O'Neill, Luke A. J.

A guide to immunometabolism for immunologists

O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 3,315

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,849

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 2,667

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Kelly, B., & O'Neill, L. A. (2015) · Cell Research

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 1,876

The history of toll-like receptors - redefining innate immunity

O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 1,765

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 1,509

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology

Inflammasome and immune disordersPancreatic function and diabetes

Cited by 1,330

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4

Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 1,254

Mitochondria are the powerhouses of immunity

Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology

Mitochondrial Function and PathologyImmune Response and Inflammation

Cited by 1,161

Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation

O'Neill, L. A. J., & Hardie, D. G. (2013) · Nature

Immune cells in cancerMetabolism, Diabetes, and Cancer

Cited by 1,133

Resolution of in flammation: state of the art, definitions and terms

Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal

Fatty Acid Research and HealthInflammatory mediators and NSAID effects

Cited by 1,045

NF-kB: a crucial transcription factor for glial and neuronal cell function

O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences

NF-κB Signaling PathwaysNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,013

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

Sheedy, F. J., Palsson-McDermott, E., Hennessy, E. J., Martin, C., O'Leary, J. J., Ruan, Q., Johnson, D. S., Chen, Y., & O'Neill, L. A. J. (2010) · Nature Immunology

Immune Response and InflammationMicroRNA in disease regulation

Cited by 1,005

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., et al. (2016) · Cell Metabolism

Immune responses and vaccinationsImmune cells in cancer

Cited by 930

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology

Immune Response and InflammationInflammation biomarkers and pathways

Cited by 831

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 571

Krebs cycle Reborn in macrophage immunometabolism

Ryan, D. G., & O'Neill, L. A. J. (2020) · Annual Review of Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 444

Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 433

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

Kelly, B., Tannahill, G. M., Murphy, M. P., & O'Neill, L. A. J. (2015) · Journal of Biological Chemistry

Inflammasome and immune disordersMetabolism, Diabetes, and Cancer

Cited by 334

A trio of microRNAs that control Toll-like receptor signalling

Quinn, S. R., & O'Neill, L. A. (2011) · International Immunology

Immune Response and InflammationMicroRNA in disease regulation

Cited by 314

Metabolic regulation of NLRP 3

Hughes, M. M., & O'Neill, L. A. J. (2018) · Immunological Reviews

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 311

Adding fuel to fire: microRNAs as a new class of mediators of inflammation

Sheedy, F. J., & O'Neill, L. A. J. (2008) · Annals of the Rheumatic Diseases

MicroRNA in disease regulationImmune Response and Inflammation

Cited by 246

TLRs: Professor Mechnikov, sit on your hat

O'Neill, L. A. J. (2004) · Trends in Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 140

The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro

Coogan, A. N., O'Neill, L. A. J., & O'Connor, J. J. (1999) · Neuroscience

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 129