Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

Differential expression analysis for sequence count data

Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works

Differential analysis of gene regulation at transcript resolution with RNA-seq

Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492 · see citing works

The accessible chromatin landscape of the human genome

Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works

Transcription factors: from enhancer binding to developmental control

Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227 · see citing works

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

Galas, D. J., & Schmitz, A. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.9.3157 · Cited by 2,109 · see citing works

A general method to improve fluorophores for live-cell and single-molecule microscopy

Grimm, J. B., English, B. P., Chen, J., Slaughter, J. P., Zhang, Z., Revyakin, A. G., Patel, R. H., Macklin, J. J., Normanno, D., Singer, R. H., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3256 · Cited by 1,509 · see citing works

Highly inclined thin illumination enables clear single-molecule imaging in cells

Tokunaga, M., Imamoto, N., & Sakata-Sogawa, K. (2008) · Nature Methods · doi:10.1038/nmeth1171 · Cited by 1,449 · see citing works

Transcriptional enhancers: from properties to genome-wide predictions

Shlyueva, D., Stampfel, G., & Stark, A. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3682 · Cited by 1,356 · see citing works

Fuel Metabolism in Starvation

Cahill, G. F. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111258 · Cited by 1,318 · see citing works

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

Altarejos, J. Y., & Montminy, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3072 · Cited by 1,035 · see citing works

Latent Enhancers Activated by Stimulation in Differentiated Cells

Ostuni, R., Piccolo, V., Barozzi, I., Polletti, S., Termanini, A., Bonifacio, S., Curina, A., Prosperini, E., Ghisletti, S., & Natoli, G. (2013) · Cell · doi:10.1016/j.cell.2012.12.018 · Cited by 867 · see citing works

The glucocorticoid receptor: rapid exchange with regulatory sites in living cells

McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802 · see citing works

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

Chen, J., Zhang, Z., Li, L., Chen, B.-C., Revyakin, A., Hajj, B., Legant, W., Dahan, M., Lionnet, T., Betzig, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.062 · Cited by 602 · see citing works

Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

Hesselberth, J. R., Chen, X., Zhang, Z., Sabo, P. J., Sandstrom, R., Reynolds, A. P., Thurman, R. E., Neph, S., Kuehn, M. S., Noble, W. S., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1313 · Cited by 559 · see citing works

Dynamic regulation of transcriptional states by chromatin and transcription factors

Voss, T. C., & Hager, G. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3623 · Cited by 504 · see citing works

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

Biddie, S. C., John, S., Sabo, P. J., Thurman, R. E., Johnson, T. A., Schiltz, R. L., Miranda, T. B., Sung, M.-H., Trump, S., Lightman, S. L., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.016 · Cited by 503 · see citing works

RU486 (MIFEPRISTONE): Mechanisms of Action and Clinical Uses

Cadepond, F., Ulmann, A., & Baulieu, E. E. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.129 · Cited by 424 · see citing works

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

Sherwood, R. I., Hashimoto, T., O'Donnell, C. W., Lewis, S., Barkal, A. A., van Hoff, J. P., Karun, V., Jaakkola, T., & Gifford, D. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2798 · Cited by 416 · see citing works

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

Stavreva, D. A., Wiench, M., John, S., Conway-Campbell, B. L., McKenna, M. A., Pooley, J. R., Johnson, T. A., Voss, T. C., Lightman, S. L., & Hager, G. L. (2009) · Nature Cell Biology · doi:10.1038/ncb1922 · Cited by 375 · see citing works

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Izeddin, I., Récamier, V., Bosanac, L., Cissé, I. I., Boudarène, L., Dugast‐Darzacq, C., Proux, F., Bénichou, O., Voituriez, R., Bensaude, O., et al. (2014) · eLife · doi:10.7554/elife.02230 · Cited by 338 · see citing works

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

Nie, Y., Erion, D. M., Yuan, Z., Dietrich, M. O., Shulman, G. I., Horváth, T. L., & Gao, Q. (2009) · Nature Cell Biology · doi:10.1038/ncb1857 · Cited by 331 · see citing works

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

Swinstead, E. E., Miranda, T. B., Paakinaho, V., Baek, S., Goldstein, I., Hawkins, M., Karpova, T. S., Ball, D., Mazza, D., Lavis, L. D., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.067 · Cited by 312 · see citing works

Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism

Voss, T. C., Schiltz, R. L., Sung, M.-H., Yen, P. M., Stamatoyannopoulos, J. A., Biddie, S. C., Johnson, T. A., Miranda, T. B., John, S., & Hager, G. L. (2011) · Cell · doi:10.1016/j.cell.2011.07.006 · Cited by 307 · see citing works

Peroxisome Proliferator-Activated Receptor γ and C/EBPα Synergistically Activate Key Metabolic Adipocyte Genes by Assisted Loading

Madsen, M. S., Siersbæk, R., Boergesen, M., Nielsen, R., & Mandrup, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01344-13 · Cited by 272 · see citing works

Bursty Gene Expression in the Intact Mammalian Liver

Halpern, K. B., Tanami, S., Landen, S., Chapal, M., Szlak, L., Hutzler, A., Nizhberg, A., & Itzkovitz, S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.027 · Cited by 248 · see citing works

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor α in Mouse Liver Reveals Extensive Sharing of Binding Sites

Boergesen, M., Pedersen, T. Å., Gross, B. S., van Heeringen, S. J., Hagenbeek, D., Bindesbøll, C., Caron, S., Lalloyer, F., Steffensen, K. R., Nebb, H. I., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06175-11 · Cited by 237 · see citing works

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.

Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J. H., & Wahli, W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31420-5 · Cited by 233 · see citing works

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

Grøntved, L., John, S., Baek, S., Liu, Y., Buckley, J. R., Vinson, C., Aguilera, G., & Hager, G. L. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.106 · Cited by 229 · see citing works

A hyper‐dynamic equilibrium between promoter‐bound and nucleoplasmic dimers controls NF‐κB‐dependent gene activity

Bosisio, D., Marazzi, I., Agresti, A., Shimizu, N., Bianchi, M. E., & Natoli, G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600977 · Cited by 201 · see citing works

Enhancers and silencers: an integrated and simple model for their function

Kolovos, P., Knoch, T., Grosveld, F. G., Cook, P. R., & Papantonis, A. (2012) · Epigenetics & Chromatin · doi:10.1186/1756-8935-5-1 · Cited by 173 · see citing works

Single molecule analysis of transcription factor binding at transcription sites in live cells

Morisaki, T., Müller, W., Golob, N., Mazza, D., & McNally, J. (2014) · Nature Communications · doi:10.1038/ncomms5456 · Cited by 167 · see citing works

DNase Footprint Signatures Are Dictated by Factor Dynamics and DNA Sequence

Sung, M., Guertin, M. J., Baek, S., & Hager, G. L. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.016 · Cited by 158 · see citing works

Analysis of computational footprinting methods for DNase sequencing experiments

Gusmao, E. G., Allhoff, M., Zenke, M., & Costa, I. G. (2016) · Nature Methods · doi:10.1038/nmeth.3772 · Cited by 152 · see citing works

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

Steineger, H. H., Sørensen, H. N., Tugwood, J. D., Skrede, S., Spydevold, Ø. S., & Gautvik, K. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.0967b.x · Cited by 145 · see citing works

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

Grøntved, L., Waterfall, J. J., Kim, D. W., Baek, S., Sung, M., Zhao, L., Park, J. W., Nielsen, R., Walker, R. L., Zhu, Y. J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8048 · Cited by 137 · see citing works

Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level

Miranda, T. B., Voss, T. C., Sung, M.-H., Baek, S., John, S., Hawkins, M., Grøntved, L., Schiltz, R. L., & Hager, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0742 · Cited by 130 · see citing works

Mouse functional genomics requires standardization of mouse handling and housing conditions

Champy, M., Selloum, M., Piard, L., Zeitler, V., Caradec, C., Chambon, P., & Auwerx, J. H. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2393-1 · Cited by 119 · see citing works

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

Soccio, R. E., Chen, E. R., Rajapurkar, S. R., Safabakhsh, P., Marinis, J. M., Dispirito, J. R., Emmett, M. J., Briggs, E. R., Fang, B., Everett, L. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.025 · Cited by 117 · see citing works

Transcriptional and Chromatin Regulation during Fasting – The Genomic Era

Goldstein, I., & Hager, G. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.005 · Cited by 110 · see citing works

Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent

Sharp, Z. D., Mancini, M. G., Hinojos, C. A., Dai, F., Berno, V., Szafran, A. T., Smith, K. P., Lele, T. T., Ingber, D. E., & Mancini, M. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03161 · Cited by 103 · see citing works

Quantifying transcription factor kinetics: At work or at play?

