Metformin Activates AMPK through the Lysosomal Pathway

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,840

Metformin: from mechanisms of action to therapies

Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.018 · Cited by 1,501

Metformin as a tool to target aging

Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096 · cited 1×

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893

AMPK—Sensing Energy while Talking to Other Signaling Pathways

Hardie, D. G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.013 · Cited by 597

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

Zhang, C., Jiang, B., Li, M., Zhu, M., Peng, Y., Zhang, Y., Wu, Y., Li, T. Y., Yu, L., Lu, Z., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.014 · Cited by 565

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483

Metformin Action: Concentrations Matter

He, L., & Wondisford, F. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.003 · Cited by 448

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

Zhang, Y., Guo, H., Zhang, C., Lin, S., Yin, Z., Peng, Y., Luo, H., Shi, Y., Lian, G., Zhang, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.005 · Cited by 278

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287

AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,198

AMPK signalling in health and disease

Carling, D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.01.005 · Cited by 797

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766

Metformin: update on mechanisms of action and repurposing potential

Foretz, M., Guigas, B., & Viollet, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00833-4 · Cited by 791

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

AMPK as a Therapeutic Target for Treating Metabolic Diseases

Day, E. A., Ford, R. J., & Steinberg, G. R. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.004 · Cited by 630

Metformin and Its Benefits for Various Diseases

Lv, Z., & Guo, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00191 · Cited by 563

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Yang, J., Zhou, Y., Xie, S., Wang, J., Li, Z., Chen, L., Mao, M., Chen, C., Huang, A., Chen, Y., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02012-7 · Cited by 399

Unraveling the regulation of hepatic gluconeogenesis

Zhang, X., Yang, S., Chen, J., & Su, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00802 · Cited by 314

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 300

Metformin as an Anticancer Agent

Vancura, A., Bu, P., Bhagwat, M., Zeng, J., & Vancurova, I. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.07.006 · Cited by 274

Metformin as Anti-Aging Therapy: Is It for Everyone?

Soukas, A. A., Hao, H., & Wu, L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.015 · Cited by 266

Metformin and Systemic Metabolism

He, L. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.001 · Cited by 248

Metformin extends C. elegans lifespan through lysosomal pathway

Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 207

Mitochondrial dynamics and transport in Alzheimer's disease

Flannery, P. J., & Trushina, E. V. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.009 · Cited by 203

25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

Xiao, J., Wang, S., Chen, L., Ding, X., Dang, Y., Han, M., Zheng, Y., Shen, H., Wu, S., Wang, M., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.021 · Cited by 220

The lysosome: a crucial hub for AMPK and mTORC1 signalling

Carroll, B., & Dunlop, E. A. (2017) · Biochemical Journal · doi:10.1042/bcj20160780 · Cited by 192

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S. W., Gu, Y., Zbinden, M., Burge, M. R., Timmins, G. S., Hallows, K. R., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.028 · Cited by 198

AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis

Sharma, A., Anand, S. K., Singh, N., Dwivedi, U. N., & Kakkar, P. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113614 · Cited by 207

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Willows, R., Sanders, M. J., Xiao, B., Patel, B. R., Martin, S. R., Read, J., Wilson, J. R., Hubbard, J., Gamblin, S. J., & Carling, D. (2017) · Biochemical Journal · doi:10.1042/bcj20170458 · Cited by 190

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Xu, X., Sun, Y., Cen, X., Shan, B., Zhao, Q., Xie, T., Wang, Z., Hou, T., Xue, Y., Zhang, M., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00858-3 · Cited by 171

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Agius, L., Ford, B. E., & Chachra, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093240 · Cited by 183

Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

Curry, D. W., Stutz, B., Andrews, Z. B., & Elsworth, J. D. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171296 · Cited by 160

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Wen, Z., Jin, K., Shen, Y., Yang, Z., Li, Y., Wu, B., Tian, L., Shoor, S., Roche, N. E., Goronzy, J. J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0296-7 · Cited by 162

Metformin and Aging: A Review

Glossmann, H. H., & Lutz, O. M. D. (2019) · Gerontology · doi:10.1159/000502257 · Cited by 149

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Zhang, Y., Lanjuin, A., Chowdhury, S. R., Mistry, M., Silva-García, C. G., Weir, H. J. M., Lee, C.-L., Escoubas, C. C., Tabakovic, E., & Mair, W. B. (2019) · eLife · doi:10.7554/elife.49158 · Cited by 136

