A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777

Object recognition test in mice

Leger, M., Quiedeville, A., Bouet, V., Haelewyn, B., Boulouard, M., Schumann-Bard, P., & Freret, T. (2013) · Nature Protocols · doi:10.1038/nprot.2013.155 · Cited by 1,357

Ketone bodies as signaling metabolites

Newman, J. C., & Verdin, E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.002 · Cited by 966

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904

A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

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Caloric restriction

Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 797

Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

Miller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., & Smith‐Wheelock, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00152.x · Cited by 681

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and mice

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1

Ben Sahra, I., Regazzetti, C., Robert, G., Laurent, K., Le Marchand-Brustel, Y., Auberger, P., Tanti, J.-F., Giorgetti-Peraldi, S., & Bost, F. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1769 · Cited by 616

Sex as a major determinant of pro-longevity drug efficacy: a review of two decades of the NIA Interventions Testing Program

Jiang, N., Xu, Z., Zhao, S., Gelfond, J., Strong, R., & Nelson, J. F. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf138 · Cited by 4

Ribosome collisions and ZAKα activation: explores the therapeutic potential of metabolic diseases

Zhang, W., Zhang, K., Kan, C., Sheng, S., Hou, N., Han, F., Zhang, J., & Sun, X. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00334.2025 · Cited by 2

Age‐Dependent Metabolomic Signatures of Dietary Restriction in Mice

Lee, J., Arachchige, V. H. J. H., Kim, E., Bang, E., & Hong, Y. (2025) · Aging Cell · doi:10.1111/acel.70309 · Cited by 2

Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine‐Induced Kidney Injury via OXCT1 ‐Mediated Ketolysis in Mice

Omachi, S., Sugahara, S., Horiguchi, J., Yasuda‒Yamahara, M., Kuwagata, S., Yamahara, K., Tanaka‒Sasaki, Y., Ida, S., Kusaba, T., Humphreys, B. D., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202503908r · Cited by 2

Exercise and nutrition as epigenetic regulators of gene expression: an exploratory scoping review with bibliometric analysis

Zhang, H., Yu, R., Cao, S., Liu, X., Chen, C. Y., Peng, F., & Qi, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1773920 · Cited by 2

Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025

Tagliafico, L., Canevelli, M., Barreto, P. D. S., Cesari, M., Ferrucci, L., Vellas, B. J., & Rolland, Y. (2026) · The Journal of Frailty & Aging · doi:10.1016/j.tjfa.2026.100147 · Cited by 3

Ketogenic Diet and Brain Health: Cerebrovascular Mechanisms, Neuroprotection, and Translational Implications

Mózes, N., Fehér, Á., Csípő, T., Fazekas‐Pongor, V., Lipécz, Á., Major, D., Lehoczki, A., Dósa, N., Pártos, K., Csík, B., et al. (2026) · Nutrients · doi:10.3390/nu18071091 · Cited by 2

Aging and cancer: current understandings and future perspectives

Li, Q., Chan, Y.-T., Wu, J., Jiang, Z., Lu, P., Xu, L., Feng, Z., Yuan, H., Feng, Y., & Wang, N. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02756-8 · Cited by 2

Genetic and dietary influences on life span

Gu, Y., Lee, J. H., & Mayeux, R. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813955-4.00050-7 · Cited by 2

Diet restriction-induced mitochondrial signaling and healthy aging

Pinkerton, M., & Barrientos, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00027-8 · Cited by 2

Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver

Benić, A., Mikašinović, S., Wensveen, F. M., & Polić, B. (2023) · Metabolites · doi:10.3390/metabo13020153 · Cited by 2

Nutritional aspects

O’Hearn, A., Westman, E. C., Yancy, W. S., & Wellington, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00002-4 · Cited by 2

Current knowledges in pharmaconutrition: “Ketogenics” in pediatric gliomas

Cecchi, N., Romanelli, R., Ricevuti, F., Amitrano, M., Carbone, M. G., Dinardo, M., & Burgio, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1222908 · Cited by 2

A Commentary on Fasting of Nonclinical Research Animals

Gauvin, D. V., McComb, M. M., & Farero, R. D. (2023) · International Journal of Toxicology · doi:10.1177/10915818231218975 · Cited by 2

P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers

Li, Y., Fan, W., Lo, T.-H., Jiang, J. X., Fish, S. R., Tomilov, A. A., Chronopoulos, A., Bansal, V., Mozes, G. D., Váncza, L., et al. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.10.022 · Cited by 2

Beyond energy metabolism: ketogenic diet and β-hydroxybutyrate protect against intestinal ischemia-reperfusion injury through anti-inflammatory and barrier-preserving effects

