Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, Luis, Chwalek, Karolina, Sinclair, David A.·2018·Cell Metabolism

DOI 10.1016/j.cmet.2018.02.011

Cites (270)

Items 201–270 of 270

A candidate NAD+ transporter in an intracellular bacterial symbiont related to Chlamydiae
Ilka Haferkamp, Stephan Schmitz‐Esser, Nicole Linka · 2004 · Nature
Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study
Ji-Sook Lee, Yong-Jun Cha, Kyung-Hea Lee, Jung‐Eun Yim · 2016 · Nutrition Research and Practice
Nicotinamide and the skin
Andrew C. Chen, Diona L. Damian · 2014 · Australasian Journal of Dermatology
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease
Haiqun Jia, Xin Li, Hongxiang Gao, Zhihui Feng, Xuesen Li, Lei Zhao, Xu Jia, Hongyu Zhang, Jiankang Liu · 2008 · Journal of Neuroscience Research
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling
Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Kim, Gene, Samant, Sadhana, Moreno-Vinasco, Liliana, Garcia, Joe G. N., Gupta, Mahesh P. · 2013 · American Journal of Physiology-Heart and Circulatory Physiology
NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy
Michelle F. Goody, Meghan W. Kelly, Christine J. Reynolds, André Khalil, Bryan D. Crawford, Clarissa A. Henry · 2012 · PLoS Biology
Role of Niacin in Current Clinical Practice: A Systematic Review
Aakash Garg, Abhishek Sharma, Parasuram Melarcode Krishnamoorthy, Jalaj Garg, Deepti Virmani, Toishi Sharma, Giulio Giuseppe Stefanini, John B. Kostis, Debabrata Mukherjee, Ekaterina Sikorskaya · 2016 · The American Journal of Medicine
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo
M. Di Stefano, Andrea Loreto, Giuseppe Orsomando, Valerio Mori, Federica Zamporlini, Richard P. Hulse, Jamie Webster, Lucy Frances Donaldson, Martin Gering, Nadia Raffaelli et al. · 2017 · Current Biology
Normal patterns of expression of glycosylphosphatidylinositol‐anchored proteins on different subsets of peripheral blood cells: A frame of reference for the diagnosis of paroxysmal nocturnal hemoglobinuria
Pilar María Hernández‐Campo, Júlia Almeida, María Luz Sánchez, Mariester Malvezzi, Alberto Órfão · 2006 · Cytometry Part B Clinical Cytometry
Safety assessment of nicotinamide riboside, a form of vitamin B 3
Dietrich B. Conze, J Crespo-Barreto, Claire L. Kruger · 2016 · Human & Experimental Toxicology
Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243
Laura M. Dutca, Steven F. Stasheff, Adam Hedberg‐Buenz, Danielle S. Rudd, N. Batra, Frederick R. Blodi, Matthew S. Yorek, Terry C. Yin, Malini Shankar, Judith A. Herlein et al. · 2014 · Investigative Ophthalmology & Visual Science
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
Yan, Tingting, Feng, Yan, Zheng, Jin, Ge, Xinjian, Zhang, Yi, Wu, Dongmei, Zhao, Jian, Zhai, Qiwei · 2010 · Neurochemistry International
Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism
David W. Frederick, James G. Davis, Antonio Dávila, Beamon Agarwal, Shaday Michán, Michelle A. Puchowicz, Eiko Nakamaru‐Ogiso, Joseph A. Baur · 2014 · Journal of Biological Chemistry
