Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing
Open accessAbstract
Manipulating gut bacteria in the microbiome, through the use of probiotics and prebiotics, has been found to have an influence on both physical and emotional wellbeing. This study uses a dietary manipulation 'The Gut Makeover' designed to elicit positive changes to the gut bacteria within the microbiome. 21 healthy participants undertook 'The Gut Makeover' for a four week period. Weight and various aspects of health were assessed pre and post intervention using the Functional Medicine Medical Symptoms Questionnaire (MSQ). Paired sample t-tests revealed a significant reduction in self-reported weight at the end of the intervention. Adverse medical symptoms related to digestion, cognition and physical and emotional wellbeing, were also significantly reduced during the course of the dietary intervention. The intervention, designed to manipulate gut bacteria, had a significant impact on digestion, reducing IBS type symptoms in this non-clinical population. There was also a striking reduction in negative symptoms related to cognition, memory and emotional wellbeing, including symptoms of anxiety and depression. Dietary gut microbiome manipulations may have the power to exert positive physical and psychological health benefits, of a similar nature to those reported in studies using pre and probiotics. The small sample size and lack of control over confounding variables means that it will be important to replicate these findings in larger-scale controlled, prospective, clinical trials. This dietary microbiome intervention has the potential to improve physical and emotional wellbeing in the general population but also to be investigated as a treatment option for individuals with conditions as diverse as IBS, anxiety, depression and Alzheimer's disease.
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The Metabolomic Underpinnings of Symptom Burden in Patients With Multiple Chronic Conditions
Corwin, E. J., Brewster, G. S., Dunbar, S. B., Wells, J., Hertzberg, V., Holstad, M. M., Song, M., & Jones, D. P. (2020) · Biological Research For Nursing · doi:10.1177/1099800420958196 · Cited by 24 · see citing works
“…to the symptoms of depression, fatigue, and anxiety (Buigues et al., 2016; Clapp et al., 2017; Dinan & Cryan, 2012, 2017; Grenham et al., 2011; Lawrence & Hyde, 2017; Mayer, 2011; Mayer et al., 2014; O’Mahony et al., 2015) including: pro-inflammatory cytokines, cortisol hormone, and the…”
Delaying memory decline: different options and emerging solutions
Schneider, F., Horowitz, A., Lesch, K., & Dandekar, T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0697-x · Cited by 21 · see citing works
The Microbiota-gut-immune-glia (MGIG) Axis in Major DepressionPreprint
Rudzki, L., & Maes, M. H. J. (2020) · Preprints.org · doi:10.20944/preprints202002.0084.v1 · Cited by 18 · see citing works
Logan, A. C., & Prescott, S. L. (2017) · Challenges · doi:10.3390/challe8020024 · Cited by 16 · see citing works
“In agreement with the minimally-processed, whole foods (Mediterranean style) diet interventions shown to improve mood and cognition (as mentioned above), emerging research is demonstrating, at least over the short-term, that such foods provide neuro-emotional benefit via the microbiome [122,123].”
BackgroundMicrobiome-targeted Alzheimer’s interventions via gut-brain axis
Qin, R., Li, C., Yuan, X., & Chen, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1729708 · Cited by 15 · see citing works
Interweaving a mindfully somatic pedagogy into an early childhood classroom
Buono, A. (2019) · Pedagogies An International Journal · doi:10.1080/1554480x.2019.1597723 · Cited by 11 · see citing works
“Current research in wellbeing and genetics has begun to unveil the nondualistic connection between the biological/ physical, emotional, social, and mental bodies (DeSalle & Perkins, 2015; Lawrence & Hyde, 2017; Maier & al’Absi, 2017); however, progress is slow.”
