The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Specialized Metabolites from the Microbiome in Health and Disease
Open accessAbstract
The microbiota, and the genes that comprise its microbiome, play key roles in human health. Host-microbe interactions affect immunity, metabolism, development, and behavior, and dysbiosis of gut bacteria contributes to disease. Despite advances in correlating changes in the microbiota with various conditions, specific mechanisms of host-microbiota signaling remain largely elusive. We discuss the synthesis of microbial metabolites, their absorption, and potential physiological effects on the host. We propose that the effects of specialized metabolites may explain present knowledge gaps in linking the gut microbiota to biological host mechanisms during initial colonization, and in health and disease.
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“Beyond these general mechanisms, the gut microbiome affects atherogenesis more specifically through its degradation of phosphatidylcholine, which is abundant in eggs, cheese, seafood and red meat (Jonsson and Bäckhed, 2017; Sharon et al., 2014; Sonnenburg and Bäckhed, 2016).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
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“The primary cause of cardiovascular disease is atherosclerosis, a process in which the microbiome has been implicated as well (Jonsson and Bäckhed, 2017; Sharon et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
In the citing paper
“the gut microbiota appears to influence nearly every aspect of host physiology, including energy balance, cardiovascular health, chronic inflammation, development of adaptive immune cells and many more systems that fall outside of the scope of this review (Rooks and Garrett, 2016; Sharon et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sharon et al., 2014
In the citing paper
“changes in the microbiome often result in altered metabolic profiles, impacting the availability and diversity of nutrients and microbial metabolites (Dodd et al., 2017; Melnik et al., 2017; Sharon et al., 2014; Wikoff et al., 2009).”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Sharon et al., 2014
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Citations
Cites
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Self-citationGut flora metabolism of phosphatidylcholine promotes cardiovascular disease
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Host-gut microbiota metabolic interactions
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Rivière, A., Selak, M., Lantin, D., Leroy, F., & Vuyst, L. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00979 · Cited by 1,810
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Self-citationControl of brain development, function, and behavior by the microbiome
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Self-citationChemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080
Metadata
- Authors
- Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K.
- Affiliations
- California Institute of Technology (US)
- University of California San Diego (US)
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mazmanian, Sarkis K.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 20
- Issue
- 5
- Pages
- 719-730
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4337795
- OpenAlex
- W2092725930
- Cited by
- 544
- References
- 155
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 46 · 2023: 48 · 2022: 59 · 2021: 62 · 2020: 66 · 2019: 46 · 2018: 59 · 2017: 42 · 2016: 36 · 2015: 27
- FWCI
- 14.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR000100)
- National Institute of Mental Health (R01MH100556, MH100556)
- National Institute of General Medical Sciences (GM099535, R01GM099535, GM095384, R01GM095384)
- National Institute of Allergy and Infectious Diseases (R01AI095125, AI095125)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 078938, R01DK078938, R56DK078938)
- National Institute of Neurological Disorders and Stroke (R01NS085910)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- gut microbiota, microbial metabolites, secondary metabolites, host-microbe interactions, dysbiosis, host-microbe signaling, host immunity, host metabolism, microbial colonization, disease
- MeSH terms
- Bacteria, Cardiovascular Diseases, Cystic Fibrosis, Health, Humans, Neoplasms, Gastrointestinal Tract, Metagenome, Microbiota
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