Wang, F., Wei, N., Dai, S.-Y., Zhong, X., Guo, M., Fan, X. D., Chen, S., Chen, Y., & Zhou, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152227 · Cited by 2

The Impact of Ketogenic Diet Consumption on the Sporadic Alzheimer's Model Through MT1 / MT2 Regulation

Çimen, Y. A., Elibol, B., Korkmaz, N. D., Yüzgüleç, M., Kinsiz, B., Kutlu, S., & Üstünova, S. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70070 · Cited by 2

Energy Metabolism and Metabolic Targeting of Neuroblastoma

Aminzadeh-Gohari, S., Feichtinger, R. G., & Kofler, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812005-7.00007-2 · Cited by 2

The Aging Epigenome and The Rejuvenation Strategies

Meiliana, A., Dewi, N. M., & Wijaya, A. (2022) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v14i1.1777 · Cited by 1

Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic dietPreprint

Shay, J. E. S., Chi, F., Tzouanas, C. N., ten Hoeve, J., Williams, K. J., Sever, T., Fuentes, I. J. R., & Yilmaz, Ö. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.06.658169 · Cited by 2

Effect of a Ketogenic Diet on Oxidative Posttranslational Protein Modifications and Brain Homogenate Denaturation in the Kindling Model of Epilepsy in Mice

Andreeva-Gateva, P. A., Sabit, Z., Bakalov, D. V., Sayıner, S., Tafradjiiska-Hadjiolova, R. K., Zaharinova, S., Abarova, S., Koynova, R. D., & Tenchov, B. G. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03579-z · Cited by 1

Circulating Biomarkers as a Window into the Relationship between Sarcopenia and Diabetes: Implications for Effective Management

Tajik, A., Mahdavizadeh, V., Hadizadeh, F., & Shakour, N. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998349193250207045239 · Cited by 1

The therapeutic potential of a polyunsaturated fatty acid-enriched high-fat diet in Leigh syndrome: Insights from a preclinical model

Willemse, L., Terburgh, K., & Louw, R. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167873 · Cited by 1

Impacts of aging on brain metabolism

Rodrigues, B. A., Santiago, T. C., & Silva, J. D. N. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.05.009 · Cited by 2

Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study

Stubbs, B. J., Stephens, E. B., Mansfield, T. A., Senadheera, C., Diaz, S. R., Peralta, S., Alexander, L. E. C., Silverman-Martin, W., Kurtzig, J., Fernando, B., et al. (2025) · The Journal of Frailty & Aging · doi:10.1016/j.tjfa.2025.100106 · Cited by 1

MİTOKONDRİYAL YAŞLANMA

SARAK, E. B. G. Ö. G., & Ceylan, Y. (2025) · Bartın University International Journal of Natural and Applied Sciences · doi:10.55930/jonas.1741124 · Cited by 1

Ketogenic diet causes bone loss in growing and adult mice and reduces the skeletal response to exercise

Osipov, B., Robison, L., Hanel, J., Orr, S. V., Lin, Y. Y., Buxton, A., Rahmati, M., Tseng, M.-C., Renato, M. R., Shenoy, R., et al. (2026) · Bone · doi:10.1016/j.bone.2026.117854 · Cited by 1

Impaired hepatic BMAL1–FGF21 signaling drives adverse metabolic outcomes of ketogenic diet

Yang, M., Guo, Y., Du, J., Li, C., Bai, H., Guo, Y., Tan, Y., Li, X., Ren, D., Li, J., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124324 · Cited by 1

Bench to bedside: is rapamycin headed for the docTOR?

Lamming, D. W. (2026) · GeroScience · doi:10.1007/s11357-026-02306-8 · Cited by 1

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Shay, J. E. S., Chi, F., Tzouanas, C. N., Han, S., Zhang, X., ten Hoeve, J., Williams, K. J., Neptun, S., Sever, T., Fuentes, I., et al. (2026) · Nature · doi:10.1038/s41586-026-10779-y · Cited by 1

Aging in Rodents

Navarro, H. G., Doğan, S., Tuna, B. G., Potter, P. K., Kõks, G., & Kõks, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11433-3 · Cited by 1

Ketogenic diets: Opportunities and limitations in practical application (LITERATURE REVIEW)

Tyminski, G. (2019) · Archiv Euromedica · doi:10.35630/2199-885x/2019/9/2/22 · Cited by 2

Ketogenic Diet, Circadian Rhythm and Aging

Jagota, A., & Sharma, S. A. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-83017-5_16 · Cited by 1