Metformin: A Novel Weapon Against Inflammation

Bai, B., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.622262 · Cited by 149

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Vara‐Ciruelos, D., Russell, F. M., & Hardie, D. G. (2019) · Open Biology · doi:10.1098/rsob.190099 · Cited by 140

Mitochondrial complex I as a therapeutic target for Alzheimer's disease

Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 131

Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry

Palacios-Rápalo, S. N., Jesús‐González, L. A. D., Cordero‐Rivera, C. D., Farfán-Morales, C. N., Osuna‐Ramos, J. F., Martínez-Mier, G., Quistián-Galván, J., Muñoz-Pérez, A., Bernal-Dolores, V., del Ángel, R. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796855 · Cited by 125

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

Savini, M., Zhao, Q., & Wang, M. C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.08.008 · Cited by 116

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Thellung, S., Corsaro, A., Nizzari, M., Barbieri, F., & Florio, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040901 · Cited by 118

Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment

Li, M., Li, X., Zhang, H., & Lü, Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01039 · Cited by 125

Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk

Paudel, Y. N., Angelopoulou, E., Piperi, C., Shaikh, M. F., & Othman, I. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104593 · Cited by 115

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Qu, Q., Chen, Y., Wang, Y., Wang, W., Long, S., Yang, H.-Y., Wu, J., Li, M., Tian, X., Wei, X., et al. (2024) · Nature · doi:10.1038/s41586-024-08348-2 · Cited by 130

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing

Prattichizzo, F., Giuliani, A., Mensa’, E., Sabbatinelli, J., Nigris, V. D., Rippo, M. R., Sala, L. L., Procopio, A. D., Olivieri, F., & Ceriello, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.003 · Cited by 114

Polysaccharides derived from natural sources regulate triglyceride and cholesterol metabolism: a review of the mechanisms

Wu, Q., Wang, Q., Fu, J., & Ren, R. (2019) · Food & Function · doi:10.1039/c8fo02375a · Cited by 112

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Qu, Q., Chen, Y., Wang, Y., Long, S., Wang, W., Yang, H.-Y., Li, M., Tian, X., Wei, X., Liu, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08329-5 · Cited by 123

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Huynh, C. Q., Ryu, J., Lee, J., Inoki, A., & Inoki, K. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00648-y · Cited by 109

New developments in AMPK and mTORC1 cross-talk

Smiles, W. J., Ovens, A. J., Kemp, B. E., Galić, S., Petersen, J., & Oakhill, J. S. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240007 · Cited by 124

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202012-4510oc · Cited by 100

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

Camacho-Encina, M., Booth, L. K., Redgrave, R. E., Folaranmi, O., Spyridopoulos, I., & Richardson, G. D. (2024) · Cells · doi:10.3390/cells13040353 · Cited by 103

Autophagy and cardiac aging

Miyamoto, S. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0286-9 · Cited by 97

Current nutritional and pharmacological anti-aging interventions

Ros, M., & Carrascosa, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 86

AMP-activated protein kinase – not just an energy sensor

Hardie, D. G., & Lin, S. (2017) · F1000Research · doi:10.12688/f1000research.11960.1 · Cited by 91

Is metformin poised for a second career as an antimicrobial?

Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 89

Pleiotropic Effects of Metformin on Cancer

Schulten, H.-J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102850 · Cited by 87

The Fatty Acid Lipid Metabolism Nexus in COVID-19

Tanner, J. E., & Alfieri, C. (2021) · Viruses · doi:10.3390/v13010090 · Cited by 87

SIRT1 Regulation in Ageing and Obesity

Pardo, P. S., & Boriek, A. M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111249 · Cited by 94

Metabolic Action of Metformin

Szymczak-Pajor, I., Wenclewska, S., & Śliwińska, A. (2022) · Pharmaceuticals · doi:10.3390/ph15070810 · Cited by 89

Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes

Jiating, L., Buyun, J., & Zhang, Y. (2019) · BioMed Research International · doi:10.1155/2019/9203934 · Cited by 80

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 83

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Shan, C., Lu, Z., Li, Z., Sheng, H., Fan, J., Qi, Q., Liu, S., & Zhang, S. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1756-1 · Cited by 72

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Wang, M., Tian, T., Zhou, H., Jiang, S., Jiao, Y., Zhu, Z., Xia, J., Ma, J., & Du, R. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03072-0 · Cited by 79

Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator

Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alnaaim, S. A., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00742-2 · Cited by 73

The Mechanism of Action of Biguanides: New Answers to a Complex Question

Magno, L. D., Pastena, F. D., Bordone, R., Coni, S., & Canettieri, G. (2022) · Cancers · doi:10.3390/cancers14133220 · Cited by 81

Metformin from mother to unborn child-are there unwarranted effects?

