Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation
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Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3-adrenergic receptor (β 3-AR), the adrenergic receptor believed to mediate BAT thermogenesis, have historically performed poorly in human clinical trials. Here we report that, in contrast to rodents, human BAT thermogenesis is not mediated by the stimulation of β 3-AR. Oral administration of the β 3-AR agonist mirabegron only elicited increases in BAT thermogenesis when ingested at the maximal allowable dose. This led to off-target binding to β 1-AR and β 2-AR, thereby increasing cardiovascular responses and white adipose tissue lipolysis, respectively. ADRB2 was co-expressed with UCP1 in human brown adipocytes. Pharmacological stimulation and inhibition of the β 2-AR as well as knockdown of ADRB1, ADRB2, or ADRB3 in human brown adipocytes all confirmed that BAT lipolysis and thermogenesis occur through β 2-AR signaling in humans (ClinicalTrials.govNCT02811289).
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The rise in catecholamines during resistance training should stimulate white adipose tissue lipolysis and activate brown adipose tissue heat production, increasing energy expenditure.
“However, the rise in catecholamines during resistance training [188] should stimulate white adipose tissue lipolysis [183] and activate brown adipose tissue heat production [189], which will increase energy expenditure.”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [189]
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180 · see citing works
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,030 · see citing works
Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985 · see citing works
Self-citationDifferent Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin
Orava, J., Nuutila, P., Lidell, M. E., Oikonen, V., Noponen, T., Viljanen, T., Scheinin, M., Taittonen, M. T., Niemi, T. S., Enerbäck, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.012 · Cited by 729 · see citing works
Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 667 · see citing works
Fat cell adrenergic receptors and the control of white and brown fat cell function
Lafontan, M., & Berlan, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37695-1 · Cited by 636 · see citing works
The selectivity of β‐adrenoceptor agonists at human β1‐, β2‐ and β3‐adrenoceptors
Baker, J. G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00754.x · Cited by 591 · see citing works
Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J. M. A., Mathur, N., Cannon, B., Nedergaard, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.011 · Cited by 539 · see citing works
Self-citationTissue distribution of beta 3-adrenergic receptor mRNA in man
Krief, S., Lönnqvist, F., Raimbault, S., Baude, B., Van Spronsen, A., Arner, P., Strosberg, A. D., Ricquier, D., & Emorine, L. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116191 · Cited by 528 · see citing works
Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis
Wolfe, R. R., & Chinkes, D. L. (2004) · Medical Entomology and Zoology · Cited by 497 · see citing works
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 428 · see citing works
Self-citationChronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
O’Mara, A. E., Johnson, J. W., Linderman, J. D., Brychta, R. J., McGehee, S., Fletcher, L. A., Fink, Y. A., Kapuria, D., Cassimatis, T. M., Kelsey, N., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131126 · Cited by 377 · see citing works
Brown Adipose Tissue Energy Metabolism in Humans
Carpentier, A. C., Blondin, D. P., Virtanen, K. A., Richard, D., Haman, F., & Turcotte, É. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00447 · Cited by 323 · see citing works
Self-citationTakasu, T., Ukai, M., Sato, S., Matsui, T., Nagase, I., Maruyama, T., Sasamata, M., Miyata, K., Uchida, H., & Yamaguchi, O. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115840 · Cited by 312 · see citing works
Cold but not sympathomimetics activates human brown adipose tissue in vivo
Cypess, A. M., Chen, Y., Sze, C., Wang, K., English, J., Chan, O., Holman, A. R., Tal, I., Palmer, M. R., Kolodny, G. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207911109 · Cited by 308 · see citing works
Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
Blondin, D. P., Labbé, S. M., Tingelstad, H. C., Noll, C., Kunach, M., Phoenix, S., Guérin, B., Turcotte, É. E., Carpentier, A. C., Richard, D., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3901 · Cited by 300 · see citing works
Self-citationThe β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