KETOJENİK BESLENME VE SAĞLIK

Ozsoz, C. F., Yıldız, E., & Gürbüz, O. (2022) · Izmir Democracy University Health Sciences Journal · doi:10.52538/iduhes.1093564 · Cited by 6

Hen egg only diets support healthy aging in adult mice

Nishio, N., & Isobe, K. (2023) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13805 · Cited by 1

Body Mass Index, Obesity, and Mortality—Part II

Sanders, L., Mestre, L. M., Ejima, K., Mehta, T. S., Keith, S. W., Maki, K. C., & Allison, D. B. (2023) · Nutrition Today · doi:10.1097/nt.0000000000000615 · Cited by 1

Molecular and Biological Factors in Aging

Litke, R. R., & Mobbs, C. V. (2023) · Springer eBooks · doi:10.1007/978-3-030-01782-8_102-1 · Cited by 1

Molecular and Biological Factors in Aging

Litke, R. R., & Mobbs, C. V. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_102 · Cited by 1

Highlights from the 2019 International Congress on Frailty and Sarcopenia Research

Maltais, M. L., Aubertin‐Leheudre, M., Dray, C., Fielding, R. A., Rolland, Y., Cesari, M., & Vellas, B. J. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.13 · Cited by 1

The ketogenic diet and healthy brain aging

Rogerson, G., & Preedy, V. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00049-4 · Cited by 1

A META-REGRESSION AND BAYESIAN REGRESSION FRAMEWORK FOR COMBINING RESULTS OF SCIENTIFIC RESEARCH AND SURVEYS OF PEOPLE’S LIFESTYLES TO MAKE RECOMMENDATIONS ON WHAT INTERVENTIONS WILL HELP THEM LIVE LONGER AND HEALTHIER

Leddo, J. (2023) · International Journal of Social Science and Economic Research · doi:10.46609/ijsser.2023.v08i03.013 · Cited by 1

Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brainPreprint

Stratton, M. S., Lopez-Dominguez, J. A., Canella, A., Ramsey, J. J., & Cortopassi, G. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.22.481437 · Cited by 1

Ketones facilitate transcriptional resolution of secondary DNA structures in premature agingPreprint

Petr, M. A., Carmona-Marin, L. M., Tulika, T., Kristensen, S. M., Reves, S., Bakula, D., Keijzers, G., Osborne, B., Mitchell, S. J., Hamilton, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.08.483430 · Cited by 1

Systems-level patterns in biological processes are changed under prolongevity interventions and across biological agePreprint

Watanabe, K., Wilmanski, T. M., Baloni, P., Robinson, M., Garcia, G. G., Hoopmann, M. R., Midha, M. K., Baxter, D. H., Maes, M., Morrone, S. R., et al. (2022) · medRxiv · doi:10.1101/2022.07.11.22277435 · Cited by 1

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysisPreprint

Litke, R. R., Vicari, J. M., Huang, B. T., Shapiro, L. R., Roh, K.-H., Silver, A. E., Talreja, P., Palacios, N., Yoon, Y., Kellner, C. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.12.544352 · Cited by 1

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restrictionPreprint

Qu, Q., Chen, Y., Wang, Y., Long, S., Wang, W., Yang, H.-Y., Li, M., Tian, X., Wei, X., Liu, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.07.570559 · Cited by 1

The ketogenic diet as a treatment paradigm for neurological disease

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Impact of Succinate Supplements on Metabolic Health and Muscle Mass after Functional Overloading and Denervation in Mice Fed High-Fat DietPreprint

Dirmontas, M., Minderis, P., & Ratkevičius, A. (2024) · Preprints.org · doi:10.20944/preprints202407.1132.v1

Diet Therapy Effective Treatment but Also Ethical and Moral Responsibility

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Cancer Stem Cell Enrichment and Metabolic Substrate Adaptability are Driven by Hydrogen Sulfide Suppression in GlioblastomaPreprint

Silver, D. J., Roversi, G. A., Bithi, N., Neumann, C. K. A., Troike, K. M., Ahuja, G. K., Reizes, O., Brown, J. M., Hine, C., & Lathia, J. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.08.982116

The zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging

Celebi-Birand, D., Tuz-Sasik, M. U., Ardic-Avci, N. I., Aydoğan, H. Ö., Erbaba, B., Karoglu-Eravsar, E. T., Kafalıgönül, H., & Adams, M. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00044-5

Injury and regeneration in renal aging

Bábíčková, J., Yang, H., & Fogo, A. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00032-9

PKOS' ta Ketojenik Beslenmenin Etkileri

Akbay, G. D. (2021) · Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.51754/cusbed.841267

Exercise-Induced Autophagy and Obesity

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Влияние ограничения питания на старение: исправление проблем с «сенсорами питания» у постмитотических клеток?

