Cited by 341Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismMuscle Physiology and Disorders

The DOI matches its Crossref record; 138 of the 139 references it cites were found in a registry or an index.

Muscle as a “Mediator” of Systemic Metabolism

Open access

Baskin, Kedryn K., Winders, Benjamin R., Olson, Eric N.·2015·Cell Metabolism

DOI 10.1016/j.cmet.2014.12.021PMC PMC4398026

Open this paper in CoChat — free account Open PDF

Abstract

Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2014.12.021

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Self-citation
Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 2×
“It functions in tissues with high oxidative capacity to regulate myofiber switching, mitochondrial biogenesis, and expression of fatty acid oxidation enzymes (Figure 1B) (reviewed in Chan and Arany, 2014; Finck and Kelly, 2006; Lin et al., 2005).”
Background
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016
Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults
Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,837
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J. A., & Olson, E. N. (2007) · Science · doi:10.1126/science.1139089 · Cited by 1,666
Self-citation
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,461
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay
Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,230
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H., Gerhold, K. A., Mayers, J. R., Wiest, M. M., Watkins, S. M., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,174
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156
Cardiac Metabolism in Heart Failure
Doenst, T., Nguyễn, T. D., & Abel, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300376 · Cited by 1,134
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.065 · Cited by 973
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A. D., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14080 · Cited by 887
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824
Signaling Pathways in Skeletal Muscle Remodeling
Bassel‐Duby, R., & Olson, E. N. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142622 · Cited by 823
Self-citation
Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
Muñoz‐Cánoves, P., Scheele, C., Pedersen, B. K., & Serrano, A. L. (2013) · The FEBS Journal · doi:10.1111/febs.12338 · Cited by 774
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Finck, B. N., Lehman, J. J., Leone, T. C., Welch, M. J., Bennett, M. J., Kovács, A., Han, X., Gross, R. W., Kozak, R., Lopaschuk, G. D., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214080 · Cited by 765
Thyroid Hormone Action in the Heart
Kahaly, G. J., & DILLMANN, W. H. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0033 · Cited by 710
Metabolic Regulation of Epigenetics
Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · cited 1×
“Consequently, BAIBA induced a browning phenotype in white adipose tissue (Roberts et al., 2014).”
Background
Metabolic Gene Expression in Fetal and Failing Human Heart
Razeghi, P., Young, M. E., Alcorn, J. L., Moravec, C. S., Frazier, O. H., & Taegtmeyer, H. (2001) · Circulation · doi:10.1161/hc4901.100526 · Cited by 616
Activation of PPARγ Coactivator-1 Through Transcription Factor Docking
Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 605
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 604
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 578
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.
Fondell, J. D., Ge, H., & Roeder, R. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8329 · Cited by 578
Muscle-specific Pparg deletion causes insulin resistance
Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G. K., Olson, P., Wilkes, J. J., Evans, R. M., & Olefsky, J. M. (2003) · Nature Medicine · doi:10.1038/nm956 · Cited by 501
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500
Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle
Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 498
Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults
Willis, L. H., Slentz, C. A., Bateman, L. A., Shields, A. T., Piner, L. W., Bales, C. W., Houmard, J. A., & Kraus, W. E. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01370.2011 · Cited by 496
Nuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 474
Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass
Gallagher, D., Belmonte, D., Deurenberg, P., Wang, Z., Krasnow, N., Pi-Sunyer, F. X., & Heymsfield, S. B. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e249 · Cited by 470
Adaptation and Maladaptation of the Heart in Diabetes: Part II
Young, M. E., McNulty, P. H., & Taegtmeyer, H. (2002) · Circulation · doi:10.1161/01.cir.0000012467.61045.87 · Cited by 467