Nguyen, L., Chan, S.-Y., & Teo, A. K. K. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.047 · Cited by 67

Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells

Kim, H.-S., Ren, G., Kim, T., Bhatnagar, S., Yang, Q., Bahk, Y. Y., & Kim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70347-w · Cited by 68

Therapeutic Repurposing of Biguanides in Cancer

Zhao, H., Swanson, K. D., & Zheng, B. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.03.001 · Cited by 69

New Insights Into the Anti-Diabetic Actions of Metformin: From the Liver to the Gut

Wu, T., Horowitz, M., & Rayner, C. K. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1273769 · Cited by 64

AMPK signalling: Implications for podocyte biology in diabetic nephropathy

Szrejder, M., & Piwkowska, A. (2019) · Biology of the Cell · doi:10.1111/boc.201800077 · Cited by 65

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways

Wang, Y., Yang, Z., Zheng, G., Yu, L., Yin, Y., Mu, N., & Ma, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.002 · Cited by 63

Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

Speirs, C., Williams, J. J. L., Riches‐Suman, K., Salt, I. P., & Palmer, T. M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.10.001 · Cited by 61

Pharmacology of metformin – An update

Glossmann, H. H., & Lutz, O. M. D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172782 · Cited by 62

Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC

Zhang, Y., Wang, H., & Xiao, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095016 · Cited by 57

Metformin: From Diabetes to Cancer—Unveiling Molecular Mechanisms and Therapeutic Strategies

Amengual-Cladera, E., Morla-Barcelo, P. M., Morán-Costoya, A., Valle, A., Pons, D. G., Sastre‐Serra, J., Roca, P., & Nadal‐Serrano, M. (2024) · Biology · doi:10.3390/biology13050302 · Cited by 74

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

Russell, F. M., & Hardie, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010186 · Cited by 57

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

Bai, L., Li, Z., Pan, T., Wang, W., Wang, D., Turner, C., Zhou, X., & He, H. (2021) · Respiratory Research · doi:10.1186/s12931-021-01760-6 · Cited by 55

Metformin: Past, Present, and Future

Chaudhary, S., & Kulkarni, A. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01539-1 · Cited by 64

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

Justice, J. N., Gubbi, S., Kulkarni, A. S., Bartley, J. M., Kuchel, G. A., & Barzilai, N. (2020) · GeroScience · doi:10.1007/s11357-020-00261-6 · Cited by 53

Repurposing Antidiabetic Drugs for Cardiovascular Disease

Schubert, M., Hansen, S., Leefmann, J., & Guan, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.568632 · Cited by 57

A role for sodium glucose cotransporter 2 inhibitors (SGLT2is) in the treatment of Alzheimer's disease?

ESTERLINE, R. L., Oscarsson, J., & Burns, J. M. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.018 · Cited by 51

Regulation of organelle function by metformin

Kim, J., & You, Y. (2017) · IUBMB Life · doi:10.1002/iub.1633 · Cited by 50

Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

Chen, X., Wu, W., Gong, B., Hou, L., Dong, X., Xu, C., Zhao, R., Yu, Q., Zhou, Z., Huang, S., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108065 · Cited by 49

Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy

Nakamura, M. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.12568 · Cited by 53

Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia

Top, W. M. C., Kooy, A., & Stehouwer, C. D. A. (2022) · Pharmaceuticals · doi:10.3390/ph15030312 · Cited by 51

The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus

Yang, W., Sun, X., Zhang, J., & Zhang, K. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108977 · Cited by 48

AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake

Rao, X. S., Cong, X. X., Gao, X. K., Shi, Y. P., Shi, L., Wang, J. F., Ni, C.-Y., He, M. J., Xu, Y., Yi, C., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00809-9 · Cited by 50

AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules

Xiao, J., Zhu, S., Guan, H., Zheng, Y., Li, F., Zhang, X., Guo, H., Wang, X., & Ye, Z. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0254-y · Cited by 47

Role of p53 Family Proteins in Metformin Anti-Cancer Activities

Yi, Y., Zhang, W., Yi, J., & Xiao, Z. J. (2019) · Journal of Cancer · doi:10.7150/jca.30659 · Cited by 47

Challenges to Improve Bone Healing Under Diabetic Conditions

Chen, Y., Zhou, Y., Lin, J., & Zhang, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.861878 · Cited by 48

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Zhou, X. E., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Xu, H. E., & Melcher, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004883 · Cited by 44

Metformin accelerates zebrafish heart regeneration by inducing autophagy

Xie, F., Xu, S., Lü, Y., Wong, K. F., Sun, L., Hasan, K. M. M., Ma, A. C. H., Tse, G., Manno, S. H. C., Tian, L., et al. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00172-w · Cited by 46

New insights on the potential anti‐epileptic effect of metformin: Mechanistic pathway

Alnaaim, S. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Ali, N. H., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17965 · Cited by 44

Metformin as a Potential Neuroprotective Agent in Prodromal Parkinson's Disease—Viewpoint

Sportelli, C., Urso, D., Jenner, P. G., & Chaudhuri, К. R. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00556 · Cited by 47

Metformin attenuates sevoflurane-induced neurocognitive impairment through AMPK-ULK1-dependent autophagy in aged mice

Zhu, J., Zongze, Z., Qiuyue, Y., Peng, F., Qi, Z., Yanlin, W., & Chang, C. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.018 · Cited by 42

Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

Yue, F., Shi, Y., Wu, S., Lin, X., He, D., Lin, W., Qiu, A., Russell, R., & Zhang, D. (2023) · iScience · doi:10.1016/j.isci.2023.108560 · Cited by 43

Metformin and cognition from the perspectives of sex, age, and disease

Chaudhari, K., Reynolds, C. D., & Yang, S.-H. (2020) · GeroScience · doi:10.1007/s11357-019-00146-3 · Cited by 43

Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness

Nowosad, A., & Besson, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042290 · Cited by 39

Association of metabolic-dysfunction associated steatotic liver disease with polycystic ovary syndrome

Xu, Q., Zhang, J., Lu, Y., & Wu, L. Y. (2024) · iScience · doi:10.1016/j.isci.2024.108783 · Cited by 43

Spatial control of AMPK signaling at subcellular compartments

Chauhan, A. S., Li, Z., & Gan, B. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1727840 · Cited by 41

Relationship between Oral Metformin Use and Age-Related Macular Degeneration

Stewart, J. M., Lamy, R., Wu, F., & Keenan, J. D. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.06.003 · Cited by 39

Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

Franco-Juárez, B., Gómez‐Manzo, S., Hernández‐Ochoa, B., Cárdenas‐Rodríguez, N., Arreguín‐Espinosa, R., de la Cruz, V. P., & Ortega-Cuéllar, D. (2021) · Cells · doi:10.3390/cells10092359 · Cited by 41

Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

Nurcahyanti, A. D. R., Jap, A., Lady, J., Prismawan, D., Sharopov, F. S., Daoud, R., Wink, M., & Sobeh, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112138 · Cited by 41

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Esam, Z. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108282 · Cited by 39

Cardiovascular complications of diabetes

Shah, A., Isath, A. M., & Aronow, W. S. (2022) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2022.2099838 · Cited by 47

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Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 46

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

Liu, Y., Jurczak, M. J., Lear, T., Lin, B., Larsen, M. B., Kennerdell, J. R., Chen, Y., Huckestein, B. R., Nguyen, M. K., Tuncer, F., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00723-0 · Cited by 37

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Cézar, A., Júnior, S., Lopes, M. R. U., Santomauro, A. T. M. G., Souto, P. D., & André, S. (2008) · Cited by 2

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Ma, T., Tian, X., Zhang, B., Li, M., Wang, Y., Yang, C., Wu, J., Wei, X., Qu, Q., Yu, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-04431-8 · Cited by 644

Metformin as an activator of AMP-activated protein kinase. Known and new mechanisms of action

Mkrtumyan, A. M., Маркова, Т. Н., Ovchinnikova, M. A., Ivanova, I. A., & Kuzmenko, K. V. (2023) · Diabetes Mellitus · doi:10.14341/dm13044 · Cited by 7

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Chen, J., Ou, Y., Li, Y., Hu, S., Shao, L.-W., & Liu, Y. (2017) · eLife · doi:10.7554/elife.31268 · Cited by 207

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Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652