Structure of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase
Tianjun Zhou, Oleg V. Kurnasov, Diana R. Tomchick, Derk D. Binns, Nick V. Grishin, Víctor E. Márquez, Andrei L. Osterman, Hong Zhang · 2002 · Journal of Biological Chemistry
Nicotinamide riboside, a form of vitamin B 3 , protects against excitotoxicity‐induced axonal degeneration
Pauline Vaur, Bernard Brugg, Mathias Mericskay, Zhenlin Li, Mark S. Schmidt, Denis Vivien, Cyrille Orset, Etienne D. Jacotot, Charles Brenner, Eric Duplus · 2017 · The FASEB Journal
Identification of NAD interacting residues in proteins
Hifzur Rahman Ansari, Gajendra P. S. Raghava · 2010 · BMC Bioinformatics
NAD replenishment with nicotinamide mononucleotide protects blood–brain barrier integrity and attenuates delayed tissue plasminogen activator‐induced haemorrhagic transformation after cerebral ischaemia
Chunchun Wei, Yuanyuan Kong, Xia Hua, Guoqiang Li, Si‐Li Zheng, Ming‐He Cheng, Pei Wang, Chao‐Yu Miao · 2017 · British Journal of Pharmacology
SIRT6, a protein with many faces
Asaf A. Gertler, Haim Yosef Cohen · 2013 · Biogerontology
ADP-Ribosyltransferases and Poly ADP-Ribosylation
Chao Liu, Xiaochun Yu · 2015 · Current Protein and Peptide Science
Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise
Lone Frydelund‐Larsen, Thorbjorn C. A. Akerstrom, Søren J. Nielsen, Pernille Keller, Charlotte Keller, Bente Klarlund Pedersen · 2006 · American Journal of Physiology-Endocrinology and Metabolism
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats
Marta V. Hamity, Stephanie R. White, Roxanne Y. Walder, Mark S. Schmidt, Charles Brenner, Donna L. Hammond · 2017 · Pain
Meningitis-Associated Central Nervous System Complications are Mediated by the Activation of Poly(ADP-ribose) Polymerase
Uwe Koedel, Frank Winkler, Barbara Angele · 2002 · Journal of Cerebral Blood Flow & Metabolism
Saccharomyces cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter Nrt1
Belenky, Peter A., Moga, Tiberiu G., Brenner, Charles · 2008 · Journal of Biological Chemistry
Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue
Elisabeth Rappou, Sakari Jukarainen, Rita Rinnankoski‐Tuikka, Sanna M. Kaye, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina M I Lundbom, Virva Saunavaara, Aila Rissanen et al. · 2016 · The Journal of Clinical Endocrinology & Metabolism
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
Minghai Zhou, Gregory K. Ottenberg, Gian Franco Sferrazza, Christopher Hubbs, Mohammad Fallahi, Gavin Rumbaugh, Alicia Faruzzi Brantley, Corinne Ida Lasmézas · 2015 · Brain
Relationship Between Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels and Adiposity in Humans
Manfred Hallschmid, Harpal Singh Randeva, Bee Kang Tan, Werner Kern, Hendrik Lehnert · 2008 · Diabetes
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3
P. K. Chan, R. Torres, Cihangir Yandım, Pui Pik Law, Sanjay P. Khadayate, Marta Mauri, Crina Groşan, Nadine Chapman‐Rothe, Paola Giunti, Mark A. Pook et al. · 2013 · Human Molecular Genetics
Treatment of interstitial cystitis with a quercetin supplement.
