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Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges
Open accessAbstract
Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
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“Later mouse studies have demonstrated benefits of TRF when using multiple variations of dietary and temporal control and also suggest that TRF can even stabilize or reverse the progression of metabolic diseases (85).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [85]
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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
The global obesity pandemic: shaped by global drivers and local environments
Swinburn, B. A., Sacks, G., Hall, K. D., McPherson, K., Finegood, D. T., Moodie, M. L., & Gortmaker, S. L. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60813-1 · Cited by 4,888
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Self-citationHigh-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
Fasting: molecular mechanisms and clinical applications
Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425
Long-term weight-loss maintenance: a meta-analysis of US studies
Anderson, J. W., Konz, E. C., Frederich, R. C., & Wood, C. L. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.579 · Cited by 1,351
Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M. W., & Milgram, K. E. (2009) · Analytical Chemistry · doi:10.1021/ac901536h · Cited by 1,317
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222
Physiology and Pathophysiology of Carnosine
Болдырев, А. А., Aldini, G., & Derave, W. (2013) · Physiological Reviews · doi:10.1152/physrev.00039.2012 · Cited by 1,133
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 956
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765
Reprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 732
Intermediary metabolism of fructose
Mayes, P. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.754s · Cited by 669
Matsusue, K., Haluzik, M., Lambert, G., Yim, S.-H., Gavrilova, O., Ward, J. M., Brewer, B., Reitman, M. L., & Gonzalez, F. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317223 · Cited by 585
The human circadian metabolome
Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552
A Mouse Model of Diet-Induced Obesity and Insulin Resistance
Wang, C., & Liao, J. K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_27 · Cited by 546
Circadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 539
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498
Manning, B. D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408161 · Cited by 485
Sharma, A. M., & Staels, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1268 · Cited by 483
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410
Coordination of the transcriptome and metabolome by the circadian clock
Eckel‐Mahan, K. L., Patel, V. R., Mohney, R. P., Vignola, K. S., Baldi, P., & Sassone‐Corsi, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118726109 · Cited by 380
Tetri, L. H., Basaranoglu, M., Brunt, E. M., Yerian, L. M., & Neuschwander-Tetri, B. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90272.2008 · Cited by 378
Hunter-gatherer energetics and human obesity
Pontzer, H., Raichlen, D. A., Wood, B. M., Mabulla, A. Z. P., Racette, S. B., & Marlowe, F. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040503 · Cited by 349 · cited 1×
“The incidence of obesity is on the increase and, although the driving causes are multifactorial, nutritional imbalance is a major contributor (Pontzer et al., 2012; Swinburn et al., 2011).”
BackgroundFructose induced lipogenesis: from sugar to fat to insulin resistance
Samuel, V. T. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.10.003 · Cited by 271
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
Barclay, J. L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S. M., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037150 · Cited by 259
Bessesen, D. H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0520 · Cited by 257
Exercise, Protein Metabolism, and Muscle Growth
Tipton, K. D., & Wolfe, R. R. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.1.109 · Cited by 253
Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome
Stanhope, K. L. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042010-113026 · Cited by 224
Mellor, K. M., Bell, J. R., Young, M. J., Ritchie, R. H., & Delbridge, L. M. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.002 · Cited by 200
Hanley, B., Dijane, J., Fewtrell, M. S., Grynberg, A., Hummel, S., Junien, C., Koletzko, B. V., Lewis, S. J., Renz, H. E., Symonds, M. E., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003338 · Cited by 165
Bray, M. S., Tsai, J.-Y., Villegas‐Montoya, C., Boland, B. B., Blasier, Z., Egbejimi, O., Kueht, M., & Young, M. E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.63 · Cited by 153
AMPK exerts dual regulatory effects on the PI3K pathway
Tao, R., Gong, J., Luo, X., Zang, M., Guo, W., Wen, R., & Luo, Z. (2010) · Journal of Molecular Signaling · doi:10.1186/1750-2187-5-1 · Cited by 152
Insulin Resistance in the Defense against Obesity
Saltiel, A. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.001 · Cited by 105
Cai, H., Chen, H., Yi, T., Daimon, C. M., Boyle, J. P., Peers, C., Maudsley, S. R., & Martin, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053388 · Cited by 105
Update on obesity pharmacotherapy
Bray, G. A., & Ryan, D. H. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12328 · Cited by 88
Jin, J., Iakova, P. A., Breaux, M., Sullivan, E. M., Jawanmardi, N., Chen, D., Jiang, Y., Medrano, E. M., & Timchenko, N. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.009 · Cited by 73
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Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605
Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.010 · Cited by 1,531
“This is consistent with rodent studies, which have reported that both eTRF and other forms of TRF reduce appetite hormones and body weight (Belkacemi et al., 2010, 2011; Chaix et al., 2014; Chung et al., 2016; Duncan et al., 2016; Garcı́aLuna et al., 2017; Hatori et al., 2012; Kudo et al., 2004;Manzanero et al., 2014;…”
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Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
“Time-restricted feeding of mice during 8 hours of the dark phase of the daily cycle does not affect overall calorie intake of mice on a high fat diet, but restores normal circadian rhythms of activity in metabolic pathways and protects the mice against weight gain, fat accumulation, inflammation, glucose intolerance,…”
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Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187
“…70% energy restriction every other day (Johnson t al., 2007; Varady et al., 2015); consuming only 500–700 cal two onsecutive days/week (Harvie et al., 2011); and restricting food ntake to a 6–8 h time period daily, which has also been termed time restricted feeding’ (TRF) (Chaix et al., 2014).”
InfluentialCircadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Self-citation
Metadata
- Authors
- Chaix, A., Zarrinpar, A., Miu, P., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Panda, Satchidananda
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 20
- Issue
- 6
- Pages
- 991-1005
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4255155
- OpenAlex
- W2171666144
- Cited by
- 956
- References
- 43
- Citations by year
- 2026: 77 · 2025: 83 · 2024: 90 · 2023: 88 · 2022: 118 · 2021: 123 · 2020: 112 · 2019: 70 · 2018: 59 · 2017: 56 · 2016: 44 · 2015: 35
- FWCI
- 30.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- American Association for the Study of Liver Diseases
- Leona M. and Harry B. Helmsley Charitable Trust
- Philippe Foundation
- National Institutes of Health
- National Eye Institute (R01EY016807, P30EY019005, EY016807)
- National Cancer Institute (P30CA014195)
- National Institute of General Medical Sciences (P50GM085764)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK080506, T32-DK07202, R01DK091618, T32DK007202, DK091618-04)
- National Institute of Neurological Disorders and Stroke (NS066457, R21NS066457)
- National Center for Research Resources (S10RR027450)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- time-restricted feeding, obesity prevention, type 2 diabetes, metabolic disorders, fasting duration, obesogenic diet, hepatic steatosis, hypercholesterolemia, intermittent fasting, ad libitum feeding
- MeSH terms
- Animals, Energy Intake, Diabetes Mellitus, Type 2, Dietary Fats, Feeding Behavior, Metabolic Diseases, Mice, Inbred C57BL, Obesity, Time Factors, Weight Gain, Mice
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