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Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis
Open accessAbstract
Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.
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“It has been demonstrated by several groups that there is a meal‐associated thermogenesis 101, 102, 103.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [102]
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Metadata
- Authors
- U Din, M., Saari, T., Raiko, J., Kudomi, N., Maurer, S. F., Lahesmaa, M., Fromme, T., Amri, E.-Z., Klingenspor, M., Solin, O., Nuutila, P., & Virtanen, K. A.
- Affiliations
- University of Turku (FI)
- Kagawa University (JP)
- Technical University of Munich (DE)
- Centre National de la Recherche Scientifique (FR)
- Åbo Akademi University (FI)
- Corresponding author
- Virtanen, Kirsi A.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 28
- Issue
- 2
- Pages
- 207-216.e3
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2808196629
- Cited by
- 196
- References
- 57
- Citations by year
- 2026: 16 · 2025: 9 · 2024: 24 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 38 · 2019: 24 · 2018: 6
- FWCI
- 17.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Åbo Akademi University Research Portal (submittedVersion)
- Funders
- Academy of Finland (259926, 265204, 292839, 269977)
- Paulo Foundation
- Finnish Cultural Foundation Southwest Finland Regional
- Turku University Hospital Research
- European Union
- ANR
- DFG
- University of Turku
- Åbo Akademi University
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, thermogenesis, postprandial state, free fatty acids, glucose uptake, oxygen consumption, insulin, lipolysis, UCP1, lipid metabolism genes, white adipose tissue, cold stress
- MeSH terms
- Diet, Carbohydrate Loading, Uncoupling Protein 1, Positron Emission Tomography Computed Tomography, Adult, Adipose Tissue, Brown, Fatty Acids, Nonesterified, Female, Humans, Insulin, Lipolysis, Male, Middle Aged, Obesity, Oxygen Consumption, Case-Control Studies, Postprandial Period, Thermogenesis, Adipose Tissue, White, Cold-Shock Response
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