Васильевна, М. Г., Шиловский, Г. А., & Khokhlov, A. N. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521100092

School Dress Code Violations and the Ensuing Controversy.

Craig, B. L. (1970)

A Benzenesulfonamide GW8510 Rejuvenates Mice and Yeast Through Interaction with P21-Activated KinasesPreprint

An, Y., Zhu, J., Wang, X., Huang, L., Huang, W., Sun, X., Luo, C., Dang, Y., Huang, B., Zhang, B., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3979179

Anti-Senescence Therapy

Alshadidi, R. (2022) · Physiology · doi:10.5772/intechopen.101585

Multi-omic analysis of the aging mouse brain

Kluever, V. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9022

Ketone Supplementation for Health and Disease

Poff, A. M., Kesl, S., Koutnik, A. P., Moss, S. E., Rogers, C. Q., & D’Agostino, D. P. (2022) · Oxford University Press eBooks · doi:10.1093/med/9780197501207.003.0033

Keto-Adaptation to the Low-Carb Diet: A Clinical Conversation with Stephen Phinney, MD, PhD, and Robert Rountree, MD

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Faculty Opinions recommendation of Carbotoxicity-Noxious Effects of Carbohydrates.

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Islet Inflammation and Metabolic Homeostasis

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The prevalence of early age-related macular generation and its relationship with dietary pattern in China: a cross-section studyPreprint

Lin, Y., Peng, T., Li, Y., & Liu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1610264/v1

Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of β- hydroxybutyrate: implications in cardioprotection and aging

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食物宏量营养素组成调控哺乳动物寿命的研究进展

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Review Article: Gut Microbiota as Biological Regulators for Human Health

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A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and alleviates experimental atherosclerosisPreprint

Castro, R., Kalecký, K., Huang, N., Petersen, K. S., Singh, V., Ross, A., Neuberger, T., & Bottiglieri, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.07.527515

Ketogenic diet administration later in life improves memory and regulates the synaptic cortical proteome through the cAMP/PKA signaling pathway in aging micePreprint

Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.07.556691

Ketogenic Diet Improves Motor Function and Motor Unit Connectivity in Aged C57BL/6 MicePreprint

Padilla, C. J., Harris, H. N., Volek, J. S., Clark, B. C., & Arnold, W. D. (2023) · Research Square · doi:10.21203/rs.3.rs-3335211/v1

The Science of Living Longer

Lopez-Guadamillas, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-47620-4_6

Editorial: Ketone bodies: friend or foe?

Sternberg, F., Nomura, M., Xie, M., & Duszka, K. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1400206

Reduced beta-hydroxybutyrate disposal after ketogenic diet feeding in micePreprint

Cousineau, C. M., Snyder, D., Redd, J. R., Turner, S., Carr, T., & Bridges, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.16.594369

Genetic and dietary influences on life span

Gu, Y., Lee, J. H., & Mayeux, R. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19176-3.00059-5

The sweet escape: Are ketones a key player in unlocking healthy aging?

Cadar, A. N., & Bartley, J. M. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100395

Pharmacological Manipulation of the Aging Pathways to Effect Health Span and Lifespan with Special Reference to SGLT2 Inhibitors as Powerful Anti-aging Agents in Humans

Murdock, D. K. (2024) · Insights in Biology and Medicine · doi:10.29328/journal.ibm.1001028

Serum β-Hydroxybutyrate decline: a common pathological factor for metabolic dysfunction-associated steatotic liver disease and cognitive impairmentPreprint

Nie, L., Yang, X., Wang, Y., Sun, J., Sun, Y., Zhang, Y., & Zhou, X. (2024) · Research Square · doi:10.21203/rs.3.rs-5403137/v1

Nutrition, Diet, and Anti-aging: Ketogenic Diet and Anti-aging

Ueki, K. (2024) · Springer eBooks · doi:10.1007/978-981-97-8514-8_96

Comprehensive quantitative score and metabonomics analysis of the effect of centenarians’ diet patterns on aging mice

Zhang, Q., Lan, H., Ma, K., Ji, F., & Li, Q. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250545

Nutrition and Aging

Mukherjee, B., Chakraborty, A., Paul, P., Bhattacharya, S., & Das, L. (2025) · Springer eBooks · doi:10.1007/978-981-97-9936-7_22-1