Floyd A. Katske, Daniel A. Shoskes, M Sender · 2001 · PubMed
A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase
Ruo-Yu Zhang, Qin Ye, Xiaoqun Lv, Pei Wang, Tian‐Ying Xu, Lei Zhang, Chao‐Yu Miao · 2011 · Analytical Biochemistry
Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation
Christian Dölle, Marc Niere, Emilia Lohndal, Mathias Ziegler · 2009 · Cellular and Molecular Life Sciences
The NAD+ salvage pathway modulates cancer cell viability via p73
Tanveer Sharif, D-G Ahn, R-Z Liu, Eric S. Pringle, Emma Martell, Cathleen Dai, Anna Nunokawa, M. Kwak, Derek R. Clements, John Patrick Murphy et al. · 2015 · Cell Death and Differentiation
Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H)
Boslett, James, Hemann, Craig, Zhao, Yong Juan, Lee, Hon-Cheung, Zweier, Jay L. · 2017 · The Journal of Pharmacology and Experimental Therapeutics
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors
Sara Duarte-Pereira, Isabel Pereira‐Castro, Sarah S. Silva, Mariana Gonçalves Correia, Célia Neto, Luís Teixeira da Costa, António Amorim, Raquel Monteiro Silva · 2015 · Oncotarget
NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway
Li Zhuo, Bo Fu, Xueyuan Bai, Bin Zhang, Lingling Wu, Jing Cui, Shaoyuan Cui, Wei Ribao, Xiangmei Chen, Guangyan Cai · 2011 · Cellular Physiology and Biochemistry
CD38: An Ecto-Enzyme at the Crossroads of Innate and Adaptive Immune Responses
Santiago Partida‐Sánchez, Laura Rivero-Nava, Guixiu Shi, Frances E. Lund · 2007 · Advances in experimental medicine and biology
Nicotinamide Attenuates Focal Ischemic Brain Injury in Rats: With Special Reference to Changes in Nicotinamide and NAD+ Levels in Ischemic Core and Penumbra
Fumiko Sadanaga, Hiroshi Yao, Sei‐ichi Tanuma, Tatsuo Nakahara, Jong Soon Hong, Setsuro Ibayashi, Hideyuki Uchimura, Masatoshi Fujishima · 2003 · Neurochemical Research
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs
Zita Nagy, Alkmini Kalousi, Audrey Furst, Marc Koch, Benoit Fischer, Evi Soutoglou · 2016 · PLoS Genetics
Anti-CD38 Antibody Therapy: Windows of Opportunity Yielded by the Functional Characteristics of the Target Molecule
Antonella Chillemi, Gianluca Zaccarello, Valeria Quarona, Manuela Ferracin, Chiara Ghimenti, Massimo Massaia, Alberto L. Horenstein, Fabio Malavasi · 2013 · Molecular Medicine
HIV Infection Decreases Intracellular Nicotinamide Adenine Dinucleotide [NAD]
Michael F. Murray, Minh Ngoc Nghiem, A. Srinivasan · 1995 · Biochemical and Biophysical Research Communications
Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis
Lindsay E. Wu, Ana P. Gomes, David A. Sinclair · 2014 · Cancer Cell
MCP-1–Activated Monocytes Induce Apoptosis in Human Retinal Pigment Epithelium
Dongli Yang, Susan G. Elner, Xun Chen · 2011 · Investigative Ophthalmology & Visual Science
Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice1
Mirella L. Meyer‐Ficca, Motomasa Ihara, Jessica J. Bader · 2015 · Biology of Reproduction
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay
Ummarino, Simone, Mozzon, Massimo, Zamporlini, Federica, Amici, Adolfo, Mazzola, Francesca, Orsomando, Giuseppe, Ruggieri, Silverio, Raffaelli, Nadia · 2017 · Food Chemistry
Assimilation of NAD + precursors in Candida glabrata
Biao Ma, Shih‐Jung Pan, Margaret L. Zupancic, Brendan P. Cormack · 2007 · Molecular Microbiology
Phase II Clinical Trial of Nicotinamide for the Treatment of Mild to Moderate Alzheimer's Disease
Michael J Phelan · 2017 · Journal of Geriatric Medicine and Gerontology
Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes
CR Zerez, EF Jr Roth, Seymour Schulman · 1990 · Blood
Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD + biosynthetic machinery in mammalian cells
Federica Zamporlini, Silverio Ruggieri, Francesca Mazzola, Adolfo Amici, Giuseppe Orsomando, Nadia Raffaelli · 2014 · FEBS Journal
Resveratrol Differentially Regulates NAMPT and SIRT1 in Hepatocarcinoma Cells and Primary Human Hepatocytes