Finlin, B. S., Memetimin, H., Zhu, B., Confides, A. L., Vekaria, H. J., Khouli, R. H. E., Johnson, Z., Westgate, P. M., Chen, J., Morris, A. J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134892 · Cited by 254 · see citing works
Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man
Astrup, A. V., Bülow, J., Madsen, J., & Christensen, N. J. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.5.e507 · Cited by 241 · see citing works
Blondin, D. P., Labbé, S. M., Noll, C., Kunach, M., Phoenix, S., Guérin, B., Turcotte, É. E., Haman, F., Richard, D., & Carpentier, A. C. (2015) · Diabetes · doi:10.2337/db14-1651 · Cited by 219 · see citing works
Self-citationBlondin, D. P., Frisch, F., Phoenix, S., Guérin, B., Turcotte, É. E., Haman, F., Richard, D., & Carpentier, A. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.005 · Cited by 196 · see citing works
Self-citationHuman adipose beiging in response to cold and mirabegron
Finlin, B. S., Memetimin, H., Confides, A. L., Kasza, I., Zhu, B., Vekaria, H. J., Harfmann, B. D., Jones, K. A., Johnson, Z., Westgate, P. M., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121510 · Cited by 194 · see citing works
Ephedrine activates brown adipose tissue in lean but not obese humans
Carey, A. L., Formosa, M. F., van Every, B., Bertovic, D. A., Eikelis, N., Lambert, G. W., Kalff, V., Duffy, S. J., Cherk, M. H., & Kingwell, B. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2748-1 · Cited by 192 · see citing works
Vosselman, M. J., van der Lans, A. A. J. J., Brans, B. T., Wierts, R., van Baak, M. A., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2012) · Diabetes · doi:10.2337/db12-0288 · Cited by 180 · see citing works
Larsen, T. M., Toubro, S., van Baak, M. A., Gottesdiener, K. M., Larson, P., Saris, W. H., & Astrup, A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.780 · Cited by 179 · see citing works
Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus
U-Din, M., Raiko, J. R. H., Saari, T., Kudomi, N., Tolvanen, T., Oikonen, V., Teuho, J., Sipilä, H. T., Savisto, N., Parkkola, R. K., et al. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3364-y · Cited by 170 · see citing works
Multiple lipolysis defects in the insulin resistance (metabolic) syndrome.
Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H., & Arner, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117271 · Cited by 164 · see citing works
Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men
Blondin, D. P., Tingelstad, H. C., Noll, C., Frisch, F., Phoenix, S., Guérin, B., Turcotte, É. E., Richard, D., Haman, F., & Carpentier, A. C. (2017) · Nature Communications · doi:10.1038/ncomms14146 · Cited by 150 · see citing works
Self-citationMalík, M., van Gelderen, E. M., Lee, J. H., Kowalski, D. L., Yen, M., Goldwater, R., MUJAIS, S. K., Schaddelee, M. P., Koning, P. D., Kaibara, A., et al. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.181 · Cited by 148 · see citing works
Baskin, A. S., Linderman, J. D., Brychta, R. J., McGehee, S., Anflick-Chames, E., Cero, C., Johnson, J. W., O’Mara, A. E., Fletcher, L. A., Leitner, B. P., et al. (2018) · Diabetes · doi:10.2337/db18-0462 · Cited by 143 · see citing works
Mirabegron: a review of recent data and its prospects in the management of overactive bladder
Sacco, E., & Bientinesi, R. (2012) · Therapeutic Advances in Urology · doi:10.1177/1756287212457114 · Cited by 138 · see citing works
de Jong, J. M. A., Sun, W., Pires, N. D., Frontini, A., Balaz, M., Jespersen, N. Z., Feizi, A., Petrovic, K., Fischer, A. W., Bokhari, M. H., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0101-4 · Cited by 137 · see citing works
Self-citationJespersen, N. Z., Feizi, A., Andersen, E. S., Heywood, S. E., Hattel, H. B., Daugaard, S., Peijs, L., Bagi, P., Feldt‐Rasmussen, B., Schultz, H. S., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.03.005 · Cited by 126 · see citing works
Self-citationHuman thermogenic adipocyte regulation by the long noncoding RNA LINC00473
Tran, K., Brown, E. L., DeSouza, T., Jespersen, N. Z., Nandrup-Bus, C., Yang, Q., Yang, Z., Desai, A., Min, S. Y., Rojas-Rodriguez, R., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0205-x · Cited by 119 · see citing works
Self-citationChallenges in β 3 -adrenoceptor agonist drug development
Arch, J. R. S. (2011) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018811398517 · Cited by 117 · see citing works
Assessment of Oxidative Metabolism in Brown Fat Using PET Imaging
Muzik, O., Mangner, T. J., & Granneman, J. G. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00015 · Cited by 114 · see citing works
Thermoregulation in the diabetic-obese (db/db) mouse
Trayhurn, P. (1979) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582901 · Cited by 108 · see citing works
BATLAS: Deconvoluting Brown Adipose Tissue.
