Cited by 102Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

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Liu, Xiaomeng, Zhang, Zhi, Song, Yajie, Xie, Hengchang, Dong, Meng·2023·Frontiers in Endocrinology

Abstract

Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity.

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Authors
Liu, X., Zhang, Z., Song, Y., Xie, H., & Dong, M.
Affiliations
  • Zhoukou Normal University (CN)
  • Chinese Academy of Sciences (CN)
  • ShanghaiTech University (CN)
Corresponding author
  • Xie, Hengchang
  • Dong, Meng
Venue
Frontiers in Endocrinology
Published
2023-01-11
Volume
13
Pages
1065263-1065263
ISSN
1664-2392 (ISSN-L)
OpenAlex
W4315498575
Cited by
102
References
156
Citations by year
2026: 23 · 2025: 32 · 2024: 37 · 2023: 10
FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Science and Technology Innovation Talents in Universities of Henan Province (XYBSKYZZ202135, 19HASTIT015)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
brown adipose tissue, obesity, thermogenesis, UCP1, white adipose tissue browning, cold exposure, physical activity, small molecule activators, batokines, sympathetic nervous system, gut microbiota, bariatric surgery, weight loss, obesity-related metabolic diseases
MeSH terms
Adipose Tissue, Brown, Humans, Obesity, Sympathetic Nervous System, Weight Loss, Adipose Tissue, White

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