The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Memory T cell homeostasis and senescence during aging
Abstract
Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in elderly subjects, a pertinent point in view of increasing human life expectancy. An emerging consensus is that cytomegalovirus (CMV), a beta-herpesvirus with a prevalence of 60-90% worldwide, is an agent that induces specific T cells to extreme differentiation. The question that begs to be answered is whether this can explain why CMV seropositivity and the presence of highly differentiated CMV-specific T cells are included in a cluster of immune parameters that have been shown recently to predict the early mortality of elderly humans.
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“Adaptive immune function declines: B cells display reduced antibody diversity, and T cells develop a more restricted T cell receptor repertoire, impaired effector cell function and skewed memory to effector cell ratio [195][196][197] .”
From Clonal haematopoiesis and dysregulation of the immune system (2023) · cites this paper as [196]
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Metadata
- Authors
- Akbar, A. N., & Fletcher, J. M.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 17
- Issue
- 5
- Pages
- 480-485
- ISSN
- 0952-7915
- Cited by
- 194
- References
- 44
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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