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Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges
Open accessAbstract
Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
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“Later mouse studies have demonstrated benefits of TRF when using multiple variations of dietary and temporal control and also suggest that TRF can even stabilize or reverse the progression of metabolic diseases (85).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [85]
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“Recently, time-restricted feeding was shown to be effective for stabilizing and reversing the progression of metabolic diseases including T2DM in mice (Chaix et al., 2014).”
BackgroundMicrobiome restoration diet improves digestion, cognition and physical and emotional wellbeing
Lawrence, K., & Hyde, J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179017 · Cited by 34
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“The mechanism of how the circadian clock adjusts to environmental perturbation has been characterized in dietary and nutritional challenge paradigms (14, 16, 19, 25), but little is known about how the clock is involved in metabolic adaption to disease states.”
BackgroundAssessing temporal eating pattern in free living humans through the myCircadianClock app
Manoogian, E. N. C., Wei-Shatzel, J., & Panda, S. (2022) · International Journal of Obesity · doi:10.1038/s41366-021-01038-3 · Cited by 35
“Preclinical studies [9, 27, 58] inspired research investigating temporal eating patterns in humans to determine (a) when people eat, (b) whether people can adopt a time-restricted eating (TRE) pattern, and (c) what can be the health benefits of TRE.”
BackgroundCsoma, B., & Bikov, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814145 · Cited by 35
“Apart from weight gain in general, time-restricted feeding influences circulating lipid levels [152] and lipid accumulation in the liver [154] in animals.”
BackgroundPolycystic Kidney Disease Diet
Chebib, F. T., Nowak, K. L., Chonchol, M. B., Bing, K., Ghanem, A., Rahbari-Oskoui, F. F., Dahl, N. K., & Mrug, M. M. (2023) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000000000326 · Cited by 33
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Natural food intake patterns have little synchronizing effect on peripheral circadian clocks
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Circadian mechanisms in adipose tissue bioenergetics and plasticityPreprint
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“In addition, histological analysis after TRF shows less visceral WAT inflammation, decreased white adipocyte size, and less whitening of BAT (Chaix et al. 2014).”
BackgroundPersonalized Medicine Using Neuroimmunological Biomarkers in Depressive Disorders
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“However, studies of the effects of TRF intervention on obesity and NAFLD severity in rodents have been less conclusive [8,10].”
BackgroundCircadian Dysfunction in Adipose Tissue: Chronotherapy in Metabolic Diseases
Civelek, E., Civelek, D. Ö., Akyel, Y. K., Durman, D. K., & Okyar, A. (2023) · Biology · doi:10.3390/biology12081077 · Cited by 35
“, 8–9 h of food access during the active phase, in C57BL/6 male mice decreased adipose tissue inflammation and changed adipokine levels while reducing and reversing the adiposity caused by obesogenic diets [235].”
BackgroundCircadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding
Roth, J. R., Varshney, S., de Moraes, R. C. M., & Melkani, G. C. (2023) · Obesity · doi:10.1002/oby.23664 · Cited by 34
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A Narrative Review of Dietary Approaches for Kidney Transplant Patients
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“In addition to what we eat and how much we eat, when we eat is a critical determinant for metabolic health (Vollmers et al., 2009; Hatori et al., 2012; Chaix et al., 2014; Zarrinpar et al., 2014; Asher and Sassone-Corsi, 2015; Gill et al., 2015; Longo and Panda, 2016; Zarrinpar et al., 2016; Manoogian and Panda, 2017;…”
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“These results are consistent with studies showing that chronodisrupted high-fat diet-induced obese mice, subjected to a TRF schedule, in both a preventive and therapeutic manner, did not gain significantly more weight than Ctrl mice that were fed ad libitum [23,26].”
