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Memory T cell homeostasis and senescence during aging
Abstract
Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in elderly subjects, a pertinent point in view of increasing human life expectancy. An emerging consensus is that cytomegalovirus (CMV), a beta-herpesvirus with a prevalence of 60-90% worldwide, is an agent that induces specific T cells to extreme differentiation. The question that begs to be answered is whether this can explain why CMV seropositivity and the presence of highly differentiated CMV-specific T cells are included in a cluster of immune parameters that have been shown recently to predict the early mortality of elderly humans.
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“Adaptive immune function declines: B cells display reduced antibody diversity, and T cells develop a more restricted T cell receptor repertoire, impaired effector cell function and skewed memory to effector cell ratio [195][196][197] .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [196]
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Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,571
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,181
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.609 · Cited by 760
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Geginat, J., Lanzavecchia, A., & Sallusto, F. (2003) · Blood · doi:10.1182/blood-2002-11-3577 · Cited by 601
Dyskeratosis congenita in all its forms
Dokal, I. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02109.x · Cited by 575
Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D., & Hale, L. P. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.529 · Cited by 502
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Gillespie, G. M. A., Wills, M. R., Appay, V., O'Callaghan, C., Murphy, M., Smith, N., Sissons, P., Rowland-Jones, S., Bell, J. I., & Moss, P. A. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8140-8150.2000 · Cited by 420
Wikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407
Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler-Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck-Loebenstein, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3675-3683.2005 · Cited by 357
Khan, N., Hislop, A., Gudgeon, N., Cobbold, M., Khanna, R., Nayak, L., Rickinson, A. B., & Moss, P. A. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7481 · Cited by 351
Hodes, R. J., Hathcock, K. S., & Weng, N.-P. (2002) · Nature Reviews Immunology · doi:10.1038/nri890 · Cited by 309
Mechanism of Telomerase Induction during T Cell Activation
Bodnar, A. G., Kim, N. W., Effros, R. B., & Chiu, C.-P. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0299 · Cited by 285
Is immunosenescence infectious?
Pawelec, G., Akbar, A., Caruso, C., Effros, R., Grubeck-Loebenstein, B., & Wikby, A. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.05.006 · Cited by 260
Self-citationValenzuela, H. (2002) · Clinical Immunology · doi:10.1006/clim.2002.5271 · Cited by 253
Ouyang, Q., Wagner, W. M., Voehringer, D., Wikby, A., Klatt, T., Walter, S., Müller, C. A., Pircher, H., & Pawelec, G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00134-7 · Cited by 245
Messaoudi, I., LeMaoult, J., Guevara-Patino, J. A., Metzner, B. M., & Nikolich‐Žugich, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040437 · Cited by 243
Amyes, E., Hatton, C., Montamat‐Sicotte, D., Gudgeon, N. H., Rickinson, A. B., McMichael, A. J., & Callan, M. F. C. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022058 · Cited by 225
Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged
Berger, R., Florent, G., & Just, M. (1981) · Infection and Immunity · doi:10.1128/iai.32.1.24-27.1981 · Cited by 217
Wills, M. R., Okecha, G., Weekes, M. P., Gandhi, M. K., Sissons, P., & Carmichael, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5455 · Cited by 208
Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans
Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 203
Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly
Ouyang, Q., Wagner, W. M., Zheng, W., Wikby, A., Remarque, E. J., & Pawelec, G. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.016 · Cited by 179
Faint, J. M., Annels, N. E., Curnow, S. J., Shields, P., Pilling, D., Hislop, A. D., Wu, L., Akbar, A. N., Buckley, C. D., Moss, P. A. H., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.212 · Cited by 171
Self-citationDunne, P. J., Faint, J. M., Gudgeon, N. H., Fletcher, J. M., Plunkett, F. J., Soares, M. V. D., Hislop, A. D., Annels, N. E., Rickinson, A. B., Salmon, M., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0160 · Cited by 144
Self-citationWill telomere erosion lead to a loss of T-cell memory?
Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135
Self-citationIFN-α and IFN-β: a link between immune memory and chronic inflammation
Akbar, A. N., Lord, J. M., & Salmon, M. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01652-2 · Cited by 135
Self-citationHuman CD28−CD8+ T Cells Contain Greatly Expanded Functional Virus-Specific Memory CTL Clones
Weekes, M. P., Carmichael, A., Wills, M. R., Mynard, K., & Sissons, J. G. P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7569 · Cited by 134
McVoy, M. A., & Adler, S. P. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/160.1.1 · Cited by 118
Direct measurement of T cell subset kinetics in vivo in elderly men and women
Wallace, D. L., Zhang, Y., Ghattas, H., Worth, A., Irvine, A., Bennett, A. R., Griffin, G. E., Beverley, P. C. L., Tough, D. F., & Macallan, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1787 · Cited by 115
Changing Patterns of Dominant TCR Usage with Maturation of an EBV-Specific Cytotoxic T Cell Response
Annels, N. E., Callan, M. F. C., Tan, L., & Rickinson, A. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4831 · Cited by 114
Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., & Beverley, P. C. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4521 · Cited by 110
Self-citationPervasive Influence of Hepatitis C Virus on the Phenotype of Antiviral CD8+ T Cells
Lucas, M., Cuero, A. L. V., Lauer, G. M., Barnes, E. J., Willberg, C. B., Semmo, N., Walker, B. D., Phillips, R., & Klenerman, P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1744 · Cited by 99
Tuberculosis in the Geriatric Patient
Nagami, P., & Yoshikawa, T. T. (1983) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1983.tb05747.x · Cited by 84
Plunkett, F. J., Franzese, O., Belaramani, L. L., Fletcher, J. M., Gilmour, K. C., Sharifi, R., Khan, N., Hislop, A. D., Cara, A., Salmon, M., et al. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.006 · Cited by 74
Self-citationCD8+ T‐cell clones in old mice
Ku, C., Kotzin, B. L., Kappler, J. W., & Marrack, P. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01034.x · Cited by 55
Dunne, P. J. (2005) · Blood · doi:10.1182/blood-2004-11-4469 · Cited by 53
Griffiths, P. D., Feinberg, J., Fry, J., Sabin, C. A., Dix, L. P., Gor, D., Ansari, A., & Emery, V. C. (1998) · The Journal of Infectious Diseases · doi:10.1086/513806 · Cited by 42
Jansen, C. A., Piriou, E., Bronke, C., Vingerhoed, J., Kostense, S., van Baarle, D., & Miedema, F. F. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.08.002 · Cited by 28
Maczek, C., Berger, T. G., Schuler‐Thurner, B., Schultz, E. S., Hamann, A., Dunbar, P. R., Cerundolo, V., Steinkasserer, A., & Schuler, G. (2005) · International Journal of Cancer · doi:10.1002/ijc.20901 · Cited by 19
Seroepidemiologic evidence of Epstein-Barr virus reactivation in a veterans' nursing home
Scott, B., Powers, D., Johnson, J., & MORLEY, J. (1994) · Serodiagnosis and Immunotherapy in Infectious Disease · doi:10.1016/0888-0786(94)90052-3 · Cited by 7
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Aw, D., Silva, A. B., & Palmer, D. B. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02555.x · Cited by 880
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Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Akbar, A. N., & Henson, S. M. (2011) · Nature Reviews Immunology · doi:10.1038/nri2959 · Cited by 474
Self-citationAgeing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436
Metadata
- Authors
- Akbar, A. N., & Fletcher, J. M.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 17
- Issue
- 5
- Pages
- 480-485
- ISSN
- 0952-7915
- Cited by
- 194
- References
- 44
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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