Cited by 341Metabolism, Diabetes, and CancerAdipose Tissue and MetabolismMuscle Physiology and Disorders

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Muscle as a “Mediator” of Systemic Metabolism

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Baskin, Kedryn K., Winders, Benjamin R., Olson, Eric N.·2015·Cell Metabolism

DOI 10.1016/j.cmet.2014.12.021PMC PMC4398026

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Abstract

Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

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Authors: Baskin, K. K., Winders, B. R., & Olson, E. N.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Olson, Eric N.
ORCID: Baskin, Kedryn K.
Olson, Eric N.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2015-02
Volume: 21
Issue: 2
Pages: 237-248
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2014.12.021
PMC: PMC4398026
OpenAlex: W2052045659
Cited by: 333
References: 139
Citations by year: 2026: 38 · 2025: 38 · 2024: 47 · 2023: 41 · 2022: 42 · 2021: 43 · 2020: 25 · 2019: 17 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 7
FWCI: 1.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01hl100401-07)
National Heart, Lung, and Blood Institute (R01HL111665, R01HL077439, HL- 111665, U01-HL-100401, R01HL053351, R01HL093039, HL077439, HL093039)
National Institute of Diabetes and Digestive and Kidney Diseases (DK099653, R01DK099653)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: Mediator complex, skeletal muscle, myocardium, muscle metabolism, transcriptional regulation, tissue-specific gene regulation, physical activity, metabolic plasticity
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Muscles

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Muscle as a “Mediator” of Systemic Metabolism

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