BackgroundResultBray, E. E., Zheng, Z., Tolbert, M. K., McCoy, B. M., Akey, J. M., Benton, B., Borenstein, E., Castelhano, M. G., Coleman, A. E., Creevy, K. E., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00575-7 · Cited by 32
“Studies of obesity, including possible associations with feeding frequency [23], will be an important area of future research.”
BackgroundAzemi, A. K., Siti-Sarah, A. R., Mokhtar, S. S., & Rasool, A. H. G. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050217 · Cited by 31
“These findings are similar to data reported in the previous studies [32,42,43].”
BackgroundResultSerra, M., Marongiu, F., Pisu, M. G., Serra, M., & Laconi, E. (2019) · Aging · doi:10.18632/aging.102021 · Cited by 30
“As reported in Figure 4E, TRF treatment was associated with significantly decreased levels of all lipid parameters, in agreement with results of previous studies [16].”
BackgroundResultInfluentialXie, Y., Zhou, K., Shang, Z., Bao, D., & Zhou, J. (2024) · Nutrients · doi:10.3390/nu16193390 · Cited by 29
“(1) Supplement S1: Table S1 Subgroup analysis results; Figure S1: Certainty of the evidence; (2) Supplement S2: Search query history for Seven electronic databases; and (3) Supplement S3: Body Fat Percentage Calculation.”
BackgroundSharifi, S., Rostami, F., Khorzoughi, K. B., & Rahmati, M. (2024) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2024.102757 · Cited by 35
“…during which food consumption occurs each day and emphasizes the importance of when we eat, along with underscoring the intricate interplay between nutrition and the body ’ s internal clock within a disciplined time frame typically ranging from 8 to 12 h (Chaix et al., 2014, Longo and Panda, 2016).”
BackgroundYang, M., Singh, A., de Araujo, A., McDougle, M. J., Ellis, H., Décarie-Spain, L., Kanoski, S. E., & de Lartigue, G. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01194-6 · Cited by 34
“The observed protection against diet-induced obesity aligns with the benefits of time-restricted eating 73,74 , suggesting that the decreased meal frequency induced by inhibiting dHPC Sugar neurons may underlie the prevention of weight gain despite unchanged daily food intake.”
Okauchi, H., Hashimoto, C., Nakao, R., & Oishi, K. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1516672 · Cited by 29
“…in experimental animals (Arble et al. 2009; Bray et al. 2010; Hatori et al. 2012; Sherman et al. 2012; Bray et al. 2013; Tsai et al. 2013; Chaix et al. 2014; Haraguchi et al. 2014; Zarrinpar et al. 2014; Chung et al. 2016; Duncan et al. 2016; Woodie et al. 2018), only a few studies have…”
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“With regard to TRF studies, one study [11] has reported that C57BL/6J mice following TRF protocols display significantly greater run time to exhaustion relative to a high-fat control, and another study demonstrated TRF improves physical performance (as measured by flight index) in Drosophila [12].”
ResultUpadhyay, A., Anjum, B., Godbole, N. M., Rajak, S., Shukla, P., Tiwari, S., Sinha, R. A., & Godbole, M. M. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.154 · Cited by 29
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An adipokine feedback regulating diurnal food intake rhythms in mice
Tsang, A. H. K., Koch, C. E., Kiehn, J., Schmidt, C. X., & Oster, H. (2020) · eLife · doi:10.7554/elife.55388 · Cited by 29
“On the contrary, protocols restricting feeding to the active phase are protective against diet-induced obesity and associated metabolic disorders in mice and humans independent of total energy intake (Chaix et al., 2014; Gill and Panda, 2015; Hatori et al., 2012).”
BackgroundHua, L., Li, J., Feng, B., Jiang, D., Jiang, X., Luo, T., Che, L., Xu, S., Lin, Y., Fang, Z., et al. (2020) · Endocrinology · doi:10.1210/endocr/bqaa244 · Cited by 30
“Consistent with previous investigations (5,43,45), the results of the present study revealed that IF significantly reduced HFD-induced body weight and adipose tissue gain, as well as improved glucose clearance (Fig.”
