Cited by 197Adipose Tissue and MetabolismLipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic Diseases

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Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

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U Din, Mueez, Saari, Teemu, Raiko, Juho, Kudomi, Nobu, Maurer, Stefanie F., Lahesmaa, Minna, Fromme, Tobias, Amri, Ez-Zoubir, Klingenspor, Martin, Solin, Olof, Nuutila, Pirjo, Virtanen, Kirsi A.·2018·Cell Metabolism

DOI 10.1016/j.cmet.2018.05.020

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Abstract

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.

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Authors: U Din, M., Saari, T., Raiko, J., Kudomi, N., Maurer, S. F., Lahesmaa, M., Fromme, T., Amri, E.-Z., Klingenspor, M., Solin, O., Nuutila, P., & Virtanen, K. A.
Affiliations: University of Turku (FI)
Kagawa University (JP)
Technical University of Munich (DE)
Centre National de la Recherche Scientifique (FR)
Åbo Akademi University (FI)
Corresponding author: Virtanen, Kirsi A.
ORCID: Saari, Teemu
Raiko, Juho
Lahesmaa, Minna
Fromme, Tobias
Amri, Ez-Zoubir
Klingenspor, Martin
Solin, Olof
Nuutila, Pirjo
Virtanen, Kirsi A.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2018-08
Volume: 28
Issue: 2
Pages: 207-216.e3
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2018.05.020
OpenAlex: W2808196629
Cited by: 196
References: 57
Citations by year: 2026: 16 · 2025: 9 · 2024: 24 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 38 · 2019: 24 · 2018: 6
FWCI: 17.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Åbo Akademi University Research Portal (submittedVersion)
Funders: Academy of Finland (259926, 265204, 292839, 269977)
Paulo Foundation
Finnish Cultural Foundation Southwest Finland Regional
Turku University Hospital Research
European Union
ANR
DFG
University of Turku
Åbo Akademi University
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: brown adipose tissue, thermogenesis, postprandial state, free fatty acids, glucose uptake, oxygen consumption, insulin, lipolysis, UCP1, lipid metabolism genes, white adipose tissue, cold stress
MeSH terms: Diet, Carbohydrate Loading, Uncoupling Protein 1, Positron Emission Tomography Computed Tomography, Adult, Adipose Tissue, Brown, Fatty Acids, Nonesterified, Female, Humans, Insulin, Lipolysis, Male, Middle Aged, Obesity, Oxygen Consumption, Case-Control Studies, Postprandial Period, Thermogenesis, Adipose Tissue, White, Cold-Shock Response

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Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

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