Perdikari, A., Leparc, G., Baláž, M., Pires, N. D., Lidell, M. E., Sun, W., Fernández-Albert, F., Müller, S., Akchiche, N., Dong, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.044 · Cited by 104 · see citing works
Riis-Vestergaard, M. J., Richelsen, B., Bruun, J. M., Li, W., Hansen, J. B., & Pedersen, S. B. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz298 · Cited by 98 · see citing works
Advances in the understanding of specific metabolic rates of major organs and tissues in humans
Müller, M. J., Wang, Z., Heymsfield, S. B., Schautz, B., & Bosy‐Westphal, A. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328363bdf9 · Cited by 96 · see citing works
Redman, L. M., de Jonge, L., Fang, X., Gamlin, B., Recker, D. P., Greenway, F. L., Smith, S. R., & Ravussin, É. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1740 · Cited by 92 · see citing works
Joris Hoeks, J., van Baak, M. A., Hesselink, M. K. C., Hul, G. B. J., Vidal, H., Saris, W. H. M., & Schrauwen, P. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00175.2003 · Cited by 84 · see citing works
Acute metabolic and cardiovascular effects of mirabegron in healthy individuals
Loh, R. K. C., Formosa, M. F., Gerche, A. L., Reutens, A. T., Kingwell, B. A., & Carey, A. L. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13516 · Cited by 67 · see citing works
Chechi, K., Voisine, P., Mathieu, P., Laplante, M., Bonnet, S., Picard, F., Joubert, P., & Richard, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15501-7 · Cited by 66 · see citing works
Self-citationDeng, C., Paoloni‐Giacobino, A., Kuehne, F., Boss, O., Revelli, J., Moinat, M., Cawthorne, M. A., Muzzin, P., & Giacobino, J. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15488.x · Cited by 64 · see citing works
Preitner, F., Muzzin, P., Revelli, J., Seydoux, J., Galitzky, J., Berlan, M., Lafontan, M., & Giacobino, J. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702007 · Cited by 60 · see citing works
Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men
Lee, P., Day, R. O., Greenfield, J. R., & Ho, K. K. Y. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.90 · Cited by 49 · see citing works
Cold-stimulated sympathetic activity in brown adipose tissue of obese (ob/ob) mice
Zaror‐Behrens, G., & Himms‐Hagen, J. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.4.e361 · Cited by 35 · see citing works
van Gelderen, M., Stölzel, M., Meijer, J., Kerbusch, V., Collins, C., & Korstanje, C. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.952 · Cited by 25 · see citing works
High incidence of chronic hypoparathyroidism secondary to total thyroidectomy.