BackgroundResultTick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock
Minteer, C. J., Morselli, M., Meer, M. V., Cao, J. P., Higgins‐Chen, A., Lang, S. M., Pellegrini, M. A., Yan, Q., & Levine, M. E. (2022) · Aging Cell · doi:10.1111/acel.13553 · Cited by 33
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“reported that TRE attenuated metabolic disease and body weight gain in mice subjected to various nutritional challenges such as high-fat diets and high-fat plus high-fructose diets [4].”
BackgroundSun, S., Hanzawa, F., Umeki, M., Ikeda, S., Mochizuki, S., & Oda, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201261 · Cited by 30
The Health-Promoting Effects and the Mechanism of Intermittent Fasting
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“It was shown that TRF also stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes [17].”
BackgroundZhang, P., Liu, N., Xue, M., Zhang, M., Xiao, Z., Xu, C., Fan, Y., Qiu, J., Zhang, Q., & Zhou, Y. K. (2024) · Animals · doi:10.3390/ani14091289 · Cited by 30
“Studies have demonstrated that peroxisome proliferator-activated receptors (PPARs) can regulate lipid synthesis and decomposition in cells [57].”
BackgroundKim, H. J., & Kwon, O. (2024) · Obesity Reviews · doi:10.1111/obr.13762 · Cited by 34
“50,51 In a human study, data suggest that a higher caloric intake earlier in the day may leads to more pronounced benefits in terms of body weight reduction, waist circumference, FBG, insulin levels, and HOMA-IR in women with obesity compared with equivalent caloric reduction in the evening, even…”
Ramos, S. F., Siguenza, N., Zhong, W., Mohanty, I., Lingaraju, A., Richter, R. A., Karthikeyan, S., Lukowski, A. L., Zhu, Q., Nunes, W. D. G., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.05.024 · Cited by 34
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“…many studies have indicated that timed feeding influences metabolic parameters in experimental animals (Arble et al. 2009; Bray et al. 2013, 2010; Chaix et al. 2014; Chung et al. 2016; Duncan et al. 2016; Haraguchi et al. 2014; Hatori et al. 2012; Sherman et al. 2012; Tsai et al. 2013; Woodie et…”
BackgroundKessler, K., Gerl, M. J., Hornemann, S., Damm, M., Klose, C. D., Petzke, K. J., Kemper, M., Weber, D., Rudovich, N. N., Grune, T., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz176 · Cited by 24
Effects of circadian restricted feeding on parameters of metabolic syndrome among healthy subjects
Singh, R., Cornélissen, G., Mojto, V., Fatima, G., Wichansawakun, S., Singh, M., Kartikey, K., Sharma, J. P., Torshin, V. I., Chibisov, S. M., et al. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1701817 · Cited by 27
“Experimental studies support our findings as well and indicate that circadian restriction of energy intake has independent effects on energy metabolism, leading to weight loss or weight gain (Baron et al. 2013; Chaix et al. 2018, 2014b; Froy 2012; Sherman et al. 2012).”
BackgroundMethodInfluentialDietary patterns affect Parkinson's disease via the microbiota-gut-brain axis
Chu, C., Yu, L., Chen, W., Tian, F., & Zhai, Q. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.07.004 · Cited by 27
Lecour, S., du Pré, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girão, H., Gollmann‐Tepeköylü, C., Gyöngyösi, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab293 · Cited by 29
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Caron, J. P., Kreher, M. A., Mickle, A. M., Wu, S., Przkora, R., Estores, I. M., & Sibille, K. T. (2022) · Nutrients · doi:10.3390/nu14122536 · Cited by 27
“- Reduced development of atherosclerosis through improved metabolic profile [13,60,71].”