Mueller, F., Stasevich, T. J., Mazza, D., & McNally, J. G. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.833891 · Cited by 96 · see citing works

Review article: Regulation of glucose production with special attention to nonclassical regulatory mechanisms: A review

Corssmit, E. P. M., Romijn, J. A., & Sauerwein, H. P. (2001) · Metabolism · doi:10.1053/meta.2001.24195 · Cited by 87 · see citing works

Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading

Zhu, B., Gates, L. A., Stashi, E., Dasgupta, S., Gonzales, N., Dean, A., Dacso, C. C., York, B., & O’Malley, B. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.024 · Cited by 75 · see citing works

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

Goldstein, I., Yizhak, K., Madar, S., Goldfinger, N., Ruppin, E., & Rotter, V. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-9 · Cited by 74 · see citing works

Genome-wide footprinting: ready for prime time?

Sung, M., Baek, S., & Hager, G. L. (2016) · Nature Methods · doi:10.1038/nmeth.3766 · Cited by 69 · see citing works

Quantitative Analysis of Genome-Wide Chromatin Remodeling

Baek, S., Sung, M., & Hager, G. L. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-477-3_26 · Cited by 32 · see citing works

Rapid genome-scale mapping of chromatin accessibility in tissue

Grøntved, L., Bandle, R., John, S., Baek, S., Chung, H., Liu, Y., Aguilera, G., Oberholtzer, J. C., Hager, G. L., & Levens, D. (2012) · Epigenetics & Chromatin · doi:10.1186/1756-8935-5-10 · Cited by 31 · see citing works

Abstract 5130: Prostate circulating tumor cells metastasize to bone via E-selectin expressed on endothelial cells.

Gakhar, G., YuLee, G., Seandel, M., Bander, N. H., & Nanus, D. M. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-5130 · Cited by 16 · see citing works

Identification of transcription factor binding sites using ATAC-seq

Li, Z., Schulz, M. H., Look, T., Begemann, M., Zenke, M., & Costa, I. G. (2019) · Genome biology · doi:10.1186/s13059-019-1642-2 · Cited by 436 · see citing works

Protocol for Primary Mouse Hepatocyte Isolation

Charni‐Natan, M., & Goldstein, I. (2020) · STAR Protocols · doi:10.1016/j.xpro.2020.100086 · Cited by 431 · see citing works

scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles

Jin, S., Zhang, L., & Nie, Q. H. (2020) · Genome biology · doi:10.1186/s13059-020-1932-8 · Cited by 174 · see citing works

Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application

Chen, Y., Liang, R., Li, Y., Jiang, L., Ma, D., Luo, Q., & Song, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02030-9 · Cited by 174 · see citing works

Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

Kinouchi, K., Magnan, C., Ceglia, N., Liu, Y., Cervantes, M., Pastore, N., Huynh, T., Ballabio, A., Baldi, P., Masri, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.077 · Cited by 130 · see citing works

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

Whirledge, S., & DeFranco, D. B. (2017) · Endocrinology · doi:10.1210/en.2017-00728 · Cited by 126 · see citing works

Hepatic transcriptional responses to fasting and feeding

Bideyan, L., Nagari, R., & Tontonoz, P. (2021) · Genes & Development · doi:10.1101/gad.348340.121 · Cited by 126 · see citing works

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.

Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Aicher, D., Gopalsamy, I. K., Fong, W., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.015 · Cited by 122 · see citing works

Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model

Garcia, D. A., Fettweis, G., Presman, D. M., Paakinaho, V., Jarzynski, C., Upadhyaya, A., & Hager, G. L. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab072 · Cited by 118 · see citing works

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Quagliarini, F., Mir, A. A., Balázs, K., Wierer, M., Dyar, K. A., Jouffe, C., Makris, K., Hawe, J. S., Heinig, M., Filipp, F. V., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.007 · Cited by 117 · see citing works

Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity

Baek, S., Goldstein, I., & Hager, G. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.003 · Cited by 105 · see citing works

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Xiong, L., Wu, F., Wu, Q., Xu, L., Cheung, O. K.-W., Kang, W., Mok, M. T. S., Szeto, L. L. M., Lun, C.-Y., Lung, R. W. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08245-z · Cited by 105 · see citing works