Susanne Schuster, Melanie Penke, Theresa Gorski, Stefanie Petzold-Quinque, Georg Damm, Rolf Gebhardt, Wieland Kieß, Antje Garten · 2014 · PLoS ONE
NAD+ in Cancer Prevention and Treatment: Pros and Cons
Borut Poljšak · 2016 · Journal of Clinical & Experimental Oncology
The first human clinical study for NMN has started in Japan
Kazuo Tsubota · 2016 · npj Aging and Mechanisms of Disease
Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity
Przemysław Leonard Wencel, Walter J. Lukiw, Joanna Benigna Strosznajder, Robert Piotr Strosznajder · 2017 · Molecular Neurobiology
Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the melas syndrome
Kari Majamaa, Harri Rusanen, Anne Marja Remes, Juhani Pyhtinen, Ilmo E. Hassinen · 1996 · Life Sciences
NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion
Silvia Diani-Moore, Jenny Shoots, Rubi Singh, Joshua B. Zuk, Arleen B. Rifkind · 2017 · Scientific Reports
Nicotinamide and neurocognitive function
George E. Rennie, Andrew C. Chen, Haryana Mary Dhillon, Janette L. Vardy, Diona L. Damian · 2014 · Nutritional Neuroscience
Niacin improved rigidity and bradykinesia in a Parkinson's disease patient but also caused unacceptable nightmares and skin rash–a case report
Alisky, Joseph Martin · 2005 · Nutritional Neuroscience
Effect of Coenzyme Q10, Riboflavin and Niacin on Serum CEA and CA 15-3 Levels in Breast Cancer Patients Undergoing Tamoxifen Therapy
Vummidi Giridhar Premkumar, Srinivasan Yuvaraj, Kothandaraman Vijayasarathy · 2007 · Biological and Pharmaceutical Bulletin
Retinol-binding Protein 4 and Nicotinamide Phosphoribosyltransferase/Visfatin in Rat Obesity Models
Josep Mercader, Nuria Granados, Antoni Caimari · 2008 · Hormone and Metabolic Research
MAP POSITIONS OF YEAST GENES SIR1, SIR3 and SIR4
John M. Ivy, James B Hicks, Amar J. S. Klar · 1985 · Genetics
PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis
Jeffrey Y. Huang, Kang Wang, Anke Vermehren‐Schmaedick, John P. Adelman, Michael S. Cohen · 2016 · Scientific Reports
Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects
Pedro Saddi-Rosa, Carolina S.V. Oliveira, Felipe Crispim, Fernando M. A. Giuffrida, Valter Correia de Lima, José Gilberto H. Vieira, Alessandro Doria, Gilberto Velho, André Fernandes Reis · 2013 · Cardiovascular Diabetology
Upregulation of mitochondrial NAD+ levels impairs the clonogenicity of SSEA1+ glioblastoma tumor-initiating cells
Myung Jin Son, Jae‐Sung Ryu, Jae Yun Kim, Youjeong Kwon, Kyung‐Sook Chung, Seon Ju Mun, Yee Sook Cho · 2017 · Experimental & Molecular Medicine
Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population
Min Kyung Lee, Hyun Sub Cheong, Youngil Koh · 2016 · Genetic Testing and Molecular Biomarkers
Mitigation of gamma-radiation induced abasic sites in genomic DNA by dietary nicotinamide supplementation: Metabolic up-regulation of NAD+ biosynthesis
Vipen Batra, Binita Kislay · 2013 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
Clinical Trials Corner
Leonie Kaye Heilbronn · 2017 · Nutrition and Healthy Aging
PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS
Almeida, Gilberto S., Bawn, Carlo M., Galler, Martin, Wilson, Ian, Thomas, Huw D., Kyle, Suzanne, Curtin, Nicola J., Newell, David R., Maxwell, Ross J. · 2017 · NMR in Biomedicine
Effect of Extended-Release Niacin on Serum Lipids and on Endothelial Function in Adults With Sickle Cell Anemia and Low High-Density Lipoprotein Cholesterol Levels
Heather M. Scoffone, Megan L. Krajewski, Suzana M. Zorca et al. · 2013 · The American Journal of Cardiology
Successful treatment of schizophrenia requires optimal daily doses of vitamin B3.
Abram Hoffer, Jonathan E. Prousky · 2008 · PubMed
Measuring CD38 (ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase) Activity by Reverse-Phase HPLC
Tanja Kirchberger, Andreas H. Guse · 2013 · Cold Spring Harbor Protocols
Clinical Trials Corner
Leonie Kaye Heilbronn · 2017 · Nutrition and Healthy Aging
Hypercholesterolemia. Use of niacin and niacin combinations in therapy.
Arthur U. Rivin · 1962 · PubMed