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
Cheng, L., Ding, G., Qin, Q., Huang, Y., Lewis, W., He, N., Evans, R. M., Schneider, M. D., Brako, F. A., Xiao, Y., et al. (2004) · Nature Medicine · doi:10.1038/nm1116 · Cited by 453
Diabetic cardiomyopathy
Spector, K. S. (1998) · Clinical Cardiology · doi:10.1002/clc.4960211205 · Cited by 442
Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5
Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418
Self-citation
Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17305 · Cited by 417
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.
Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Yang, F., Vought, B. W., Satterlee, J. S., Walker, A. K., Jim Sun, Z.-Y., Watts, J. L., DeBeaumont, R., Mako Saito, R., Hyberts, S. G., Yang, S., et al. (2006) · Nature · doi:10.1038/nature04942 · Cited by 405
Thyroid hormones and skeletal muscle—new insights and potential implications
Salvatore, D., Simonides, W. S., Dentice, M., Zavacki, A. M., & Larsen, P. R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.238 · Cited by 400
A mediator required for activation of RNA polymerase II transcription in vitro
Flanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., & Kornberg, R. D. (1991) · Nature · doi:10.1038/350436a0 · Cited by 386 · cited 1×
“First discovered in yeast as an essential regulator of activatorinduced transcription (Flanagan et al., 1991), the Mediator complex has been isolated from mammalian cells in active and inactive forms.”
Background
IGF-1 Overexpression Inhibits the Development of Diabetic Cardiomyopathy and Angiotensin II–Mediated Oxidative Stress
Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., Limana, F., Nadal‐Ginard, B., Leri, A., & Anversa, P. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1414 · Cited by 384
PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes
Schuler, M. J., Ali, F., Chambon, C., Duteil, D., Bornert, J., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., & METZGER, D. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.003 · Cited by 378
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Grueter, C. E., van Rooij, E., Johnson, B. A., DeLeon, S. M., Sutherland, L. B., Qi, X., Gautron, L., Elmquist, J. K., Bassel‐Duby, R., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.03.029 · Cited by 368
Self-citation
The Mediator complex and transcription regulation
Poss, Z. C., Ebmeier, C. C., & Taatjes, D. J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.840259 · Cited by 364
Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781930 · Cited by 362 · cited 1×
“Insulin resistance, a hallmark of metabolic syndrome and diabetes, correlates with a higher composition of fast-twitch myofibers (Simoneau et al., 1995).”
Background
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
Son, N.-H., Park, T., Yamashita, H., Yokoyama, M., Huggins, L. A., Okajima, K., Homma, S., Szabolcs, M. J., Huang, L., & Goldberg, I. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30335 · Cited by 340
The human Mediator complex: a versatile, genome-wide regulator of transcription
Taatjes, D. J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.02.004 · Cited by 335
ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart
Alaynick, W. A., Kondo, R. P., Xie, W., He, W., Dufour, C. R., Downes, M., Jonker, J. W., Giles, W. R., Naviaux, R. K., Giguère, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.007 · Cited by 311
Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease
Pearen, M. A., & Muscat, G. E. O. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0015 · Cited by 308
Diabetic Cardiomyopathy
Hamby, R. I. (1974) · JAMA · doi:10.1001/jama.1974.03230510023016 · Cited by 305
Nuclear Receptors and Their Selective Pharmacologic Modulators
Burris, T. P., Solt, L. A., Wang, Y., Crumbley, C., Banerjee, S., Griffett, K., Lundåsen, T., Hughes, T., & Kojetin, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006833 · Cited by 304
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development · doi:10.1101/gad.214023.113 · Cited by 297
Exercise for the management of type 2 diabetes: a review of the evidence
Zanuso, S., Jiménez, A., Pugliese, G., Corigliano, G., & Balducci, S. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0126-3 · Cited by 283
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
Burkart, E. M., Sambandam, N., Han, X., Gross, R. W., COURTOIS, M. R., Gierasch, C. M., Shoghi, K. I., Welch, M. J., & Kelly, D. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32578 · Cited by 281
The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?
Pedersen, B. K., Steensberg, A., Fischer, C. P., Keller, C., Keller, P., Plomgaard, P., Petersen, E. W., & Febbraio, M. A. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004338 · Cited by 279
Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
Taatjes, D. J., Näär, A. M., Andel, F., Nogales, E., & Tjian, R. (2002) · Science · doi:10.1126/science.1065249 · Cited by 277
The Nuclear Receptor ERRα Is Required for the Bioenergetic and Functional Adaptation to Cardiac Pressure Overload
Huss, J. M., Imahashi, K., Dufour, C. R., Weinheimer, C. J., COURTOIS, M. R., Kovács, A., Giguère, V., Murphy, E., & Kelly, D. P. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.005 · Cited by 270
A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes
Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258
Modulation of transcription factor function by O-GlcNAc modification
Özcan, S., Andrali, S. S., & Cantrell, J. E. L. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.02.005 · Cited by 256
MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease
Olson, E. N. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009008 · Cited by 255
Self-citation
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · cited 2×
“Mouse gene deletion studies have revealed a role for ERRa in regulation of cardiac energy metabolism and adaptation to pressure overload (Huss et al., 2007; Huss and Kelly, 2004; Villena and Kralli, 2008).”
Background
Coordination of p300-Mediated Chromatin Remodeling and TRAP/Mediator Function through Coactivator PGC-1α
Wallberg, A. E., Yamamura, S., Malik, S., Spiegelman, B. M., & Roeder, R. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00391-5 · Cited by 247
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
Madrazo, J., & Kelly, D. P. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.021 · Cited by 247
Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells
Muoio, D. M., Way, J. M., Tanner, C. J., Winegar, D. A., Kliewer, S. A., Houmard, J. A., Kraus, W. E., & Dohm, G. L. (2002) · Diabetes · doi:10.2337/diabetes.51.4.901 · Cited by 226
Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1
Zhao, X., Feng, D., Wang, Q., Abdulla, A., Xie, X.-J., Zhou, J., Sun, Y., Yang, E. S. T., Liu, L., Vaitheesvaran, B., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61462 · Cited by 219
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
Gan, Z., Rumsey, J. W., Hazen, B. C., Lai, L., Leone, T. C., Vega, R. B., Xie, H., Conley, K. E., Auwerx, J. H., Smith, S. R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67652 · Cited by 204
Self-citation
Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ
Narkar, V. A., Fan, W., Downes, M., Yu, R. T., Jonker, J. W., Alaynick, W. A., Banayo, E., Karunasiri, M. S., Lorca, S., & Evans, R. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.019 · Cited by 192
Regulation of triglyceride metabolism by Angiopoietin-like proteins
Mattijssen, F., & Kersten, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.010 · Cited by 180
Physiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161
Myostatin: A novel insight into its role in metabolism, signal pathways, and expression regulation
Huang, Z., Chen, X., & Chen, D. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.003 · Cited by 155
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77
Chao, L. C., Wroblewski, K., Zhang, Z., Pei, L., Vergnes, L., Ilkayeva, O. R., Ding, S. Y., Reue, K., Watt, M. J., Newgard, C. B., et al. (2009) · Diabetes · doi:10.2337/db09-0763 · Cited by 154 · cited 1×
“Nur77 knockout mice develop skeletal muscle insulin resistance in response to a high-fat diet (Chao et al., 2009), whereas overexpression of Nur77 in muscle increases oxidative metabolism (Chao et al., 2012).”
Diabetic cardiomyopathy: mechanisms and therapeutic targets
Battiprolu, P. K., Gillette, T. G., Wang, Z. V., Lavandero, S., & Hill, J. A. (2010) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2010.08.001 · Cited by 144
Cdk8 Is Essential for Preimplantation Mouse Development
Westerling, T., Kuuluvainen, E., & Mäkelä, T. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01302-06 · Cited by 141
MicroRNA 146 (Mir146) Modulates Spermatogonial Differentiation by Retinoic Acid in Mice1
Huszar, J. M., & Payne, C. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.103747 · Cited by 140
Deletion of PBP/PPARBP, the Gene for Nuclear Receptor Coactivator Peroxisome Proliferator-activated Receptor-binding Protein, Results in Embryonic Lethality
Zhu, Y., Qi, C., Jia, Y., Nye, J. S., Rao, M. S., & Reddy, J. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000121200 · Cited by 131
The many roles of PGC-1α in muscle — recent developments
Chan, M. C., & Arany, Z. P. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.006 · Cited by 127
MiR‐205 silences MED1 in hypoxic primary human trophoblasts
Mouillet, J., Chu, T., Nelson, D. M., Mishima, T., & Sadovsky, Y. (2010) · The FASEB Journal · doi:10.1096/fj.09-149724 · Cited by 125