Quantifying transcription factor binding dynamics at the single-molecule level in live cells

Presman, D. M., Ball, D. A., Paakinaho, V., Grimm, J. B., Lavis, L. D., Karpova, T., & Hager, G. L. (2017) · Methods · doi:10.1016/j.ymeth.2017.03.014 · Cited by 102 · see citing works

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Goldstein, I., Paakinaho, V., Baek, S., Sung, M.-H., & Hager, G. L. (2017) · Nature Communications · doi:10.1038/s41467-017-02055-5 · Cited by 97 · see citing works

Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting

Ruppert, P. M. M., & Kersten, S. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.002 · Cited by 97 · see citing works

The impact of fasting on adipose tissue metabolism

Kersten, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159262 · Cited by 86 · see citing works

Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation

Packer, J. S., & Trapnell, C. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.06.001 · Cited by 84 · see citing works

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Loft, A., Schmidt, S. F., Caratti, G., Stifel, U., Havelund, J., Sekar, R., Kwon, Y., Sulaj, A., Chow, K. K., Alfaro, A. J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.004 · Cited by 76 · see citing works

Endocrine disruptors of sex hormone activities

Varticovski, L., Stavreva, D. A., McGowan, A., Raziuddin, R., & Hager, G. L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111415 · Cited by 75 · see citing works

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

Sommars, M. A., Ramachandran, K., Senagolage, M. D., Futtner, C. R., Germain, D. M., Allred, A. L., Omura, Y., Bederman, I. R., & Barish, G. D. (2019) · eLife · doi:10.7554/elife.43922 · Cited by 66 · see citing works

Transcription Factor Dynamics: One Molecule at a Time

Wagh, K., Stavreva, D. A., Upadhyaya, A., & Hager, G. L. (2023) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-022823-013847 · Cited by 66 · see citing works

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalviša, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stöhr, O., Vettorazzi, S., Tuckermann, J. P., White, M. F., Mandrup, S., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006249 · Cited by 64 · see citing works

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

Hunter, L., Pelekanou, C. E., Barron, N. J., Northeast, R. C., Grudzien, M., Adamson, A. D., Downton, P. J., Cornfield, T., Cunningham, P. S., Billaud, J.-N., et al. (2021) · eLife · doi:10.7554/elife.63324 · Cited by 63 · see citing works

Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes

Aatsinki, S., Elkhwanky, M., Kummu, O., Karpale, M., Buler, M., Viitala, P., Rinne, V. M., Mutikainen, M., Tavi, P., Frankó, A., et al. (2019) · Diabetes · doi:10.2337/db18-1050 · Cited by 61 · see citing works

Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles

Li, K., Qiu, C., Sun, P. G., Liu, D.-C., Wu, T., Wang, K., Zhou, Y., Chang, X.-A., Yin, Y., Chen, F., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.035 · Cited by 57 · see citing works

Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism

Hunter, A. L., Pelekanou, C. E., Adamson, A., Downton, P., Barron, N. J., Cornfield, T., Poolman, T. M., Humphreys, N., Cunningham, P. S., Hodson, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005330117 · Cited by 54 · see citing works

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting

Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 54 · see citing works

Identification of Transcription Factor Binding Sites using ATAC-seqPreprint

Li, Z., Schulz, M. H., Zenke, M., & Costa, I. G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/362863 · Cited by 53 · see citing works

HNF4A modulates glucocorticoid action in the liver

Hunter, A. L., Poolman, T. M., Kim, D., Gonzalez, F. J., Bechtold, D. A., Loudon, A. S. I., Iqbal, M., & Ray, D. W. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110697 · Cited by 49 · see citing works

Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis

Qi, Q., Li, C., Tang, X., He, Y., Li, Y., Yee, T., Shrestha, D., Feng, R., Xu, P., Zhou, X., et al. (2020) · Blood · doi:10.1182/blood.2020005780 · Cited by 44 · see citing works

Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor

Cohen, D. M., & Steger, D. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.04.001 · Cited by 45 · see citing works

Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism

Præstholm, S. M., Correia, C. M., & Grøntved, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572981 · Cited by 44 · see citing works

Structures and consequences of pioneer factor binding to nucleosomes

Luzete-Monteiro, E., & Zaret, K. S. (2022) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2022.102425 · Cited by 44 · see citing works

Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

Zhao, Y., Li, S., Chen, Y., Wang, Y., Wei, Y., Zhou, T., Zhang, Y., Yang, Y., Chen, L., Liu, Y., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.007 · Cited by 39 · see citing works

Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis

Korenfeld, N., Finkel, M., Buchshtab, N., Bar‐Shimon, M., Charni‐Natan, M., & Goldstein, I. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.04.017 · Cited by 37 · see citing works

Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

Xiao, Y., Kim, M., & Lazar, M. A. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101119 · Cited by 38 · see citing works

The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic

Goldstein, I., & Hager, G. L. (2017) · Endocrinology · doi:10.1210/en.2017-00521 · Cited by 32 · see citing works

Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle

Bengtsen, M., Winje, I. M., Eftestøl, E., Landskron, J., Sun, C., Nygård, K., Domańska, D., Millay, D. P., Meza‐Zepeda, L. A., & Gundersen, K. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009907 · Cited by 26 · see citing works

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Wortham, M., Liu, F., Harrington, A. R., Fleischman, J. Y., Wallace, M., Mulas, F., Mallick, M., Vinckier, N. K., Cross, B. R., Chiou, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci165208 · Cited by 27 · see citing works

Dynamic enhancer function in the chromatin context

Goldstein, I., & Hager, G. L. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1390 · Cited by 25 · see citing works

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids

Caratti, G., Desgeorges, T., Juban, G., Stifel, U., Fessard, A., Koenen, M., Caratti, B., Théret, M., Skurk, C., Chazaud, B., et al. (2022) · EMBO Reports · doi:10.15252/embr.202255363 · Cited by 23 · see citing works

Gut microbiota—a positive contributor in the process of intermittent fasting-mediated obesity control

Rong, B., Wu, Q., Saeed, M., & Sun, C. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.09.009 · Cited by 24 · see citing works

Chromatin reprogramming in breast cancer

Swinstead, E. E., Paakinaho, V., & Hager, G. L. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0033 · Cited by 23 · see citing works

Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver disease

Antwi, M. B., Jennings, A., Lefere, S., Clarisse, D., Geerts, A. M., Devisscher, L., & Bosscher, K. D. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00013-6 · Cited by 22 · see citing works

Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer

Helminen, L., Huttunen, J., Tulonen, M., Aaltonen, N., Niskanen, E. A., Palvimo, J. J., & Paakinaho, V. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1126 · Cited by 22 · see citing works

Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle

Fan, L., Sweet, D. R., Fan, E., Prosdocimo, D. A., Madera, A., Jiang, Z., Padmanabhan, R., Haldar, S. M., Vinayachandran, V., & Jain, M. K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101926 · Cited by 21 · see citing works

An integrative transcriptional logic model of hepatic insulin resistance

Kitamoto, T., Kuo, T., Okabe, A., Kaneda, A., & Accili, D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102222118 · Cited by 21 · see citing works

Nuclear receptors and liver disease: summary of the 2017 basic research symposium

Tran, M., Liu, Y., Huang, W., & Wang, L. (2018) · Hepatology Communications · doi:10.1002/hep4.1203 · Cited by 20 · see citing works

Hormone-controlled cooperative binding of transcription factors drives synergistic induction of fasting-regulated genes

Goldberg, D. T., Charni‐Natan, M., Buchshtab, N., Bar‐Shimon, M., & Goldstein, I. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac358 · Cited by 20 · see citing works

How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids

Strickland, B. A., Ansari, S. A., Dantoft, W., & Uhlenhaut, N. H. (2022) · FEBS Letters · doi:10.1002/1873-3468.14409 · Cited by 21 · see citing works

Targeting nuclear receptors for NASH/MASH: From bench to bedside

Sinha, R. A. (2024) · Liver Research · doi:10.1016/j.livres.2024.03.002 · Cited by 18 · see citing works

PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα

Lin, Y., Chen, L., You, X., Li, Z., Li, C., & Chen, Y. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101331 · Cited by 19 · see citing works

Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk

Hiltunen, J., Helminen, L., & Paakinaho, V. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1437179 · Cited by 18 · see citing works

Transcriptome Responses to Dexamethasone Depending on Dose and Glucocorticoid Receptor Sensitivity in the Liver