Jørgensen, C. U., Homøe, P., Dahl, M., & Hitz, M. F. (2020) · PubMed · Cited by 20 · see citing works
Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesityPreprint
Jespersen, N. Z., Andersen, M. W., Hirschberg, V., Stærkær, T. W., Severinsen, M. C. K., Peijs, L., Soares, R., Forss, I., Andersen, E. S., Hahn, C. H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082057 · Cited by 18 · see citing works
Self-citationKudomi, N., Kalliokoski, K. K., Oikonen, V., Han, C., Kemppainen, J., Sipilä, H. T., Knuuti, J. M., & HEINONEN, I. H. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00741 · Cited by 13 · see citing works
Adipogenesis in Primary Cell Culture
Larsen, T. J., Jespersen, N. Z., & Scheele, C. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_142 · Cited by 12 · see citing works
Self-citationLiu, J., Kuipers, E. N., Sips, H. C. M., Dorleijn, J. C., van Dam, A. D., Christodoulides, C., Karpe, F., Zhou, G., Boon, M. R., Rensen, P. C. N., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.08.007 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
The cellular and functional complexity of thermogenic fat
Cohen, P., & Kajimura, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00350-0 · Cited by 553 · see citing works
Reassessing human adipose tissue
Cypess, A. M. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2032804 · Cited by 404 · see citing works
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis
Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 237 · see citing works
Brown Adipose Tissue—A Translational Perspective
Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 202 · see citing works
Self-citationAdipose Tissue and Metabolic Health
An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184 · see citing works
Walczak, K., & Siemińśka, L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189434 · Cited by 182 · see citing works
The evolving view of thermogenic adipocytes — ontogeny, niche and function
Shamsi, F., Wang, C.-H., & Tseng, Y.-H. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00562-6 · Cited by 154 · see citing works
Christoffersen, B. Ø., Sanchez‐Delgado, G., John, L. M., Ryan, D. H., Raun, K., & Ravussin, E. (2022) · Obesity · doi:10.1002/oby.23374 · Cited by 142 · see citing works
“The discovery that adults express significant amounts of BAT that can be recruited by cold exposure or appropriate pharmacological treatments has spurred interest (61).”
BackgroundInfluentialGhesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139 · see citing works
Johansen, O. S., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.037 · Cited by 134 · see citing works
Self-citationβ3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153357 · Cited by 134 · see citing works
Martínez-Sánchez, N., Sweeney, O., Sidarta-Oliveira, D., Caron, A., Stanley, S., & Domingos, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.017 · Cited by 105 · see citing works
Of mice and men: Pinpointing species differences in adipose tissue biology
Börgeson, E., Boucher, J., & Hagberg, C. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1003118 · Cited by 109 · see citing works
Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 109 · see citing works
Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk
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β-Adrenergic Receptors and Adipose Tissue Metabolism: Evolution of an Old Story
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Oeckl, J., Janovská, P., Adamcová, K., Bardová, K., Brunner, S. P., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101499 · Cited by 96 · see citing works
Modelling metabolic diseases and drug response using stem cells and organoids
Hu, W., & Lazar, M. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00733-z · Cited by 98 · see citing works
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Yang, F. T., & Stanford, K. I. (2022) · Current Obesity Reports · doi:10.1007/s13679-021-00465-7 · Cited by 94 · see citing works
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Gaspar, R. C., Pauli, J. R., Shulman, G. I., & Muñoz, V. R. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2020 · Cited by 91 · see citing works
Carpentier, A. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2020 · Cited by 89 · see citing works
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van der Vaart, J. I., Boon, M. R., & Houtkooper, R. H. (2021) · Cells · doi:10.3390/cells10051122 · Cited by 82 · see citing works
Self-citationSøberg, S., Löfgren, J., Philipsen, F. E., Jensen, M., Hansen, A. E., Ahrens, E., Nystrup, K. B., Nielsen, R. D., Sølling, C., Wedell‐Neergaard, A., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100408 · Cited by 67 · see citing works
Self-citationHarney, D., Cielesh, M., Chu, R., Cooke, K. C., James, D. E., Stöckli, J., & Larance, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108804 · Cited by 67 · see citing works
Substrate Utilization by Brown Adipose Tissue: What’s Hot and What’s Not?
