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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
Open accessAbstract
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.
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“Other potentially mTORC1-lowering diets include a ketogenic diet, which has been shown to extend the lifespan of mice while reducing mTORC1 activity 154.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [154]
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Metadata
- Authors
- Roberts, M. N., Wallace, M. A., Tomilov, A. A., Zhou, Z., Marcotte, G. R., Tran, D., Perez, G., Gutierrez-Casado, E., Koike, S., Knotts, T. A., Imai, D. M., Griffey, S. M., Kim, K., Hagopian, K., McMackin, M. Z., Haj, F. G., Baar, K., Cortopassi, G. A., Ramsey, J. J., & Lopez-Dominguez, J. A.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Ramsey, Jon J.
- Lopez-Dominguez, Jose Alberto
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 26
- Issue
- 3
- Pages
- 539-546.e5
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5609489
- OpenAlex
- W2750582921
- Cited by
- 514
- References
- 34
- Citations by year
- 2026: 33 · 2025: 63 · 2024: 67 · 2023: 68 · 2022: 67 · 2021: 66 · 2020: 65 · 2019: 43 · 2018: 32 · 2017: 7
- FWCI
- 29.73
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-05-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Gredos (University of Salamanca) (acceptedVersion, other-oa)
- Hispana (acceptedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (2P01AG025532)
- UC Davis (U2CDK092993)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- ketogenic diet, low-carbohydrate diet, longevity, healthspan, lifespan extension, aging, fatty acid beta-oxidation, glycolysis, protein acetylation, mTORC1 signaling, aged mice, physiological function
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Acetylation, Adaptation, Physiological, Animals, Health, Longevity, Male, Mice, Inbred C57BL, Organ Specificity, Signal Transduction, Diet, Carbohydrate-Restricted, Diet, Ketogenic
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