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Cited by 194

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Memory T cell homeostasis and senescence during aging

Akbar, Arne N, Fletcher, Jean M·2005·Current Opinion in Immunology
DOI 10.1016/j.coi.2005.07.019
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Abstract

Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in elderly subjects, a pertinent point in view of increasing human life expectancy. An emerging consensus is that cytomegalovirus (CMV), a beta-herpesvirus with a prevalence of 60-90% worldwide, is an agent that induces specific T cells to extreme differentiation. The question that begs to be answered is whether this can explain why CMV seropositivity and the presence of highly differentiated CMV-specific T cells are included in a cluster of immune parameters that have been shown recently to predict the early mortality of elderly humans.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.coi.2005.07.019

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

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Verification

Claims the paper makes

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Claims other papers make about this one

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Citations

Cites

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Cited by

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Metadata

Authors
Akbar, A. N., & Fletcher, J. M.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2005-10
Volume
17
Issue
5
Pages
480-485
ISSN
0952-7915
DOI
10.1016/j.coi.2005.07.019
Cited by
194
References
44
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

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This page
CoChat. (2026). Citation check: Memory T cell homeostasis and senescence during aging. https://app.cochat.ai/papers/10.1016/j.coi.2005.07.019
The paper
Akbar, A. N., & Fletcher, J. M. (2005). Memory T cell homeostasis and senescence during aging. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2005.07.019

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.