Muráni, E., Trakooljul, N., Hadlich, F., Ponsuksili, S., & Wimmers, K. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00559 · Cited by 18 · see citing works

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

Wang, J., Wen, Y., Zhao, W., Zhang, Y. T., Lin, F., Ouyang, C., Wang, H., Yao, L., Ma, H., Zhuo, Y., et al. (2023) · eLife · doi:10.7554/elife.87419.3 · Cited by 17 · see citing works

EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor

Quagliarini, F., Makris, K., Friano, M. E., & Uhlenhaut, N. H. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad048 · Cited by 18 · see citing works

Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis

Liu, B., Mao, X., Huang, D., Li, F. Y., & Dong, N. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s206558 · Cited by 16 · see citing works

Transcriptional Regulation of Hepatic Autophagy by Nuclear Receptors

Kim, E. Y., & Lee, J. M. (2022) · Cells · doi:10.3390/cells11040620 · Cited by 16 · see citing works

Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma

Jinesh, G. G., Napoli, M., Ackerman, H. D., Raulji, P., Montey, N., Flores, E. R., & Brohl, A. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-69179-5 · Cited by 15 · see citing works

Hepatic Peroxisome Proliferator-Activated Receptor Alpha Dysfunction in Porcine Septic Shock

Vandewalle, J., Garcia, B., Timmermans, S., Vanderhaeghen, T., Wyngene, L. V., Eggermont, M., Dufoor, H., Dender, C. V., Halimi, F., Croubels, S., et al. (2022) · Cells · doi:10.3390/cells11244080 · Cited by 12 · see citing works

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

Wang, J., Wen, Y., Zhao, W., Zhang, Y. T., Lin, F., Ouyang, C., Wang, H., Yao, L., Ma, H., Zhuo, Y., et al. (2023) · eLife · doi:10.7554/elife.87419 · Cited by 10 · see citing works

Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting

Huang, S. S. Y., Makhlouf, M., AbouMoussa, E. H., Segura, M. L. R. T., Mathew, L. S., Wang, K., Leung, M. C., Chaussabel, D., Logan, D. W., Scialdone, A., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101038 · Cited by 11 · see citing works

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression

Mostafa, M., Necker‐Brown, A., Gao, A., Thorne, A. J., Bansal, A., Swift, L. H., Maj, A. M., Sasse, S. K., Colarusso, P., Gerber, A. N., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114206 · Cited by 10 · see citing works

Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies

Sen, D., Maniyadath, B., Chowdhury, S., Kaur, A., Khatri, S., Chakraborty, A., Mehendale, N., Nadagouda, S., Sandra, U. S., Kamat, S. S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107128 · Cited by 10 · see citing works

Genomic annotation of disease-associated variants reveals shared functional contexts

Kyono, Y., Kitzman, J. O., & Parker, S. C. J. (2019) · Diabetologia · doi:10.1007/s00125-019-4823-3 · Cited by 10 · see citing works

Preoperative Fasting and General Anaesthesia Alter the Plasma Proteome

Gyllensten, U. B., Enroth, S. B., Stålberg, K., Sundfeldt, K., & Enroth, S. (2020) · Cancers · doi:10.3390/cancers12092439 · Cited by 10 · see citing works

Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

Hunter, L., & Ray, D. W. (2019) · Biology · doi:10.3390/biology8040079 · Cited by 9 · see citing works

Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis

Korenfeld, N., Charni‐Natan, M., Bruse, J., Goldberg, D. T., Marciano-Anaki, D., Rotaro, D., Gorbonos, T., Radushkevitz-Frishman, T., Polizzi, A., Nasereddin, A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1161 · Cited by 9 · see citing works

Dynamic chromatin accessibility during nutritional iron overload reveals a BMP6-independent induction of cell cycle genes

Radushkevitz-Frishman, T., Charni‐Natan, M., & Goldstein, I. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109407 · Cited by 9 · see citing works

Gut microbiota and transcriptome dynamics in every-other-day fasting are associated with neuroprotection in rats with spinal cord injury

Wang, J., Zhao, X., Zhou, R.-H., Wang, M., Xiang, W., You, Z., Li, M., Tang, R., Zheng, J., Li, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1206909 · Cited by 9 · see citing works

Activation of Crtc2/Creb1 in skeletal muscle enhances weight loss during intermittent fasting