BackgroundInfluentialShu, Y.-Y., Gao, W., Chu, H., Yang, L., Pan, X., & Ye, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8063897 · Cited by 25
“While exploring the mechanism of TRF action in metabolic disease, some animal studies showed that TRF protected against weight gain and improved glucose tolerance and lipid metabolism [6, 10].”
Circadian rhythms as modulators of brain health during development and throughout aging
Drunen, R. V., & Eckel‐Mahan, K. L. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.1059229 · Cited by 31
Time‐restricted eating for chronodisruption‐related chronic diseases
Cheng, W., Desmet, L., & Depoortere, I. (2023) · Acta Physiologica · doi:10.1111/apha.14027 · Cited by 28
Kimball, S. R., Ravi, S., Gordon, B. S., Dennis, M. D., & Jefferson, L. S. (2015) · Journal of Nutrition · doi:10.3945/jn.115.215491 · Cited by 27
“Recent studies (21, 22) have shown that, in contrast to mice given ad libitum access to an HFD, mice fed the same diet for#9 h/d gain significantly less weight and remain insulin sensitive, even though total daily energy consumption is similar in the 2 feeding paradigms.”
BackgroundCircadian Disruption and the Risk of Developing Obesity
Duez, H., & Staels, B. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00610-6 · Cited by 36
“In rodents, TRF promotes/restores robust circadian and metabolic cycles, thereby mitigating obesity and metabolic dysfunction, even without a significant decrease in caloric intake [79, 80].”
Time-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
Lee, Y., Kim, Y., Lee, M., Wu, D., & Pae, M. (2021) · Nutrients · doi:10.3390/nu13113780 · Cited by 26
“Similarly, the decreased expressions of Ccl8 and Tnfα were observed when transferring the mice from ad libitum to TRF of high-fat diet [2].”
BackgroundResultInfluentialFan, X., Chen, D., Wang, Y., Tan, Y., Zhao, H., Jing, Z., Li, Y., Guo, X., Qiu, H., & Gu, Y. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00025.2021 · Cited by 26
Ramírez‐Plascencia, O. D., Saderi, N., Escobar, C., & Salgado‐Delgado, R. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13563 · Cited by 26
“This evidence, together with the unchanged food intake and body weight, suggests that food restricted to the activity phase does not affect the circadian system and does not affect energy homeostasis (Hatori et al., 2012; Chaix et al., 2014).”
BackgroundÇelik, Ö. M., Köksal, E., & Aktürk, M. (2023) · BMC Nutrition · doi:10.1186/s40795-023-00753-6 · Cited by 27
Photoperiod and metabolic health: evidence, mechanism, and implications
Regmi, P., Young, M. J., Minigo, G., Milic, N. L., & Gyawali, P. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155770 · Cited by 26
Manoogian, E. N. C., & Panda, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601786113 · Cited by 27
Ribas‐Aulinas, F., Ribó, S., Parra-Vargas, M., Fernández-Pérez, A., Cebrià, J., Guardiola-Perello, M., Ramon‐Krauel, M., Lerín, C., Díaz, R., Kalko, S. G., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101162 · Cited by 25
Palomba, A., Tanca, A., Abbondio, M., Sau, R., Serra, M., Marongiu, F., Fraumene, C., Pagnozzi, D., Laconi, E., & Uzzau, S. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00256-x · Cited by 26
Mohr, A. E., Mcevoy, C. N., Sears, D. D., Arciero, P. J., & Sweazea, K. L. (2021) · Advances in Redox Research · doi:10.1016/j.arres.2021.100026 · Cited by 29
The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease
Ezzati, A., & Pak, V. M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112033 · Cited by 28
“oxidative stress and inflammation (Hatroi et al., 2012; Chaix et al., 2014).”
Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila
He, L., Wu, B., Shi, J., Du, J., & Zhao, Z. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112912 · Cited by 25
Circadian clocks, feeding time, and metabolic homeostasis
Paschos, G. K. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00112 · Cited by 30
“Several studies provide support for the role of the time of food intake in body weight homeostasis (Masaki et al., 2004; Fonken et al., 2010; Salgado-Delgado et al., 2010; Hatori et al., 2012; Stucchi et al., 2012; Chaix et al., 2014).”
