Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

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Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

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Planarians SET New Paths for Innate Immune Memory

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mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium tuberculosis Infection and BCG Vaccination

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A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome

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Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor propertiesPreprint

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Immunometabolic effects of β-glucan-trained immunity in newborn goats

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Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?

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Heterogeneity of Innate Immunity

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2-Deoxy-D-glucose reshapes the sepsis-trained stressed granulocytes by comprehensive alterations of the transcriptional landscape

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Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study

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The impact of macrophage phenotype during Mycobacterium tuberculosis infection and in host-directed therapeutic interventions

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A Revolutionary Concept in Innate Immunity and its Implications for Vaccine Development and Immune Therapies: A Comprehensive Review of Trained Immunity

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Butyrate-induced trained immunity enhances bacterial killing ability of head kidney macrophages in turbot (Scophthalmus maximus L.)

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DM9CP-integrin-RhoA pathway promotes the hemocyte phagocytosis in the immune priming of Crassostrea gigas

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Key Role of Histone Modifiers in Coupling Metabolism to Epigenetic Reprogramming Associated with “Trained Immunity” in Innate Immune Cells

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Trained immunity responses across infectious diseases and cancer vaccines

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From Chronic Inflammation to Cancer: The Role of Trained Immunity in IBD-Associated Colorectal Carcinogenesis

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Metabolic characterization of the tumor microenvironment orchestrates therapeutic strategies and clinical outcomes in pancreatic cancer

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Myeloid-avid mammalian target of rapamycin-inhibiting nanobiologic attenuates allograft fibrosis after lung transplantation

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Fumarate and fumarate hydratase: an immunometabolite regulator of inflammation and diseases

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The potential role of trained immunity in HIV-associated atherosclerotic cardiovascular disease: mechanisms and therapeutic implications

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The helminth‐derived peptide, FhHDM‐1, reverses the trained phenotype of NOD bone‐marrow‐derived macrophages and regulates proinflammatory responses

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“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

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Potential Contributions of Human Endogenous Retroviruses in Innate Immune Memory

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Therapeutic potential of trained immunity for malignant disease

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Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis

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Statin Disruption of Cholesterol Metabolism and Altered Innate Inflammatory Responses in Atherosclerosis

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The mitochondrial carboxylase PCCA interacts with Listeria monocytogenes phospholipase PlcB to modulate bacterial survival

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Mesenchymal stromal cells can block palmitate training of macrophages via cyclooxygenase-2 and interleukin-1 receptor antagonist

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Role of the Hematopoietic Stem Cells in Immunological Memory

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Recent developments and future perspectives in aging and macrophage immunometabolism

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Recovery training or over‐training? The contribution of TLR10 to monocyte fitness

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Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in ESRDPreprint

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β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injuryPreprint

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Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic MechanismsPreprint

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Metabolic imprinting drives epithelial memory during mucosal fungal infectionPreprint

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Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex

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The role of trained immunity in broad-spectrum antiviral defense against respiratory viral infections

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Nanomaterials-mediated trained immunity: Progress and prospects for disease treatment

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The involvement of CLec-HTM/IgR-Syk-BCL10-mTOR/ERK signaling pathway in immune priming of oysters

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The genetic regulation of immune cells upon activation

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Epigenetic Mechanisms in Early Life Viral Respiratory Infections

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Interactions between Innate Immune Memory and the Central Nervous System

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Trained immunity in the treatment for haematological malignancy

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Immunometabolic regulation in gouty arthritis: current evidence, mechanistic insights, and remaining challenges

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Metabolic and epigenetic regulation of microglia memory in neurological disorders

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Trained immunity in chronic rhinosinusitis: epigenetic reprogramming of innate immune memory as a driver of mucosal inflammation and recurrence

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Metabolic danger signals: TCA cycle metabolites regulate immunity and disease

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The IL-1 system in inflammation and cancer

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Trained immunity in autoinflammatory diseases: Cellular reprogramming across the monogenic–polygenic spectrum

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Gut Microbiota-Derived Butyrate Induces Trained Immunity in Intestinal Macrophages to Potentiate Antitumor Immunity

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Utilization and validation of dried blood spot-based metabolomics in plasma-derived diagnostic models

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Plant-made trained immunity-based vaccines: Beyond one approach

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Tissue context as a determinant of trained innate immunity: a conserved molecular toolkit with divergent functional outputs

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The case for exploring innate memory in Plasmodium infection

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WTAP‐Mediated m 6 A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

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Perspectives on the Development of Immune Memory Associated with Vaccination

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Bibliometric analysis of the association between asthma and cancer: Mechanistic insights and directions for clinical translation

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Trained immunity in diabetic kidney disease: a hypothesis for metabolic memory and therapeutic targeting

Liao, C., Ran, Y., Zheng, Z., & Du, X. (2026) · Medical Hypotheses · doi:10.1016/j.mehy.2026.112008 · Cited by 1

Metabolic–epigenetic crosstalk in innate immune cell plasticity within the tumor microenvironment

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Macrophage plasticity and metabolic control in muscle repair and disease

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Nuclear NAD + promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation

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Differentiation Kinetics of Hematopoietic Stem and Progenitor Cells In Vivo Are Not Affected by β-Glucan Treatment in Trained Immunity

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Exercise-induced fumarate accumulation: a potential mediator of mitochondrial biogenesis in mammalian skeletal muscle

