The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process
Open accessAbstract
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS has a strong heritable component, but its pathogenesis has been unclear. Here, we performed RNA sequencing and genome-wide DNA methylation profiling of ovarian tissue from control and third-generation PCOS-like mice. We found that DNA hypomethylation regulates key genes associated with PCOS and that several of the differentially methylated genes are also altered in blood samples from women with PCOS compared with healthy controls. Based on this insight, we treated the PCOS mouse model with the methyl group donor S-adenosylmethionine and found that it corrected their transcriptomic, neuroendocrine, and metabolic defects. These findings show that the transmission of PCOS traits to future generations occurs via an altered landscape of DNA methylation and propose methylome markers as a possible diagnostic landmark for the condition, while also identifying potential candidates for epigenetic-based therapy.
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Cited by
Joham, A. E., Norman, R. J., Stener-Victorin, E., Legro, R. S., Franks, S., Moran, L. J., Boyle, J., & Teede, H. J. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00163-2 · Cited by 838
Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics
Singh, S., Pal, N., Shubham, S., Sarma, D. K., Verma, V., Marotta, F., & Kumar, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041454 · Cited by 521
Stener-Victorin, E., Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00511-3 · Cited by 495
Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification
Dapas, M., & Dunaif, A. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac001 · Cited by 300
Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation
Dumesic, D. A., Padmanabhan, V., Chazenbalk, G. D., & Abbott, D. H. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00878-y · Cited by 63
Metadata
- Authors
- Mimouni, N. E. H., Paiva, I., Barbotin, A.-L., Timzoura, F. E., Plassard, D., Le Gras, S., Ternier, G., Pigny, P., Catteau-Jonard, S., Simon, V., Prevot, V., Boutillier, A.-L., & Giacobini, P.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 33
- Issue
- 3
- Pages
- 513-530.e8
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W3126884841
- Cited by
- 253
- References
- 86
- FWCI
- 28.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mimouni, N. E. H., Paiva, I., Barbotin, A.-L., Timzoura, F. E., Plassard, D., Le Gras, S., Ternier, G., Pigny, P., Catteau-Jonard, S., Simon, V., Prevot, V., Boutillier, A.-L., & Giacobini, P. (2021). Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process. Cell Metabolism. https://doi.org/10.1016/j.cmet.2021.01.004
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