BackgroundShima, H., Masuda, S., Date, Y., Shino, A., Tsuboi, Y., Kajikawa, M., Inoue, Y. H., Kanamoto, T., & Kikuchi, J. (2017) · Nutrients · doi:10.3390/nu9121307 · Cited by 27
“Many researchers have attempted to clarify effect of microbiota to host responses using mice, because the results obtained from such studies could be applied to humans [19,20].”
BackgroundCircadian dysfunction and cardio-metabolic disorders in humans
MARHEFKOVÁ, N., Sládek, M., Sumová, A., & Dubský, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1328139 · Cited by 32
“This method has been shown to increase longevity and health in male mice without affecting the usual diet or daily calorie intake (75).”
MethodDisruption of circadian rhythm as a potential pathogenesis of nocturia
Song, Q., Suadicani, S. O., Negoro, H., Jiang, H., Jabr, R. I., Fry, C. H., Xue, W., & Damaser, M. S. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00961-0 · Cited by 28
“…period during the active phase) was shown to be effective in treating type II diabetes through improving insulin sensitivity and β cell responsiveness 239 , and also in preventing other metabolic disorders, such as obesity, cardiovascular events, hepatic steatosis, and hypercholesterolaemia 240 .”
Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice
Oike, H., Ogawa, Y., & Azami, K. (2020) · Nutrients · doi:10.3390/nu12051416 · Cited by 25
“Therefore, when time-restricted feeding is performed during the active phase, the circadian rhythm amplitude is restored and the induction of obesity is significantly suppressed, even though the HFD contain the same calories as the ad libitum feeding [5,6].”
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Xiao, Q., Bauer, C., Layne, T. M., & Playdon, M. C. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00715-z · Cited by 28
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“Panda and colleagues reported that an HFd causes dysregulation of circadian gene expression for fat metabolism and thermogenesis and that the TR feeding regimen successfully normalizes them [20, 21].”
InfluentialTomtheelnganbee, E., Sah, P., & Sharma, R. (2022) · Biogerontology · doi:10.1007/s10522-022-09978-7 · Cited by 26
Kim, Y., Lee, Y., Lee, M. N., Nah, J., Yun, N., Wu, D., & Pae, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1054875 · Cited by 22
“Chaix and others reported that serum leptin levels were lower in mice on HFD with TRF intervention, compared to HFD ad libitum (17, 50).”
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de Lima, R. D., Vieira, R. F. L., Muñoz, V. R., Chaix, A., Macêdo, A. P. A., Antunes, G. C., Felonato, M., Braga, R. R., Nakandakari, S. C. B. R., Gaspar, R. C., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00129.2023 · Cited by 28
Fang, G., Wang, S., Chen, Q., Luo, H., Lian, X., & Shi, D. (2023) · Neoplasia · doi:10.1016/j.neo.2023.100943 · Cited by 24
“Studies have shown that TRF alleviates metabolic diseases caused by various obesity-causing diets, and the benefits are proportional to the duration of fasting [29].”
BackgroundIs time of eating associated with BMI and obesity? A population-based study
Crispim, C. A., Rinaldi, A. E. M., Azeredo, C. M., Skene, D. J., & Moreno, C. R. D. C. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03282-x · Cited by 26
“Some studies on this theme have proposed nutritional interventions based on maintaining a consistent daily cycle of eating and fasting (time-restricted eating) to treat obesity and other metabolic disorders, with promising results in animal and human models [15, 16].”
