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Cited by 293

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease

Open access
Mori, Yutaro, Ajay, Amrendra K., Chang, Jae-Hyung, Mou, Shan, Zhao, Huiping, Kishi, Seiji, Li, Jiahua, Brooks, Craig R., Xiao, Sheng, Woo, Heung-Myong, Sabbisetti, Venkata S., Palmer, Suetonia C., Galichon, Pierre, Li, Li, Henderson, Joel M., Kuchroo, Vijay K., Hawkins, Julie, Ichimura, Takaharu, Bonventre, Joseph V.·2021·Cell Metabolism
DOI 10.1016/j.cmet.2021.04.004
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Abstract

Summary Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease (DKD) and their targeting may be an effective means for prevention. Proximal tubular (PT) expression of kidney injury molecule (KIM)-1, as well as blood and urinary levels, are increased early in human diabetes and can predict the rate of disease progression. Here, we report that KIM-1 mediates PT uptake of palmitic acid (PA)-bound albumin, leading to enhanced tubule injury with DNA damage, PT cell cycle arrest, interstitial inflammation and fibrosis, and secondary glomerulosclerosis. Such injury can be ameliorated by genetic ablation of the KIM-1 mucin domain in a high fat-fed, streptozotocin mouse model of DKD. We also identified TW-37 as a small molecule inhibitor of KIM-1-mediated PA-albumin uptake and showed in vivo in a kidney injury model in mice that it ameliorates renal inflammation and fibrosis. Together, our findings support KIM-1 as a new therapeutic target for DKD.

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Metadata

Authors
Mori, Y., Ajay, A. K., Chang, J.-H., Mou, S., Zhao, H., Kishi, S., Li, J., Brooks, C. R., Xiao, S., Woo, H.-M., Sabbisetti, V. S., Palmer, S. C., Galichon, P., Li, L., Henderson, J. M., Kuchroo, V. K., Hawkins, J., Ichimura, T., & Bonventre, J. V.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2021-05
Volume
33
Issue
5
Pages
1042-1061.e7
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2021.04.004
OpenAlex
W3157114931
Cited by
293
References
88
FWCI
24.00
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. https://app.cochat.ai/papers/10.1016/j.cmet.2021.04.004
The paper
Mori, Y., Ajay, A. K., Chang, J.-H., Mou, S., Zhao, H., Kishi, S., Li, J., Brooks, C. R., Xiao, S., Woo, H.-M., Sabbisetti, V. S., Palmer, S. C., Galichon, P., Li, L., Henderson, J. M., Kuchroo, V. K., Hawkins, J., Ichimura, T., & Bonventre, J. V. (2021). KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metabolism. https://doi.org/10.1016/j.cmet.2021.04.004

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.