McNeill, B. T., Morton, N. M., & Stimson, R. H. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.571659 · Cited by 63 · see citing works
Scheel, A. K., Espelage, L., & Chadt, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094759 · Cited by 64 · see citing works
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP
Rahbani, J. F., Scholtes, C., Lagarde, D., Hussain, M. F., Roesler, A. A., Dykstra, C. B., Bunk, J., Samborska, B., O’Brien, S. L., Tripp, E., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00667-w · Cited by 60 · see citing works
The metabolic and functional roles of sensory nerves in adipose tissues
Mishra, G., & Townsend, K. L. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00868-x · Cited by 57 · see citing works
Thyroid hormones in the regulation of brown adipose tissue thermogenesis
Sentis, S. C., Oelkrug, R., & Mittag, J. (2021) · Endocrine Connections · doi:10.1530/ec-20-0562 · Cited by 60 · see citing works
Lipolysis-Derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation via CD36
Abe, I., Oguri, Y., Verkerke, A. R. P., Monteiro, L. D. B., Knuth, C. M., Auger, C., Qiu, Y., Westcott, G. P., Cinti, S., Shinoda, K., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.11.007 · Cited by 55 · see citing works
Brown adipose tissue involution associated with progressive restriction in progenitor competence
Huang, Z., Zhang, Z.-D., Moazzami, Z., Heck, R., Hu, P., Nanda, H. A., Ren, K., Sun, Z., Bartolomucci, A., Gao, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110575 · Cited by 44 · see citing works
Brown adipose tissue and regulation of human body weight
Harb, E., Kheder, O., Poopalasingam, G., Rashid, R., Srinivasan, A., & Izzi‐Engbeaya, C. N. (2022) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3594 · Cited by 51 · see citing works
McNeill, B. T., Suchacki, K. J., & Stimson, R. H. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1439 · Cited by 52 · see citing works
Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review
Schaik, L. V., Kettle, C., Green, R., Irving, H. R., & Rathner, J. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.621356 · Cited by 48 · see citing works
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works
Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes
Ivanova, Y. M., & Blondin, D. P. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00934.2020 · Cited by 44 · see citing works
Self-citationYing, Z., Tramper, N., Zhou, E., Boon, M. R., Rensen, P. C. N., & Kooijman, S. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac131 · Cited by 43 · see citing works
Self-citationTakeda, Y., & Dai, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-10644-8 · Cited by 43 · see citing works
Jagtap, U. A., & Paul, A. T. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103717 · Cited by 43 · see citing works
Cho, Y., Kim, S., Kim, P.-K., Jo, M. J., Park, S.-E., Choi, Y., Jung, S. M., & Kang, H. J. (2025) · Biomolecules · doi:10.3390/biom15020291 · Cited by 43 · see citing works
Kessler, C. (2021) · Nursing Clinics of North America · doi:10.1016/j.cnur.2021.08.001 · Cited by 43 · see citing works
Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation
Tournissac, M., Leclerc, M., Valentin‐Escalera, J., Vandal, M., Bosoi, C. R., Planel, E., & Calon, F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101462 · Cited by 41 · see citing works
Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue
Straat, M. E., Hoekx, C. A., van Velden, F. H. P., Arias‐Bouda, L. M. P., Dumont, L., Blondin, D. P., Boon, M. R., Martínez‐Téllez, B., & Rensen, P. C. N. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100942 · Cited by 41 · see citing works
Self-citationRoles of estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes
Lizcano, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921504 · Cited by 45 · see citing works
Nutritional Regulation of Human Brown Adipose Tissue
Suchacki, K. J., & Stimson, R. H. (2021) · Nutrients · doi:10.3390/nu13061748 · Cited by 40 · see citing works
The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?