Energy balance drives diurnal and nocturnal brain transcriptome rhythms
van Rosmalen, L., Deota, S., Maier, G., Le, H. D., Lin, T. C., Ramasamy, R. K., Hut, R. A., & Panda, S. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113951 · Cited by 23
Circadian disruption of food availability significantly reduces reproductive success in mice
Swamy, S., Xie, X., Kukino, A., Calcagno, H., Lasarev, M. R., Park, J., & Butler, M. P. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.07.006 · Cited by 24
“Meals eaten during the biological active phase (night-time in nocturnal organisms) can promote health, whereas meals consumed during the rest phase can be deleterious in both human and rodent studies (Arble et al., 2009; Chaix et al., 2014; Salgado-Delgado et al., 2010; Scheer et al., 2009).”
Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice
Hou, T., Wang, C., Joshi, S., O’Hara, B. F., Gong, M. C., & Guo, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00969 · Cited by 24
Intermittent fasting in health and disease
Mishra, A., Sobha, D., Patel, D., & Suresh, P. S. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2268301 · Cited by 28
“2020). the impacts of tRF include a reduction in weight gain, improvement in sleep quality, slowing down of age-and diet-induced declines in cardiac function, lowering of blood pressure, and reduced risk of atherogenic lipid build-up (chaix et al .”
Wang, X., Du, X., Zhou, Y., Wang, S., Su, F., & Zhang, S. (2017) · Biogerontology · doi:10.1007/s10522-017-9699-3 · Cited by 23
Parsanathan, R., & Jain, S. K. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.07.019 · Cited by 23
Pilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome
Świątkiewicz, I., Mila-Kierzenkowska, C., Woźniak, A., Szewczyk‐Golec, K., Nuszkiewicz, J., Wróblewska, J., Rajewski, P., Eussen, S. J. P. M., Færch, K., Manoogian, E. N. C., et al. (2021) · Nutrients · doi:10.3390/nu13020346 · Cited by 23
Kesztyüs, D., Vorwieger, E., Schönsteiner, D., Gulich, M., & Kesztyüs, T. (2021) · PubMed Central · doi:10.3205/000291 · Cited by 27
“Overall, these results are unsatisfactory with respect to the positive results from trials with rodents [13].”
BackgroundResultJia, M., Zhang, H., Xu, J., Su, Y., & Zhu, W. (2021) · Livestock Science · doi:10.1016/j.livsci.2021.104558 · Cited by 23
Wang, Y., Guo, D., Chen, X., Wang, S., Hu, J., & Liu, X. (2022) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2022.02.019 · Cited by 23
Metadata
- Authors
- Chaix, A., Zarrinpar, A., Miu, P., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Panda, Satchidananda
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 20
- Issue
- 6
- Pages
- 991-1005
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4255155
- OpenAlex
- W2171666144
- Cited by
- 956
- References
- 43
- Citations by year
- 2026: 77 · 2025: 83 · 2024: 90 · 2023: 88 · 2022: 118 · 2021: 123 · 2020: 112 · 2019: 70 · 2018: 59 · 2017: 56 · 2016: 44 · 2015: 35
- FWCI
- 30.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- American Association for the Study of Liver Diseases
- Leona M. and Harry B. Helmsley Charitable Trust
- Philippe Foundation
- National Institutes of Health
- National Eye Institute (R01EY016807, P30EY019005, EY016807)
- National Cancer Institute (P30CA014195)
- National Institute of General Medical Sciences (P50GM085764)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK080506, T32-DK07202, R01DK091618, T32DK007202, DK091618-04)
- National Institute of Neurological Disorders and Stroke (NS066457, R21NS066457)
- National Center for Research Resources (S10RR027450)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- time-restricted feeding, obesity prevention, type 2 diabetes, metabolic disorders, fasting duration, obesogenic diet, hepatic steatosis, hypercholesterolemia, intermittent fasting, ad libitum feeding
- MeSH terms
- Animals, Energy Intake, Diabetes Mellitus, Type 2, Dietary Fats, Feeding Behavior, Metabolic Diseases, Mice, Inbred C57BL, Obesity, Time Factors, Weight Gain, Mice
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