Cited by 828Autophagy in Disease and TherapyCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

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Autophagy and Tumor Metabolism

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Kimmelman, Alec C., White, Eileen·2017·Cell Metabolism

DOI 10.1016/j.cmet.2017.04.004PMC PMC5604466

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Abstract

Autophagy is a critical cellular process that generally protects cells and organisms from stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy plays a role in pathological processes such as cancer. Indeed, there has been substantial work exploring the complex and context-dependent role of autophagy in cancer. One of the emerging themes is that in certain cancer types, autophagy is important to support tumor growth; therefore, inhibiting autophagy as a therapeutic approach is actively being tested in clinical trials. A key mechanism of how autophagy promotes the growth and survival of various cancers is its ability to support cellular metabolism. The diverse metabolic fuel sources that can be produced by autophagy provide tumors with metabolic plasticity and can allow them to thrive in what can be an austere microenvironment. Therefore, understanding how autophagy can fuel cellular metabolism will enable more effective combinatorial therapeutic strategies.

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Authors: Kimmelman, A. C., & White, E.
Affiliations: NYU Langone Health (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Kimmelman, Alec C.
White, Eileen
ORCID: Kimmelman, Alec C.
White, Eileen
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2017-05
Volume: 25
Issue: 5
Pages: 1037-1043
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2017.04.004
PMC: PMC5604466
OpenAlex: W2611224317
Cited by: 826
References: 80
Citations by year: 2026: 37 · 2025: 58 · 2024: 99 · 2023: 88 · 2022: 109 · 2021: 150 · 2020: 112 · 2019: 95 · 2018: 61 · 2017: 17
FWCI: 10.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA157490, R01CA188048, P01CA117969)
ACS (RSG-13-298-01-TBG)
NIH (R01GM095567, R01CA163591, R01CA130893, R01CA188096, R01CA193970)
Robert Wood Johnson Foundation (P30CA72720)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: autophagy, cancer metabolism, cancer, metabolic plasticity, nutrient deprivation, autophagy inhibition, cancer therapy, tumor microenvironment, tumor growth
MeSH terms: Animals, Autophagy, Cell Survival, Humans, Neoplasms, Cell Proliferation, Metabolic Networks and Pathways, Tumor Microenvironment

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