Metabolic benefits of resistance training and fast glycolytic skeletal muscle
LeBrasseur, N. K., Walsh, K. X., & Arany, Z. P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2010 · Cited by 123
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development
Ito, M., Okano, H. J., Darnell, R. B., & Roeder, R. G. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf348 · Cited by 122
Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
Amin, R., Mathews, S. T., Camp, H. S., Ding, L., & Leff, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2009 · Cited by 120
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart
Doroudgar, S., & Glembotski, C. C. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.12.003 · Cited by 117
Cardiokines: recent progress in elucidating the cardiac secretome
Shimano, M., Ouchi, N., & Walsh, K. (2012) · Circulation · doi:10.1161/circulationaha.112.150656 · Cited by 116
Transcriptional Coregulators: Fine-Tuning Metabolism
Mouchiroud, L., Eichner, L. J., Shaw, R. J., & Auwerx, J. H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.027 · Cited by 116
The SCF–Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with MediatorPreprint
Davis, M. A., Larimore, E. A., Fissel, B. M., Swanger, J., Taatjes, D. J., & Clurman, B. E. (2013) · Genes & Development · doi:10.1101/gad.207720.112 · Cited by 115
Transcription Coactivator PBP, the Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein, Is Required for PPARα-regulated Gene Expression in Liver
Jia, Y., Qi, C., Kashireddy, P. V., Surapureddi, S., Zhu, Y., Rao, M. S., Roith, D. L., Chambon, P., Gonzalez, F. J., & Reddy, J. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402391200 · Cited by 114
Involvement of Mediator complex in malignancy
Schiano, C., Casamassimi, A., Rienzo, M., de Nigris, F., Sommese, L., & Claudio Napoli, A. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.001 · Cited by 108
Mediator and human disease
Spaeth, J. M., Kim, N. H., & Boyer, T. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.024 · Cited by 107
Mediator-dependent nuclear receptor function
Chen, W., & Roeder, R. G. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.026 · Cited by 104
Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response
Flamant, F., & Gauthier, K. C. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.06.003 · Cited by 98
Diabetic cardiomyopathy.
Hamby, R. I., Zoneraich, S., & Sherman, L. (1974) · PubMed · Cited by 98
Distinct functions for RIP140 in development, inflammation, and metabolism
Nautiyal, J., Christian, M., & Parker, M. G. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.001 · Cited by 94
MED13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
Baskin, K. K., Grueter, C. E., Kusminski, C. M., Holland, W. L., Bookout, A. L., Satapati, S., Kong, Y. M., Burgess, S. C., Malloy, C. R., Scherer, P. E., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404218 · Cited by 92
Self-citation
Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles
Yu, F., Göthe, S., Wikström, L., Forrest, D., Vennström, B., & Larsson, L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.6.r1545 · Cited by 89
Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer
Hulf, T., Sibbritt, T., Wiklund, E. D., Patterson, K., Song, J. Z., Stirzaker, C., Qu, W., Nair, S. S., Horvath, L. G., Armstrong, N. J., et al. (2012) · Oncogene · doi:10.1038/onc.2012.300 · Cited by 88
Complexity in Transcription Control at the Activation Domain–Mediator Interface
Balamotis, M. A., Pennella, M. A., Stevens, J. L., Wasylyk, B., Belmont, A. S., & Berk, A. J. (2009) · Science Signaling · doi:10.1126/scisignal.1164302 · Cited by 84
The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney
Hong, S., Haldin, C. E., Lawson, N. D., Weinstein, B. M., Dawid, I. B., & Hukriede, N. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509457102 · Cited by 81
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
Chao, L. C., Wroblewski, K., Ilkayeva, O., Stevens, R. D., Bain, J. R., Meyer, G. A., Schenk, S., Martinez, L., Vergnes, L., Narkar, V. A., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m029355 · Cited by 81
A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism
Chen, W., Zhang, X., Birsoy, K., & Roeder, R. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005626107 · Cited by 79
Estrogen‐related receptor‐α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury
LaBarge, S., McDonald, M., Smith‐Powell, L., Auwerx, J., & Huss, J. M. (2014) · The FASEB Journal · doi:10.1096/fj.13-229211 · Cited by 74
Acetylation and nuclear receptor action
Wang, C., Tian, L., Popov, V. M., & Pestell, R. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.003 · Cited by 71
Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity
Chu, Y., Rosso, L. A. G., Huang, P., Wang, Z., Xu, Y., Xiao, Y., Bao, M., Yan, J., Song, H., & Wang, G. (2014) · Cell Research · doi:10.1038/cr.2014.120 · Cited by 70
Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
Brahma, M. K., Adam, R. C., Pollak, N. M., Jaeger, D., Zierler, K. A., Poecher, N., Schreiber, R., Romauch, M., Moustafa, T., Eder, S., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044784 · Cited by 70
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
Krebs, P., Fan, W., Chen, Y., Tobita, K., Downes, M., Wood, M. R., Sun, L., Li, X., Xia, Y., Ding, N., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117835108 · Cited by 66
Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation
Belakavadi, M., & Fondell, J. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01541-09 · Cited by 65
The road to nuclear receptors of thyroid hormone
Tata, J. R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.02.017 · Cited by 64
The secretome of the working human skeletal muscle—A promising opportunity to combat the metabolic disaster?
Weigert, C., Lehmann, R., Hartwig, S., & Lehr, S. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300094 · Cited by 61
MED1 Phosphorylation Promotes Its Association with Mediator: Implications for Nuclear Receptor Signaling
Belakavadi, M., Pandey, P. K., Vijayvargia, R., & Fondell, J. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02191-07 · Cited by 61
The roles of Mediator complex in cardiovascular diseases
Schiano, C., Casamassimi, A., Vietri, M. T., Rienzo, M., & Claudio Napoli, A. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.012 · Cited by 59
Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila
Lee, J.-H., Bassel‐Duby, R., & Olson, E. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409427111 · Cited by 59
Self-citation
Road to exercise mimetics: targeting nuclear receptors in skeletal muscle
Fan, W., Atkins, A. R., Yu, R. T., Downes, M., & Evans, R. M. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0258 · Cited by 57
Unraveling framework of the ancestral Mediator complex in human diseases
Claudio Napoli, A., Sessa, M., Infante, T., & Casamassimi, A. (2011) · Biochimie · doi:10.1016/j.biochi.2011.09.016 · Cited by 55
The Mediator complex in thyroid hormone receptor action
Fondell, J. D. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.02.012 · Cited by 55
Cardiac Dysfunction Caused by Myocardium-Specific Expression of a Mutant Thyroid Hormone Receptor
Pazos-Moura, C. C., Abel, E. D., Boers, M.-E., de Moura, E. G., Hampton, T., Wang, J., Morgan, J. P., & Wondisford, F. E. (2000) · Circulation Research · doi:10.1161/01.res.86.6.700 · Cited by 46
Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions
Miller, C., Matić, I., Maier, K. C., Schwalb, B., Röther, S., Sträßer, K., Tresch, A., Mann, M., & Cramer, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.430140 · Cited by 44
Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy
Magida, J. A., & Leinwand, L. A. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302852 · Cited by 44
Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor
Kim, G. H., Oh, G., Yoon, J. H., Lee, G. G., Lee, K.-U., & Kim, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73615 · Cited by 39
The heart‐liver metabolic axis: defective communication exacerbates disease
Baskin, K. K., Bookout, A. L., & Olson, E. N. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303800 · Cited by 30
Self-citation
MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31
Jiang, C., Chen, H., SHAO, L., & Wang, Q. (2014) · Oncology Reports · doi:10.3892/or.2014.3274 · Cited by 21
Mediator Complex Dependent Regulation of Cardiac Development and Disease
Grueter, C. E. (2013) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2013.05.002 · Cited by 20
Cardiac glucose utilization in mice with mutated α- and β-thyroid hormone receptors
Esaki, T., Suzuki, H., Cook, M., Shimoji, K., Cheng, S.-Y., Sokoloff, L., & Nunez, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00078.2004 · Cited by 18
The Mediator Complex and Lipid Metabolism.
Zhang, Y., Xiaoli, Zhao, X., & Yang, F. (2013) · PubMed · Cited by 14
Cardioselective dominant-negative thyroid hormone receptor (Δ337T) modulates myocardial metabolism and contractile efficiency
Hyyti, O. M., Olson, A. K., Ge, M. J., Ning, X.-H., Buroker, N. E., Chung, Y., Jue, T., & Portman, M. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90329.2008 · Cited by 14
Large-Scale Identification of MicroRNA Targets in Murine Dgcr8-Deficient Embryonic Stem Cell Lines
Davis, M. P. A., Abreu‐Goodger, C., van Dongen, S., Lu, D., Tate, P. H., Bartoniček, N., Kutter, C., Liu, P., Skarnes, W. C., Enright, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041762 · Cited by 8

