Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495 · see citing works

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,281 · see citing works

The Metabolic Syndrome: Time for a Critical Appraisal

Kahn, R., Buse, J. B., Ferrannini, E., & D, M. P. S. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2289 · Cited by 2,389 · see citing works

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968 · see citing works

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317 · see citing works

FOXO transcription factors at the interface between longevity and tumor suppression

Greer, E. L., & Brunet, A. (2005) · Oncogene · doi:10.1038/sj.onc.1209086 · Cited by 1,306 · see citing works

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works

Gut Microbiota-Dependent Trimethylamine <i>N</i> -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

Paik, J.-H., Kollipara, R., Chu, G., Ji, H., Xiao, Y., Ding, Z., Miao, L., Tothova, Z., Horner, J. W., Carrasco, D. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.029 · Cited by 1,032 · see citing works

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works

FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 700 · see citing works

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

Wang, Y., Shen, J., Arenzana, N., Tirasophon, W., Kaufman, R. J., & Prywes, R. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61473-0 · Cited by 617 · see citing works

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585 · see citing works

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

Heianza, Y., Ma, W., Manson, J. E., Rexrode, K. M., & Qi, L. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004947 · Cited by 544 · see citing works

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

Wang, Y., Shen, J., Arenzana, N., et al. (2000) · PubMed · doi:10.1074/jbc.m003322200 · Cited by 539 · see citing works

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

Sun, X., Jiao, X., Ma, Y., Liu, Y., Zhang, L., He, Y., & Chen, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.017 · Cited by 507 · see citing works

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Pike, L. S., Smift, A., Croteau, N. J., Ferrick, D. A., & Wu, M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.022 · Cited by 473 · see citing works

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Vogt, N. M., Romano, K. A., Darst, B. F., Engelman, C. D., Johnson, S. C., Carlsson, C. M., Asthana, S., Blennow, K., Zetterberg, H., Bendlin, B. B., et al. (2018) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-018-0451-2 · Cited by 471 · see citing works

A Naturally Occurring Protective System in Urea-Rich Cells: Mechanism of Osmolyte Protection of Proteins against Urea Denaturation

Wang, A., & Bolen, D. W. (1997) · Biochemistry · doi:10.1021/bi970247h · Cited by 448 · see citing works

A review of the mammalian unfolded protein response

Chakrabarti, A., Chen, A. W., & Varner, J. D. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23282 · Cited by 408 · see citing works

ER stress induces NLRP3 inflammasome activation and hepatocyte death

Lebeaupin, C., Proïcs, E., de Bieville, C.-H. D., Rousseau, D., Bonnafous, S., Patouraux, S., Adam, G., Lavallard, V., Rovère, C., Thuc, O. L., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.248 · Cited by 400 · see citing works

That which does not kill me makes me stronger: adapting to chronic ER stress

Rutkowski, D. T., & Kaufman, R. J. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.09.003 · Cited by 398 · see citing works

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

Miao, J., Ling, A. V., Manthena, P. V., Gearing, M. E., Graham, M. J., Crooke, R. M., Croce, K. J., Esquejo, R. M., Clish, C. B., Morbid Obesity Study Group, et al. (2015) · Nature Communications · doi:10.1038/ncomms7498 · Cited by 368 · see citing works

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., & Wang, Y. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.03.001 · Cited by 360 · see citing works

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

Tam, A. B., Mercado, E. L., Hoffmann, A., & Niwa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045078 · Cited by 349 · see citing works

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m051680 · Cited by 335 · see citing works

TMAO: A small molecule of great expectations

Ufnal, M., Żądło‐Dobrowolska, A., & Ostaszewski, R. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.006 · Cited by 319 · see citing works

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

Rhee, E. P., Clish, C. B., Ghorbani, A., Larson, M. G., Elmariah, S., McCabe, E., Yang, Q., Cheng, S., Pierce, K., Deik, A., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012101006 · Cited by 307 · see citing works

Unfolded Protein Response Signaling and Metabolic Diseases

Lee, J., & Özcan, U. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.534743 · Cited by 306 · see citing works

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

Lin, J. H., Li, H., Zhang, Y., Ron, D., & Walter, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004170 · Cited by 305 · see citing works

Trimethylamine‐<i>N</i>‐oxide promotes brain aging and cognitive impairment in mice

Li, D., Ke, Y., Zhan, R., Liu, C., Zhao, M., Zeng, A., Shi, X., Ji, L., Cheng, S., Pan, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12768 · Cited by 304 · see citing works

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway

Geng, J., Yang, C., Wang, B., Zhang, X., Hu, T., Gu, Y., & Li, J. (2018) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2017.11.016 · Cited by 297 · see citing works