Ketone Body Supplementation Upon a Standard High-Carbohydrate Diet Induces Autophagy-Mediated Developmental Delay in Drosophila Melanogaster Larvae

Becher, M. L., Zhai, F., Gilbert, M. L., Mota, D. I., Griffiths, L. A., Pierre, M., Athreya, A. R., Boyd, F. S., Cameron, A. M., Cameron, M. R., et al. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2025.07.020

Nutrition and Aging

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Sex- and ketogenesis-dependent effects of intermittent fasting against diet-induced obesity and fatty liver diseasePreprint

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Additional file 3 of Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: insights from the Twins Nutrition Study (TwiNS)

Dwaraka, V. B., Aronica, L., Carreras-Gallo, N., Robinson, J. L., Hennings, T., Carter, M. M., Corley, M. J., Lin, A., Turner, L., Smith, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26751362

Additional file 1 of The frequency of early age-related macular degeneration and its relationship with dietary pattern in Hunan, China: a cross-sectional study

Lin, Y., Peng, T., Li, Y., & Liu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20390832

Additional file 4 of The frequency of early age-related macular degeneration and its relationship with dietary pattern in Hunan, China: a cross-sectional study

Lin, Y., Peng, T., Li, Y., & Liu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20390841

Additional file 3 of The frequency of early age-related macular degeneration and its relationship with dietary pattern in Hunan, China: a cross-sectional study

Lin, Y., Peng, T., Li, Y., & Liu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20390838

Additional file 2 of Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: insights from the Twins Nutrition Study (TwiNS)

Dwaraka, V. B., Aronica, L., Carreras-Gallo, N., Robinson, J. L., Hennings, T., Carter, M. M., Corley, M. J., Lin, A., Turner, L., Smith, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26391705

Additional file 2 of The frequency of early age-related macular degeneration and its relationship with dietary pattern in Hunan, China: a cross-sectional study

Lin, Y., Peng, T., Li, Y., & Liu, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20390835

Additional file 1 of Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: insights from the Twins Nutrition Study (TwiNS)

Dwaraka, V. B., Aronica, L., Carreras-Gallo, N., Robinson, J. L., Hennings, T., Carter, M. M., Corley, M. J., Lin, A., Turner, L., Smith, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26391680

Additional file 4 of Unveiling the epigenetic impact of vegan vs. omnivorous diets on aging: insights from the Twins Nutrition Study (TwiNS)

Dwaraka, V. B., Aronica, L., Carreras-Gallo, N., Robinson, J. L., Hennings, T., Carter, M. M., Corley, M. J., Lin, A., Turner, L., Smith, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26751365

Faster but less accurate: An explorative study on the effects of three weeks of ketogenic diet on cognitive functions in undergraduate students

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Physiology and Health Effect of Ketogenic Diet

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Endogenous β-hydroxybutyrate and the risk of cognitive decline: a nested case-control study in the UK Biobank cohort

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Ketogenic Diet Modulates Cerebellar AQP4 in an Age-dependent Manner and Parallels Reduced Anxiety-like Behavior in Rats

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Physical activity and microglial metabolism in neurodegenerative diseases

Andoh, M., & Koyama, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27340-7.00013-9

The Relationship Between a Low‐Carbohydrate Diet and the Prevalence of Diabetic Kidney Disease in Patients With Type 2 Diabetes: A Cross‐Sectional Study

Gao, W., Ma, R., Gu, H. C., Zhang, X., Liu, H., Xiao, M., Li, Z., Wang, Y., Sun, Y., & Xiao, X. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71462

Long-Term Fructose Intake Induces Moderate Liver Inflammation but Does not Overlap with the Detrimental Effects of the Ketogenic Diet on Hepatic Steatosis in Rats

de Souza, J. G., Gurgel, G. G., Rodrigues, F. M., Braga, R. A. M., Soares, R. A. M., Lage, L. A. D. P. C., Soares, I. C., Levy, D., & Damasceno, N. R. T. (2026) · Inflammation · doi:10.1007/s10753-025-02367-5

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Newman, J. C., Covarrubias, A. J., Zhao, M., Yu, X., Gut, P., Ng, C.-P., Huang, Y., Haldar, S., & Verdin, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.004 · Cited by 493

Metformin improves healthspan and lifespan in mice

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Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

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INTERMITTENT KETOGENIC DIETS EXTEND LIFESPAN AND ATTENUATE INFLAMMAGING IN MALE MICE

Zhou, Z., Kim, K., Ramsey, J. J., & Rutkowsky, J. M. (2022) · Innovation in Aging · doi:10.1093/geroni/igac059.2671

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

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