BackgroundA New Insight on Feasibility of Pre-, Pro-, and Synbiotics-based Therapies in Alzheimer’s Disease
Talebi, M., Ebrahimi, V., Rasouli, A., Farjami, A., Soofiyani, S. R., Soleimanian, A., Forouhandeh, H., & Tarhriz, V. (2022) · Journal of Reports in Pharmaceutical Sciences · doi:10.4103/jrptps.jrptps_170_21 · Cited by 8 · see citing works
Dancing Our Microbiome at the Science Museum: A Dance/STEAM Collaboration
Buono, A., & Burnidge, A. (2020) · Journal of Dance Education · doi:10.1080/15290824.2020.1790568 · Cited by 7 · see citing works
“…methods (Fraleigh 1996; Barratt 2010), current cross-disciplinary efforts can work to integrate or re-member the holistic connections existing between our physical, emotional, social, mental, and microbial bodies (DeSalle and Perkins 2015; Lawrence and Hyde 2017; Maier and al’Absi 2017).”
MethodHidalgo, V. S., Witney, A. A., Chico, M. E., Vaca, M. G., Arévalo‐Cortes, A., Schuyler, A. J., Platts‐Mills, T. A. E., Ster, I. C., & Cooper, P. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-89224-5 · Cited by 7 · see citing works
GenBank as a source to monitor and analyze Host-Microbiome data
Ramanan, V., Mechery, S., & Sarkar, I. N. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac487 · Cited by 4 · see citing works
Wpływ mikrobiomu jelitowego na mózg i psychikę
Żakowicz, J., Bramorska, A., Zarzycka, W., Kovbasiuk, A., Kuć, K., & Brzezicka, A. (2020) · Kosmos · doi:10.36921/kos.2020_2634 · Cited by 3 · see citing works
Biodiversity and Human Health: A Scoping Review and Case Studies on Underrepresented LinkagesPreprint
Robinson, J. M., Breed, A. C., Camargo, A., Redvers, N., & Breed, M. F. (2022) · Preprints.org · doi:10.20944/preprints202210.0275.v1 · Cited by 2 · see citing works
Implementing gut microbiota, ROS, and SCF modulation in cancer care: Research into practice
Jana, K., Ghosh, S., Debnath, B., Rai, V. K., Dash, P., Das, C., Rout, S. K., Kar, B., Ghosh, G., & Rath, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33459-7.00013-2 · Cited by 2 · see citing works
Editors, T. P. O. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194851 · Cited by 1 · see citing works
RetractedGut microbiome analysis of fast- and slow-growing Rainbow Trout (Oncorhynchus mykiss)Preprint
Chapagain, P., Arivett, B. A., Cleveland, B. M., Walker, D. M., & Salem, M. (2019) · Research Square · doi:10.21203/rs.2.9137/v1 · Cited by 1 · see citing works
مدي شيوع متلازمة القولون العصبي لمترددي عيادات الهلال الاحمر للرعاية الأولية بمدينة المرج ليبيا
Awami, S. M., Mohamed, F. A., & Mohamed, N. (2018) · AL-MUKHTAR JOURNAL OF SCIENCES · doi:10.54172/mjsc.v33i2.113
“%) have used different remedies (traditional treatments or herbal treatments) (Ikechi et al., 2017), and probiotics and prebiotics, (Lawrence & Hyde, 2017).”
BackgroundIntegrative Health: Combining Exercise, Lifestyle Changes, and Gut Microbiome for Metabolic Syndrome
Srivastava, R., & Singh, G. (2025) · Springer eBooks · doi:10.1007/978-981-96-6246-3_6
- Authors
- Lawrence, K., & Hyde, J.
- Affiliations
- St Mary's University Twickenham London (GB)
- Corresponding author
- Lawrence, Kate
- ORCID
- Lawrence, Kate
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-06-14
- Volume
- 12
- Issue
- 6
- Pages
- e0179017
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5470704
- OpenAlex
- W2737893396
- Cited by
- 34
- References
- 54
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 4 · 2018: 9 · 2017: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2018-03-20)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- St Mary's University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, dietary intervention, probiotics, prebiotics, irritable bowel syndrome, anxiety, depression, cognitive function, memory, emotional well-being, physical well-being, weight loss, functional medicine, clinical symptoms
- MeSH terms
- Adult, Aged, Cognition, Digestion, Emotions, Female, Humans, Male, Mental Health, Middle Aged, Prospective Studies, Treatment Outcome, Probiotics, Prebiotics, Microbiota
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