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

Zhou, Y., Lee, J., Reno, C. M., Sun, C., Park, S. W., Chung, J., Lee, J., Fisher, S. J., White, M. F., Biddinger, S. B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2293 · Cited by 295 · see citing works

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

Li, X., Leng, S. X., & Song, D. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s74042 · Cited by 294 · see citing works

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291 · see citing works

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Axten, J. M., Romeril, S. P., Shu, A. Y. L., Ralph, J. M., Medina, J. R., Feng, Y., Li, W. H. H., Grant, S. W., Heerding, D. A., Minthorn, E. A., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400228e · Cited by 233 · see citing works

Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

Tang, W. H. W., Wang, Z., Li, X. S., Fan, Y., Li, D. S., Wu, Y., & Hazen, S. L. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.263640 · Cited by 232 · see citing works

Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

Tan, X., Liu, Y., Long, J., Chen, S., Liao, G., Wu, S., Li, C., Wang, L., Ling, W., & Zhu, H. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900257 · Cited by 231 · see citing works

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

Dambrova, M., Latkovskis, G., Kuka, J., Strele, I., Konrade, I., Grinberga, S., Hartmane, D., Pugovics, O., Erglis, A., & Liepinsh, E. (2016) · Experimental and Clinical Endocrinology &amp; Diabetes · doi:10.1055/s-0035-1569330 · Cited by 229 · see citing works

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano, K. A., Martinez-del Campo, A., Kasahara, K., Chittim, C. L., Vivas, E. I., Amador-Noguez, D., Balskus, E. P., & Rey, F. E. (2017) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2017.07.021 · Cited by 224 · see citing works

Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study

Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., McEntyre, C. J., Elmslie, J. L., Atkinson, W., Molyneux, S. L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114969 · Cited by 223 · see citing works

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

Mueller, D. M., Allenspach, M., Othman, A., Saely, C. H., Muendlein, A., Vonbank, A., Drexel, H., & von Eckardstein, A. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.091 · Cited by 217 · see citing works

Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes

Shan, Z., Sun, T., Huang, H., Chen, S., Chen, L., Luo, C., Yang, W., Yang, X., Yao, P., Cheng, J., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.157107 · Cited by 210 · see citing works

FFA‐Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways

Jiao, P., Ma, J., Feng, B., Zhang, H., Diehl, J. A., Eugene‐Chin, Y., Yan, W., & Xu, H. (2010) · Obesity · doi:10.1038/oby.2010.200 · Cited by 197 · see citing works

Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response

Li, Q., Korzan, W. J., Ferrero, D. M., Chang, R. B., Roy, D. S., Buchi, M., Lemon, J. K., Kaur, A. W., Stowers, L., Fendt, M., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.10.047 · Cited by 190 · see citing works

The metabolic syndrome and chronic kidney disease

Zhang, X., & Lerman, L. O. (2016) · Translational research · doi:10.1016/j.trsl.2016.12.004 · Cited by 177 · see citing works

Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease

Mercado, G., Castillo, V., Soto, P., López, N., Axten, J. M., Sardi, S. P., Hoozemans, J. J. M., & Hetz, C. A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.004 · Cited by 176 · see citing works

Trimethylamine N‐oxide: breathe new life

Subramaniam, S., & Fletcher, C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13959 · Cited by 171 · see citing works

PERK (eIF2α kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

Liang, S.-H., Zhang, W., McGrath, B. C., Zhang, P., & Cavener, D. R. (2005) · Biochemical Journal · doi:10.1042/bj20050374 · Cited by 152 · see citing works

Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis

Chiang, C., Hsu, S. P., Wu, C.-T., Huang, J., Cheng, H., Chang, Y.-W., Hung, K., Wu, K.-D., & Liu, S. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00131 · Cited by 151 · see citing works

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylationPreprint

Zhang, W., Hietakangas, V., Wee, S., Lim, S. C., Gunaratne, J., & Cohen, S. M. (2013) · Genes & Development · doi:10.1101/gad.201731.112 · Cited by 149 · see citing works

The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization

Wang, P., Li, J., Tao, J., & Sha, B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001294 · Cited by 141 · see citing works

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

Chen, S., Blank, M. F., Iyer-Bierhoff, A., Huang, B., Wang, L., Grummt, I., & Voit, R. (2016) · Nature Communications · doi:10.1038/ncomms10734 · Cited by 126 · see citing works

Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism

Obeid, R., Awwad, H. M., Rabagny, Y., Graeber, S., Herrmann, W., & Geisel, J. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.121269 · Cited by 117 · see citing works

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum

McQuiston, A. S., & Diehl, J. A. (2017) · F1000Research · doi:10.12688/f1000research.12138.1 · Cited by 116 · see citing works

