The DOI matches its Crossref record; 138 of the 139 references it cites were found in a registry or an index.
Muscle as a “Mediator” of Systemic Metabolism
Open accessAbstract
Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.
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“Consistently, the metabolic adaptations occurring in skeletal muscles are assumed to work as a disease modifier and the quality of muscle mass is an important predictor of mortality1.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [1]
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“Being the most abundant tissue (40–50% of the total mass in healthy-weight individual) and the protein reservoir in the human body, skeletal muscles not only control locomotion but they are fundamental for breathing, eating, energy expenditure, as well as for glucose, amino acids, and lipids homeostasis and for maintaining a high quality of life1.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [1]
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Self-citationThyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 2×
“It functions in tissues with high oxidative capacity to regulate myofiber switching, mitochondrial biogenesis, and expression of fatty acid oxidation enzymes (Figure 1B) (reviewed in Chan and Arany, 2014; Finck and Kelly, 2006; Lin et al., 2005).”
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Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940
Tezze, C., Romanello, V., Desbats, M. A., Fadini, G. P., Albiero, M., Favaro, G., Ciciliot, S., Soriano, M. E., Morbidoni, V., Cerqua, C., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.021 · Cited by 568
“This is an emerging concept that considers the metabolic adaptations occurring in skeletal muscles as disease modifier/controller (Baskin et al., 2015) and explains why physical activity elicits several beneficial effects in many different diseases.”
InfluentialEffects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 517
Self-citationCsapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 458
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 438
Metadata
- Authors
- Baskin, K. K., Winders, B. R., & Olson, E. N.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Olson, Eric N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 21
- Issue
- 2
- Pages
- 237-248
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4398026
- OpenAlex
- W2052045659
- Cited by
- 333
- References
- 139
- Citations by year
- 2026: 38 · 2025: 38 · 2024: 47 · 2023: 41 · 2022: 42 · 2021: 43 · 2020: 25 · 2019: 17 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 7
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01hl100401-07)
- National Heart, Lung, and Blood Institute (R01HL111665, R01HL077439, HL- 111665, U01-HL-100401, R01HL053351, R01HL093039, HL077439, HL093039)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK099653, R01DK099653)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- Mediator complex, skeletal muscle, myocardium, muscle metabolism, transcriptional regulation, tissue-specific gene regulation, physical activity, metabolic plasticity
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Humans, Muscles
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