Sorted by citations

Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence
Tezze, C., Romanello, V., Desbats, M. A., Fadini, G. P., Albiero, M., Favaro, G., Ciciliot, S., Soriano, M. E., Morbidoni, V., Cerqua, C., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.021 · Cited by 568
“This is an emerging concept that considers the metabolic adaptations occurring in skeletal muscles as disease modifier/controller (Baskin et al., 2015) and explains why physical activity elicits several beneficial effects in many different diseases.”
Influential
Effects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 517
Self-citation
Skeletal Muscle Extracellular Matrix – What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review
Csapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 458
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 438

See all 341

Authors: Baskin, K. K., Winders, B. R., & Olson, E. N.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Olson, Eric N.
ORCID: Baskin, Kedryn K.
Olson, Eric N.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2015-02
Volume: 21
Issue: 2
Pages: 237-248
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2014.12.021
PMC: PMC4398026
OpenAlex: W2052045659
Cited by: 333
References: 139
Citations by year: 2026: 38 · 2025: 38 · 2024: 47 · 2023: 41 · 2022: 42 · 2021: 43 · 2020: 25 · 2019: 17 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 7
FWCI: 1.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01hl100401-07)
National Heart, Lung, and Blood Institute (R01HL111665, R01HL077439, HL- 111665, U01-HL-100401, R01HL053351, R01HL093039, HL077439, HL093039)
National Institute of Diabetes and Digestive and Kidney Diseases (DK099653, R01DK099653)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: Mediator complex, skeletal muscle, myocardium, muscle metabolism, transcriptional regulation, tissue-specific gene regulation, physical activity, metabolic plasticity
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Muscles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Muscle as a “Mediator” of Systemic Metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks