The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
Open accessAbstract
Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fumarate was shown to cause succination of the mitochondrial aconitase, ACO2, leading to an additional truncation of the TCA cycle86”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · cited 1×
“Citric acid cycle metabolites (e.g., fumarate and succinate) have previously been reported to regulate HIF1a stabilization by inhibiting hydroxylation and therefore stabilizing HIF1a (Koi- vunen et al., 2007; Tannahill et al., 2013).”
BackgroundSelf-citationCaspi, R., Billington, R., Ferrer, L., Foerster, H., Fulcher, C. A., Keseler, I. M., Kothari, A., Krummenacker, M., Latendresse, M., Mueller, L. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1164 · Cited by 3,395
Trained immunity: A program of innate immune memory in health and– disease
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768
Self-citationMetaboAnalyst 3.0—making metabolomics more meaningful
Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv380 · Cited by 2,680
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224
Self-citationIDH mutation impairs histone demethylation and results in a block to cell differentiation
Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature · doi:10.1038/nature10860 · Cited by 1,985
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Saeed, S., Quintin, J., Kerstens, H. H. D., Rao, N. A., Aghajanirefah, A., Matarese, F., Cheng, S.-C., Ratter, J., Berentsen, K., van der Ent, M. A., et al. (2014) · Science · doi:10.1126/science.1251086 · Cited by 1,761
Self-citationTrained Immunity: A Memory for Innate Host Defense
Netea, M. G., Quintin, J., & van der Meer, J. W. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.006 · Cited by 1,760
Self-citationKleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728
Self-citationHypoxia-Inducible Factor-1 (HIF-1)
Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,690
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 927
The impact of trained immunity in respiratory viral infections
Piret, J., & Boivin, G. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2510 · Cited by 8
LL37/self-DNA complexes mediate monocyte reprogramming
Damara, A., Wegner, J., Trzeciak, E. R., Kolb, A., Nastaranpour, M., Khatri, R., Tuettenberg, A., Kramer, D., Grabbe, S., & Shahneh, F. Z. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110287 · Cited by 8
Zhang, Z., Wang, Y., Xia, L., & Zhang, Y. (2024) · Current Microbiology · doi:10.1007/s00284-024-03801-x · Cited by 10
The immune memory of innate immune systems
Kato, Y., & Kumanogoh, A. (2024) · International Immunology · doi:10.1093/intimm/dxae067 · Cited by 10
Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges
Carvalho, A., Duarte‐Oliveira, C., Gonçalves, S. M., Campos, A., de Lacerda, J. F., & Cunha, C. (2017) · Current Fungal Infection Reports · doi:10.1007/s12281-017-0272-y · Cited by 8
Self-citationTrained immunity in the mucosal diseases
Yu, D., Zhang, J., & Wang, S. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1543 · Cited by 8
Self-citationGut-Evolved Candida albicans Induces Metabolic Changes in Neutrophils
Reales‐Calderón, J. A., Tso, G. H. W., Tan, A. S. M., Hor, P. X., Böhme, J., Teng, K. W. W., Newell, E. W., Singhal, A., & Pavelka, N. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.743735 · Cited by 8
Trained immunity against diseases in domestic animals
Angulo, M., & Angulo, C. (2022) · Acta Tropica · doi:10.1016/j.actatropica.2022.106361 · Cited by 8
Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonistPreprint
Um, P. K., Praharaj, M., Lombardo, K. A., Yoshida, T., Matoso, A., Baras, A. S., Zhao, L., Srikrishna, G., Huang, J., Prasad, P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.15.571740 · Cited by 9
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 10
Trained immunity in farm animals
Báez-Magaña, M., Alva-Murillo, N., Ochoa‐Zarzosa, A., & López-Meza, J. E. (2025) · Veterinary Research · doi:10.1186/s13567-025-01594-w · Cited by 7
Trained immunity in skin infections: Macrophages and beyond
Gres, V., Göcer, M., Kolter, J., & Henneke, P. (2025) · eLife · doi:10.7554/elife.106688 · Cited by 7
Nano-strategy empowering trained immunity in vaccines
Wang, L., Zhang, Y., Wang, S., Shen, X., Zhang, J., You, J., & Luo, L. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114359 · Cited by 7
Self-citationTrained Immunity in Interorgan Communication and Vascular Inflammation
Liesz, A. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323130 · Cited by 7
Trained immunity: A key player of “metabolic memory” in diabetes
Naruse, K. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13734 · Cited by 7
Pérez-Hernández, C. A., Moreno‐Altamirano, M. M. B., López‐Villegas, E. O., Butkevičiūtė, E., Ali, M., Kronsteiner, B., Dunachie, S. J., Dockrell, H. M., Smith, S. G., & Sánchez‐García, F. J. (2022) · Biology · doi:10.3390/biology11081132 · Cited by 7
BCG Vaccination and the Risk of Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Jamshidi, P. K., Danaei, B., Mohammadzadeh, B., Arbabi, M., Nayebzade, A., Sechi, L. A., & Nasiri, M. J. (2023) · Pathogens · doi:10.3390/pathogens12040581 · Cited by 7
Mussap, M., Puddu, M., & Fanos, V. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230509110108 · Cited by 8
Re‐recognition of innate immune memory as an integrated multidimensional concept
Tang, C., Kurata, S., & Fuse, N. (2023) · Microbiology and Immunology · doi:10.1111/1348-0421.13083 · Cited by 8
Trained immunity: A link between risk factors and cardiovascular disease
Chen, M., Kang, X., Zhang, Y., & Liu, Y. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16472 · Cited by 8
Insights into the multifaceted role of interleukin-37 on human immune cell regulation
Teufel, L. U., Matzaraki, V., Folkman, L., ter Horst, R., Moorlag, S. J. C. F. M., Mulders‐Manders, C. M., Netea, M. G., Krausgruber, T., Joosten, L. A. B., & Arts, R. J. W. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110368 · Cited by 7
Self-citationTrained immunity-based vaccines: A vision from the one health initiative
Angulo, M., & Angulo, C. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126505 · Cited by 7
Cruz-Carrillo, G., & Camacho‐Morales, A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02154-3 · Cited by 7
CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice
Thomas, A. M., Yang, E., Smith, M. D., Chu, C., Calabresi, P. A., Glunde, K., van Zijl, P. C. M., & Bulte, J. W. M. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02493-z · Cited by 7
Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice
Kraemer, A. N., Schäfer, A.-L., Sprenger, D. T. L., Sehnert, B., Williams, J. P., Luo, A., Riechert, L., Al-Kayyal, Q., Dumortier, H., Fauny, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.933191 · Cited by 7
Knowledge mapping of trained immunity/innate immune memory: Insights from two decades of studies
He, J., Cui, H., Jiang, G., Fang, L., & Hao, J. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2415823 · Cited by 6
Role of Trained Immunity in Heath and Disease
Das, S., & Lavine, K. J. (2025) · Current Cardiology Reports · doi:10.1007/s11886-024-02167-7 · Cited by 6
Bruno, M., Kröger, C., Ferreira, A. V., Zhang, B.-W., Röring, R. J., Liu, R., van der Made, C. I., van Rhijn, N., Groh, L. A., Klück, V., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025016213 · Cited by 6
Self-citationDjebri, N. C., Zoudji, S., Messaoud, A., Messali, R., Loudjedi, S., & Aribi, M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115299 · Cited by 6
Innate immunity and training to subvert original antigenic sin by the humoral immune response
Mohamed, F. A. N., & Lingwood, D. (2025) · eLife · doi:10.7554/elife.106654 · Cited by 6
Divergent metabolic rewiring shapes altered innate immunity
Liu, M., Wang, X., Qu, X., Wang, Y., Shen, X., & Xu, L. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.105025 · Cited by 6
Trained immunity in acute and chronic neurological diseases
Zhang, S., & Liesz, A. (2026) · eLife · doi:10.7554/elife.106037 · Cited by 7
Li, W., Wei, J., Li, L., & Sun, W. (2026) · Cells · doi:10.3390/cells15090752 · Cited by 6
Trained immunity in monocytes and macrophages in atherosclerotic cardiovascular disease
Zhang, X., Wang, M., Wang, Y., Li, L., Wang, S., & Xiang, Y. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag109 · Cited by 6
Self-citationTrained Innate Immunity in Animal Models of Cardiovascular Diseases
Kleimann, P., Irschfeld, L.-M., Grandoch, M., Flögel, U., & Temme, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042312 · Cited by 6
Kumar, R., Kolloli, A., Singh, P., Shi, L., Kupz, A., & Subbian, S. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00473-24 · Cited by 6
Potential Impact of Extracorporeal Photopheresis on Trained Immunity and Organ Transplant Acceptance
Tocco, C., & Ochando, J. (2025) · Transplantation Direct · doi:10.1097/txd.0000000000001835 · Cited by 6
Understanding the genetic basis of immune responses to fungal infection
Gonçalves, S. M., Cunha, C., & Carvalho, A. (2022) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2063839 · Cited by 6
Self-citationChen, K., Wu, T., Wang, D., Li, R., Shen, X., Zhao, T., Ozato, K., & Li, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004232 · Cited by 6
Barbosa, M. M. F., Kanno, A. I., Farias, L. P., Madej, M. P., Sipos, G., Sbrana, S., Romani, L. R., Boraschi, D., Leite, L. C. C., & Italiani, P. (2021) · Nanomaterials · doi:10.3390/nano11040931 · Cited by 6
Zhou, F., Sun, L., Shao, Y., Zhang, X., & Li, C. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.02.012 · Cited by 6
T cell metabolism in graft-versus-host disease
Zou, Y., & Chen, B. J. (2020) · Blood Science · doi:10.1097/bs9.0000000000000035 · Cited by 6
Training myeloid precursors with fungi, bacteria and chips
Köpf, M., & Nielsen, P. J. (2018) · Nature Immunology · doi:10.1038/s41590-018-0073-7 · Cited by 6
Li, F., Wang, D., Gao, Y., & Cui, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648698 · Cited by 6
Multidimensional study on mitochondrial dysfunction in pulmonary hypertension
Yuan, X.-T., Zhang, Y., Liu, Y., Guo, X., Jia, S., Xiong, X., Xiuying, S., & Jin, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1716485 · Cited by 5
Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair
Xu, Y., Forni, M. F., Benvie, A. M., Castano, N., King, D. E., Sun, Q., Siebel, S., Tran, V. A., Kibbey, R. G., Miller‐Jensen, K., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117001 · Cited by 5
Trained immunity: new paradigm in the immunological memory of cardiovascular disease
Hope, E. C., Gonzalez, A. L., Norman, L. S., Smith, H. C., Wassenaar, J. W., Vickers, K. C., Brown, J. D., & Doran, A. C. (2026) · ImmunoHorizons · doi:10.1093/immhor/vlag008 · Cited by 5
Kang, J., li, N., Wang, F., Wei, Y., Zeng, Y., Luo, Q., Sun, X., Xu, H., Peng, J., & Zhou, F. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.832331 · Cited by 5
Dihydroartemisinin is an inhibitor of trained immunity through Akt/mTOR/HIF1α signaling pathway
Gao, Y., Liu, Z., Zhang, J., Zhou, C., Zhang, J.-G., Lin, X.-Q., Yin, Q., Chen, W., & Yang, Y. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114052 · Cited by 5
Pal, S., Rafiq, Z., Kumari, R., Aiyan, A. A., al-Ramadi, B. K., Kishore, U., & Ponnachan, P. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-85340-1_11 · Cited by 5
Cues of Trained Immunity in Multiple Sclerosis Macrophages
Popa, E., Cheval, H., & Zujovic, V. (2025) · Cells · doi:10.3390/cells14141054 · Cited by 5
Guo, Y., Xu, D., Fang, Z., Xu, S., Liu, J., Xu, Z., Zhou, J., Bu, Z., Yingyi, Z., He, J., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.718743 · Cited by 5
Liu, Y., Chen, Y., Cheng, J., Yan, J., Xue, C.-Y., Pan, H.-Y., Shen, X.-Y., Zhou, J., Jiang, P., Zhou, Y., et al. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03573 · Cited by 5
The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison
Arneth, B. M. (2023) · Endocrines · doi:10.3390/endocrines4010016 · Cited by 6
Leacy, E. J., Batten, I., Sanelli, L., McElheron, M., Brady, G., Little, M. A., & Khouri, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1116760 · Cited by 5
Emerging roles of ECSIT in immunity and tumorigenesis