Hostrup, M., & Onslev, J. (2021) · The Journal of Physiology · doi:10.1113/jp281819 · Cited by 40 · see citing works
Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling
Bagchi, R. A., Robinson, E. L., Hu, T., Cao, J., Hong, J. Y., Tharp, C. A., Qasim, H., Gavin, K. M., Silva, J. P. D., Major, J. L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119678119 · Cited by 40 · see citing works
The serotonin transporter sustains human brown adipose tissue thermogenesis
Suchacki, K. J., Ramage, L. E., Kwok, T. C., Kelman, A., McNeill, B. T., Rodney, S., Keegan, M., Gray, C. D., Macnaught, G., Patel, D. K., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00839-2 · Cited by 38 · see citing works
Davies, M., Garcia, S. M., Liu, M., Chi, H. M., Kim, H. T., Raffaı̈, R. L., Liu, X., & Feeley, B. T. (2022) · The American Journal of Sports Medicine · doi:10.1177/03635465221095568 · Cited by 38 · see citing works
Effects of multi-organ crosstalk on the physiology and pathology of adipose tissue
Wang, S., Liu, Y., Chen, J., He, Y., Ma, W., Liu, X., & Sun, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1198984 · Cited by 40 · see citing works
Xiao, F., Jiang, H., Li, Z., Jiang, X., Chen, S., Niu, Y., Yin, H., Shu, Y., Peng, B., Lu, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38141-0 · Cited by 36 · see citing works
Gong, D., Lei, J., He, X., Hao, J., Zhang, F., Huang, X., Gu, W., Yang, X., & Yu, J. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02300-z · Cited by 36 · see citing works
Richard, G. M., Blondin, D. P., Syed, S. A., Rossi, L., Fontes, M. E., Fortin, M., Phoenix, S., Frisch, F., Dubreuil, S., Guérin, B., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100742 · Cited by 36 · see citing works
Self-citationAdipose tissue ageing: implications for metabolic health and lifespan
Wang, G., Song, A., & Wang, Q. A. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01142-8 · Cited by 35 · see citing works
The good and the BAT of metabolic sex differences in thermogenic human adipose tissue
Keuper, M., & Jastroch, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111337 · Cited by 37 · see citing works
Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart
Michel, L. Y. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097745 · Cited by 34 · see citing works
The Heartwarming Effect of Brown Adipose Tissue
Pinckard, K. M., & Stanford, K. I. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000328 · Cited by 33 · see citing works
Shao, M., Zhang, Q., Truong, A., Shan, B., Vishvanath, L., Li, L., Seale, P., & Gupta, R. K. (2021) · Genes & Development · doi:10.1101/gad.348780.121 · Cited by 33 · see citing works
Jia, Z., Wang, Z., Pan, H., Zhang, J., Wang, Q., Zhou, C., & Liu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-02176-w · Cited by 32 · see citing works
Diet Change Improves Obesity and Lipid Deposition in High-Fat Diet-Induced Mice
Ji, T., Fang, B., Wu, F., Liu, Y., Cheng, L., Li, Y., Wang, R., & Zhu, L. (2023) · Nutrients · doi:10.3390/nu15234978 · Cited by 29 · see citing works
Thermogenic adipose tissue in energy regulation and metabolic health
Xue, S., Lee, D. P. H., & Berry, D. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150059 · Cited by 30 · see citing works
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL
Yu, H. C., Jeon, Y. G., Na, A., Han, C. Y., Lee, M. R., Yang, J. D., Yu, H. C., Son, J. B., Kim, N. D., Kim, J. B., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00957-x · Cited by 30 · see citing works
McKie, G. L., Medak, K. D., Shamshoum, H., & Wright, D. C. (2022) · The FASEB Journal · doi:10.1096/fj.202101905rr · Cited by 30 · see citing works
Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess
Luk, C., Haywood, N. J., Bridge, K., & Kearney, M. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882923 · Cited by 29 · see citing works
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases
Poursharifi, P., Madiraju, S. R. M., Oppong, A. K., Kajimura, S., Nolan, C. J., Blondin, D. P., & Prentki, M. (2025) · Physiological Reviews · doi:10.1152/physrev.00024.2024 · Cited by 29 · see citing works
Self-citationUncoupling Protein 1 Does Not Produce Heat without Activation
Li, Y., & Fromme, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052406 · Cited by 29 · see citing works
Kong, Y., Yang, H., Nie, R., Zhang, X., Zhang, H., & Nian, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-02738-6 · Cited by 40 · see citing works
Lévy, S., & Leonard, W. R. (2021) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21930 · Cited by 28 · see citing works
Montastier, É., Ye, R. Z., Noll, C., Bouffard, L., Fortin, M., Frisch, F., Phoenix, S., Guérin, B., Turcotte, É. E., Lewis, G. F., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2020 · Cited by 27 · see citing works
Self-citationCheong, L. Y., & Xu, A. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab038 · Cited by 27 · see citing works
The novel importance of miR-143 in obesity regulation
Liu, J., Wang, H., Zeng, D., Xiong, J., Luo, J., Chen, X., Chen, T., Xi, Q., Sun, J., Ren, X., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01245-6 · Cited by 27 · see citing works
Human brown adipose tissue is not enough to combat cardiometabolic diseases
Carpentier, A. C., & Blondin, D. P. (2023) · Journal of Clinical Investigation · doi:10.1172/jci175288 · Cited by 26 · see citing works
Self-citationβ-Arrestins as Important Regulators of Glucose and Energy Homeostasis
Pydi, S. P., Barella, L. F., Zhu, L., Meister, J., Rossi, M., & Wess, J. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092948 · Cited by 25 · see citing works
The Adipose Tissue Macrophages Central to Adaptive Thermoregulation
Rahman, M. S., & Jun, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884126 · Cited by 26 · see citing works
The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity
Willows, J. W., Blaszkiewicz, M., & Townsend, K. L. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220030 · Cited by 45 · see citing works
Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity
Negroiu, C. E., Tudorașcu, I., Bezna, C. M., Godeanu, S., Diaconu, M., Dănoiu, R., & Dănoiu, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13071973 · Cited by 27 · see citing works
Therapeutic Perspectives of Thermogenic Adipocytes in Obesity and Related Complications
Wang, C., & Wei, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137177 · Cited by 25 · see citing works
Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?
Münzberg, H., Floyd, Z. E., & Chang, J. S. (2021) · Physiology · doi:10.1152/physiol.00038.2020 · Cited by 23 · see citing works
Influences of ovarian hormones on physiological responses to cold in women
Greenfield, A. M., Charkoudian, N., & Alba, B. K. (2021) · Temperature · doi:10.1080/23328940.2021.1953688 · Cited by 25 · see citing works
Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?
Henningsen, J. B., & Scheele, C. C. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032420-042950 · Cited by 24 · see citing works
Self-citationCold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
Khani, S., Topel, H., Kardinal, R., Tavanez, A. R., Josephrajan, A., Larsen, B. D., Gaudry, M. J., Leyendecker, P., Egedal, N. M., Güller, A. S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01033-8 · Cited by 24 · see citing works
The (dys)regulation of energy storage in obesity
Levin, B. E., Geary, N., & Lutz, T. A. (2025) · Physiological Reviews · doi:10.1152/physrev.00002.2024 · Cited by 26 · see citing works
Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
Brandão, B. B., Poojari, A., & Rabiee, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115906 · Cited by 23 · see citing works
Exercise-Induced Adipose Tissue Thermogenesis and Browning: How to Explain the Conflicting Findings?
