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Cited by 474T-cell and B-cell ImmunologyCytomegalovirus and herpesvirus researchHIV Research and Treatment

Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study

Olsson, Jadwiga, Wikby, Anders, Johansson, Boo, Löfgren, Sture, Nilsson, Bengt-Olof, Ferguson, Frederick G.·2001·Mechanisms of Ageing and Development
DOI 10.1016/s0047-6374(00)00210-4
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Abstract

Results from the previous times (Times 1-3) of the Swedish longitudinal OCTO immune study indicated that a combination of high CD8 and low CD4 percentages and poor T-cell proliferation in PBL was associated with a higher 2-year mortality in a sample of very old Swedish individuals. The combination of immune parameters was closely related to an inverted CD4/CD8 ratio. In the present study at Time 4 (T4) results are reported from the final follow-up of this longitudinal study, 8 years after it was initiated in 1989. An additional goal at this time point was to examine the immune system alterations in the very old in relation to evidence of lymphocyte activation and cytomegalovirus antibody status. In the present study immune system changes were identified that suggest a loss of T-cell homeostasis, as reflected by a decrease in the number of CD4 cells and a very significant increase in the number of CD8 cells in individuals with an inverted CD4/CD8 ratio. When considered over the duration of the OCTO study the inversion occurred in a high percentage (32%) of the individuals included in the original sample and was associated with non-survival. At T4 the changes were apparent in a number of the T-cell subsets, but particularly in the CD8+CD28-and CD57+ subsets. T-cell activation was significantly associated with the inversion of the CD4/CD8 ratio. In this very old sample the subset alterations were associated with evidence of cytomegalovirus (CMV) infection.

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  • These immunosenescence changes are largely driven by infection with Cytomegalovirus.

    “These changes are largely driven by infection with Cytomegalovirus, which has been directly linked with increased inflammatory activity, poor responses to vaccination, frailty, accelerated cognitive decline, and early mortality.”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Olsson et al. 2000

  • Infection with CMV was also clustered into the IRP.

    “In addition, infection with CMV was also clustered into the IRP (Olsson et al. 2000) and together, these characteristics predicted greater all-cause mortality at 2-, 4- and 6-year follow up.”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Olsson et al. 2000

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Authors
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G.
Affiliations
  • Ryhov Hospital Jönköping (SE)
  • Jönköping University (SE)
  • Pennsylvania State University (US)
Corresponding author
Ferguson, Frederick G.
ORCID
Johansson, Boo
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2001-01
Volume
121
Issue
1-3
Pages
187-201
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/s0047-6374(00)00210-4
OpenAlex
W2071843907
Cited by
474
References
45
Citations by year
2026: 8 · 2025: 11 · 2024: 13 · 2023: 18 · 2022: 17 · 2021: 20 · 2020: 22 · 2019: 32 · 2018: 19 · 2017: 26 · 2016: 28 · 2015: 23 · 2014: 25 · 2013: 26 · 2012: 18
FWCI
4.10
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
T cell subsets, cytomegalovirus infection, oldest old, T cell homeostasis, CD8+CD28- T cells, CD57+ T cells, T cell activation, peripheral blood lymphocytes, mortality, aging immune system
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Antibodies, Viral, Cytomegalovirus Infections, Cytomegalovirus, HLA-DR Antigens, Humans, Immunoglobulin G, Immune System, Longitudinal Studies, Middle Aged, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, CD4-CD8 Ratio, CD28 Antigens, CD8-Positive T-Lymphocytes, CD57 Antigens

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