Yang, S., & Humphries, F. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.09.003 · Cited by 5
European Respiratory Society Research Seminar on Preventing Pediatric Asthma
Grigg, J., Barratt, B., Bønnelykke, K., Čustović, A., Ege, M. J., Pasquali, C., Palomares, Ó., Shaheen, S. O., Sokołowska, M., Vercelli, D., et al. (2024) · Pediatric Pulmonology · doi:10.1002/ppul.27401 · Cited by 5
Reinhold, A., Jentho, E., Schäfer, S. T., Bauer, M. W., & Rittner, H. L. (2018) · Der Anaesthesist · doi:10.1007/s00101-018-0424-7 · Cited by 5
Epigenetic Rewiring of Monocytes in BCG Vaccination
Arts, R. J. W., & Netea, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814603-3.00008-2 · Cited by 5
Self-citationKiernan, E. A., Ewald, A. C., Ouellette, J. N., Wang, T., Agbeh, A., Knutson, A. O., Roopra, A., & Watters, J. J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.535549 · Cited by 5
Getting to the Marrow of Trained Immunity
Groh, L. A., Netea, M. G., Riksen, N. P., & Keating, S. T. (2018) · Epigenomics · doi:10.2217/epi-2018-0098 · Cited by 5
Self-citationLipid Droplet-Accumulating Microglia as a Therapeutic Node in Neurodegenerative Disease
Guo, S., Zhang, Q. Y., Guo, R., Fu, L., Zhu, H., & Zhang, Q. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00284 · Cited by 4
Luo, W., Xu, C., Li, L., Ji, Y., Wang, Y., Li, Y., & Ye, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01299 · Cited by 4
Lian, X., Wang, W., Li, Y., Zhou, X., Li, X., Zuo, J., Song, L., Wang, L., & Song, L. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110236 · Cited by 4
Hematopoietic stem and progenitor cells fine-tuning the “sweet” of trained immunity
Li, J., Wang, H., & Xia, S. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf043 · Cited by 4
Kersch, C., Masutin, V., Kuhlmann, L., Alsaleh, R., Kaifie, A., & Schmitz‐Spanke, S. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04155-4 · Cited by 4
Zarin, R., Guedri, K., Makhdoum, B. M., Niyazi, H. A., & Khalifa, H. A. E. (2025) · Advanced Theory and Simulations · doi:10.1002/adts.202501124 · Cited by 4
Fang, Y., Dou, A., Zhang, Y., Zhang, Y., Gao, Y., & Xie, K. (2025) · Shock · doi:10.1097/shk.0000000000002714 · Cited by 4
Antomagesh, F., & Vijayan, M. M. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1670637 · Cited by 5
Trained immunity in myocardial infarction: From mechanisms to translational potential
Xu, S., Liu, Y., Zhu, M., 徐凤芹, & Liu, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116518 · Cited by 4
Western lifestyle linked to maladaptive trained immunity
Merbecks, A. J., Mennicken, C., de Graaf, D. M., Shkarina, K., Wagner, T., & Latz, E. (2026) · eLife · doi:10.7554/elife.105835 · Cited by 5
Schiller, H. R., Zeigermann, C., & Schülke, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1748337 · Cited by 4
Guso, E., Lupoli, A., Olivieri, E., Bottoni, A., Gironi, M., Missarelli, D. M., Toosy, A., Rossi, E., & Furlan, R. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.02.047 · Cited by 4
Metabolic support of trained immune responses in myeloid cells
Jarit-Cabanillas, A., Dunphy, G., Virga, F., den Bossche, J. V., & Sancho, D. (2026) · eLife · doi:10.7554/elife.108814 · Cited by 4
Innate immunity: current understandings and future perspectives
Zou, C., Ma, T., Li, J., & Zhou, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02920-0 · Cited by 8
Effects of Bacillus Calmette-Guérin on immunometabolism, microbiome and liver diseases
Ijaz, M. U., Vaziri, F., & Wan, Y. Y. (2023) · Liver Research · doi:10.1016/j.livres.2023.05.001 · Cited by 4
Torres, J., & Touati, E. (2023) · Current topics in microbiology and immunology · doi:10.1007/978-3-031-47331-9_3 · Cited by 4
Colocalization Analysis Reveals Shared Genetic Loci Contributing to Gout and Metabolite Levels
Takei, R., Sumpter, N. A., Leask, M., & Merriman, T. R. (2025) · Gout Urate and Crystal Deposition Disease · doi:10.3390/gucdd3020006 · Cited by 4
Incalcaterra, S., & Dominguez, J. A. (2020) · Advanced Journal of Graduate Research · doi:10.21467/ajgr.8.1.68-81 · Cited by 4
[Latest Findings on the Function of Immune Metabolism in Tumor Immunity].
Yang, Y., Fan, D., Zheng, B.-H., & Zhou, S. (2023) · 四川大学学报：医学版 · doi:10.12182/20230560304 · Cited by 4
Influence of Maternal Immune Activation and Stressors on the Hippocampal Metabolome
Southey, B. R., Johnson, R. W., & Rodriguez‐Zas, S. L. (2023) · Metabolites · doi:10.3390/metabo13080881 · Cited by 4
Jyonouchi, H. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87167 · Cited by 4
5: Animal nutrition and immunity in pigs and poultry
Bouwens, M., & Savelkoul, H. F. J. (2019) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-884-1_5 · Cited by 4
DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation
Land, W. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53868-2_5 · Cited by 4
Li, M., Jin, H., Liu, Y., Wang, Z., Li, L., Wang, T., Wang, X., Zhang, H., Huo, B., Yu, T., et al. (2025) · eLife · doi:10.7554/elife.104138.3 · Cited by 4
Self-citationAdvancing veterinary vaccines design through trained immunity insights
Wang, X., & Yu, G. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1524668 · Cited by 3
Niu, L., Li, H., Guo, J., Jia, Z., Chang, Q., Liu, N., Zhang, S., & Ge, J. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10769-y · Cited by 3
Xian, J., Pan, X., Kang, Y., Zheng, L., Yin, X., Zhang, M., Wei, Y., Tan, J., Zhang, M., Nie, L., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03195-y · Cited by 3
Pleiotropic Mucosal Innate Immune Memory in the Gastrointestinal Tract
Cohen, R. H., Colgan, S. P., & Cartwright, I. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010093 · Cited by 4
Jiang, R., Liu, X., Xing, F., Fu, Y., & Zhengjun, Y. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11218-3 · Cited by 3
Gong, Q., Huang, Y., Liu, F., Zhou, T., Huang, W. G., & Xu, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101940 · Cited by 3
Romero‐Rodríguez, D. P., Montes, E., Rocha-González, H. I., Torres, M., Zúñiga, J., & Juárez, E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1664444 · Cited by 3
Wang, S., Wang, B., Qiu, Y., Gu, H., Gu, H., Wang, B., & Wang, J. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02658-w · Cited by 4
Self-citationPKM2: A gatekeeper in macrophage metabolic reprogramming
Li, K., Wu, M., Zhang, Q., Wu, J., Ding, X., & Xiao, W. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101564 · Cited by 3
Obesity Disrupts H3K4me3 ‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages
Takahashi, K., Drolet, J., Liu, J., Jackson, J. R., Babcock, M., Thiruppathi, M., Fang, M. M., Paul, T., Ganesh, G., Fukasawa, Y., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202502626r · Cited by 3
Trained immunity induction by vaccines adjuvants
Sodaifi, G., & Netea, M. G. (2026) · Current Opinion in Virology · doi:10.1016/j.coviro.2026.101530 · Cited by 3
Self-citationPan, R., Sun, Y., Chen, L., 潘建平, & Guo, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1808474 · Cited by 3
Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets
Wang, Z. Q., Zhang, Y., Li, L., & Wang, Z. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.047847 · Cited by 3
Teng, Y., Bian, W., Li, Q., Eyk, J. E. V., Yan, X., & Zhang, S. Y. (2026) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2026-0043 · Cited by 3
Exercise, mitochondrial stress, and trained immunity: metabolic adaptation of innate immunity
Xie, E., He, Y., & Sun, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1902029 · Cited by 3
Metadata
- Authors
- Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., Habibi, E., Gonçalves, L. G., Mesquita, I., Cunha, C., van Laarhoven, A., van de Veerdonk, F. L., Williams, D. L., van der Meer, J. W. M., Logie, C., O'Neill, L. A., Dinarello, C. A., Riksen, N. P., van Crevel, R., Clish, C., Notebaart, R. A., Joosten, L. A. B., Stunnenberg, H. G., Xavier, R. J., & Netea, M. G.