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Dumas, M.-E., Rothwell, A. R., Hoyles, L., Aranias, T., Chilloux, J., Calderari, S., Noll, E. M., Péan, N., Boulangé, C. L., Blancher, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.039 · Cited by 114 · see citing works

Endoplasmic Reticulum Stress Promotes Macrophage-derived Foam Cell Formation by Up-regulating Cluster of Differentiation 36 (CD36) Expression

Yao, S., Miao, C., Tian, H., Sang, H., Yang, N., Jiao, P., Han, J., Zong, C., & Qin, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.524512 · Cited by 104 · see citing works

Lipid-Induced Endoplasmic Reticulum Stress in Liver Cells Results in Two Distinct Outcomes: Adaptation with Enhanced Insulin Signaling or Insulin Resistance

Achard, C. S., & Laybutt, D. R. (2012) · Endocrinology · doi:10.1210/en.2011-1881 · Cited by 102 · see citing works

Trimethylaminuria: causes and diagnosis of a socially distressing condition.

Mackay, R. J., McEntyre, C. J., Henderson, C., Lever, M., & George, P. M. (2011) · Europe PMC (PubMed Central) · Cited by 94 · see citing works

In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles

Cashman, J. R., Xiong, Y., Lin, J., Verhagen, H., van Poppel, G., van Bladeren, P. J., Larsen-Su, S., & Williams, D. E. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00166-5 · Cited by 93 · see citing works

Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes

Svingen, G. F. T., Schartum-Hansen, H., Pedersen, E. R., Ueland, P. M., Tell, G. S., Mellgren, G., Njølstad, P. R., Seifert, R., Strand, E., Karlsson, T. R., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.250761 · Cited by 91 · see citing works

Trace Amine‐associated Receptors Are Olfactory Receptors in Vertebrates

Liberles, S. D. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04014.x · Cited by 87 · see citing works

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

Harding, H. P., Zhang, Y., Khersonsky, S. M., Marciniak, S. J., Scheuner, D. L., Kaufman, R. J., Javitt, N. B., Chang, Y., & Ron, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.005 · Cited by 87 · see citing works

Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis

Onat, U. İ., Yıldırım, A., Tufanlı, Ö., Çimen, İ., Kocatürk, B., Veli, Z., Hamid, S. M., Shimada, K., Chen, S., Sin, J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.055 · Cited by 84 · see citing works

Endoplasmic reticulum stress is induced and modulated by enterovirus 71

Jheng, J.-R., Lau, K. S., Tang, W., Wu, M.-S., & Horng, J. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01434.x · Cited by 73 · see citing works

Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria

Yeung, C. K., Adman, E. T., & Rettie, A. E. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.014 · Cited by 68 · see citing works

Partial restoration of defective chloride conductance in ΔF508 CF mice by trimethylamine oxide

Fischer, H., Fukuda, N., Barbry, P., Illek, B., Sartori, C. S., & Matthay, M. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l52 · Cited by 64 · see citing works

Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by 1H NMR Spectroscopy

Won, E.-Y., Yoon, M., Kim, S. W., Jung, Y., Bae, H.-W., Lee, D., Park, S. G., Lee, C., Hwang, G., & Chi, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075998 · Cited by 61 · see citing works

Endoplasmic Reticulum (ER) Chaperone Regulation and Survival of Cells Compensating for Deficiency in the ER Stress Response Kinase, PERK

Yamaguchi, Y., Larkin, D. D., Lara‐Lemus, R., Ramos‐Castañeda, J., Liu, M. R., & Arvan, P. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802466200 · Cited by 55 · see citing works

Indole-3-Carbinol and Its Role in Chronic Diseases

Licznerska, B. E., & Baer‐Dubowska, W. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41334-1_6 · Cited by 52 · see citing works

Concurrent Flavin-Containing Monooxygenase Down Regulation and Cytochrome P450 Induction by Dietary Indoles in the Rat: Implication for Drug-Drug Interactions

Williams, D. E., Katchamart, S., Larsen-Su, S. A., Stresser, D. M., Dehal, S. S., & Kupfer, D. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0667-6_95 · Cited by 50 · see citing works

Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin

Shepshelovich, J., Goldstein-Magal, L., Levin, A. G., Yen, P. M., Rotman‐Pikielny, P., & Hirschberg, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02294 · Cited by 47 · see citing works

Dietary indole-3-carbinol inhibits FMO activity and the expression of flavin-containing monooxygenase form 1 in rat liver and intestine.