Bruno, N. E., Nwachukwu, J. C., Hughes, D. C., Srinivasan, S., Hawkins, R., Sturgill, D., Hager, G. L., Hurst, S., Sheu, S., Bodine, S. C., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100171r · Cited by 10 · see citing works

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

Goldberg, D. T., Buchshtab, N., Charni‐Natan, M., & Goldstein, I. (2024) · Liver International · doi:10.1111/liv.16077 · Cited by 7 · see citing works

Mechanisms for DNA Interplay in Eukaryotic Transcription Factors

Muñoz, V., Goluguri, R. R., Ghosh, C., Tanielian, B., & Sadqi, M. (2025) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-071524-111008 · Cited by 6 · see citing works

Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice

Sato, N., Sudo, K., Mori, M., Imai, C., Muramatsu, M., & Sugimoto, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10380-4 · Cited by 6 · see citing works

Intermittent Fasting and Probiotics: Synergistic Modulation of Gut Health for Therapeutic Advantages

Shehbaz, A., Afzaal, M., Akram, N., Saeed, F., Khan, W., Ahmed, F., Ahmed, A., Asghar, A., & Faisal, Z. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10358-5 · Cited by 6 · see citing works

Liver gene regulatory networks: Contributing factors to nonalcoholic fatty liver disease

Cebola, I. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1480 · Cited by 5 · see citing works

p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting

Reinisch, I., Klymiuk, I., Michenthaler, H., Moyschewitz, E., Galhuber, M., Krstić, J., Domingo, M., Zhang, F., Karbiener, M., Vujić, N., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.913030 · Cited by 6 · see citing works

Circadian Rhythm and Nuclear Receptors

Ray, D. W. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_8 · Cited by 6 · see citing works

Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming

Sun, G., Zhao, C., Han, J., Wu, S., Chen, Y., Yao, J., & Li, L. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01011-y · Cited by 5 · see citing works

Hierarchical regulation of autophagy during adipocyte differentiation

Ahmed, M., Lai, T. H., Pham, T. M., Zada, S., Elashkar, O., Hwang, J. S., & Kim, D. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0250865 · Cited by 5 · see citing works

LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot

Korenfeld, N., Gorbonos, T., Florian, M. C. R., Rotaro, D., Goldberg, D. T., Radushkevitz-Frishman, T., Charni‐Natan, M., Bar‐Shimon, M., Cummins, C. L., & Goldstein, I. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002735 · Cited by 5 · see citing works

Effects of stocking density on growth and glucose metabolism in rainbow trout (Oncorhynchus mykiss)

Li, Z., Feng, Z., Luo, S., Wang, Y., Xu, Y., Dong, K., Hou, Z.-S., Gao, Q., & Dong, S. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743413 · Cited by 4 · see citing works

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling

Régnier, M., Polizzi, A., Fougeray, T., Fougerat, A., Perrier, P., Anderson, K. E., Lippi, Y., Smati, S., Lukowicz, C., Lasserre, F., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003112 · Cited by 4 · see citing works

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity

Gegenhuber, B., Sonoda, T., Traunmüller, L., Davis, C. P., Koren, S. A., Griffith, E. C., Chen, C., & Greenberg, M. E. (2026) · Nature · doi:10.1038/s41586-026-10512-9 · Cited by 4 · see citing works

Unraveling the mysteries of hepatic insulin signaling: deconvoluting the nuclear targets of insulin

Kitamoto, T., & Accili, D. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej23-0150 · Cited by 4 · see citing works

Intermittent fasting shifts the diurnal transcriptome atlas of transcription factors

Fu, M., Lu, S., Gong, L., Zhou, Y., Wei, F., Duan, Z., Xiang, R., Gonzalez, F. J., & Li, G. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04928-y · Cited by 4 · see citing works

Chromatin Regulation and Transcription Factor Cooperation in Liver Cells

Goldstein, I. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch81 · Cited by 4 · see citing works

Genomic Crosstalk Between Nuclear Receptors in Hormone-dependent Cancers

Campbell, M. J. (2025) · Endocrinology · doi:10.1210/endocr/bqaf149 · Cited by 3 · see citing works

Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences

Goldberg, D. T., & Goldstein, I. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01228-3 · Cited by 7 · see citing works

