The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
The hallmarks of cancer metabolism: Still emerging
Open accessAbstract
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the metabolic resources within the local tissue are finite, this can lead to nutrient depletion and accumulation of metabolic waste. To maintain growth in these conditions, cancer cells employ a variety of metabolic adaptations, the nature of which is collectively determined by the physiology of their cell of origin, the identity of transforming lesions, and the tissue in which cancer cells reside. Furthermore, select metabolites not only serve as substrates for energy and biomass generation, but can also regulate gene and protein expression and influence the behavior of non-transformed cells in the tumor vicinity. As they grow and metastasize, tumors can also affect and be affected by the nutrient distribution within the body. In this hallmark update, recent advances are incorporated into a conceptual framework that may help guide further research efforts in exploring cancer cell metabolism.
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“In other words, cancer cells primarily use glucose, fatty acids, and amino acids to meet their biosynthetic needs [49–52].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [50]
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“While glycolysis is less efficient than oxidative phosphorylation (OXPHOS) in generating ATP per molecule of glucose, the switch to glycolysis enables maintained bioenergetic flux during oxygen deprivation, and generates glycolytic intermediates that can be diverted into biosynthetic processes such as the pentose phosphate pathway (PPP) for nucleotide biosynthesis or fatty acid and amino acid”
From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [39]
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“Both hallmarks exhibit clear commonalities, but there are also some differences or even antagonisms between aging-associated deregulated nutrient sensing and cancer-associated deregulation of cellular energy metabolism.[204][205][206]”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [204]
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“However, several chemical intermediates of the TCA cycle also serve as critical precursors for biosynthetic reactions, which we will discuss in detail later (5, 6).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [6]
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Cites
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Self-citationFerroptosis: mechanisms, biology and role in disease
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The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Self-citationTGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
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Tumors: Wounds That Do Not Heal
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Metabolic regulation of gene expression by histone lactylation
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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Cited by
Sorted by citations
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535
“However, several chemical intermediates of the TCA cycle also serve as critical precursors for biosynthetic reactions, which we will discuss in detail later (5, 6).”
BackgroundMethodDrug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443
“101 In the past decade, only a few metabolism-based cancer drugs have been successfully developed, some of which are in or nearing clinical trials.”
BackgroundRegulatory mechanisms of one-carbon metabolism enzymes
Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105457 · Cited by 103
Metabolic reprogramming: a bridge between aging and tumorigenesis
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The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation
Acuña-Pilarte, K., & Koh, M. Y. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.06.005 · Cited by 64
Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27
Li, Z., Fan, K., Suo, C., Gu, X., Zhu, C., Wei, H., Chen, L., Gao, P., & Sun, L. (2025) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaf001 · Cited by 13
Prehabilitation- Do We Need Metabolic Flexibility
Tetlow, N., & Whittle, J. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000545266 · Cited by 6
Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2
Metadata
- Authors
- Pavlova, N. N., Zhu, J., & Thompson, C. B.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Center for Life Sciences (CN)
- Corresponding author
- Thompson, Craig B.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 34
- Issue
- 3
- Pages
- 355-377
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC8891094
- OpenAlex
- W4220798004
- Cited by
- 1,418
- References
- 216
- Citations by year
- 2026: 314 · 2025: 392 · 2024: 386 · 2023: 241 · 2022: 85
- FWCI
- 33.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P30 CA008748, R01 CA248355-01)
- Agios Pharmaceuticals
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, cancer hallmarks, tumor cell proliferation, biomass production, nutrient depletion, metabolic waste accumulation, metabolic adaptation, tumor microenvironment, metastasis
- MeSH terms
- Nutrients, Energy Metabolism, Humans, Neoplasms
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