Larsen-Su, S. A., & Williams, D. E. J. (1996) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07485-9 · Cited by 46 · see citing works

Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors

Petriello, M. C., Hoffman, J. B., Sunkara, M., Wahlang, B., Perkins, J. T., Morris, A. J., & Hennig, B. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.03.016 · Cited by 45 · see citing works

Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins

Miao, J., Haas, J. T., Manthena, P. V., Wang, Y., Zhao, E., Vaitheesvaran, B., Kurland, I. J., & Biddinger, S. B. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m043711 · Cited by 39 · see citing works

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

Key, C.-C. C., Liu, M., Kurtz, C. L., Chung, S., Boudyguina, E. Y., Dinh, T. A., Bashore, A. C., Phelan, P. E., Freedman, B. I., Osborne, T. F., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.032 · Cited by 38 · see citing works

Inhibition of endoplasmic reticulum stress improves coronary artery function in type 2 diabetic mice

Choi, S. K., Lim, M., Yeon, S., & Lee, Y. (2016) · Experimental Physiology · doi:10.1113/ep085508 · Cited by 35 · see citing works

Concurrent Flavin-Containing Monooxygenase Down-Regulation and Cytochrome P-450 Induction by Dietary Indoles in Rat: Implications for Drug-Drug Interaction

Katchamart, S., Stresser, D. M., Dehal, S. S., & Williams, D. E. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15166-5 · Cited by 34 · see citing works

FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice

Ling, A. V., Gearing, M. E., Semova, I., Shin, D., Clements, R. L., Lai, Z. W., & Biddinger, S. B. (2017) · Endocrinology · doi:10.1210/en.2017-00870 · Cited by 29 · see citing works

Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes

Liao, B. M., McManus, S. A., Hughes, W. E., & Schmitz‐Peiffer, C. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1217 · Cited by 13 · see citing works

Gut microbiota and cardiovascular disease.

Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

Targher, G., Byrne, C. D., & Tilg, H. (2020) · Gut · doi:10.1136/gutjnl-2020-320622 · Cited by 848 · see citing works

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Yang, W., & Cong, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00661-4 · Cited by 701 · see citing works

Role of the gut microbiota in type 2 diabetes and related diseases

Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., Meng, L., Xin, Y., & Jiang, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154712 · Cited by 418 · see citing works

The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

Wang, H., Rong, X., Zhao, G., Zhou, Y., Xiao, Y., Ma, D., Jin, X., Wu, Y., Yan, Y., Yang, H., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.010 · Cited by 411 · see citing works

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359 · see citing works

From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism

Koh, A., & Bäckhed, F. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.005 · Cited by 307 · see citing works

TMAO: how gut microbiota contributes to heart failure

Zhang, Y., Wang, Y., Ke, B., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.007 · Cited by 306 · see citing works

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Jiang, S., Shui, Y., Cui, Y., Tang, C., Wang, X., Qiu, X., Hu, W., Fei, L., Li, Y., Zhang, S., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102115 · Cited by 237 · see citing works

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Chen, W., & Pang, Y. (2021) · Metabolites · doi:10.3390/metabo11120869 · Cited by 228 · see citing works

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

Grander, C., Grabherr, F., & Tilg, H. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad095 · Cited by 216 · see citing works

Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

Zhang, Y., Chen, R., Zhang, D., Qi, S., & Liu, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114295 · Cited by 209 · see citing works

Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease

Gupta, N., Buffa, J. A., Roberts, A. B., Sangwan, N., Skye, S. M., Li, L., Ho, K. J., Varga, J., DiDonato, J. A., Tang, W. H. W., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314139 · Cited by 184 · see citing works

Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms

Benson, T. W., Conrad, K. A., Li, X. S., Wang, Z., Helsley, R. N., Schugar, R. C., Coughlin, T. M., Wadding-Lee, C., Fleifil, S., Russell, H., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.060573 · Cited by 165 · see citing works

Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota

Zhang, H.-Y., Tian, J., Lian, F., Li, M., Liu, W., Zhong, Z., Liao, J., & Tong, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110857 · Cited by 163 · see citing works

The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review

Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Zhang, W., Miikeda, A., Zuckerman, J. E., Jia, X., Charugundla, S., Zhou, Z., Kaczor‐Urbanowicz, K. E., Magyar, C. E., Guo, F., Wang, Z., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80063-0 · Cited by 148 · see citing works

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

Saaoud, F., Liu, L., Xu, K., Cueto, R., Shao, Y., Lu, Y., Sun, Y., Snyder, N. W., Wu, S., Yang, L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158183 · Cited by 153 · see citing works

Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?

Papandreou, C., Moré, M. I., & Bellamine, A. (2020) · Nutrients · doi:10.3390/nu12051330 · Cited by 150 · see citing works

Gut microbes in cardiovascular diseases and their potential therapeutic applications

Jin, L., Shi, X., Yang, J., Zhao, Y., Xue, L., Xu, L., & Cai, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00785-9 · Cited by 143 · see citing works

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Organ, C. L., Li, Z., Sharp, T. E., Polhemus, D. J., Gupta, N., Goodchild, T. T., Tang, W. H. W., Hazen, S. L., & Lefer, D. J. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.016223 · Cited by 127 · see citing works

A male germ-cell-specific ribosome controls male fertility

Li, H., Huo, Y., He, X., Yao, L., Zhang, H., Cui, Y., Xiao, H., Xie, W., Zhang, D., Wang, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-05508-0 · Cited by 125 · see citing works

ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response

Kumar, V., & Maity, S. (2021) · Biomolecules · doi:10.3390/biom11020173 · Cited by 117 · see citing works

Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease

Fang, Q., Zheng, B., Liu, N., Liu, J., Liu, W., Huang, X., Zeng, X., Chen, L., Li, Z., & Ouyang, D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.682482 · Cited by 116 · see citing works

Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus

Du, L., Li, Q., Yi, H., Kuang, T., Tang, Y. P., & Fan, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112839 · Cited by 115 · see citing works

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

Witkowski, M., Witkowski, M., Friebel, J., Buffa, J. A., Li, X. S., Wang, Z., Sangwan, N., Li, L., DiDonato, J. A., Tizian, C., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab263 · Cited by 116 · see citing works

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Govindarajulu, M., Pinky, P. D., Steinke, I., Bloemer, J., Ramesh, S., Kariharan, T., Rella, R. T., Bhattacharya, S., Dhanasekaran, M., Suppiramaniam, V., et al. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00138 · Cited by 113 · see citing works

Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

Simó, C., & García‐Cañas, V. (2020) · Food & Function · doi:10.1039/d0fo01237h · Cited by 110 · see citing works

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Wang, B., Qiu, J., Lian, J., Yang, X., & Zhou, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.723886 · Cited by 108 · see citing works

Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure

Snelson, M., Muralitharan, R. R., Liu, C., Markó, L., Forslund, S. K., Marques, F. Z., & Tang, W. H. W. (2025) · Circulation Research · doi:10.1161/circresaha.125.325516 · Cited by 106 · see citing works

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Kong, L., Zhao, Q., Jiang, X., Hu, J., Jiang, Q., Li, S., Peng, X., Wang, S., Chen, Y., Wan, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46829-0 · Cited by 98 · see citing works

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Zou, Y., Wang, S., Zhang, H., Gu, Y., Chen, H., Huang, Z., Yang, F., Li, W., Chen, C., Men, L., et al. (2023) · Medicinal Research Reviews · doi:10.1002/med.21989 · Cited by 97 · see citing works

The Specific Alteration of Gut Microbiota in Diabetic Kidney Diseases—A Systematic Review and Meta-Analysis

Wang, Y., Zhao, J., Qin, Y., Yu, Z., Zhang, Y., Ning, X., & Sun, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.908219 · Cited by 94 · see citing works

Gut microbiota and metabolic biomarkers in metabolic dysfunction–associated steatotic liver disease

Long, Q., Luo, F., Li, B., Li, Z., Guo, Z., Chen, Z., Wu, W., & Hu, M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000310 · Cited by 94 · see citing works

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

Constantino-Jonapa, L. A., Espinoza-Palacios, Y., Escalona‐Montaño, A. R., Hernández-Ruiz, P., Amezcua-Guerra, L. M., Amedei, A., & Aguirre‐García, M. M. (2023) · Biomedicines · doi:10.3390/biomedicines11020431 · Cited by 97 · see citing works

Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Austad, S. N., Ballinger, S. W., Buford, T. W., Carter, C. S., Smith, D. L., Darley-Usmar, V. M., & Zhang, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.06.014 · Cited by 94 · see citing works

TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

Ye, Z., Lulu, C., Xiangchang, Z., Fang, Q., Binjie, Z., Chunyang, L., Rao, T., & Dongsheng, O. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.929262 · Cited by 90 · see citing works

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 87 · see citing works

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M. N., Sikorska, E., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043494 · Cited by 85 · see citing works

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Andrikopoulos, P., Aron‐Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S. K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira‐Silva, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39824-4 · Cited by 86 · see citing works

The gut microbiota derived metabolite trimethylamine N-oxide: Its important role in cancer and other diseases

Zhou, Y., Zhang, Y., Jin, S., Lv, J., Li, M., & Feng, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117031 · Cited by 92 · see citing works

Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health

Caradonna, E., Abate, F., Schiano, E., Paparella, F., Ferrara, F., Vanoli, E., Difruscolo, R., Goffredo, V. M., Amato, B., Setacci, C., et al. (2025) · Metabolites · doi:10.3390/metabo15040220 · Cited by 88 · see citing works

The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway

Kapetanaki, S., Kumawat, A. K., Persson, K., & Demirel, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111864 · Cited by 80 · see citing works

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study

Wang, M., Wang, Z., Lee, Y., Lai, H. T. M., Otto, M. C. D. O., Lemaître, R. N., Fretts, A. M., Sotoodehnia, N., Budoff, M. J., DiDonato, J. A., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316533 · Cited by 81 · see citing works

Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta

Husso, A., Pessa‐Morikawa, T., Koistinen, V., Kärkkäinen, O. K., Kwon, H. N., Lahti, L., Iivanainen, A., Hanhineva, K., & Niku, M. (2023) · BMC Biology · doi:10.1186/s12915-023-01709-9 · Cited by 83 · see citing works

Intestinal microbial metabolites in human metabolism and type 2 diabetes

Herrema, H., & Niess, J. H. (2020) · Diabetologia · doi:10.1007/s00125-020-05268-4 · Cited by 79 · see citing works

Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis

Wang, M., Li, X. S., Wang, Z., Otto, M. C. D. O., Lemaître, R. N., Fretts, A. M., Sotoodehnia, N., Budoff, M. J., Nemet, I., DiDonato, J. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad089 · Cited by 80 · see citing works

The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review

Oktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 87 · see citing works

Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes

Yang, K., Li, G., Li, Q., Wang, W., Zhao, X. X., Shao, N., Qiu, H., Liu, J., Xu, L., & Zhao, J. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01385-y · Cited by 88 · see citing works

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

Schugar, R. C., Gliniak, C. M., Osborn, L. J., Massey, W. J., Sangwan, N., Horak, A. J., Banerjee, R., Orabi, D., Helsley, R. N., Brown, A. L., et al. (2022) · eLife · doi:10.7554/elife.63998 · Cited by 73 · see citing works

Local and systemic effects of microbiome‐derived metabolites

Spivak, I., Fluhr, L., & Elinav, E. (2022) · EMBO Reports · doi:10.15252/embr.202255664 · Cited by 74 · see citing works

Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease

Samarraie, A. A., Pichette, M., & Rousseau, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065420 · Cited by 76 · see citing works

Association of TrimethylamineN-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes

Lemaître, R. N., Jensen, P. N., Wang, Z., Fretts, A. M., McKnight, B., Nemet, I., Biggs, M. L., Sotoodehnia, N., Otto, M. C. D. O., Psaty, B. M., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.22844 · Cited by 71 · see citing works

Roles of Gut Microbial Metabolites in Diabetic Kidney Disease

Fang, Q., Liu, N., Zheng, B., Guo, F., Zeng, X., Huang, X., & Ouyang, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636175 · Cited by 69 · see citing works

Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds

Ilyas, A., Wijayasinghe, Y. S., Khan, I., Samaloty, N. M. E., Adnan, M., Dar, T. A., Poddar, N. K., Singh, L. R., Sharma, H., & Khan, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.964624 · Cited by 71 · see citing works

Blood–brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins

Hernandez, L. N., Ward, L. J., Arefin, S., Ebert, T., Laučytė-Cibulskienė, A., Collaborators, G.-F., Pilote, L., Norris, C. M., Raparelli, V., Kautzky‐Willer, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08387-7 · Cited by 70 · see citing works

Clinical significance and potential role of trimethylamine N-oxide in neurological and neuropsychiatric disorders

Mudimela, S., Vishwanath, N. K., Pillai, A., Morales, R., Marrelli, S. P., Barichello, T., & Giridharan, V. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.08.002 · Cited by 70 · see citing works

Cellular and organismal function of choline metabolism

Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 66 · see citing works

Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites

Verdugo‐Meza, A., Ye, J., Dadlani, H., Ghosh, S., & Gibson, D. L. (2020) · Nutrients · doi:10.3390/nu12051434 · Cited by 69 · see citing works

Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy

He, J., Zhou, Y. L., & Sun, L. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01438-0 · Cited by 69 · see citing works

Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide

Loo, R. L., Chan, Q. M., Nicholson, J. K., & Holmes, E. C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00851 · Cited by 60 · see citing works

Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota

Golonka, R. M., Xiao, X., Abokor, A. A., Joe, B., & Vijay–Kumar, M. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108360 · Cited by 60 · see citing works

Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study

Li, S., Chen, S. X., Lu, X., Fang, A., Chen, Y., Huang, R.-Z., Lin, X., Huang, Z.-H., Ma, J.-F., Huang, B., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03581-7 · Cited by 62 · see citing works

Gut microbiota metabolites as integral mediators in cardiovascular diseases (Review)

Zhu, Y., Shui, X., Liang, Z., Huang, Z., Qi, Y., He, Y., Chen, C., Luo, H., & Lei, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4674 · Cited by 60 · see citing works

Sequence meets function—microbiota and cardiovascular disease

Kim, M., Huda, M. N., & Bennett, B. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab030 · Cited by 59 · see citing works

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

Helsley, R. N., Miyata, T., Kadam, A., Varadharajan, V., Sangwan, N., Huang, E., Banerjee, R., Brown, A. L., Fung, K. K., Massey, W. J., et al. (2022) · eLife · doi:10.7554/elife.76554 · Cited by 56 · see citing works

Metabolites of Gut Microbiota and Possible Implication in Development of Diabetes Mellitus

Guo, Z., Pan, J., Zhu, H., & Chen, Z. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07851 · Cited by 57 · see citing works

The Gut Microbial Endocrine Organ in Type 2 Diabetes

Massey, W. J., & Brown, J. M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa235 · Cited by 61 · see citing works

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

Li, X., Hong, J. W., Wang, Y., Pei, M., Wang, L., & Gong, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.733507 · Cited by 58 · see citing works

Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism

Lee, Y., & Lee, H. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0220 · Cited by 56 · see citing works

Circulating trimethylamine N-oxide in association with diet and cardiometabolic biomarkers: an international pooled analysis

Yang, J. J., Shu, X., Herrington, D. M., Moore, S. C., Meyer, K. A., Ose, J., Menni, C., Palmer, N. D., Eliassen, A. H., Harada, S., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa430 · Cited by 53 · see citing works

Structure, functions, and diversity of the healthy human microbiome

Ahrodia, T., Das, S., Bakshi, S., & Das, B. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.003 · Cited by 54 · see citing works

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

Kuka, J., Ozola, M., Makrecka‐Kuka, M., Liepinsh, E., Grı̄nberga, S., Sevostjanovs, E., Vilks, K., Liepinsh, E., & Dambrova, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-71470-4 · Cited by 52 · see citing works

Mechanisms linking gut microbial metabolites to insulin resistance

Jang, H. R., & Lee, H. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i6.730 · Cited by 52 · see citing works

Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain

Swann, J. R., Spitzer, S. O., & Heijtz, R. D. (2020) · Metabolites · doi:10.3390/metabo10050172 · Cited by 52 · see citing works

Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome

Rong, J., Zhang, Z., Peng, X., Li, P., Zhao, T., & Zhong, Y. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.100394 · Cited by 54 · see citing works

Gut microbiota dependant trimethylamine N-oxide and hypertension

Mutengo, K. H., Masenga, S. K., Mweemba, A., Mutale, W., & Kirabo, A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1075641 · Cited by 52 · see citing works

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

Lee, M. (2021) · Cancer Communications · doi:10.1002/cac2.12200 · Cited by 50 · see citing works

The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review

Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., Dey, A., Babu, A., Renu, K., Vellingiri, B., et al. (2023) · Metabolites · doi:10.3390/metabo13010129 · Cited by 52 · see citing works

A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases

Losol, P., Wolska, M., Wypych, T. P., Yao, L., O’Mahony, L., & Sokołowska, M. (2024) · Clinical and Translational Allergy · doi:10.1002/clt2.12339 · Cited by 49 · see citing works

A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles

Xu, K., Saaoud, F., Shao, Y., Lu, Y., Yang, Q., Jiang, X., Wang, H., & Yang, X. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103331 · Cited by 49 · see citing works

Metabolic phenotyping and cardiovascular disease: an overview of evidence from epidemiological settings

Iliou, A., Mikros, E., Karaman, İ., Elliott, F., Griffin, J. L., Tzoulaki, I., & Elliott, P. (2021) · Heart · doi:10.1136/heartjnl-2019-315615 · Cited by 49 · see citing works

The gut microbiota–brain axis: Role of the gut microbial metabolites of dietary food in obesity

Song, X., Wang, L., Liu, Y., Zhang, X., Weng, P., Liu, L., Zhang, R., & Wu, Z. (2022) · Food Research International · doi:10.1016/j.foodres.2022.110971 · Cited by 56 · see citing works

Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice

Wei, X., Yang, D., Zhang, B., Fan, X., Du, H., Zhu, R., Sun, X., Zhao, M., & Gu, N. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156815 · Cited by 48 · see citing works

Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery

Chung, M. K., Rappaport, S. M., Wheelock, C. E., Nguyen, V. K., van der Meer, T. P., Miller, G. W., Vermeulen, R. C. H., & Patel, C. J. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8327 · Cited by 48 · see citing works

Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis

Budoff, M. J., Otto, M. C. D. O., Li, X. S., Lee, Y., Wang, M., Lai, H. T. M., Lemaître, R. N., Pratt, A., Tang, W. H. W., Psaty, B. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-05903-3 · Cited by 49 · see citing works

Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases

He, S., Jiang, H., Zhuo, C., & Jiang, W. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09656-z · Cited by 45 · see citing works

Trimethylamine N-oxide: a meta-organismal axis linking the gut and fibrosis

Jang, J. W., Capaldi, E., Smith, T. L., Verma, P., Varga, J., & Ho, K. J. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00895-8 · Cited by 47 · see citing works

Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites

Wang, D., Liu, J. Y., Zhou, L., Zhang, Q., Li, M., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.905171 · Cited by 46 · see citing works

Drug Discovery and Development of Novel Therapeutics for Inhibiting TMAO in Models of Atherosclerosis and Diabetes

Steinke, I., Ghanei, N., Govindarajulu, M., Yoo, S., Zhong, J., & Amin, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567899 · Cited by 42 · see citing works

Protecting thermodynamic stability of protein: The basic paradigm against stress and unfolded protein response by osmolytes

Sharma, G. S., Krishna, S., Khan, S., Dar, T. A., Khan, K. A., & Singh, L. R. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.102 · Cited by 43 · see citing works

Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy

Dong, F., Jiang, S., Tang, C., Wang, X., Ren, X., Wei, Q., Tian, J., Hu, W., Guo, J. Z., Fu, X., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.010 · Cited by 44 · see citing works

Inhibition of Trimethylamine N-Oxide Attenuates Neointimal Formation Through Reduction of Inflammasome and Oxidative Stress in a Mouse Model of Carotid Artery Ligation

Chen, C., Leu, H., Wang, S., Tsai, S., Chou, R., Lu, Y., Tsai, Y., Kuo, C., Huang, P., Chen, J., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0115 · Cited by 41 · see citing works

The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction

Li, Z.-H., Jiang, Y., Long, C., Peng, Q., & Yue, R. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14077 · Cited by 41 · see citing works

Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway

Luo, Z., Yu, X., Wang, C., Zhao, H., Wang, X., & Guan, X. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00984-y · Cited by 41 · see citing works

The Gut Microbiota-Related Antihyperglycemic Effect of Metformin

Szymczak-Pajor, I., Drzewoski, J., Kozłowska, M., Krekora, J., & Śliwińska, A. (2025) · Pharmaceuticals · doi:10.3390/ph18010055 · Cited by 41 · see citing works

The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It’s Not All Bad

Krueger, E. S., Lloyd, T. S., & Tessem, J. S. (2021) · Nutrients · doi:10.3390/nu13082873 · Cited by 40 · see citing works

VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

Li, T., Zhao, H., Gaofeng, G., Xia, S., & Wang, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112209 · Cited by 41 · see citing works

Melatonin relieves hepatic lipid dysmetabolism caused by aging via modifying the secondary bile acid pattern of gut microbes

Wei, D., Li, Y., Che, M., Li, C., Wu, Q., & Sun, C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04412-0 · Cited by 40 · see citing works

A novel therapeutic concern: Antibiotic resistance genes in common chronic diseases

Pan, X., Zhou, Z., Liu, B., & Wu, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1037389 · Cited by 40 · see citing works

Abstract 14071: Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction

Boini, K. M., Singh, A. S. C., & Koka, S. S. (2021) · Circulation · doi:10.1161/circ.144.suppl_1.14071 · Cited by 8 · see citing works

PERK specific inhibitor AMG-44 protects against Trimethylamine N-oxide (TMAO)-induced Endoplasmic Reticular Stress and Endothelial Dysfunction

Koka, S., Pasham, S., & Boini, K. M. (2024) · Physiology · doi:10.1152/physiol.2024.39.s1.2075

Trimethylamine N-Oxide: A Dual-function Compound at the Intersection of Gut Microbiota Metabolism and Systemic Disease

Alvi, A. D., Zhao, Y., Iqbal, Z., Abubakar, M., Afzal, M., & Habib, A. (2025) · Journal of Advances in Medical and Pharmaceutical Sciences · doi:10.9734/jamps/2025/v27i11825 · Cited by 1 · see citing works

Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis

Wang, B., Jun, Q., Bingyang, L., Xi, Y., Jianqing, Z., & Jiangfang, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113209 · Cited by 25 · see citing works

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

Saaoud, F., Liu, L., Xu, K., Cueto, R., Shao, Y., Lu, Y., Sun, Y., Snyder, N. W., Wu, S., Yang, L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158183 · Cited by 153 · see citing works