Kimoloi, S. (2023) · International Journal of Sport Exercise and Health Research · doi:10.31254/sportmed.7208 · Cited by 1

Multifaceted roles of trained immunity in diverse pathological contexts

Park, H. J., Kim, S. M., Choi, U. Y., & Kim, L. K. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0045 · Cited by 1

Regulation of cytokine secretion by immunometabolites

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Metabolic Reprogramming of Myeloid Cells Upon TLR4 Stimulation

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Linear Predictive Modeling for Immune Metabolites Related to Other Metabolites

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Metabolic Regulation of Antiviral Immune Responses in Macrophages

Ahmed, D. (2021) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2021-14431 · Cited by 1

A role played by sex in innate immune memory and disease severity

Earhart, A. (2023) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/98753 · Cited by 1

Author response: Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

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Setdb2 Regulates Inflammatory Trigger Induced Trained Immunity of Macrophages Through Two Different Epigenetic MechanismsPreprint

Jaiswal, A., Halász, L., Williams, D. L., & Osborne, T. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.18.644013 · Cited by 1

Metabolic Regulation of Innate Immunity to Fungal Infection

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Immunomodulation by raw bovine milk and its ingredients: effects in nutritional intervention, oral vaccination and trained immunity

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Role of SHIP-1 phosphatase in trained immunity modulation

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Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis

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Modulation of innate immunity in carp : Diverse approaches to ß-glucanmediated responses

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Polybacterial mucosal vaccine protects against viral respiratory infections and induces trained immunity

Brandi, P. (2020) · doi:10.4321/repisalud.13457

Innate immune responses to Mycobacterium tuberculosis infection : How extracellular traps and trained immunity can restrict bacterial growth.

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The Mammalian Target of Rapamycin Complex 1 (mTORC1): An Ally of M. tuberculosis in Host Cells

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Fuelling the fire : Immunometabolism of monocytes and macrophages in obesity & diabetes

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Harnessing the power of trained immunity in the setting of pancreatic cancer: a novel mechanism of immune trafficking and tumor control.

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Metabolic Profile of Innate Immune Cells

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Faculty Opinions recommendation of Defining trained immunity and its role in health and disease.

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Dairy Products

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Type 2 Immune Response Plays A Critical Role in Trained ImmunityPreprint

Cheng, S., Dang, B., Zhang, J., Gao, Q., Zhong, Q., Zhang, L., Zhu, Y., Liu, J., Niu, Y., Xiao, N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1322480/v1

Faculty Opinions recommendation of Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Netea, M. G., & Domínguez‐Andrés, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736126018.793562936

Faculty Opinions recommendation of LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.

Saas, P., & Cherrier, T. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737631289.793574734

Hematopoietic stem cells are a reservoir for trained immunity in autoimmune diseasePreprint

Mills, T., Kain, B. N., Burchill, M. A., Danis, E. P., Culp‐Hill, R., Goodspeed, A. E., Ferrara, S. E., Roede, J. R., D’Alessandro, A., King, K. Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.20.492533

Trained innate immunity and transgenerational effects in chickens : A conceptual approach of non-genetic inheritability

Verwoolde, M. B. (2022) · doi:10.18174/570385

Macrophages in gouty inflammation

Malyshev, I. Y., Chernysheva, O. O., Kuznetsova, L. V., & Pikhlak, A. (2022) · Russian Journal of Immunology · doi:10.46235/1028-7221-1096-mig

Induction of trained immunity by particulate β-glucan controls cancer metastasis through the sphingolipids-mediated mitochondrial fission pathway.

Shrestha, R. (2022) · doi:10.18297/etd/3932

The glycolysis/HIF-1α axis defines the inflammatory role of IL-4-primed 2 macrophagesPreprint

Cheng, S., Dang, B., Zhang, J., Gao, Q., Zhong, Q., Zhang, L., Zhu, Y., Liu, J., Niu, Y., Xiao, N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1322480/v2

Epigenetic basis of infectious diseases

Kaçar, S., Sen, C. K., & Singh, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85730-7.00018-7

Infection, immunity, and vaccine development

Singh, B., Kumar, A., Tiwari, R., Chauhan, S. B., Singh, O. P., Singh, S. K., Gautam, V., Sundar, S., & Kumar, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85941-7.00006-1

Relationship between Tuberculin Skin Test and COVID-19 Outcomes among Patients with COVID-19 in Zahedan, Iran.

Alavi-Naini, R., Sargolzaie, N., & Metanat, M. (2022) · PubMed Central

Reviewer #3 (Public Review): Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in ESRD

Young, K. H., Hyun, K. D., Jeong, L. S., et al. (2023) · eLife · doi:10.7554/elife.87316.1.sa0

Non-specific Effects of Vaccines

Pittet, L. F., Netea, M. G., & Curtis, N. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00003-7

Immunometabolic control of trained immunity

Riksen, N. P., & Netea, M. G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100897 · Cited by 176

miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α

Su, H., Liang, Z., Weng, S., Sun, C., Huang, J., Zhang, T., Wang, X., Wu, S., Zhang, Z., Zhang, Y., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.144260 · Cited by 35

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224

Immunometabolic circuits in trained immunity

Arts, R. J. W., Joosten, L. A. B., & Netea, M. G. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.09.002 · Cited by 228

Metabolic Regulation in the Induction of Trained Immunity

Ferreira, A. V., Domínguez‐Andrés, J., Pich, L. M. M., Joosten, L. A. B., & Netea, M. G. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01015-8 · Cited by 104