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A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

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Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

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CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

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Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

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NMNATs, evolutionarily conserved neuronal maintenance factors

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Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

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Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes

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Mitochondria in Alzheimer’s Disease Pathogenesis

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Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration

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Nmnat exerts neuroprotective effects in dendrites and axons

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Overexpression of Wlds or Nmnat2 in mauthner cells by single‐cell electroporation delays axon degeneration in live zebrafish

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A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

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Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

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Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

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Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

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EGCG inhibits pressure overload‐induced cardiac hypertrophy via the PSMB5/Nmnat2/SIRT6‐dependent signalling pathways

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Nicotinamide Mononucleotide Adenylyltransferase Is a Stress Response Protein Regulated by the Heat Shock Factor/Hypoxia-inducible Factor 1α Pathway

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Macrophage depletion blocks congenital SARM1-dependent neuropathy

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Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration

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Axon degeneration is key component of neuronal death in amyloid-β toxicity

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The NAD+synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target

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The biochemical pathways of central nervous system neural degeneration in niacin deficiency

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Axonal degeneration in the peripheral nervous system: Implications for the pathogenesis of amyotrophic lateral sclerosis

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Preserve and protect: maintaining axons within functional circuits

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The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions

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New targets of pemphigus vulgaris antibodies identified by protein array technology

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NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

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WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity

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SARM1-Dependent Axon Degeneration: Nucleotide Signaling, Neurodegenerative Disorders, Toxicity, and Therapeutic Opportunities

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Short‐term tamoxifen treatment has long‐term effects on metabolism in high‐fat diet‐fed mice with involvement of Nmnat2 in POMC neurons

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Targeting the programmed axon degeneration pathway as a potential therapeutic for Charcot-Marie-Tooth disease

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Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer

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Increased ROS Level in Spinal Cord of Wobbler Mice due to Nmnat2 Downregulation

Röderer, P., Klatt, L., John, F., Theis, V., Winklhofer, K. F., Theiß, C., & Matschke, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0999-7 · Cited by 22 · see citing works

Impact of Genetic Reduction of NMNAT2 on Chemotherapy-Induced Losses in Cell Viability In Vitro and Peripheral Neuropathy In Vivo

Slivicki, R. A., Ali, Y., Lu, H., & Hohmann, A. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147620 · Cited by 21 · see citing works

NMNAT2: An important metabolic enzyme affecting the disease progression

Li, W., Gao, M., Hu, C., Chen, X., & Zhou, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114143 · Cited by 21 · see citing works

Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT

Fang, C., Decker, H., & Banker, G. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.013 · Cited by 19 · see citing works

p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture

Yu, Y., Gamage, K. K., Cheng, I., Barford, K., Spano, A., Winckler, B., & Deppmann, C. D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1867-19.2019 · Cited by 19 · see citing works

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Cheng, X., Shi, F.-X., Zhao, K.-P., Lin, W., Li, X.-Y., Zhang, J., Bu, Y.-Y., Zhu, R., Li, X.-H., Duan, D.-X., et al. (2021) · Aging · doi:10.18632/aging.203634 · Cited by 18 · see citing works

Niacin

Penberthy, W. T., & Kirkland, J. B. (2012) · doi:10.1002/9781119946045.ch19 · Cited by 15 · see citing works

Niacin

Penberthy, W. T., & Kirkland, J. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-66162-1.00012-3 · Cited by 14 · see citing works

Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Parsons, R. B., Kocinaj, A., Ruiz-Pulido, G., Prendergast, S. A., Parsons, A. E., Facey, P. D., & Hirth, F. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac077 · Cited by 13 · see citing works

Wallerian Degeneration☆

Carroll, S. L., & Worley, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02077-0 · Cited by 13 · see citing works

NMNAT1 and hereditary spastic paraplegia (HSP): expanding the phenotypic spectrum of NMNAT1 variants

Sadr, Z., Ghasemi, A., Rohani, M., & Alavi, A. (2023) · Neuromuscular Disorders · doi:10.1016/j.nmd.2023.02.001 · Cited by 12 · see citing works

Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers

Myong, S., Nguyen, A. Q., & Challa, S. (2024) · Cancers · doi:10.3390/cancers16173085 · Cited by 10 · see citing works

Programmed axon degeneration: mechanism, inhibition and therapeutic potential

Loreto, A., & Neukomm, L. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00986-3 · Cited by 8 · see citing works

Nicotinamide Adenine Dinucleotide (NAD+) Repletion Attenuates Bupivacaine-Induced Neurotoxicity

Zheng, T., Xu, S., Zhou, S. Q., Lai, L. Y., & Li, L. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1094-0 · Cited by 8 · see citing works

Lack of nicotinamide mononucleotide adenylyltransferase 2 ( N mnat2): Consequences for mouse bladder development and function

Hicks, A. N., Campeau, L., Burmeister, D. M., Bishop, C. E., & Andersson, K. (2013) · Neurourology and Urodynamics · doi:10.1002/nau.22372 · Cited by 7 · see citing works

Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis

Liu, P., Huang, H., Fang, F., Liu, L., Li, L., Feng, X., Chen, W., Dalal, R., Sun, Y., & Hu, Y. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.754651 · Cited by 7 · see citing works

Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves

Dingwall, C. B., Sasaki, Y., Strickland, A. M., Wu, T., Summers, D. W., Bloom, A. J., DiAntonio, A., & Milbrandt, J. (2025) · iScience · doi:10.1016/j.isci.2025.112626 · Cited by 6 · see citing works

Upregulated Nmnat2 causes neuronal death and increases seizure susceptibility in temporal lobe epilepsy

Wu, H., Meng, Q., Zhang, Y., Li, H., Liu, Y. U., Dong, S., Liu, B., & Zhang, H. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.11.019 · Cited by 6 · see citing works

Diverse cell types establish a pathogenic immune environment in peripheral neuropathy

Choi, J. Y., Strickland, A. M., Loo, H. Q., Dong, W., Barbar, L., Bloom, A. J., Sasaki, Y., Jin, S. C., DiAntonio, A., & Milbrandt, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03459-7 · Cited by 5 · see citing works

SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury

Long, W., Li, S., Wang, Q., Yue, W., Fu, Y., Wang, H., Jiang, M., Hu, X., Li, Y., Cui, J., et al. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202501072 · Cited by 4 · see citing works

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Niou, Z., Yang, S., Enriquez, A., Espinas, N. A., Sri, A., Hines, C. D., Tennessen, J. M., Wu, C., Huang, J.-Y., & Lu, H. (2025) · Advanced Science · doi:10.1002/advs.202509950 · Cited by 4 · see citing works

MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing

Park, J., Zhu, Y., Tao, X., Brazill, J. M., Li, C. V., Wuchty, S., & Zhai, R. G. (2019) · iScience · doi:10.1016/j.isci.2019.08.052 · Cited by 4 · see citing works

NICOTINAMIDE RIBOSIDE DELIVERY GENERATES NAD+ RESERVES TO PROTECT VASCULAR CELLS AGAINST OXIDATIVE DAMAGE

Hawrylyshyn, K., Yin, H. R., O’Neil, C. H., Watson, A., & Pickering, J. G. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.07.477 · Cited by 4 · see citing works

NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal healthPreprint

Niou, Z., Yang, S., Sri, A., Rodriquez, H., Gilley, J., Coleman, M. P., & Lu, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.05.479195 · Cited by 4 · see citing works

A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2

Yue, W., Wu, Z., Zhang, K., Long, W., Cui, J., Li, A., & Fang, Y. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116931 · Cited by 2 · see citing works

Nmnat2 deficiency in the arcuate nucleus or paraventricular nucleus induces Sarm 1‐independent neuron loss and liraglutide‐reversible obesity

Yu, H., Feng, N., Zhong, W., Han, Y., Cheng, Y., Zhang, Z., Wang, Y., Gao, P., Huang, R., Zhang, C., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402546r · Cited by 1 · see citing works

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in micePreprint

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.06.479307 · Cited by 1 · see citing works

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transportPreprint

Yang, S., Niou, Z., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar‐Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2859584/v1 · Cited by 1 · see citing works

Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation

Avery, M. A. (2010) · eScholarship@UMassChan · doi:10.13028/ejya-6w71

THE P53-NMNAT2 FEEDBACK REGULATORY LOOP: MECHANISMS UNDERLYING P53 ACTIVATION

Pan, L.-Z. (2012) · Library and Archives Canada (Government of Canada)

The molecular intersection between axon-specific pruning and neuronal apoptosis

Cusack, C. L. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/rrx2-2p18

NMNAT2-SARM1 Axis Drives Redox Failure and Disrupts APP Processing in NeuronsPreprint

Enriquez, A., Yang, S., Ling, K., Jafar‐Nejad, P., & Lu, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.16.718990

Role of NMDAR-NMNAT in sevoflurane exposure-induced learning memory deficits

Hu, N., Ji, W., Dou, J., & Chen, X. (2026) · Brain and Development · doi:10.1016/j.braindev.2026.104540

Neurodegenerative NMNAT2 Deficiency Promotes APP Processing in a SARM1-Dependent Manner

Enriquez, A., Yang, S., Ling, K., Jafar‐Nejad, P., & Lu, H. (2026) · Cells · doi:10.3390/cells15121100

Axon degeneration: Mechanisms and implications of a distinct program from cell death

Yan, T., Feng, Y., & Zhai, Q. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.01.013 · Cited by 36 · see citing works

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

Sasaki, Y., Vohra, B., Lund, F., & Milbrandt, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5469-08.2009 · Cited by 254 · see citing works

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Sasaki, Y., Araki, T., & Milbrandt, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2320-06.2006 · Cited by 269 · see citing works

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M., Nascimento-Ferreira, I., Orsomando, G., Mori, V, Gilley, J., Brown, R., Janeckova, L., Vargas, M. E., Worrell, L. A., Loreto, A., et al. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.164 · Cited by 246 · see citing works

Mechanistic insights into an axon death pathway controlled by NAD-related metabolism

Loreto, A. (2018) · Nottingham ePrints (University of Nottingham)