Cited by 244T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model OrganismsImmunotherapy and Immune Responses

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Effects of aging on T cell function

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Haynes, Laura, Maue, Alexander C·2009·Current Opinion in Immunology

DOI 10.1016/j.coi.2009.05.009PMC PMC3800142

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Abstract

Immunosenescence influences many components of the immune system. Most importantly, profound changes in T cell function are evident in older individuals. The impact of aging on specific T cell subsets has been difficult to examine, but recent advances in murine model systems and new insights into T cell function have allowed for the more precise examination of how T cell responses change with aging. Importantly, recent studies have shown that age-related enhancement of both Th17 generation and regulatory T cell function may contribute to significant changes in immune function. In this review, we summarize the current views on how aging influences the factors that impact T cell function and how this can affect the immune response to infections, vaccinations, and tumors.

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Germinal Centers
MacLennan, I. C. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001001 · Cited by 1,795
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Authors: Haynes, L., & Maue, A. C.
Affiliations: Trudeau Institute (US)
SUNY Upstate Medical University (US)
Corresponding author: Haynes, Laura
Maue, Alexander C
ORCID: Haynes, Laura
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2009-08
Volume: 21
Issue: 4
Pages: 414-417
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2009.05.009
PMC: PMC3800142
OpenAlex: W2048088192
Cited by: 244
References: 32
Citations by year: 2026: 2 · 2025: 11 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 2 · 2016: 13 · 2015: 13 · 2014: 23 · 2013: 22 · 2012: 24
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG021600)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: immunosenescence, T cell function, aging, Th17 cells, regulatory T cells, T cell response, infection immunity, vaccination, antitumor immunity
MeSH terms: Aging, Animals, Bacterial Infections, Humans, Immune Tolerance, Neoplasms, Vaccination, Virus Diseases, T-Lymphocyte Subsets, Interleukin-17, T-Lymphocytes, Regulatory, Mice

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