, K., Tanaka, R., & Arany, Z.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 19
- Issue
- 2
- Pages
- 246-258
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2124724949
- Cited by
- 163
- References
- 14
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sawada, N., Jiang, A., Takizawa, F., Safdar, A., Manika, A., Tesmenitsky, Y., Kang, K.-T., Bischoff, J., Kalwa, H., Sartoretto, J. L., Kamei, Y., Benjamin, L. E., Watada, H., Ogawa, Y., Higashikuni, Y., Kessinger, C. W., Jaffer, F. A., Michel, T., Sata, M., . . . Arany, Z. (2014). Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.12.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