Exploring recent insights on intermittent fasting in regulating glucocorticoid levels and diet-induced metabolic disorders with focus on MAFLD and hepatic outcomes

Elechi, J. O. G., de Mendonça, C. R., Bandeira, V. C. D. A., da Silva, M. S. P., de Melo, A. P. R., Guedes, R. C. A., Hirabara, S. M., Cione, E., & de Vasconcelos, D. A. A. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112736 · Cited by 4 · see citing works

LncRNA Ctcflos modulates glucocorticoid receptor-mediated induction of hepatic phosphoenolpyruvate carboxykinase in mice

Yoon, J.-Y., Kim, J., Kim, H., Ka, N., Lee, S.-H., & Lee, M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121254 · Cited by 3 · see citing works

ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion

Tan, W. X., Lim, L. Y., Afsha, N., Chan, G. M. E., Ching, C., Oguz, G., Neo, S. P., Ali, S. M., Ramasamy, A., Gunaratne, J., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae568 · Cited by 3 · see citing works

Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility dataPreprint

Luo, K., Zhong, J., Safi, A., Hong, L. K., Tewari, A. K., Song, L., Reddy, T. E., Ma, L., Crawford, G. E., & Hartemink, A. J. (2022) · Genome Research · doi:10.1101/gr.272203.120 · Cited by 3 · see citing works

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesPreprint

Gallage, S., Ali, A., Avila, J. E. B., Seymen, N., Ramadori, P., Joerke, V., Zizmare, L., Kosla, J., Li, X., Focaccia, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.562885 · Cited by 3 · see citing works

Activation-derepression synergy enables a bHLH network to coordinate a signal-specific fate response

Nandagopal, N., Terrio, A., Vicente, F. P., Megason, S. G., Jambhekar, A., & Lahav, G. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115077 · Cited by 2 · see citing works

Starvation

Weissman, C., & Hashem, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-39781-4_5 · Cited by 2 · see citing works

Pparα and fatty acid oxidation coordinate hepatic transcriptional architecturePreprint

Cavagnini, K. S., & Wolfgang, M. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.12.451949 · Cited by 2 · see citing works

Decoding the pituitary gonadotrope regulatory architecture governing the preovulatory surge in vivoPreprint

Ciclé, C. L., Garrel, G., Chauvin, S., Giton, F., Taboureau, O., Miralles, F., Cohen-Tannoudji, J., & L’Hôte, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.18.689023 · Cited by 2 · see citing works

Reversible and causal epigenetic information loss in liver aging and disease

Shtark, R. B., Sagy, N., Korenfeld, N., Gal, M., Goldstein, I., & Bar, D. Z. (2026) · PNAS Nexus · doi:10.1093/pnasnexus/pgag109 · Cited by 1 · see citing works

Population Genomics of Giant Mice from the Faroe Islands: Hybridization, Colonization, and a Novel Challenge to Identifying Genomic Targets of Selection

Payseur, B. A., Jing, P., Howell, E. K., Frayer, M. E., Jones, E. P., Magnussen, E., Jensen, J., Chan, Y. F., & Searle, J. B. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf141 · Cited by 1 · see citing works

Transcriptional and Chromatin Regulation during Fasting – The Genomic Era

Goldstein, I., & Hager, G. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.005 · Cited by 110 · see citing works

Liver X receptors participate in the fasting response by assisting CEBPB binding to enhancers and promoting the fasting transcriptional programPreprint

Gorbonos, T., Florian, M. C. R., Shalev, H., Korenfeld, N., Sahin, C., Shawky, S. A., Goldberg, D. T., Radushkevitz-Frishman, T., Anosov-Babi, M., Yan, A., et al. (2026) · Genome Research · doi:10.1101/gr.282119.126

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

Goldberg, D. T., Buchshtab, N., Charni‐Natan, M., & Goldstein, I. (2024) · Liver International · doi:10.1111/liv.16077 · Cited by 7 · see citing works

OR33-05 Glucocorticoids Instigate Transcriptional Waves To Maintain Temporally Organized Fuel Production During Fasting

Goldberg, D. T., & Goldstein, I. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad114.1773

OR07-3 Hormone-Controlled Cooperative Binding of Transcription Factors Within Enhancer Clusters Drives Synergistic Induction of Fasting-Regulated Genes

Charni‐Natan, M., Goldberg, D. T., & Goldstein, I. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac150.1490