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IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins
Open accessAbstract
Although variants in the IGF2BP2/IMP2 gene confer risk for type 2 diabetes, IMP2, an RNA binding protein, is not known to regulate metabolism. Imp2(-/-) mice gain less lean mass after weaning and have increased lifespan. Imp2(-/-) mice are highly resistant to diet-induced obesity and fatty liver and display superior glucose tolerance and insulin sensitivity, increased energy expenditure, and better defense of core temperature on cold exposure. Imp2(-/-) brown fat and Imp2(-/-) brown adipocytes differentiated in vitro contain more UCP1 polypeptide than Imp2(+/+) despite similar levels of Ucp1 mRNA; the Imp2(-/-)adipocytes also exhibit greater uncoupled oxygen consumption. IMP2 binds the mRNAs encoding Ucp1 and other mitochondrial components, and most exhibit increased translational efficiency in the absence of IMP2. In vitro IMP2 inhibits translation of mRNAs bearing the Ucp1 untranslated segments. Thus IMP2 limits longevity and regulates nutrient and energy metabolism in the mouse by controlling the translation of its client mRNAs.
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“Mice subjected to fasting display decreased IMP2 protein in their livers and white adipose tissue [40].”
From IMPlications of IMP2 in RNA Biology and Disease (2025) · cites this paper as [40]
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“IMP2 expression is impacted by diet and age.”
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Metadata
- Authors
- Dai, N., Zhao, L., Wrighting, D., Krämer, D., Majithia, A., Wang, Y., Cracan, V., Borges-Rivera, D., Mootha, V. K., Nahrendorf, M., Thorburn, D. R., Minichiello, L., Altshuler, D., & Avruch, J.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- European Molecular Biology Laboratory (IT)
- Massachusetts General Hospital (US)
- Royal Children's Hospital (AU)
- University of Oxford (GB)
- Corresponding author
- Altshuler, David
- Avruch, Joseph
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 21
- Issue
- 4
- Pages
- 609-621
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4663978
- OpenAlex
- W2019615270
- Cited by
- 188
- References
- 38
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 17 · 2023: 19 · 2022: 36 · 2021: 21 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 1
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Health and Medical Research Council
- National Institute of General Medical Sciences (T32GM007287)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, R37DK017776, R37DK17776, P30DK043351, P30DK040561)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- IGF2BP2, RNA-binding proteins, diet-induced obesity, brown adipocytes, UCP1, mitochondrial translation, translational regulation, mRNA untranslated regions, energy expenditure, glucose tolerance, insulin sensitivity, hepatic steatosis, lifespan, cold tolerance, type 2 diabetes risk
- MeSH terms
- Uncoupling Protein 1, Analysis of Variance, Animals, Base Sequence, Body Temperature Regulation, Adipose Tissue, Brown, Energy Metabolism, Gene Expression Regulation, Insulin Resistance, Ion Channels, Molecular Sequence Data, Obesity, RNA-Binding Proteins, Sequence Analysis, RNA, Mice, Knockout, Mitochondrial Proteins, Mice
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