- Affiliations
- Radboud University Medical Center (NL)
- Radboud University Nijmegen (NL)
- University of Minho (PT)
- National Tsing Hua University (TW)
- Instituto de Tecnologia Química e Biológica António Xavier (PT)
- East Tennessee State University (US)
- Trinity College Dublin (IE)
- Broad Institute (US)
- Corresponding author
- Arts, Rob J.W.
- ORCID
- Arts, Rob J.W.
- Novakovic, Boris
- Carvalho, Agostinho
- Bekkering, Siroon
- Rodrigues, Fernando
- Silvestre, Ricardo
- Cheng, Shih-Chin
- Wang, Shuang-Yin
- Habibi, Ehsan
- Gonçalves, Luís G.
- Mesquita, Inês
- Cunha, Cristina
- Williams, David L.
- Logie, Colin
- O'Neill, Luke A.
- Dinarello, Charles A.
- Riksen, Niels P.
- Clish, Clary
- Notebaart, Richard A.
- Joosten, Leo A.B.
- Stunnenberg, Hendrik G.
- Xavier, Ramnik J.
- Netea, Mihai G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 24
- Issue
- 6
- Pages
- 807-819
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5742541
- OpenAlex
- W2557169014
- Cited by
- 930
- References
- 42
- Citations by year
- 2026: 134 · 2025: 120 · 2024: 101 · 2023: 81 · 2022: 118 · 2021: 111 · 2020: 108 · 2019: 66 · 2018: 62 · 2017: 28 · 2016: 1
- FWCI
- 31.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion, cc-by-nc-nd)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- ERC Consolidator (310372)
- Spinoza
- Netherlands Organization for Scientific Research
- NHMRC
- CJ Martin Early Career Fellowship
- Dr. Dekker
- Netherlands Heart Foundation (2012T051)
- H2020
- European Union (667837)
- Fundação para a Ciência e Tecnologia (IF/00735/2014, IF/00021/2014, RECI/BBB-BQB/0230/2012, SFRH/BPD/96176/2013)
- FCT (RECI/BBB-BQB/0230/2012)
- Programa Operacional Regional do Norte (ON.2—O Novo Norte)
- Quadro de Referência Estratégico Nacional
- Fundo Europeu de Desenvolvimento Regional
- Projeto Estratégico (LA 26 – 2013–2014 (PEst-C/SAU/LA0026/2013)
- NIH (DK43351, DK097485, GM53522, GM083016, GM119197, C06RR0306551)
- Helmsley Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- trained immunity, glutaminolysis, fumarate accumulation, monocytes, β-glucan, epigenetic reprogramming, cholesterol biosynthesis, glycolysis, TCA cycle, immunometabolism, epigenetic rewiring
- MeSH terms
- Cholesterol, Fumarates, Glucose, Glutamine, Glycolysis, Humans, Immune Tolerance, Immunity, Innate, Macrophages, Models, Biological, Pentose Phosphate Pathway, Epigenesis, Genetic, Hypoxia-Inducible Factor 1, alpha Subunit, Proteolysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