Zhu, Y., Qi, Z., & Ding, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113142 · Cited by 26 · see citing works
Tarantini, S., Subramanian, M., Butcher, J. T., Yabluchanskiy, A., Li, X., Miller, R. A., & Balasubramanian, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101912 · Cited by 24 · see citing works
Gupta, A., Efthymiou, V., Kodani, S., Shamsi, F., Patti, M., Tseng, Y.-H., & Streets, A. M. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101746 · Cited by 17 · see citing works
Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis
Zhu, H., Xu, H., Zhang, Y., Brodský, J., Gablech, I., Korabečná, M., & Neužil, P. (2024) · Advanced Science · doi:10.1002/advs.202402135 · Cited by 23 · see citing works
Schaik, L. V., Kettle, C., Green, R. A., Sievers, W., Hale, M. W., Irving, H. R., Whelan, D. R., & Rathner, J. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-80505-9 · Cited by 23 · see citing works
Park, J. S., Choi, S. B., Jang, W. S., Kim, J., & Ham, W. S. (2024) · European Urology Focus · doi:10.1016/j.euf.2024.02.002 · Cited by 22 · see citing works
Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
Yoneshiro, T., Matsushita, M., Fuse-Hamaoka, S., Kuroiwa, M., Kurosawa, Y., Yamada, Y., Arai, M., Wei, Y., Iida, M., Kuma, K., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01249-2 · Cited by 22 · see citing works
de Melo, D. G., Anaruma, C. P., Rodrigues, K. C. D. C., Pereira, R. M., de Campos, T. D. P., Canciglieri, R. D. S., Ramos, C. O., Cintra, D. E., Ropelle, E. R., da Silva, A. S. R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10688-w · Cited by 21 · see citing works
Targeting skeletal muscle mitochondrial health in obesity
Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21 · see citing works
Ishida, Y., Matsushita, M., Yoneshiro, T., Saito, M., Fuse, S., Hamaoka, T., Kuroiwa, M., Tanaka, R., Kurosawa, Y., Nishimura, T., et al. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01522-6 · Cited by 21 · see citing works
GPCR in Adipose Tissue Function—Focus on Lipolysis
Malfacini, D., & Pfeifer, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020588 · Cited by 20 · see citing works
Zhu, Y., Liu, W., & Qi, Z. (2023) · The Journal of Physiology · doi:10.1113/jp285269 · Cited by 20 · see citing works
Finlin, B. S., Memetimin, H., Zhu, B., Confides, A. L., Vekaria, H. J., Khouli, R. H. E., Johnson, Z., Westgate, P. M., Chen, J., Morris, A. J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.143650 · Cited by 20 · see citing works
- Authors
- Blondin, D. P., Nielsen, S., Kuipers, E. N., Severinsen, M. C., Jensen, V. H., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., Phoenix, S., Frisch, F., Guérin, B., Turcotte, É. E., Haman, F., Richard, D., Picard, F., Rensen, P. C. N., Scheele, C., & Carpentier, A. C.
- Affiliations
- Université de Sherbrooke (CA)
- Leiden University Medical Center (NL)
- University of Copenhagen (DK)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Centre de recherche du CHUS (CA)
- University of Ottawa (CA)
- Corresponding author
- Scheele, Camilla
- Carpentier, André C.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 32
- Issue
- 2
- Pages
- 287-300.e7
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W3047205014
- Cited by
- 331
- References
- 56
- Citations by year
- 2026: 43 · 2025: 48 · 2024: 57 · 2023: 59 · 2022: 54 · 2021: 61 · 2020: 8
- FWCI
- 27.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Canada
- Danmarks Grundforskningsfond (DNRF55)
- Novo Nordisk Fonden (NNF18CC0034900)
- Diabetes Fonds (2015.81.1808)
- Centre Hospitalier Universitaire de Québec
- Canadian Institutes of Health Research (299962, PJT 159758, PJT 148550)
- Novartis Pharmaceuticals Canada
- HLS Therapeutics
- Eli Lilly and Company
- Københavns Universitet
- Fonds de Recherche du Québec - Santé
- Strategiske Forskningsråd (09-075724, 09-067009)
- Danish Diabetes Academy (PD007-18)
- TrygFonden (101390, 20045)
- ZonMw
- Hartstichting (CVON2017-20, 2009T038)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipocytes, thermogenesis, beta2-adrenergic receptor, cold acclimation
- MeSH terms
- Adolescent, Adult, Animals, Humans, Male, Mice, Inbred C57BL, Middle Aged, Receptors, Adrenergic, beta-2, Thermogenesis, Mice, Adipocytes, Brown, Young Adult
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